AR010977A1 - Proceso para la preparacion de conjugados de interferon-polimero - Google Patents

Proceso para la preparacion de conjugados de interferon-polimero

Info

Publication number
AR010977A1
AR010977A1 ARP960105277A ARP960105277A AR010977A1 AR 010977 A1 AR010977 A1 AR 010977A1 AR P960105277 A ARP960105277 A AR P960105277A AR P960105277 A ARP960105277 A AR P960105277A AR 010977 A1 AR010977 A1 AR 010977A1
Authority
AR
Argentina
Prior art keywords
interferon
compositions
polymer
conjugate
mole
Prior art date
Application number
ARP960105277A
Other languages
English (en)
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Publication of AR010977A1 publication Critical patent/AR010977A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describe un conjugado de interferon-polímero que contiene composiciones que presentan altos niveles de actividad de interferon reteniday una vida circulante relativamente larga in vivo. Las composiciones contienen una mezcla de conjugado de mono-interferon-polímero y conjugado de bis-interferon-polímero, conteniendo ambas especies substancialmente una ramificacion polimérica unica. Las composiciones de conjugado están preparadaspor medio de hacer reaccionar aproximadamente 1 mol de un interferon con aproximadamente 0.125 a aproximadamente 1 mol de un polímero substancialmenteno antigénico bis-activado bajo condiciones suficientes para efectuar una conjugacion covalente del interferon y el polímero.Asimismo están descriptosmétodos de tratamiento de condiciones susceptibles al interferon con estas composiciones.
ARP960105277A 1995-11-21 1996-11-21 Proceso para la preparacion de conjugados de interferon-polimero AR010977A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/561,616 US5738846A (en) 1994-11-10 1995-11-21 Interferon polymer conjugates and process for preparing the same

Publications (1)

Publication Number Publication Date
AR010977A1 true AR010977A1 (es) 2000-08-02

Family

ID=24242714

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960105277A AR010977A1 (es) 1995-11-21 1996-11-21 Proceso para la preparacion de conjugados de interferon-polimero

Country Status (9)

Country Link
US (1) US5738846A (es)
EP (1) EP0862455B1 (es)
AR (1) AR010977A1 (es)
AT (1) ATE381940T1 (es)
AU (1) AU7600496A (es)
CO (1) CO4520232A1 (es)
DE (1) DE69637382T2 (es)
WO (1) WO1997018832A1 (es)
ZA (1) ZA969557B (es)

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ZA969557B (en) 1997-06-12
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ATE381940T1 (de) 2008-01-15
CO4520232A1 (es) 1997-10-15

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