CO5251420A1 - MIMETIC COMPOUNDS OF PEPTIDES OF GETA BETA, LIBRARIES OF SUCH COMPOUNDS, AND PROCESS FOR THE MANUFACTURE OF THE SAME - Google Patents
MIMETIC COMPOUNDS OF PEPTIDES OF GETA BETA, LIBRARIES OF SUCH COMPOUNDS, AND PROCESS FOR THE MANUFACTURE OF THE SAMEInfo
- Publication number
- CO5251420A1 CO5251420A1 CO00097142A CO00097142A CO5251420A1 CO 5251420 A1 CO5251420 A1 CO 5251420A1 CO 00097142 A CO00097142 A CO 00097142A CO 00097142 A CO00097142 A CO 00097142A CO 5251420 A1 CO5251420 A1 CO 5251420A1
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- manufacture
- aryl
- libraries
- geta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se relaciona con un compuesto que tiene la siguiente estructura: <EMI FILE="00097142_1" ID="1" IMF=JPEG >en donde: a) R1 es hidrógeno; y R2 se selecciona de hidrógeno, alquilo, arilo, heterocíclilo, carboxi y sus ésteres y aminas; o R1 y R2 están fijados y juntos son alquileno o heteroalquileno; b) R4 se selecciona de arilo, heteroarilo, y arilo conjugados o heteroarilo a, b-insaturado, y c) R5 se selecciona de hidrógeno, alquilo, arilo y heterocíclilo; y un isómetro óptico, diastereómero, o enantiómero de éste; una sal, hidrato, éster, amida, o imida de éste. La presente invención también incluye bibliotecas de tales compuestos, y procesos para la fabricación de Ios mismos.The present invention relates to a compound having the following structure: <EMI FILE = "00097142_1" ID = "1" MFI = JPEG> wherein: a) R1 is hydrogen; and R2 is selected from hydrogen, alkyl, aryl, heterocyclyl, carboxy and its esters and amines; or R1 and R2 are fixed and together they are alkylene or heteroalkylene; b) R4 is selected from conjugated aryl, heteroaryl, and aryl or heteroaryl a, b-unsaturated, and c) R5 is selected from hydrogen, alkyl, aryl and heterocyclyl; and an optical isometer, diastereomer, or enantiomer thereof; a salt, hydrate, ester, amide, or imide thereof. The present invention also includes libraries of such compounds, and processes for the manufacture thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17282399P | 1999-12-21 | 1999-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5251420A1 true CO5251420A1 (en) | 2003-02-28 |
Family
ID=22629385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00097142A CO5251420A1 (en) | 1999-12-21 | 2000-12-21 | MIMETIC COMPOUNDS OF PEPTIDES OF GETA BETA, LIBRARIES OF SUCH COMPOUNDS, AND PROCESS FOR THE MANUFACTURE OF THE SAME |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1240169A1 (en) |
| JP (1) | JP2003518124A (en) |
| KR (1) | KR20020062352A (en) |
| CN (1) | CN1413214A (en) |
| AU (1) | AU2286401A (en) |
| BR (1) | BR0016518A (en) |
| CA (1) | CA2393759A1 (en) |
| CO (1) | CO5251420A1 (en) |
| CZ (1) | CZ20022110A3 (en) |
| HU (1) | HUP0300100A2 (en) |
| IL (1) | IL149834A0 (en) |
| MX (1) | MXPA02006330A (en) |
| NO (1) | NO20022953L (en) |
| PE (1) | PE20010955A1 (en) |
| PL (1) | PL355971A1 (en) |
| WO (1) | WO2001046197A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020139044A1 (en) * | 2018-12-27 | 2020-07-02 | 홀로스메딕 주식회사 | Novel compound and pharmaceutical composition comprising same for enhancing anticancer activity |
| US20220064171A1 (en) * | 2018-12-27 | 2022-03-03 | Holosmedic | Novel compound and pharmaceutical composition comprising same for enhancing anticancer activity |
| CA3159791A1 (en) * | 2019-10-31 | 2021-05-06 | Holosmedic | Hexahydro-2h-pyrazino[1,2-a]pyrazine-6,9-dione derivatives and pharmaceutical compositions for prevention or treatment of cancer comprising same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5929237A (en) * | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6013458A (en) * | 1995-10-27 | 2000-01-11 | Molecumetics, Ltd. | Reverse-turn mimetics and methods relating thereto |
-
2000
- 2000-12-19 PE PE2000001366A patent/PE20010955A1/en not_active Application Discontinuation
- 2000-12-20 HU HU0300100A patent/HUP0300100A2/en unknown
- 2000-12-20 CA CA002393759A patent/CA2393759A1/en not_active Abandoned
- 2000-12-20 CN CN00817604A patent/CN1413214A/en active Pending
- 2000-12-20 AU AU22864/01A patent/AU2286401A/en not_active Abandoned
- 2000-12-20 IL IL14983400A patent/IL149834A0/en unknown
- 2000-12-20 BR BR0016518-2A patent/BR0016518A/en not_active IP Right Cessation
- 2000-12-20 EP EP00986673A patent/EP1240169A1/en not_active Withdrawn
- 2000-12-20 WO PCT/US2000/034832 patent/WO2001046197A1/en not_active Application Discontinuation
- 2000-12-20 MX MXPA02006330A patent/MXPA02006330A/en unknown
- 2000-12-20 JP JP2001547107A patent/JP2003518124A/en not_active Withdrawn
- 2000-12-20 KR KR1020027007839A patent/KR20020062352A/en not_active Application Discontinuation
- 2000-12-20 CZ CZ20022110A patent/CZ20022110A3/en unknown
- 2000-12-20 PL PL00355971A patent/PL355971A1/en not_active Application Discontinuation
- 2000-12-21 CO CO00097142A patent/CO5251420A1/en not_active Application Discontinuation
-
2002
- 2002-06-19 NO NO20022953A patent/NO20022953L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02006330A (en) | 2002-12-13 |
| JP2003518124A (en) | 2003-06-03 |
| BR0016518A (en) | 2002-09-24 |
| KR20020062352A (en) | 2002-07-25 |
| NO20022953D0 (en) | 2002-06-19 |
| CZ20022110A3 (en) | 2002-11-13 |
| WO2001046197A1 (en) | 2001-06-28 |
| AU2286401A (en) | 2001-07-03 |
| EP1240169A1 (en) | 2002-09-18 |
| CA2393759A1 (en) | 2001-06-28 |
| HUP0300100A2 (en) | 2003-05-28 |
| PL355971A1 (en) | 2004-05-31 |
| NO20022953L (en) | 2002-06-19 |
| PE20010955A1 (en) | 2001-10-11 |
| CN1413214A (en) | 2003-04-23 |
| IL149834A0 (en) | 2002-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |