CO5580739A2 - Procesado de polvo con fluidos gaseosos presurizados - Google Patents

Procesado de polvo con fluidos gaseosos presurizados

Info

Publication number
CO5580739A2
CO5580739A2 CO04034727A CO04034727A CO5580739A2 CO 5580739 A2 CO5580739 A2 CO 5580739A2 CO 04034727 A CO04034727 A CO 04034727A CO 04034727 A CO04034727 A CO 04034727A CO 5580739 A2 CO5580739 A2 CO 5580739A2
Authority
CO
Colombia
Prior art keywords
solid
semi
carrier material
pressurized gaseous
particles
Prior art date
Application number
CO04034727A
Other languages
English (en)
Inventor
Saim Said
Stephen Horhota
David Joseph Bochniak
Kenneth J Koenig
Original Assignee
Boehringer Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Pharmaceuticals Inc filed Critical Boehringer Pharmaceuticals Inc
Publication of CO5580739A2 publication Critical patent/CO5580739A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

1.- Un método para la precipitación de partículas y para la retención en un material vehículo que comprende las etapas de:(a) (1) disolver un material sólido o semisólido en un fluido gaseoso presurizado, formando con ello una disolución que comprende un disolvente fluido gaseoso y un soluto disuelto del material sólido o semisólido o(a) (2) disolver un material sólido o semisólido en un disolvente líquido, formando con ello una disolución líquida que comprende un disolvente líquido y un soluto disuelto de material sólido o semisólido;(b)(1) precipitar partículas de un material sólido o semisólido desde la disolución de fluido gaseoso producida en la etapa (a)(1) introduciendo la disolución en una región de menor presión o en una región que contiene un gas inerte o(b)(2) precipitar partículas del material sólido o semisólido desde la disolución líquida producida en la etapa (a)(2) introduciendo la disolución bien en: (1) una región que contiene un fluido gaseoso presurizado en el que dicho disolvente liquido es sustancialmente soluble pero dicho material sólido o semisólido es sustancialmente insoluble, o bien en (2): una región en la que se introduce posteriormente dicho fluido gaseoso presurizado para provocar la solubilización del disolvente líquido dentro del fluido gaseoso presurizado y la precipitación de las partículas del material sólido o semisólido;(c) dirigir la disolución introducida y las partículas precipitadas resultantes producidas en la etapa (b)(1) ó (b)(2) sobre o dentro de un lecho mixto de material vehículo; y(d) retener y dispersar en el material vehículo al menos parte de las partículas precipitadas para producir una mezcla de las partículas de material sólido o semisólido y de material vehículo, una granulación de las partículas de material sólido o semisólido con el material vehículo parcial o totalmente recubierto con las partículas de material sólido o semisólido, o mezclas de ellos;y en el que el material vehículo del lecho mixto se mantiene en un estado mixto al menos durante las etapas (c) y (d).2.- Un método de acuerdo con la reivindicación 1, en el que las partículas precipitadas de material sólido o semisólido comprenden micropartículas o nanopartículas de material sólido o semisólido, o mezclas de ellas.
CO04034727A 2001-10-10 2004-04-15 Procesado de polvo con fluidos gaseosos presurizados CO5580739A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32830101P 2001-10-10 2001-10-10

Publications (1)

Publication Number Publication Date
CO5580739A2 true CO5580739A2 (es) 2005-11-30

Family

ID=23280401

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04034727A CO5580739A2 (es) 2001-10-10 2004-04-15 Procesado de polvo con fluidos gaseosos presurizados

Country Status (23)

Country Link
US (1) US6858166B2 (es)
EP (1) EP1435916B1 (es)
JP (2) JP2005511521A (es)
KR (1) KR20050035146A (es)
CN (1) CN1273113C (es)
AT (1) ATE324102T1 (es)
AU (1) AU2002334935B2 (es)
BR (1) BR0213155A (es)
CA (1) CA2462338C (es)
CO (1) CO5580739A2 (es)
DE (1) DE60211004T2 (es)
DK (1) DK1435916T3 (es)
EA (1) EA006064B1 (es)
ES (1) ES2261782T3 (es)
HK (1) HK1069994A1 (es)
HR (1) HRP20040334A2 (es)
IL (1) IL160931A0 (es)
MX (1) MXPA04003321A (es)
NZ (1) NZ532759A (es)
PL (1) PL368346A1 (es)
RS (1) RS29104A (es)
WO (1) WO2003030871A1 (es)
ZA (1) ZA200402222B (es)

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KR101102834B1 (ko) 2010-02-24 2012-01-05 충남대학교산학협력단 신규한 리포좀 제조 방법 및 장치
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Also Published As

Publication number Publication date
JP2009051842A (ja) 2009-03-12
US20030066800A1 (en) 2003-04-10
US6858166B2 (en) 2005-02-22
HRP20040334A2 (en) 2004-08-31
BR0213155A (pt) 2004-09-14
AU2002334935B2 (en) 2008-04-03
HK1069994A1 (en) 2005-06-10
WO2003030871A1 (en) 2003-04-17
EP1435916B1 (en) 2006-04-26
CA2462338A1 (en) 2003-04-17
IL160931A0 (en) 2004-08-31
DE60211004T2 (de) 2006-08-31
EP1435916A1 (en) 2004-07-14
EA200400483A1 (ru) 2004-10-28
CA2462338C (en) 2011-04-19
JP2005511521A (ja) 2005-04-28
DE60211004D1 (de) 2006-06-01
ATE324102T1 (de) 2006-05-15
CN1273113C (zh) 2006-09-06
ZA200402222B (en) 2006-05-31
RS29104A (en) 2006-12-15
NZ532759A (en) 2005-10-28
PL368346A1 (en) 2005-03-21
KR20050035146A (ko) 2005-04-15
DK1435916T3 (da) 2006-08-21
JP4778997B2 (ja) 2011-09-21
EA006064B1 (ru) 2005-08-25
MXPA04003321A (es) 2004-07-23
CN1568179A (zh) 2005-01-19
ES2261782T3 (es) 2006-11-16

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