BR0113439A - Processo para a manufatura de um imunógeno para vacina, derivado de maleimida de peptìdeo de ige, uso do mesmo, conjugado adequado para uso em uma vacina e composição de vacina - Google Patents

Processo para a manufatura de um imunógeno para vacina, derivado de maleimida de peptìdeo de ige, uso do mesmo, conjugado adequado para uso em uma vacina e composição de vacina

Info

Publication number
BR0113439A
BR0113439A BR0113439-6A BR0113439A BR0113439A BR 0113439 A BR0113439 A BR 0113439A BR 0113439 A BR0113439 A BR 0113439A BR 0113439 A BR0113439 A BR 0113439A
Authority
BR
Brazil
Prior art keywords
vaccine
peptide
disulfide
immunogens
pharmaceutical compositions
Prior art date
Application number
BR0113439-6A
Other languages
English (en)
Inventor
Martin Friede
Sean Mason
William Gordon Turnell
Carlota Vinals Y De Bassols
Original Assignee
Glaxosmithkline Biolog Sa
Acambis Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biolog Sa, Acambis Res Ltd filed Critical Glaxosmithkline Biolog Sa
Publication of BR0113439A publication Critical patent/BR0113439A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

"PROCESSO PARA A MANUFATURA DE UM IMUNóGENO PARA VACINA, DERIVADO DE MALEIMIDA DE PEPTìDEO DE IgE, USO DO MESMO, CONJUGADO ADEQUADO PARA USO EM UMA VACINA E COMPOSIçãO DE VACINA". A presente invenção refere-se a um novo processo químico para a conjugação covalente de peptídeos ciclisados por ponte de dissulfeto em moléculas veículo imunogênicas por ligações de tio-éter para formar imunógenos para vacina. Em particular, a nova química envolve a reação de um veículo tiolado com um peptídeo cíclico contendo uma ponte de dissulfeto, cujo peptídeo cíclico (aqui um peptídeo ciclisado por ponte de dissulfeto) tem ligado nele, usualmente via um ligador, um grupo reativo capaz de formar ligações de tio-éter com o veículo. A invenção refere-se em adição aos intermediários de peptídeo ativado do processo, aos medicamentos produzidos pelo processo, às composições farmacêuticas contendo os medicamentos, e ao uso das composições farmacêuticas na medicina. O processo da presente invenção é particularmente útil para a preparação de imunógenos elevadamente puros para vacinas, compreendendo peptídeos ciclisados por ponte de dissulfeto. Também novos imunógenos são proporcionados, baseados em peptídeos derivados da seq³ência da IgE humana, que são úteis em imunoterapia de alergia. Conseq³entemente, a invenção também se refere a um processo para a conjugação de peptídeos ciclisados por ponte de dissulfeto de IgE em veículos, aos imunógenos produzidos pelo processo e às vacinas e às composições farmacêuticas compreendendo-os e ao seu uso no tratamento de alergia.
BR0113439-6A 2000-08-22 2001-08-17 Processo para a manufatura de um imunógeno para vacina, derivado de maleimida de peptìdeo de ige, uso do mesmo, conjugado adequado para uso em uma vacina e composição de vacina BR0113439A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0020717.5A GB0020717D0 (en) 2000-08-22 2000-08-22 Novel compounds and process
PCT/EP2001/009576 WO2002016409A2 (en) 2000-08-22 2001-08-17 Vaccine immunogens comprising disulphide bridged cyclised peptide and use thereof in the treatment of allergies

Publications (1)

Publication Number Publication Date
BR0113439A true BR0113439A (pt) 2004-07-06

Family

ID=9898110

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113439-6A BR0113439A (pt) 2000-08-22 2001-08-17 Processo para a manufatura de um imunógeno para vacina, derivado de maleimida de peptìdeo de ige, uso do mesmo, conjugado adequado para uso em uma vacina e composição de vacina

Country Status (17)

Country Link
US (1) US20040030106A1 (pt)
EP (1) EP1311536A2 (pt)
JP (1) JP2004514655A (pt)
KR (1) KR20030062405A (pt)
CN (1) CN1471539A (pt)
AR (1) AR030458A1 (pt)
AU (1) AU2002214951A1 (pt)
BR (1) BR0113439A (pt)
CA (1) CA2420086A1 (pt)
GB (1) GB0020717D0 (pt)
HU (1) HUP0301725A3 (pt)
IL (1) IL154532A0 (pt)
MX (1) MXPA03001631A (pt)
NO (1) NO20030822L (pt)
PL (1) PL365788A1 (pt)
WO (1) WO2002016409A2 (pt)
ZA (1) ZA200301437B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0026334D0 (en) * 2000-10-27 2000-12-13 Smithkline Beecham Biolog Vaccine
GB0209878D0 (en) * 2002-04-30 2002-06-05 Glaxosmithkline Biolog Sa Vaccine
KR20070008578A (ko) * 2004-02-02 2007-01-17 타녹스 인코퍼레이티드 신규한 ＩｇＥ 에피토프의 확인
EP2046815B1 (en) * 2006-07-21 2012-08-08 Cristália Produtos Químicos Farmacêuticos Ltda. Anti-inflammatory and antiallergic cyclic peptides
CA2657338C (en) * 2006-07-21 2013-10-22 Cristalia Produtos Quimicos Farmaceuticos Ltda. Anti-inflammatory and antiallergic cyclic peptides
WO2008013454A2 (en) * 2006-07-26 2008-01-31 Pepscan Systems B.V. Immunogenic compounds and protein mimics
MX2012005428A (es) * 2009-11-16 2012-06-14 Hoffmann La Roche Reactivo de calibracion y sus usos.
EP2458467B1 (en) 2010-11-26 2013-08-28 ABB Research Ltd. Method and system for monitoring an industrial system
CN106366160B (zh) * 2016-10-11 2019-06-14 厦门大学 基于二硫键精准配对构建富含二硫键多肽分子骨架的方法
WO2019194656A1 (ko) * 2018-04-06 2019-10-10 (주)에스엘에스바이오 신규한 면역글로불린 e의 에피토프, 그와 결합하는 항체 및 상기 항체를 포함하는 시료 중 면역글로불린 e를 분석하기 위한 키트

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981979A (en) * 1987-09-10 1991-01-01 Neorx Corporation Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity
CA2047078A1 (en) * 1990-07-19 1992-01-20 Steven S. Bondy Cyclic hiv principal neutralizing determinant peptides
TWI227241B (en) * 1998-06-20 2005-02-01 United Biomedical Inc IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate

Also Published As

Publication number Publication date
JP2004514655A (ja) 2004-05-20
AR030458A1 (es) 2003-08-20
WO2002016409A3 (en) 2002-08-29
HUP0301725A2 (hu) 2003-08-28
GB0020717D0 (en) 2000-10-11
PL365788A1 (en) 2005-01-10
EP1311536A2 (en) 2003-05-21
WO2002016409A2 (en) 2002-02-28
MXPA03001631A (es) 2004-09-10
ZA200301437B (en) 2004-05-21
NO20030822D0 (no) 2003-02-21
HUP0301725A3 (en) 2004-11-29
CA2420086A1 (en) 2002-02-28
AU2002214951A1 (en) 2002-03-04
KR20030062405A (ko) 2003-07-25
US20040030106A1 (en) 2004-02-12
CN1471539A (zh) 2004-01-28
NO20030822L (no) 2003-03-31
IL154532A0 (en) 2003-09-17

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]