CO5690589A2 - Antagonistas de la hormona concentradora de melanina - Google Patents
Antagonistas de la hormona concentradora de melaninaInfo
- Publication number
- CO5690589A2 CO5690589A2 CO06035263A CO06035263A CO5690589A2 CO 5690589 A2 CO5690589 A2 CO 5690589A2 CO 06035263 A CO06035263 A CO 06035263A CO 06035263 A CO06035263 A CO 06035263A CO 5690589 A2 CO5690589 A2 CO 5690589A2
- Authority
- CO
- Colombia
- Prior art keywords
- independently
- substituted
- unsubstituted
- cyclic
- branched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/79—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1.- Un compuesto que incluye todas las formas enantioméricas y diastereoméricas y las sales farmacéuticamente aceptables de éstas; el compuesto tiene la fórmula: caracterizado porque J es una unidad que contiene por lo menos un anillo de arilo o heteroarilo sustituido o no sustituido;R es una unidad de amino que tiene la fórmula: R1 y R2 cada una se selecciona independientemente de :i) Hidrógeno;ii) -OH;iii) alquilo C1-C8 lineal, ramificado o cíclico, sustituido o no sustituido;iv) alquenilo C2-C8 lineal, ramificado o cíclico, sustituido o no sustituido; y v) R1 y R2 se pueden tomar juntos para formar un anillo heterocíclico o de heteroarilo, sustituido o no sustituido, que tiene de 3 a 5 átomos en el anillo;L y L1 son grupos de enlace cada uno de los cuales tiene independientemente la fórmula: Z, Z1, y Z2 cada uno independientemente es una unidad seleccionada del grupo que comprende:i) -NR5-;ii) -O-;iii) -SO2-;iv) -NR5SO2-; y v) -SO2NR5-;cada uno de los índices j es independientemente 0 ó 1;cada R5 es independientemente:Hidrógeno; o Alquilo C1-C4 Iineal, ramificado o cíclico;...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50777303P | 2003-10-01 | 2003-10-01 | |
| US53664004P | 2004-01-15 | 2004-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5690589A2 true CO5690589A2 (es) | 2006-10-31 |
Family
ID=34426018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO06035263A CO5690589A2 (es) | 2003-10-01 | 2006-04-11 | Antagonistas de la hormona concentradora de melanina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7304065B2 (es) |
| EP (1) | EP1667958A2 (es) |
| JP (1) | JP2007508303A (es) |
| KR (1) | KR20060060047A (es) |
| CN (1) | CN101068773A (es) |
| AR (1) | AR045958A1 (es) |
| AU (1) | AU2004278352B2 (es) |
| BR (1) | BRPI0415051A (es) |
| CA (1) | CA2540826A1 (es) |
| CO (1) | CO5690589A2 (es) |
| IL (1) | IL174370A0 (es) |
| IS (1) | IS8360A (es) |
| MA (1) | MA28079A1 (es) |
| MX (1) | MXPA06003654A (es) |
| NO (1) | NO20061953L (es) |
| PE (1) | PE20050475A1 (es) |
| RU (1) | RU2006110272A (es) |
| SG (1) | SG146692A1 (es) |
| TW (1) | TW200526554A (es) |
| WO (1) | WO2005033063A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008001160A1 (en) * | 2006-06-23 | 2008-01-03 | The Procter & Gamble Company | Melanin concentrating hormone antagonists |
| JP5028484B2 (ja) * | 2006-06-28 | 2012-09-19 | グラクソ グループ リミテッド | Ｇｐｒ３８受容体媒介疾患の治療に有用なピペラジニル誘導体 |
| EP2098509A4 (en) * | 2006-10-06 | 2010-04-07 | Taisho Pharmaceutical Co Ltd | 1-NAPHTHYLALKYLPIPERIDINDERIVATE |
| CA2688662A1 (en) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2307377A1 (en) * | 2008-06-18 | 2011-04-13 | Pfizer Limited | Nicotinamide derivatives |
| AR075402A1 (es) * | 2009-02-13 | 2011-03-30 | Sanofi Aventis | Derivados heterociclicos oxigenados y/o nitrogenados de tetrahidronaftaleno, medicamentos que los contienen y uso de los mismos en el tratamiento de trastornos metabolicos, tales como obesidad,entre otros. |
| UY32442A (es) | 2009-02-13 | 2010-09-30 | Sanofi Aventis | Nuevos indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento |
| CN102781914B (zh) * | 2010-01-06 | 2014-09-17 | 武田药品工业株式会社 | 吲哚衍生物 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206428A (en) * | 1989-11-16 | 1993-04-27 | Tanabe Seiyaku Co., Ltd. | Tetrahydronaphthalene derivatives and preparation thereof |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| WO1994018204A1 (en) * | 1993-02-12 | 1994-08-18 | Merck & Co., Inc. | Spiro (2h-1-benzopyran-2, 4' piperidine) class iii antiarrhythmics |
| WO1994027597A1 (en) * | 1993-05-21 | 1994-12-08 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acid angiotensin ii receptor antagonists |
| WO1995032967A1 (en) | 1994-05-28 | 1995-12-07 | Smithkline Beecham Plc | Amide derivatives having 5ht1d-antagonist activity |
| DE4438029A1 (de) * | 1994-10-25 | 1996-05-02 | Thomae Gmbh Dr K | N.N-disubstituierte Benzocycloalkylamine, ihre Salze mit verträglichen organischen oder anorganischen Säuren, Verfahren zur Herstellung dieser Verbindungen und diese enthaltende Arzneimittel |
| WO1996030333A1 (en) | 1995-03-27 | 1996-10-03 | Smithkline Beecham Plc | Bicyclic amine derivatives and their use as anti-psychotic agents |
| DE19614718A1 (de) * | 1996-04-15 | 1997-10-16 | Hoechst Schering Agrevo Gmbh | Substituierte Pyridine/Pyrimidine, Verfahren zu ihrer Herstellung, und ihre Verwendung als Schädlingsbekämpfungsmittel |
| DE69839305T2 (de) | 1997-02-27 | 2009-04-09 | Takeda Pharmaceutical Co. Ltd. | Aminderivate, ihre herstellung und verwendung als inhibitoren der produktion von amyloid-beta |
| WO2000009480A1 (fr) * | 1998-08-11 | 2000-02-24 | Daiichi Pharmaceutical Co., Ltd. | Nouveaux derives sulfonyle |
| EP1218336A2 (en) | 1999-09-20 | 2002-07-03 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
| CA2407149C (en) * | 2000-04-28 | 2010-10-12 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
| AU2001256733A1 (en) | 2000-05-16 | 2001-11-26 | Takeda Chemical Industries Ltd. | Melanin-concentrating hormone antagonist |
| WO2002051809A1 (en) | 2000-12-22 | 2002-07-04 | Schering Corporation | Piperidine mch antagonists and their use in the treatment of obesity |
| US6900329B2 (en) | 2001-03-21 | 2005-05-31 | Schering Corporation | MCH antagonists and their use in the treatment of obesity |
| CN1582281A (zh) | 2001-10-01 | 2005-02-16 | 大正制药株式会社 | Mch受体拮抗剂 |
| AU2002337956B2 (en) | 2001-10-25 | 2006-02-23 | Schering Corporation | MCH Antagonists for the treatment of obesity |
| EP1448526B1 (en) | 2001-11-26 | 2009-10-21 | Schering Corporation | Piperidine-based mch antagonists for treatment of obesity and cns disorders |
| AU2002352878B2 (en) | 2001-11-27 | 2007-11-22 | Merck Sharp & Dohme Corp. | 2-Aminoquinoline compounds |
| EP1451156A4 (en) | 2001-11-27 | 2005-05-25 | Merck & Co Inc | 4-AMINOQUINOLINE COMPOUNDS |
| DE60228317D1 (de) | 2001-12-04 | 2008-09-25 | Schering Corp | N-aryl-n'-arylcycloalkyl-harnstoff als mch antagonisten zur behandlung von fettleibigkeit |
| DE10238865A1 (de) | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| WO2004037777A1 (en) * | 2002-10-21 | 2004-05-06 | Janssen Pharmaceutica, N.V. | Treating syndrome x with substituted tetralins and indanes |
| EP1631542A1 (en) | 2003-04-10 | 2006-03-08 | Amgen, Inc. | Bicyclic compounds having bradykinin receptors affinity and pharmaceutical compositions thereof |
-
2004
- 2004-09-24 CA CA002540826A patent/CA2540826A1/en not_active Abandoned
- 2004-09-24 CN CNA2004800284489A patent/CN101068773A/zh active Pending
- 2004-09-24 WO PCT/US2004/031631 patent/WO2005033063A2/en not_active Application Discontinuation
- 2004-09-24 MX MXPA06003654A patent/MXPA06003654A/es unknown
- 2004-09-24 BR BRPI0415051-1A patent/BRPI0415051A/pt not_active IP Right Cessation
- 2004-09-24 AU AU2004278352A patent/AU2004278352B2/en not_active Expired - Fee Related
- 2004-09-24 RU RU2006110272/04A patent/RU2006110272A/ru not_active Application Discontinuation
- 2004-09-24 KR KR1020067006228A patent/KR20060060047A/ko not_active Application Discontinuation
- 2004-09-24 SG SG200807343-9A patent/SG146692A1/en unknown
- 2004-09-24 JP JP2006533994A patent/JP2007508303A/ja active Pending
- 2004-09-24 EP EP04789086A patent/EP1667958A2/en not_active Withdrawn
- 2004-09-24 US US10/949,841 patent/US7304065B2/en not_active Expired - Fee Related
- 2004-09-30 AR ARP040103561A patent/AR045958A1/es not_active Application Discontinuation
- 2004-09-30 TW TW093129687A patent/TW200526554A/zh unknown
- 2004-10-01 PE PE2004000964A patent/PE20050475A1/es not_active Application Discontinuation
-
2006
- 2006-03-16 IL IL174370A patent/IL174370A0/en unknown
- 2006-03-17 IS IS8360A patent/IS8360A/is unknown
- 2006-03-31 MA MA28903A patent/MA28079A1/fr unknown
- 2006-04-11 CO CO06035263A patent/CO5690589A2/es not_active Application Discontinuation
- 2006-05-02 NO NO20061953A patent/NO20061953L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1667958A2 (en) | 2006-06-14 |
| IL174370A0 (en) | 2006-08-01 |
| AU2004278352B2 (en) | 2008-10-30 |
| US20050075324A1 (en) | 2005-04-07 |
| TW200526554A (en) | 2005-08-16 |
| CN101068773A (zh) | 2007-11-07 |
| IS8360A (is) | 2006-03-17 |
| JP2007508303A (ja) | 2007-04-05 |
| US7304065B2 (en) | 2007-12-04 |
| KR20060060047A (ko) | 2006-06-02 |
| MA28079A1 (fr) | 2006-08-01 |
| RU2006110272A (ru) | 2007-11-10 |
| BRPI0415051A (pt) | 2006-11-28 |
| WO2005033063A2 (en) | 2005-04-14 |
| PE20050475A1 (es) | 2005-10-05 |
| AU2004278352A1 (en) | 2005-04-14 |
| CA2540826A1 (en) | 2005-04-14 |
| NO20061953L (no) | 2006-06-13 |
| MXPA06003654A (es) | 2006-06-05 |
| WO2005033063A3 (en) | 2007-03-22 |
| SG146692A1 (en) | 2008-10-30 |
| AR045958A1 (es) | 2005-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |