CO5251420A1 - Compuestos mimeticos de peptidos de giros beta, bibliotecas de tales compuestos, y proceso para la fabricacion de los mismos - Google Patents

Compuestos mimeticos de peptidos de giros beta, bibliotecas de tales compuestos, y proceso para la fabricacion de los mismos

Info

Publication number
CO5251420A1
CO5251420A1 CO00097142A CO00097142A CO5251420A1 CO 5251420 A1 CO5251420 A1 CO 5251420A1 CO 00097142 A CO00097142 A CO 00097142A CO 00097142 A CO00097142 A CO 00097142A CO 5251420 A1 CO5251420 A1 CO 5251420A1
Authority
CO
Colombia
Prior art keywords
compounds
manufacture
aryl
libraries
geta
Prior art date
Application number
CO00097142A
Other languages
English (en)
Inventor
Adam Golebiowski
Sean Rees Klopfenstein
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO5251420A1 publication Critical patent/CO5251420A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención se relaciona con un compuesto que tiene la siguiente estructura: <EMI FILE="00097142_1" ID="1" IMF=JPEG >en donde: a) R1 es hidrógeno; y R2 se selecciona de hidrógeno, alquilo, arilo, heterocíclilo, carboxi y sus ésteres y aminas; o R1 y R2 están fijados y juntos son alquileno o heteroalquileno; b) R4 se selecciona de arilo, heteroarilo, y arilo conjugados o heteroarilo a, b-insaturado, y c) R5 se selecciona de hidrógeno, alquilo, arilo y heterocíclilo; y un isómetro óptico, diastereómero, o enantiómero de éste; una sal, hidrato, éster, amida, o imida de éste. La presente invención también incluye bibliotecas de tales compuestos, y procesos para la fabricación de Ios mismos.
CO00097142A 1999-12-21 2000-12-21 Compuestos mimeticos de peptidos de giros beta, bibliotecas de tales compuestos, y proceso para la fabricacion de los mismos CO5251420A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17282399P 1999-12-21 1999-12-21

Publications (1)

Publication Number Publication Date
CO5251420A1 true CO5251420A1 (es) 2003-02-28

Family

ID=22629385

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00097142A CO5251420A1 (es) 1999-12-21 2000-12-21 Compuestos mimeticos de peptidos de giros beta, bibliotecas de tales compuestos, y proceso para la fabricacion de los mismos

Country Status (16)

Country Link
EP (1) EP1240169A1 (es)
JP (1) JP2003518124A (es)
KR (1) KR20020062352A (es)
CN (1) CN1413214A (es)
AU (1) AU2286401A (es)
BR (1) BR0016518A (es)
CA (1) CA2393759A1 (es)
CO (1) CO5251420A1 (es)
CZ (1) CZ20022110A3 (es)
HU (1) HUP0300100A2 (es)
IL (1) IL149834A0 (es)
MX (1) MXPA02006330A (es)
NO (1) NO20022953D0 (es)
PE (1) PE20010955A1 (es)
PL (1) PL355971A1 (es)
WO (1) WO2001046197A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7195027B2 (ja) * 2018-12-27 2022-12-23 ホロスメディック 新規の化合物およびこれを含む抗癌活性増進用薬学組成物
WO2020139044A1 (ko) * 2018-12-27 2020-07-02 홀로스메딕 주식회사 신규한 화합물 및 이를 포함하는 항암 활성 증진용 약학 조성물
BR112022007998A2 (pt) * 2019-10-31 2022-07-05 Holosmedic Novo composto e composição farmacêutica para prevenção ou tratamento de câncer que compreende os mesmos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929237A (en) * 1995-10-27 1999-07-27 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
US6013458A (en) * 1995-10-27 2000-01-11 Molecumetics, Ltd. Reverse-turn mimetics and methods relating thereto

Also Published As

Publication number Publication date
KR20020062352A (ko) 2002-07-25
MXPA02006330A (es) 2002-12-13
JP2003518124A (ja) 2003-06-03
WO2001046197A1 (en) 2001-06-28
IL149834A0 (en) 2002-11-10
NO20022953L (no) 2002-06-19
PE20010955A1 (es) 2001-10-11
EP1240169A1 (en) 2002-09-18
AU2286401A (en) 2001-07-03
CN1413214A (zh) 2003-04-23
BR0016518A (pt) 2002-09-24
HUP0300100A2 (en) 2003-05-28
CA2393759A1 (en) 2001-06-28
CZ20022110A3 (cs) 2002-11-13
PL355971A1 (en) 2004-05-31
NO20022953D0 (no) 2002-06-19

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