DE69224988D1 - Aminosäurederivat und bromacetyl-modifizierte peptide - Google Patents
Aminosäurederivat und bromacetyl-modifizierte peptideInfo
- Publication number
- DE69224988D1 DE69224988D1 DE69224988T DE69224988T DE69224988D1 DE 69224988 D1 DE69224988 D1 DE 69224988D1 DE 69224988 T DE69224988 T DE 69224988T DE 69224988 T DE69224988 T DE 69224988T DE 69224988 D1 DE69224988 D1 DE 69224988D1
- Authority
- DE
- Germany
- Prior art keywords
- peptide
- bbal
- peptides
- polymers
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 150000003862 amino acid derivatives Chemical class 0.000 title abstract 2
- FCHUPHLUKSIOHS-UHFFFAOYSA-N n-butyl-n-(5-oxooxolan-2-yl)nitrous amide Chemical compound CCCCN(N=O)C1CCC(=O)O1 FCHUPHLUKSIOHS-UHFFFAOYSA-N 0.000 abstract 4
- 229920000642 polymer Polymers 0.000 abstract 3
- -1 bromoacetyl group Chemical group 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 1
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 102400000745 Potential peptide Human genes 0.000 abstract 1
- 101800001357 Potential peptide Proteins 0.000 abstract 1
- 239000000919 ceramic Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 210000003298 dental enamel Anatomy 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000863 peptide conjugate Substances 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 229920003023 plastic Polymers 0.000 abstract 1
- 239000004033 plastic Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000003568 thioethers Chemical class 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/715,650 US5286846A (en) | 1991-06-14 | 1991-06-14 | Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides |
PCT/US1992/004694 WO1992022318A1 (en) | 1991-06-14 | 1992-06-10 | Amino acid derivative and bromoacetyl modified peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69224988D1 true DE69224988D1 (de) | 1998-05-07 |
Family
ID=24874927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69224988T Expired - Lifetime DE69224988D1 (de) | 1991-06-14 | 1992-06-10 | Aminosäurederivat und bromacetyl-modifizierte peptide |
Country Status (7)
Country | Link |
---|---|
US (2) | US5286846A (de) |
EP (1) | EP0590038B1 (de) |
AT (1) | ATE164590T1 (de) |
AU (1) | AU666858B2 (de) |
CA (1) | CA2111465A1 (de) |
DE (1) | DE69224988D1 (de) |
WO (1) | WO1992022318A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
CA2133834C (en) * | 1992-04-07 | 2009-07-21 | Stephen B.H. Kent | Process for preparing modified proteins |
ATE177843T1 (de) * | 1994-01-19 | 1999-04-15 | Us Health | Peptomere mit erhöhter immunogenizität |
EP0866802A1 (de) * | 1995-11-21 | 1998-09-30 | Novartis AG | Multivalente polymere, deren herstellung und verwendung zur herstellung von biologisch aktiven verbindungen |
US6759509B1 (en) * | 1996-11-05 | 2004-07-06 | Bristol-Myers Squibb Company | Branched peptide linkers |
IL132156A0 (en) * | 1997-04-18 | 2001-03-19 | Novartis Ag | Neoglycoproteins |
US5908783A (en) * | 1997-12-04 | 1999-06-01 | Southern University, Bd. Of Trustee | Alternating lysine-alanine copolymer substrate for promoting neuron survival and axon growth |
CA2404082A1 (en) * | 2000-03-27 | 2001-10-04 | Zyomyx, Inc. | Site-specific, covalent bioconjugation of proteins |
WO2002081637A2 (en) * | 2001-04-06 | 2002-10-17 | Chiron Corporation | Peptides incorporating chemoselective functionalities |
ATE371680T1 (de) * | 2002-01-16 | 2007-09-15 | Biocompatibles Uk Ltd | Polymerkonjugate |
GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
IL156263A0 (en) * | 2003-06-02 | 2004-01-04 | Hadasit Med Res Service | Livin-derived peptides, compositions and uses thereof |
US7786213B2 (en) * | 2003-10-15 | 2010-08-31 | The Regents Of The University Of California | Biomacromolecule polymer conjugates |
US8658180B2 (en) | 2008-08-15 | 2014-02-25 | Mark A. Miller | Vaccines against influenza virus |
IL199618A0 (en) | 2009-06-29 | 2010-04-29 | Two To Biotech Ltd | Novel antibodies and their use in diagnostic methods |
IL200202A0 (en) | 2009-08-02 | 2010-05-31 | Orly Devary | Novel proteins |
US11173199B2 (en) | 2019-11-13 | 2021-11-16 | Alopexx Inc. | Low contaminant compositions |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59164797A (ja) * | 1983-03-09 | 1984-09-17 | Wakunaga Seiyaku Kk | タンパク誘導体およびその製造法 |
US5066716A (en) * | 1988-12-13 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides |
-
1991
- 1991-06-14 US US07/715,650 patent/US5286846A/en not_active Expired - Lifetime
-
1992
- 1992-06-10 AT AT92913815T patent/ATE164590T1/de active
- 1992-06-10 EP EP92913815A patent/EP0590038B1/de not_active Expired - Lifetime
- 1992-06-10 AU AU21798/92A patent/AU666858B2/en not_active Ceased
- 1992-06-10 CA CA002111465A patent/CA2111465A1/en not_active Abandoned
- 1992-06-10 DE DE69224988T patent/DE69224988D1/de not_active Expired - Lifetime
- 1992-06-10 WO PCT/US1992/004694 patent/WO1992022318A1/en active IP Right Grant
-
1993
- 1993-11-19 US US08/154,786 patent/US5444150A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2111465A1 (en) | 1992-12-23 |
WO1992022318A1 (en) | 1992-12-23 |
AU2179892A (en) | 1993-01-12 |
US5286846A (en) | 1994-02-15 |
EP0590038A1 (de) | 1994-04-06 |
AU666858B2 (en) | 1996-02-29 |
EP0590038A4 (en) | 1994-08-24 |
US5444150A (en) | 1995-08-22 |
ATE164590T1 (de) | 1998-04-15 |
EP0590038B1 (de) | 1998-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |