CO5550467A2 - Conjugados inmunogenicos de acido hialuronico de bajo peso molecular con toxinas polipeptidas - Google Patents

Conjugados inmunogenicos de acido hialuronico de bajo peso molecular con toxinas polipeptidas

Info

Publication number
CO5550467A2
CO5550467A2 CO03099742A CO03099742A CO5550467A2 CO 5550467 A2 CO5550467 A2 CO 5550467A2 CO 03099742 A CO03099742 A CO 03099742A CO 03099742 A CO03099742 A CO 03099742A CO 5550467 A2 CO5550467 A2 CO 5550467A2
Authority
CO
Colombia
Prior art keywords
molecular weight
low molecular
hyaluronic acid
immunogenic conjugates
acid
Prior art date
Application number
CO03099742A
Other languages
English (en)
Inventor
Francis Michon
Samuel Moore
Laude-Sharp Maryline
Milan Blake
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of CO5550467A2 publication Critical patent/CO5550467A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

1.- Una molécula de conjugado inmunogénico que comprende ácido hialurónico ligado covalentemente a un portador de polipéptido inmunologicamente aceptable.2.- El conjugado inmunogénico de acuerdo con la reivindicación 1, en donde mayor acerca de 50% de las moléculas de ácido hialurónico poseen un terminal no reductor de ácido glucurónico y/o un residuo de ácido glucurónico no saturado.3.- El conjugado inmunogénico de acuerdo con la reivindicación 2, en donde el ácido hialurónico es un ácido hialurónico de bajo peso molecular con un paso molecular de alrededor de 400 Kd o menos y un peso molecular de alrededor de 600 daltons o más.
CO03099742A 2001-05-11 2003-11-11 Conjugados inmunogenicos de acido hialuronico de bajo peso molecular con toxinas polipeptidas CO5550467A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/853,367 US20020192205A1 (en) 2001-05-11 2001-05-11 Immunogenic compositions of low molecular weight hyaluronic acid and methods to prevent, treat and diagnose infections and diseases caused by group A and group C streptococci

Publications (1)

Publication Number Publication Date
CO5550467A2 true CO5550467A2 (es) 2005-08-31

Family

ID=25315838

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03099742A CO5550467A2 (es) 2001-05-11 2003-11-11 Conjugados inmunogenicos de acido hialuronico de bajo peso molecular con toxinas polipeptidas

Country Status (15)

Country Link
US (1) US20020192205A1 (es)
EP (1) EP1385554A2 (es)
JP (1) JP2005508854A (es)
KR (1) KR20030096369A (es)
CN (1) CN1525869A (es)
AR (1) AR034331A1 (es)
BR (1) BR0209562A (es)
CA (1) CA2446555A1 (es)
CO (1) CO5550467A2 (es)
EC (1) ECSP034888A (es)
HU (1) HUP0400840A3 (es)
MX (1) MXPA03010283A (es)
PL (1) PL366692A1 (es)
SK (1) SK15122003A3 (es)
WO (1) WO2002092131A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2251699C1 (ru) * 2003-09-25 2005-05-10 Киселев Всеволод Иванович Способ ранней и доклинической диагностики цервикального рака
JP4576583B2 (ja) * 2005-03-22 2010-11-10 キユーピー株式会社 ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
US20070225484A1 (en) * 2006-03-25 2007-09-27 Framroze Bomi P Process for the Isolation and Stabilization of Low-Molecular Weight Aminoglycans from Waste Egg Shells
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
US9687559B2 (en) 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
EP2341941A4 (en) * 2008-09-09 2014-12-10 Univ Oklahoma HEPAROSANE POLYMERS AND METHODS OF MAKING AND USING THEM TO ENHANCE THERAPEUTIC COMPOUNDS
US11065323B2 (en) * 2008-10-27 2021-07-20 Glaxosmithkline Biologicals Sa Purification method
CN102010469B (zh) * 2010-10-22 2013-02-27 上海贝西生物科技有限公司 一种抗透明质酸单克隆抗体及其用途
CN104302670A (zh) 2012-02-07 2015-01-21 Phi生物医药股份有限公司 制造用于经皮给药的透明质酸-蛋白结合体的方法以及由该方法制造的用于经皮给药的透明质酸-蛋白结合体
CN104237500B (zh) * 2014-09-30 2016-09-28 博奥赛斯（天津）生物科技有限公司 一种透明质酸固相包被方法
WO2018175752A1 (en) 2017-03-22 2018-09-27 Genentech, Inc. Optimized antibody compositions for treatment of ocular disorders
IT201900022626A1 (it) 2019-12-02 2021-06-02 Ub Care S R L Metodo per la determinazione del contenuto di sodio ialuronato in un idrogel
CN115590774B (zh) * 2022-10-20 2024-05-03 珠海原妙医学科技股份有限公司 透明质酸脂质体组装体及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866135A (en) * 1994-04-21 1999-02-02 North American Vaccine, Inc. Group A streptococcal polysaccharide immunogenic compositions and methods
JPH0912600A (ja) * 1995-06-22 1997-01-14 Shiseido Co Ltd ヒアルロン酸ナトリウムに対するモノクローナル抗体及びその製造方法
CN1272062A (zh) * 1997-07-17 2000-11-01 北美疫苗公司 含有b组脑膜炎球菌膜孔蛋白和流感嗜血菌多糖的免疫偶联物
CA2332455C (en) * 1998-06-01 2012-08-14 Chiron Corporation Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants

Also Published As

Publication number Publication date
MXPA03010283A (es) 2004-12-06
ECSP034888A (es) 2004-05-28
HUP0400840A3 (en) 2004-10-28
AR034331A1 (es) 2004-02-18
HUP0400840A2 (hu) 2004-07-28
WO2002092131A3 (en) 2003-03-20
BR0209562A (pt) 2004-03-30
JP2005508854A (ja) 2005-04-07
EP1385554A2 (en) 2004-02-04
CA2446555A1 (en) 2002-11-21
WO2002092131A2 (en) 2002-11-21
PL366692A1 (en) 2005-02-07
KR20030096369A (ko) 2003-12-24
CN1525869A (zh) 2004-09-01
US20020192205A1 (en) 2002-12-19
SK15122003A3 (sk) 2004-10-05

Similar Documents

Publication Publication Date Title
CO5550467A2 (es) Conjugados inmunogenicos de acido hialuronico de bajo peso molecular con toxinas polipeptidas
ATE375387T1 (de) Modifiziertes polypeptid
Duance et al. The location of three collagen types in skeletal muscle
KR910016770A (ko) 글리코사미노글리칸-변형된 단백질
SG149039A1 (en) Ass IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME
BRPI0114994B8 (pt) composição de vacina
CA2489712A1 (en) Crosslinked compounds and methods of making and using thereof
TR199701547T1 (xx) Polisakarit antijen protein e�leni�i i�eren a��.
TR200001956A2 (tr) Eritropoietin türevleri.
ES2119769T3 (es) Derivado del factor viii humano recombinante.
AR008378A1 (es) Conjudados de interferon
KR890004730A (ko) G_7rh에 대한 면역반응을 유발시키고 포유동물을 면역 불임시키기 위한 제제 및 방법
ES2460926T3 (es) Redes de proteína heterogéneas reticuladas con enlaces que contienen silicona, y procedimientos de producción de las mismas
PT1148866E (pt) Poliamidas de terminacao de amida (atpa) e utilizacao das mesmas
AR010977A1 (es) Proceso para la preparacion de conjugados de interferon-polimero
LV11692B (en) Modified human g-csf
KR830006333A (ko) 의약용 신규의 황산화 다당류 제조방법
AU608901B2 (en) Conjugates of superoxide dismutase
Sini et al. Role of decorin on in vitro fibrillogenesis of type I collagen
KR930019220A (ko) 폴리하이드록시메틸렌 유도체를 함유하는 약제, 이의 제조방법 및 용도
BR0112612A (pt) Misturas de polissacarìdeos sulfatados, processo de preparação das mesmas e composições farmacêuticas
ES2087881T3 (es) Composicion de esmalte de uñas del tipo con disolvente.
DE59209525D1 (de) Neues rekombinantes Human-IFN-beta, Verfahren zu dessen Herstellung und dieses enthaltende pharmazeutische Zubereitungen
FR2622587B1 (fr) Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
DE69224988D1 (de) Aminosäurederivat und bromacetyl-modifizierte peptide

Legal Events

Date Code Title Description
FC Application refused