CO2024012158A2 - Formas polimórficas de aticaprant para usar en el tratamiento del trastorno depresivo mayor - Google Patents
Formas polimórficas de aticaprant para usar en el tratamiento del trastorno depresivo mayorInfo
- Publication number
- CO2024012158A2 CO2024012158A2 CONC2024/0012158A CO2024012158A CO2024012158A2 CO 2024012158 A2 CO2024012158 A2 CO 2024012158A2 CO 2024012158 A CO2024012158 A CO 2024012158A CO 2024012158 A2 CO2024012158 A2 CO 2024012158A2
- Authority
- CO
- Colombia
- Prior art keywords
- aticaprant
- depressive disorder
- major depressive
- amorphous
- treatment
- Prior art date
Links
- ZHPMYDSXGRRERG-DEOSSOPVSA-N aticaprant Chemical compound CC1=CC(C)=CC([C@H]2N(CCC2)CC=2C=CC(OC=3C(=CC(=CC=3)C(N)=O)F)=CC=2)=C1 ZHPMYDSXGRRERG-DEOSSOPVSA-N 0.000 title abstract 6
- 229940121408 aticaprant Drugs 0.000 title abstract 6
- 208000024714 major depressive disease Diseases 0.000 title abstract 5
- 208000007415 Anhedonia Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263317475P | 2022-03-07 | 2022-03-07 | |
| PCT/IB2023/052088 WO2023170550A1 (en) | 2022-03-07 | 2023-03-06 | Polymorph forms of aticaprant for use in treating major depressive disorder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2024012158A2 true CO2024012158A2 (es) | 2024-09-30 |
Family
ID=85706849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2024/0012158A CO2024012158A2 (es) | 2022-03-07 | 2024-09-06 | Formas polimórficas de aticaprant para usar en el tratamiento del trastorno depresivo mayor |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11998524B2 (https=) |
| EP (1) | EP4489747A1 (https=) |
| JP (1) | JP2025508051A (https=) |
| KR (1) | KR20240156409A (https=) |
| CN (1) | CN119156211A (https=) |
| AU (1) | AU2023232536A1 (https=) |
| CA (1) | CA3254365A1 (https=) |
| CL (1) | CL2024002627A1 (https=) |
| CO (1) | CO2024012158A2 (https=) |
| IL (1) | IL315409A (https=) |
| JO (1) | JOP20240197A1 (https=) |
| MX (1) | MX2024010980A (https=) |
| TW (1) | TW202345796A (https=) |
| WO (1) | WO2023170550A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12161622B2 (en) | 2021-05-04 | 2024-12-10 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| EP4489730B1 (en) | 2022-03-07 | 2026-01-21 | Janssen Pharmaceuticals, Inc. | Compositions comprising aticaprant |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457208A (en) | 1993-06-21 | 1995-10-10 | Regents Of The University Of Minnesota | Kappa opioid receptor antagonists |
| WO2000069858A1 (en) | 1999-05-12 | 2000-11-23 | F. Hoffmann-La Roche Ag | Imidazodiazepine derivative |
| JP2004510789A (ja) | 2000-10-05 | 2004-04-08 | モーラー，ハンス | 選択的抗不安治療薬 |
| JP2004518654A (ja) | 2000-12-21 | 2004-06-24 | ザ マクレーン ホスピタル コーポレーション | 鬱病の治療法 |
| US6974824B2 (en) | 2001-01-08 | 2005-12-13 | Research Triangle Institute | Kappa opioid receptor ligands |
| DE60319812T2 (de) | 2002-03-28 | 2009-04-23 | Wisys Technology Foundation, Inc., Madison | Angstlösende wirkstoffe mit verminderten beruhigenden und ataktischen nebenwirkungen |
| KR101025633B1 (ko) | 2002-09-19 | 2011-03-30 | 일라이 릴리 앤드 캄파니 | 오피오이드 수용체 안타고니스트로서의 디아릴 에테르 |
| US7396943B2 (en) | 2003-03-07 | 2008-07-08 | Eli Lilly And Company | Opioid receptor antagonists |
| CN1756746A (zh) | 2003-03-07 | 2006-04-05 | 伊莱利利公司 | 作为阿片样物质受体拮抗剂的6－取代的烟酰胺衍生物 |
| BRPI0417156A (pt) | 2003-12-12 | 2007-03-06 | Lilly Co Eli | composto, composição farmacêutica, e, métodos para bloquear receptor mu, capa, delta ou combinação (heterodìmero) dos mesmos em mamìferos, para tratar e/ou prevenir doenças relacionadas com obesidade e obesidade, para suprimir apetite em um paciente, para efetuar perda de peso em um paciente obeso |
| CN1894240A (zh) | 2003-12-22 | 2007-01-10 | 伊莱利利公司 | 阿片受体拮抗剂 |
| EP1730140B1 (en) | 2004-03-12 | 2008-06-25 | Eli Lilly And Company | Opioid receptor antagonists |
| EP1727788B1 (en) | 2004-03-12 | 2010-07-28 | Eli Lilly And Company | Opioid receptor antagonists |
| AU2005222640A1 (en) | 2004-03-12 | 2005-09-29 | The Mclean Hospital Corporation | Salvinorin derivatives and uses thereof |
| CA2557794A1 (en) | 2004-03-15 | 2005-10-06 | Eli Lilly And Company | Opioid receptor antagonists |
| JP2007529523A (ja) | 2004-03-15 | 2007-10-25 | イーライ リリー アンド カンパニー | 肥満症を治療するためのオピオイド受容体拮抗物質としての４−（５−アミノメチル）−インドール−１−イルメチル）−ベンズアミド誘導体および関連化合物 |
| US8551986B2 (en) | 2005-12-08 | 2013-10-08 | The Mclean Hospital Corporation | Treatment of sequelae of psychiatric disorders |
| DK2001456T3 (da) | 2006-04-04 | 2010-04-12 | Emodys Gmbh | Anvendelse af kappa-opiodreceptorantagonistholde sammensætninger til behandling af dissociative forstyrrelser |
| US20100222345A1 (en) | 2006-08-09 | 2010-09-02 | Caroline Jean Diaz | Novel compounds as antagonists or inverse agonists for opioid receptors |
| WO2008021849A2 (en) | 2006-08-09 | 2008-02-21 | Smithkline Beecham Corporation | Novel compounds as antagonists or inverse agonists at opioid receptors |
| CN101511808A (zh) | 2006-09-08 | 2009-08-19 | 辉瑞产品公司 | 二芳基醚衍生物及其用途 |
| WO2009094260A1 (en) | 2008-01-22 | 2009-07-30 | Eli Lilly And Company | Kappa selective opioid receptor antagonist |
| BR112013002846A2 (pt) | 2010-08-05 | 2016-06-07 | Conrig Pharma Aps | derivados de tandospirona deuterada como agonista do receptor de 5-ht1a |
| EP2773352B1 (en) | 2011-12-09 | 2017-06-28 | Research Triangle Institute | 1-substituted 4-arylpiperazine as kappa opioid receptor antagonists |
| MX368870B (es) | 2013-12-20 | 2019-10-21 | H Lundbeck As | Uso de un antagonista de receptores de opioides con actividad kappa y vortioxetina para el tratamiento de trastorno depresivo con características melancólicas. |
| US10377698B2 (en) | 2015-03-30 | 2019-08-13 | University Of Innsbruck | Diphenethylamine derivatives which are inter alia useful as analgesics and method for their production |
| US10709685B2 (en) | 2015-05-28 | 2020-07-14 | Georgetown University | Use of methadone metabolites for treatment of anxiety and depression |
| WO2017218518A1 (en) | 2016-06-13 | 2017-12-21 | Board Of Regents Of The University Of Texas System | Pharmaceutical compositions and methods for treatment of pain |
| EP3490542A4 (en) | 2016-07-26 | 2020-07-08 | Flagship Pioneering Innovations V, Inc. | NEUROMODULATION COMPOSITIONS AND RELATED THERAPEUTIC METHODS FOR THE TREATMENT OF CANCER BY MODULATION OF AN ANTI-CANCER RESPONSE |
| JP7048572B6 (ja) | 2016-09-16 | 2023-12-20 | リサーチ トライアングル インスティテュート | テトラヒドロイソキノリンカッパーオピオイドアンタゴニスト |
| US10316021B2 (en) | 2016-11-28 | 2019-06-11 | Pfizer Inc. | Heteroarylphenoxy benzamide kappa opioid ligands |
| ES2926533T3 (es) | 2017-03-17 | 2022-10-26 | Scripps Research Inst | Antagonistas del receptor opioideo kappa y productos y métodos relacionados con los mismos |
| PH12018000077B1 (en) | 2017-07-05 | 2021-07-09 | Frimline Private Ltd | A pharmaceutical composition for neuropathic pain |
| US20190255036A1 (en) | 2018-02-16 | 2019-08-22 | Alexander Kariman | Compound and method for reducing neuropathic pain and depression |
| WO2019183556A1 (en) | 2018-03-23 | 2019-09-26 | University Of Kansas | Cyclic tetrapeptide analogs |
| US11491144B2 (en) | 2018-03-30 | 2022-11-08 | The Florida State University Research Foundation, Incorporated | Methods of treating fragile X mental retardation syndrome |
| JP2022505676A (ja) | 2018-10-23 | 2022-01-14 | ブラックソーン セラピューティクス インコーポレイテッド | 患者のスクリーニング、診断、及び層別化のためのシステム及び方法 |
| US20200171025A1 (en) | 2018-11-29 | 2020-06-04 | Srinivasa Rao Parella | Pharmaceutical composition comprising brexpiprazole and process for preparation thereof |
| US11266627B1 (en) * | 2021-05-04 | 2022-03-08 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| CN114195693A (zh) * | 2020-09-17 | 2022-03-18 | 广东东阳光药业有限公司 | 一种酰胺化合物的晶型及其制备方法 |
| US12161622B2 (en) | 2021-05-04 | 2024-12-10 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| AU2022268720A1 (en) | 2021-05-04 | 2023-12-21 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| EP4489730B1 (en) | 2022-03-07 | 2026-01-21 | Janssen Pharmaceuticals, Inc. | Compositions comprising aticaprant |
| WO2023170547A1 (en) | 2022-03-07 | 2023-09-14 | Janssen Pharmaceuticals, Inc. | Pure forms of crystalline aticaprant |
-
2023
- 2023-03-06 CN CN202380038808.6A patent/CN119156211A/zh active Pending
- 2023-03-06 CA CA3254365A patent/CA3254365A1/en active Pending
- 2023-03-06 TW TW112108148A patent/TW202345796A/zh unknown
- 2023-03-06 EP EP23712343.5A patent/EP4489747A1/en active Pending
- 2023-03-06 KR KR1020247033176A patent/KR20240156409A/ko active Pending
- 2023-03-06 AU AU2023232536A patent/AU2023232536A1/en active Pending
- 2023-03-06 WO PCT/IB2023/052088 patent/WO2023170550A1/en not_active Ceased
- 2023-03-06 IL IL315409A patent/IL315409A/en unknown
- 2023-03-06 US US18/178,961 patent/US11998524B2/en active Active
- 2023-03-06 JP JP2024553358A patent/JP2025508051A/ja active Pending
-
2024
- 2024-05-31 US US18/679,720 patent/US12171743B2/en active Active
- 2024-09-02 CL CL2024002627A patent/CL2024002627A1/es unknown
- 2024-09-05 JO JOJO/P/2024/0197A patent/JOP20240197A1/ar unknown
- 2024-09-06 MX MX2024010980A patent/MX2024010980A/es unknown
- 2024-09-06 CO CONC2024/0012158A patent/CO2024012158A2/es unknown
- 2024-12-23 US US18/991,891 patent/US20250325515A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20250325515A1 (en) | 2025-10-23 |
| US20230277499A1 (en) | 2023-09-07 |
| US11998524B2 (en) | 2024-06-04 |
| JOP20240197A1 (ar) | 2024-09-05 |
| CL2024002627A1 (es) | 2025-01-24 |
| IL315409A (en) | 2024-11-01 |
| CN119156211A (zh) | 2024-12-17 |
| MX2024010980A (es) | 2024-12-06 |
| JP2025508051A (ja) | 2025-03-21 |
| TW202345796A (zh) | 2023-12-01 |
| US20240316003A1 (en) | 2024-09-26 |
| CA3254365A1 (en) | 2023-09-14 |
| AU2023232536A1 (en) | 2024-10-24 |
| KR20240156409A (ko) | 2024-10-29 |
| US12171743B2 (en) | 2024-12-24 |
| WO2023170550A1 (en) | 2023-09-14 |
| EP4489747A1 (en) | 2025-01-15 |
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