AR039001A1 - 1,2-dihidropirazol-3-onas que controlan citoquinas inflamatorias - Google Patents
1,2-dihidropirazol-3-onas que controlan citoquinas inflamatoriasInfo
- Publication number
- AR039001A1 AR039001A1 ARP030100936A ARP030100936A AR039001A1 AR 039001 A1 AR039001 A1 AR 039001A1 AR P030100936 A ARP030100936 A AR P030100936A AR P030100936 A ARP030100936 A AR P030100936A AR 039001 A1 AR039001 A1 AR 039001A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- branched
- linear
- Prior art date
Links
- 230000002757 inflammatory effect Effects 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Un compuesto, incluyendo todas las formas enantioméricas y diastereoméricas o sales farmacéuticamente aceptables de éste, el compuesto antes mencionado tiene la fórmula (1): en donde R es: a) -O[CH2]nR4; o b) -NR5aR5b; R4 es alquilo C1-10 sustituido o no sustituido, lineal, ramificado, o cíclico; arilo sustituido o no sustituido; heterocíclico sustituido o no sustituido; o heteroarilo sustituido o no sustituido; el índice n es de 0 a 5; R5a y R5b cada uno independientemente son: a) hidrógeno; o b) -[C(R6aR6b)]mR7; cada R6a y R6b independientemente es: hidrógeno; -OR8; -N(R8)2; -CO2R8; -CON(R8)2; alquilo C1-4 sustituido o no sustituido, lineal, ramificado, o cíclico; y mezclas de éstos; R7 es hidrógeno; alquilo C1-6 sustituido o no sustituido, lineal, ramificado, o cíclico; heterocíclico sustituido o no sustituido; arilo sustituido o no sustituido; heteroarilo sustituido o no sustituido; -OR8; -N(R8)2; -CO2R8; y -CON(R8)2; R8 es hidrógeno, un catión soluble en agua, alquilo C1-4, o arilo sustituido o no sustituido, m es de 0 a 5; R1 es fenilo sustituido; cada unidad R2 y R3 independientemente se selecciona del grupo que consiste de: a) hidrógeno; y b) hidrocarbilo C1-10 sustituido o no sustituido que se selecciona del grupo que consiste de: alquilo C1-10 lineal, ramificado o cíclico; arilo C6-10; heterocíclico C1-10; heteroarilo C1-10.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36570102P | 2002-03-19 | 2002-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039001A1 true AR039001A1 (es) | 2005-02-02 |
Family
ID=28454704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100936A AR039001A1 (es) | 2002-03-19 | 2003-03-18 | 1,2-dihidropirazol-3-onas que controlan citoquinas inflamatorias |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6677337B2 (es) |
| EP (1) | EP1485167A1 (es) |
| JP (1) | JP2006502093A (es) |
| KR (1) | KR20040093158A (es) |
| CN (1) | CN1642600A (es) |
| AR (1) | AR039001A1 (es) |
| AU (1) | AU2003220216A1 (es) |
| BR (1) | BR0308579A (es) |
| CA (1) | CA2477091A1 (es) |
| CO (1) | CO5611175A2 (es) |
| IL (1) | IL163712A0 (es) |
| MA (1) | MA27784A1 (es) |
| MX (1) | MXPA04009088A (es) |
| MY (1) | MY134226A (es) |
| NO (1) | NO20044413L (es) |
| NZ (1) | NZ534869A (es) |
| PE (1) | PE20040160A1 (es) |
| PL (1) | PL372882A1 (es) |
| RU (1) | RU2004130843A (es) |
| TW (1) | TW200306182A (es) |
| WO (1) | WO2003080184A1 (es) |
| ZA (1) | ZA200407135B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
| EP1542680B1 (en) * | 2002-09-09 | 2007-03-07 | Amgen Inc. | 1, 4, 5-substituted 1, 2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivatives as tnf-alpha and interleukin lowering agents for the treatment of inflammations |
| US7482356B2 (en) * | 2003-11-10 | 2009-01-27 | The Procter & Gamble Company | Bicyclic pyrazolone cytokine inhibitors |
| CA2587427A1 (en) * | 2004-11-17 | 2006-05-26 | Miikana Therapeutics, Inc. | Kinase inhibitors |
| AU2006279794B2 (en) | 2005-08-12 | 2011-04-07 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate HSP90 activity |
| NZ567241A (en) * | 2005-09-30 | 2010-08-27 | Miikana Therapeutics Inc | Substituted pyrazole compounds |
| JP2010529193A (ja) * | 2007-06-11 | 2010-08-26 | ミイカナ セラピューティクス インコーポレイテッド | 置換ピラゾール化合物 |
| WO2018192793A1 (en) | 2017-04-20 | 2018-10-25 | Basf Se | Substituted rhodanine derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4663327A (en) * | 1984-05-23 | 1987-05-05 | Bayer Aktiengesellschaft | 1-heteroaryl-4-aryl-pyrazolin-5-ones |
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| AU2002228783A1 (en) * | 2000-12-05 | 2002-06-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| CA2446864C (en) * | 2001-05-16 | 2011-02-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of src and other protein kinases |
| US6566357B1 (en) * | 2001-09-20 | 2003-05-20 | The Procter & Gamble Co. | Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
-
2003
- 2003-03-05 US US10/382,060 patent/US6677337B2/en not_active Expired - Fee Related
- 2003-03-12 CN CNA038062003A patent/CN1642600A/zh active Pending
- 2003-03-12 EP EP03716512A patent/EP1485167A1/en not_active Withdrawn
- 2003-03-12 BR BR0308579-1A patent/BR0308579A/pt not_active IP Right Cessation
- 2003-03-12 AU AU2003220216A patent/AU2003220216A1/en not_active Abandoned
- 2003-03-12 NZ NZ534869A patent/NZ534869A/en unknown
- 2003-03-12 CA CA002477091A patent/CA2477091A1/en not_active Abandoned
- 2003-03-12 RU RU2004130843/04A patent/RU2004130843A/ru not_active Application Discontinuation
- 2003-03-12 KR KR10-2004-7014642A patent/KR20040093158A/ko active IP Right Grant
- 2003-03-12 MX MXPA04009088A patent/MXPA04009088A/es unknown
- 2003-03-12 PL PL03372882A patent/PL372882A1/xx not_active Application Discontinuation
- 2003-03-12 IL IL16371203A patent/IL163712A0/xx unknown
- 2003-03-12 JP JP2003578007A patent/JP2006502093A/ja active Pending
- 2003-03-12 WO PCT/US2003/007635 patent/WO2003080184A1/en active Application Filing
- 2003-03-14 TW TW092105683A patent/TW200306182A/zh unknown
- 2003-03-14 PE PE2003000262A patent/PE20040160A1/es not_active Application Discontinuation
- 2003-03-18 MY MYPI20030939A patent/MY134226A/en unknown
- 2003-03-18 AR ARP030100936A patent/AR039001A1/es not_active Application Discontinuation
-
2004
- 2004-09-07 ZA ZA200407135A patent/ZA200407135B/en unknown
- 2004-09-09 MA MA27850A patent/MA27784A1/fr unknown
- 2004-09-23 CO CO04094890A patent/CO5611175A2/es not_active Application Discontinuation
- 2004-10-18 NO NO20044413A patent/NO20044413L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1485167A1 (en) | 2004-12-15 |
| NZ534869A (en) | 2006-09-29 |
| US20030225082A1 (en) | 2003-12-04 |
| WO2003080184A1 (en) | 2003-10-02 |
| CO5611175A2 (es) | 2006-02-28 |
| AU2003220216A1 (en) | 2003-10-08 |
| IL163712A0 (en) | 2005-12-18 |
| KR20040093158A (ko) | 2004-11-04 |
| RU2004130843A (ru) | 2005-08-27 |
| JP2006502093A (ja) | 2006-01-19 |
| CA2477091A1 (en) | 2003-10-02 |
| CN1642600A (zh) | 2005-07-20 |
| ZA200407135B (en) | 2005-09-21 |
| BR0308579A (pt) | 2005-01-25 |
| US6677337B2 (en) | 2004-01-13 |
| TW200306182A (en) | 2003-11-16 |
| MY134226A (en) | 2007-11-30 |
| PE20040160A1 (es) | 2004-04-30 |
| PL372882A1 (en) | 2005-08-08 |
| NO20044413L (no) | 2004-10-18 |
| MA27784A1 (fr) | 2006-03-01 |
| MXPA04009088A (es) | 2004-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |