BR0016518A - Beta peptide rotating mimetic compounds and processes for producing them - Google Patents

Beta peptide rotating mimetic compounds and processes for producing them

Info

Publication number
BR0016518A
BR0016518A BR0016518-2A BR0016518A BR0016518A BR 0016518 A BR0016518 A BR 0016518A BR 0016518 A BR0016518 A BR 0016518A BR 0016518 A BR0016518 A BR 0016518A
Authority
BR
Brazil
Prior art keywords
processes
compounds
aryl
producing
rotating
Prior art date
Application number
BR0016518-2A
Other languages
Portuguese (pt)
Inventor
Adam Golebiowski
Sean Rees Klopfenstein
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR0016518A publication Critical patent/BR0016518A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTOS MIMéTICOS DE ROTAçãO BETA PEPTìDICOS E PROCESSOS PARA PRODUçãO DOS MESMOS". A presente invenção envolve compostos com a estrutura (I) onde: a) R~ 1~ é hidrogênio ou alquila; e R~ 2~ é selecionado dentre hidrogênio, alquila, arila, heterociclila, carbóxi e seus ésteres e amidas; ou R~ 1~ e R~ 2~ são ligados e são em conjunto alquileno ou heteroalquileno; b) R~ 4~ é selecionado dentre arila, heteroarila, e arila ou heteroarila conjugados <244>,<225>-insaturados; e c) R~ 5~ é selecionado dentre hidrogênio, alquila, arila e heterociclila; e um isómero óptico, diastereoisómero ou enanciómeros destes; um sal, hidrato, éster, amida ou imida destes. A presente invenção inclui ainda bibliotecas de tais compostos e processos para produzir os presentes compostos e bibliotecas."PEPTIC BETA ROTATION MIMETIC COMPOUNDS AND PROCESSES FOR THE PRODUCTION OF THE SAME". The present invention involves compounds with structure (I) where: a) R ~ 1 ~ is hydrogen or alkyl; and R ~ 2 ~ is selected from hydrogen, alkyl, aryl, heterocyclyl, carboxy and its esters and amides; or R ~ 1 ~ and R ~ 2 ~ are bonded and together are alkylene or heteroalkylene; b) R ~ 4 ~ is selected from aryl, heteroaryl, and conjugated <244>, <225> -insaturated aryl or heteroaryl; and c) R ~ 5 ~ is selected from hydrogen, alkyl, aryl and heterocyclyl; and an optical isomer, diastereoisomer or enantiomers thereof; a salt, hydrate, ester, amide or imide thereof. The present invention further includes libraries of such compounds and processes for producing the present compounds and libraries.

BR0016518-2A 1999-12-21 2000-12-20 Beta peptide rotating mimetic compounds and processes for producing them BR0016518A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17282399P 1999-12-21 1999-12-21
PCT/US2000/034832 WO2001046197A1 (en) 1999-12-21 2000-12-20 PEPTIDE β-TURN MIMETIC COMPOUNDS AND PROCESSES FOR MAKING THEM

Publications (1)

Publication Number Publication Date
BR0016518A true BR0016518A (en) 2002-09-24

Family

ID=22629385

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016518-2A BR0016518A (en) 1999-12-21 2000-12-20 Beta peptide rotating mimetic compounds and processes for producing them

Country Status (16)

Country Link
EP (1) EP1240169A1 (en)
JP (1) JP2003518124A (en)
KR (1) KR20020062352A (en)
CN (1) CN1413214A (en)
AU (1) AU2286401A (en)
BR (1) BR0016518A (en)
CA (1) CA2393759A1 (en)
CO (1) CO5251420A1 (en)
CZ (1) CZ20022110A3 (en)
HU (1) HUP0300100A2 (en)
IL (1) IL149834A0 (en)
MX (1) MXPA02006330A (en)
NO (1) NO20022953L (en)
PE (1) PE20010955A1 (en)
PL (1) PL355971A1 (en)
WO (1) WO2001046197A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020139044A1 (en) * 2018-12-27 2020-07-02 홀로스메딕 주식회사 Novel compound and pharmaceutical composition comprising same for enhancing anticancer activity
US20220064171A1 (en) * 2018-12-27 2022-03-03 Holosmedic Novel compound and pharmaceutical composition comprising same for enhancing anticancer activity
CA3159791A1 (en) * 2019-10-31 2021-05-06 Holosmedic Hexahydro-2h-pyrazino[1,2-a]pyrazine-6,9-dione derivatives and pharmaceutical compositions for prevention or treatment of cancer comprising same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929237A (en) * 1995-10-27 1999-07-27 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
US6013458A (en) * 1995-10-27 2000-01-11 Molecumetics, Ltd. Reverse-turn mimetics and methods relating thereto

Also Published As

Publication number Publication date
MXPA02006330A (en) 2002-12-13
JP2003518124A (en) 2003-06-03
KR20020062352A (en) 2002-07-25
NO20022953D0 (en) 2002-06-19
CZ20022110A3 (en) 2002-11-13
WO2001046197A1 (en) 2001-06-28
AU2286401A (en) 2001-07-03
EP1240169A1 (en) 2002-09-18
CA2393759A1 (en) 2001-06-28
HUP0300100A2 (en) 2003-05-28
PL355971A1 (en) 2004-05-31
NO20022953L (en) 2002-06-19
PE20010955A1 (en) 2001-10-11
CN1413214A (en) 2003-04-23
CO5251420A1 (en) 2003-02-28
IL149834A0 (en) 2002-11-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A, 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1929 DE 26/12/2007.