CO4600683A1 - Bikunina humana - Google Patents
Bikunina humanaInfo
- Publication number
- CO4600683A1 CO4600683A1 CO97013175A CO97013175A CO4600683A1 CO 4600683 A1 CO4600683 A1 CO 4600683A1 CO 97013175 A CO97013175 A CO 97013175A CO 97013175 A CO97013175 A CO 97013175A CO 4600683 A1 CO4600683 A1 CO 4600683A1
- Authority
- CO
- Colombia
- Prior art keywords
- dsedhssdmf
- clvskvvgrc
- enpplplgsk
- seq
- adrersihdf
- Prior art date
Links
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 101800001691 Inter-alpha-trypsin inhibitor light chain Proteins 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 102100032859 Protein AMBP Human genes 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1310696P | 1996-03-11 | 1996-03-11 | |
US1979396P | 1996-06-14 | 1996-06-14 | |
US72525196A | 1996-10-04 | 1996-10-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4600683A1 true CO4600683A1 (es) | 1998-05-08 |
Family
ID=27359773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO97013175A CO4600683A1 (es) | 1996-03-11 | 1997-03-11 | Bikunina humana |
Country Status (27)
Country | Link |
---|---|
US (3) | US6583108B1 (enEXAMPLES) |
EP (1) | EP0891426B1 (enEXAMPLES) |
JP (2) | JP3469584B2 (enEXAMPLES) |
KR (1) | KR100356956B1 (enEXAMPLES) |
AR (3) | AR006188A1 (enEXAMPLES) |
AT (1) | ATE328083T1 (enEXAMPLES) |
AU (1) | AU716923B2 (enEXAMPLES) |
BR (1) | BR9708021A (enEXAMPLES) |
CA (1) | CA2247888A1 (enEXAMPLES) |
CO (1) | CO4600683A1 (enEXAMPLES) |
DE (1) | DE69735996T2 (enEXAMPLES) |
DK (1) | DK0891426T3 (enEXAMPLES) |
ES (1) | ES2263174T3 (enEXAMPLES) |
HR (1) | HRP970144B1 (enEXAMPLES) |
HU (1) | HU226419B1 (enEXAMPLES) |
ID (1) | ID16224A (enEXAMPLES) |
IL (1) | IL126115A (enEXAMPLES) |
IN (1) | IN192874B (enEXAMPLES) |
MY (1) | MY120693A (enEXAMPLES) |
NZ (1) | NZ331540A (enEXAMPLES) |
PA (1) | PA8426301A1 (enEXAMPLES) |
PL (1) | PL188387B1 (enEXAMPLES) |
PT (1) | PT891426E (enEXAMPLES) |
SV (1) | SV1997000018A (enEXAMPLES) |
TR (1) | TR199801794T2 (enEXAMPLES) |
WO (1) | WO1997033996A2 (enEXAMPLES) |
YU (1) | YU8997A (enEXAMPLES) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
DE69632435T2 (de) * | 1995-07-24 | 2005-05-12 | Mitsubishi Chemical Corp. | Inhibitor des Hepatozytwachstumsfaktoraktivators |
ES2263174T3 (es) | 1996-03-11 | 2006-12-01 | Bayer Corporation | Bikunina humana. |
US6262233B1 (en) * | 1997-01-31 | 2001-07-17 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
WO2000037099A2 (en) * | 1998-12-22 | 2000-06-29 | Bayer Aktiengesellschaft | Method for accelerating the rate of mucociliary clearance by using a kunitz-type serine protease inhibitor |
US6489308B1 (en) | 1999-03-05 | 2002-12-03 | Trustees Of University Of Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions |
AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
US20040235715A1 (en) * | 1999-11-12 | 2004-11-25 | Bayer Corporation | Method of producing glycosylated bikunin |
IL140993A0 (en) | 2000-05-15 | 2002-02-10 | Bayer Ag | Trypsin substrate and diagnostic device, and method of using same |
IL140994A (en) * | 2000-05-15 | 2005-12-18 | Bayer Ag | Urinary trypsin inhibitor assay containing a chelating agent |
US6955921B2 (en) * | 2001-04-30 | 2005-10-18 | Bayer Corporation | Trypsin substrate and diagnostic device, and method of using same |
EP1539985A4 (en) * | 2001-11-05 | 2006-06-28 | Curagen Corp | THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING THESE POLYPEPTIDES, AND METHODS OF USE |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
DK1583562T3 (da) | 2003-01-06 | 2011-09-19 | Angiochem Inc | Angiopep-1, beslægtede forbindelser og anvendelser deraf |
US8460243B2 (en) | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
US7244616B2 (en) | 2003-06-27 | 2007-07-17 | Bayer Pharmaceuticals Corporation | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells |
US7722536B2 (en) | 2003-07-15 | 2010-05-25 | Abbott Diabetes Care Inc. | Glucose measuring device integrated into a holster for a personal area network device |
DK2520654T3 (en) | 2003-08-26 | 2017-05-01 | Univ Colorado Regents | Inhibitors of serine protease activity and their use in methods and compositions for the treatment of bacterial infections |
EP1704227B1 (en) * | 2003-10-10 | 2010-01-27 | Multicell Technologies, Inc. | Immortalized hepatocytes |
EP1675874A1 (en) * | 2003-10-16 | 2006-07-05 | Bayer HealthCare LLC | Monoclonal antibodies for detection of urinary trypsin inhibitors |
EP1586587A1 (en) * | 2004-04-16 | 2005-10-19 | Exonhit Therapeutics SA | Compositions and methods for detecting angiogenesis |
CA3110101A1 (en) | 2004-06-04 | 2005-12-15 | Abbott Diabetes Care Inc. | Systems and methods for managing diabetes care data |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
JP5175108B2 (ja) | 2005-02-18 | 2013-04-03 | アンジオケム・インコーポレーテッド | 血液脳関門を介して化合物を輸送するためのアプロチニンポリペプチド |
US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
WO2007011693A2 (en) * | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
EP2471555A3 (en) | 2005-07-15 | 2012-10-17 | Angiochem Inc. | Use of aprotinin polypeptides as carriers in pharmaceutical conjugates |
US8093017B2 (en) | 2005-12-07 | 2012-01-10 | Siemens Heathcare Diagnostics Inc. | Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics |
EP1981519B1 (en) | 2005-12-29 | 2017-12-27 | Dyax Corp. | Protease inhibition |
WO2008034161A1 (en) * | 2006-09-19 | 2008-03-27 | Phylogica Limited | Neuroprotective peptide inhibitors of ap-1 signaling and uses therefor |
WO2008058167A2 (en) * | 2006-11-07 | 2008-05-15 | Case Western Reserve University | Method for treating disorders associated with complement activation |
WO2008077478A1 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene |
US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
US8822409B2 (en) * | 2007-06-20 | 2014-09-02 | Phylogica Limited | Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith |
JP2010536870A (ja) * | 2007-08-21 | 2010-12-02 | ジェンザイム・コーポレーション | カリクレイン阻害剤を用いた治療 |
DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
MX355683B (es) * | 2008-04-18 | 2018-04-26 | Angiochem Inc | Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso. |
RU2011118056A (ru) | 2008-10-15 | 2012-11-27 | Ангиокем Инк. | Конъюгаты агонистов glp-1 и их применение |
CN102245636A (zh) | 2008-10-15 | 2011-11-16 | 安吉奥开米公司 | 用于药物递送的依托泊苷和多柔比星结合物 |
JP5759379B2 (ja) | 2008-12-05 | 2015-08-05 | アンジオケム インコーポレーテッド | ニューロテンシンまたはニューロテンシンアナログおよびその使用 |
EP2373789A4 (en) | 2008-12-17 | 2012-08-29 | Angiochem Inc | MEMBRANTYP-1 MATRIX METALLOPROTEINASE INHIBITORS AND THEIR USE |
AU2010203712A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
US9173891B2 (en) | 2009-04-20 | 2015-11-03 | Angiochem, Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
JP5932642B2 (ja) | 2009-07-02 | 2016-06-08 | アンジオケム インコーポレーテッド | 多量体ペプチドコンジュゲートおよびその使用 |
EP3459564B1 (en) | 2010-01-06 | 2021-10-27 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
EP2371857A1 (en) * | 2010-04-01 | 2011-10-05 | CSL Behring GmbH | Factor XII inhibitors for treating interstitial lung disease |
CN105713092B (zh) | 2011-01-06 | 2019-09-10 | 戴埃克斯有限公司 | 血浆前激肽释放酶结合蛋白 |
US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
US9938353B2 (en) | 2011-06-24 | 2018-04-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
CA2896951A1 (en) | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
WO2014026283A1 (en) | 2012-08-14 | 2014-02-20 | Angiochem Inc. | Peptide-dendrimer conjugates and uses thereof |
NZ760008A (en) | 2014-02-24 | 2023-03-31 | Takeda Pharmaceuticals Co | Uti fusion proteins |
JP6719384B2 (ja) | 2014-03-27 | 2020-07-15 | ダイアックス コーポレーション | 糖尿病黄斑浮腫の治療のための組成物および方法 |
EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
CN116077648A (zh) | 2015-12-11 | 2023-05-09 | 武田药品工业株式会社 | 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途 |
CA3174478A1 (en) | 2020-03-05 | 2021-09-10 | DiaMedica USA Inc. | Ulinastatin polypeptides |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223482A (en) | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
US5106833A (en) | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
DE59007737D1 (de) * | 1989-05-13 | 1995-01-05 | Bayer Ag | Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel. |
DK408089D0 (da) | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
ES2086521T3 (es) | 1990-01-25 | 1996-07-01 | Univ Washington | Proteina hibrida laci-factor x. |
DE69233760D1 (de) | 1991-03-01 | 2009-06-25 | Dyax Corp | Inhibitoren der menschlichen Elastase von Neutrophilen |
RU2054180C1 (ru) | 1991-08-21 | 1996-02-10 | Жирнов Олег Петрович (н/п) | Способ лечения вирусных респираторных инфекций |
IL104325A (en) | 1992-01-07 | 2000-10-31 | Novo Nordisk As | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above |
IL104326A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
WO1994001461A1 (en) | 1992-07-13 | 1994-01-20 | Corvas International, Inc. | BOVINE PANCREATIC TRYPSIN INHIBITOR DERIVED INHIBITORS OF FACTOR Xa |
US5436153A (en) | 1992-12-02 | 1995-07-25 | Sprecher; Cindy A. | Human amyloid protein precursor homolog and Kunitz-type inhibitor |
WO1994012637A2 (en) | 1992-12-02 | 1994-06-09 | Zymogenetics, Inc. | Novel human amyloid protein precursor homologue and kunitz-type inhibitors |
JP2769083B2 (ja) | 1993-02-22 | 1998-06-25 | 日清食品株式会社 | エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法 |
US5455338A (en) | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
DE69533544T2 (de) | 1994-01-11 | 2006-02-23 | Dyax Corp., Cambridge | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
ATE275583T1 (de) | 1994-01-11 | 2004-09-15 | Dyax Corp | KALLIKREINHEMMENDE ßKUNITZ-DOMÄNEß-PROTEINE UND DERIVATEN DAVON |
US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
WO1996003503A1 (fr) | 1994-07-21 | 1996-02-08 | The Green Cross Corporation | Procede de production d'un inhibiteur de la trypsine urinaire et des domaines de celui-ci, nouveau polypeptide associe et procede de production de ce polypeptide |
US5541228A (en) * | 1994-10-14 | 1996-07-30 | Bristol-Myers Squibb Co. | Melatonergic agents |
EP0827539A2 (en) | 1995-05-08 | 1998-03-11 | Scios Inc. | Kunitz type protease inhibitors |
US5786328A (en) | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
DE69632435T2 (de) | 1995-07-24 | 2005-05-12 | Mitsubishi Chemical Corp. | Inhibitor des Hepatozytwachstumsfaktoraktivators |
US5736364A (en) | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
ES2263174T3 (es) | 1996-03-11 | 2006-12-01 | Bayer Corporation | Bikunina humana. |
US6262233B1 (en) | 1997-01-31 | 2001-07-17 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
US6294648B1 (en) * | 1999-07-20 | 2001-09-25 | Bayer Corporation | Protein having proteinase inhibitor activity |
-
1997
- 1997-03-10 ES ES97915029T patent/ES2263174T3/es not_active Expired - Lifetime
- 1997-03-10 AU AU22077/97A patent/AU716923B2/en not_active Ceased
- 1997-03-10 PL PL97328822A patent/PL188387B1/pl not_active IP Right Cessation
- 1997-03-10 EP EP97915029A patent/EP0891426B1/en not_active Expired - Lifetime
- 1997-03-10 WO PCT/US1997/003894 patent/WO1997033996A2/en active IP Right Grant
- 1997-03-10 DK DK97915029T patent/DK0891426T3/da active
- 1997-03-10 NZ NZ331540A patent/NZ331540A/en unknown
- 1997-03-10 TR TR1998/01794T patent/TR199801794T2/xx unknown
- 1997-03-10 PT PT97915029T patent/PT891426E/pt unknown
- 1997-03-10 AT AT97915029T patent/ATE328083T1/de not_active IP Right Cessation
- 1997-03-10 IL IL126115A patent/IL126115A/en not_active IP Right Cessation
- 1997-03-10 JP JP53280497A patent/JP3469584B2/ja not_active Expired - Fee Related
- 1997-03-10 CA CA002247888A patent/CA2247888A1/en not_active Abandoned
- 1997-03-10 BR BR9708021A patent/BR9708021A/pt not_active Application Discontinuation
- 1997-03-10 KR KR10-1998-0707163A patent/KR100356956B1/ko not_active Expired - Fee Related
- 1997-03-10 YU YU8997A patent/YU8997A/sh unknown
- 1997-03-10 DE DE69735996T patent/DE69735996T2/de not_active Expired - Fee Related
- 1997-03-10 HU HU9902698A patent/HU226419B1/hu not_active IP Right Cessation
- 1997-03-11 ID IDP970779A patent/ID16224A/id unknown
- 1997-03-11 CO CO97013175A patent/CO4600683A1/es unknown
- 1997-03-11 AR ARP970100967A patent/AR006188A1/es active IP Right Grant
- 1997-03-11 PA PA19978426301A patent/PA8426301A1/es unknown
- 1997-03-11 IN IN601DE1997 patent/IN192874B/en unknown
- 1997-03-11 MY MYPI97001015A patent/MY120693A/en unknown
- 1997-03-11 HR HR970144A patent/HRP970144B1/xx not_active IP Right Cessation
- 1997-03-11 SV SV1997000018A patent/SV1997000018A/es not_active Application Discontinuation
-
1998
- 1998-08-31 US US09/144,428 patent/US6583108B1/en not_active Expired - Fee Related
-
2001
- 2001-10-10 US US09/974,026 patent/US7019123B2/en not_active Expired - Fee Related
-
2003
- 2003-04-23 JP JP2003119118A patent/JP2004000208A/ja active Pending
-
2006
- 2006-03-27 US US11/390,775 patent/US7452859B2/en not_active Expired - Fee Related
- 2006-04-20 AR ARP060101562A patent/AR053063A2/es unknown
-
2007
- 2007-01-11 AR ARP070100116A patent/AR058982A1/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO4600683A1 (es) | Bikunina humana | |
Boman et al. | Chemical synthesis and enzymic processing of precursor forms of cecropins A and B | |
Speicher et al. | Erythrocyte spectrin is comprised of many homologous triple helical segments | |
DE3485568D1 (de) | Peptide aus alpha-aminoboronsaeuren. | |
EP0722461A4 (en) | EXPRESSION OF FUSION POLYPEPTIDES TRANSPORTED OUT OF CYTOPLASM WITHOUT HEAD SEQUENCE | |
DK0542863T3 (da) | Ekspression af rekombinante polypeptider med forbedret oprensning | |
ES2073571T3 (es) | Aplicacion de nuevos fragmentos de adn como secuencia que codifica un peptido señal para la secrecion de proteinas maduras, mediante levaduras recombinantes, cassettes de expresion, levaduras transformadas y procedimiento correspondiente de preparacion de proteinas. | |
AR036196A1 (es) | Agentes de contraste multimericos dirigidos a base de peptidos | |
DK289688D0 (da) | Ekspression af proapolipoprotein a-i. | |
ATE384787T1 (de) | Tripeptidyl-aminopeptidase | |
ES2196088T3 (es) | Analogos del factor de crecimiento de los queratinocitos. | |
AU5232886A (en) | Serine protease inhibitors and methods for isolation of same | |
ATE110742T1 (de) | Peptid-verbindungen. | |
NO930428D0 (no) | Proteinstrukturen til plantetoksingelonin | |
MX9701720A (es) | Proceso para la fabricacion de una palidipina modificada, inhibidora de la agregacion plaquetaria inducida por colageno. | |
KR940009329A (ko) | 딕티오스텔륨 디펩티딜아미노펩티다아제 | |
DK0794255T3 (da) | Fremgangsmåde til spaltning af kimært protein ved anvendelse af processeringsenzym | |
CO4480058A1 (es) | Genes codificantes y procedimiento de expresion de una nueva enzima: ftalil amidasa | |
FR2766190B1 (fr) | Nouveaux peptides et polypeptides utiles dans la regeneration du systeme nerveux | |
ES2060134T3 (es) | Inhibidor de tejido de metaloproteasas (timp-2). | |
PE20001068A1 (es) | Produccion de analogos de tripsinogeno recombinante solubles | |
KR880701073A (ko) | 제조합 dna 기법에 의해 생성된 민악티빈 | |
DK0616642T3 (da) | Hidtil ukendte thrombininhibitoriske proteiner fra landblodigler | |
BR9807616A (pt) | Aminopeptidase derivada de bacillus licheniformis e processo para preparação de proteìnas tipo natural | |
CO5210980A1 (es) | PROTEINA V[sub E] Y SECUENCIAS DE ACIDO NUCLEICO, COMPOSICIONES, Y METODOS DE RESISTENCIA A PATOGENOS VEGETALES |