CO2023000396A2 - Nuevo inhibidor de la secreción de ácido y uso del mismo - Google Patents

Nuevo inhibidor de la secreción de ácido y uso del mismo

Info

Publication number
CO2023000396A2
CO2023000396A2 CONC2023/0000396A CO2023000396A CO2023000396A2 CO 2023000396 A2 CO2023000396 A2 CO 2023000396A2 CO 2023000396 A CO2023000396 A CO 2023000396A CO 2023000396 A2 CO2023000396 A2 CO 2023000396A2
Authority
CO
Colombia
Prior art keywords
acid secretion
new inhibitor
present
novel compound
inhibitor
Prior art date
Application number
CONC2023/0000396A
Other languages
English (en)
Inventor
Hong Chul Yoon
Kyung Mi An
A Rang Im
Woo Jin Jeon
Jae Ho Heo
Chang Hee Hong
Jung Eun Park
Te Ik Sohn
Da Hae Hong
Jung Ho Kim
Jae Eui Shin
Yeong Ran Yoo
Min Whan Chang
In Gyu Je
Joon Tae Park
Jung Woo Lee
Su Yeon Kang
Yoon Sung Song
Joo Yun Lee
Original Assignee
Ildong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ildong Pharmaceutical Co Ltd filed Critical Ildong Pharmaceutical Co Ltd
Publication of CO2023000396A2 publication Critical patent/CO2023000396A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona un nuevo compuesto representado por la Fórmula Química 2 o una sal farmacéuticamente aceptable del mismo. El nuevo compuesto de acuerdo con la presente invención presenta un excelente efecto inhibidor de la secreción de ácido.
CONC2023/0000396A 2020-06-17 2023-01-13 Nuevo inhibidor de la secreción de ácido y uso del mismo CO2023000396A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20200073900 2020-06-17
PCT/KR2021/007572 WO2021256861A1 (ko) 2020-06-17 2021-06-16 신규한 산 분비 억제제 및 이의 용도

Publications (1)

Publication Number Publication Date
CO2023000396A2 true CO2023000396A2 (es) 2023-02-27

Family

ID=79176045

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0000396A CO2023000396A2 (es) 2020-06-17 2023-01-13 Nuevo inhibidor de la secreción de ácido y uso del mismo

Country Status (16)

Country Link
US (2) US11767311B2 (es)
EP (1) EP4148050A4 (es)
JP (1) JP7404561B2 (es)
KR (2) KR102432523B1 (es)
CN (1) CN115884968A (es)
AU (1) AU2021293694B2 (es)
BR (1) BR112022025613A2 (es)
CA (1) CA3182882A1 (es)
CL (1) CL2022003601A1 (es)
CO (1) CO2023000396A2 (es)
DO (1) DOP2022000291A (es)
EC (1) ECSP23002606A (es)
MX (1) MX2022016515A (es)
PE (1) PE20231652A1 (es)
TW (1) TWI797645B (es)
WO (1) WO2021256861A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021293694B2 (en) 2020-06-17 2023-12-21 Ildong Pharmaceutical Co., Ltd. Novel Acid Secretion Inhibitor and use thereof
WO2023113474A1 (ko) * 2021-12-15 2023-06-22 일동제약(주) 1-설포닐 피롤 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물
WO2023113458A1 (en) * 2021-12-15 2023-06-22 Ildong Pharmaceutical Co., Ltd. Novel salt of 1-sulfonyl pyrrole derivative, preparation method thereof and pharmaceutical composition comprising thereof
KR20230102353A (ko) * 2021-12-30 2023-07-07 주식회사 대웅제약 삼중음성유방암의 예방 또는 치료용 약학적 조성물
CN114539219A (zh) * 2022-03-17 2022-05-27 日照正济药业有限公司 一种富马酸伏诺拉生的制备方法
WO2023211843A1 (en) * 2022-04-25 2023-11-02 Daewoong Pharmaceutical Co., Ltd. Potassium-competitive acid blockers for the treatment of pathological hypersecretory conditions
WO2023229323A1 (ko) * 2022-05-23 2023-11-30 일동제약(주) 6-메톡시피리딘-3-일 유도체의 제조방법
WO2023229322A1 (ko) * 2022-05-23 2023-11-30 일동제약(주) 6-메톡시피리딘-3-일 유도체의 제조방법

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003242390A1 (en) * 2002-06-14 2003-12-31 Takeda Pharmaceutical Company Limited Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. peptic ulcers
EP2336107B1 (en) * 2004-09-30 2015-09-23 Takeda Pharmaceutical Company Limited Proton pump inhibitors
PL1919865T3 (pl) * 2005-08-30 2011-09-30 Takeda Pharmaceuticals Co 1-heterocyklilosulfonylo, 2-aminometylo, 5-(hetero-) arylo podstawione pochodne 1-h-pirolu jako kwasowe inhibitory wydzielania
WO2007114338A1 (ja) * 2006-03-31 2007-10-11 Takeda Pharmaceutical Company Limited 酸分泌抑制薬
US8933105B2 (en) * 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
AU2009284867B2 (en) * 2008-08-27 2014-08-28 Takeda Pharmaceutical Company Limited Pyrrole compounds
NZ595890A (en) * 2009-03-26 2013-09-27 Takeda Pharmaceutical Pyrazole compound
CN110200903B (zh) * 2012-06-27 2022-07-29 武田药品工业株式会社 用盐稳定的胺和有机酸的液体制剂
EP2963019B1 (en) * 2013-02-28 2020-08-12 Takeda Pharmaceutical Company Limited Method for producing pyridine-3-sulfonyl chloride
CN105693693A (zh) * 2014-11-27 2016-06-22 江苏柯菲平医药股份有限公司 一种吡咯类胃酸分泌和抑制剂化合物盐的制备
CN105985278A (zh) * 2015-01-27 2016-10-05 江苏柯菲平医药股份有限公司 吡咯磺酰类衍生物、其制备方法及其在医药上的应用
KR101613245B1 (ko) * 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
CN106432191A (zh) * 2015-08-10 2017-02-22 陕西合成药业股份有限公司 一种新的吡咯类衍生物、其制备方法及其在医药上的应用
KR20170113040A (ko) 2016-03-25 2017-10-12 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민의 신규한 산부가염
CN109843869B (zh) * 2016-09-29 2021-07-16 江苏吉贝尔药业股份有限公司 1-[(吡啶-3-基-磺酰基)-1h-吡咯-3-基]甲胺衍生物及其药物组合物和用途
BR112020000318A2 (pt) 2017-07-10 2020-07-14 Takeda Pharmaceutical Company Limited preparação
CN110396080B (zh) * 2018-04-24 2022-07-08 广东东阳光药业有限公司 一种富马酸沃诺拉赞代谢物及其氘代物的制备方法
CN108558831B (zh) * 2018-06-08 2021-07-27 上海璃道医药科技有限公司 取代吡咯-4-烷基胺类化合物及其用途
AU2021293694B2 (en) 2020-06-17 2023-12-21 Ildong Pharmaceutical Co., Ltd. Novel Acid Secretion Inhibitor and use thereof
CN111943932B (zh) * 2020-08-06 2023-07-14 四川国康药业有限公司 一种可以治疗消化性溃疡的3-吡啶磺酰-1-n-杂吡咯衍生物及其制备方法和用途

Also Published As

Publication number Publication date
EP4148050A4 (en) 2023-10-25
EP4148050A1 (en) 2023-03-15
WO2021256861A1 (ko) 2021-12-23
DOP2022000291A (es) 2023-01-15
CA3182882A1 (en) 2021-12-23
ECSP23002606A (es) 2023-03-31
JP7404561B2 (ja) 2023-12-25
CN115884968A (zh) 2023-03-31
TW202325702A (zh) 2023-07-01
AU2021293694B2 (en) 2023-12-21
JP2023524172A (ja) 2023-06-08
TW202214588A (zh) 2022-04-16
PE20231652A1 (es) 2023-10-17
KR102432523B1 (ko) 2022-08-16
US20230192650A1 (en) 2023-06-22
KR20210156235A (ko) 2021-12-24
US20230373954A1 (en) 2023-11-23
US11767311B2 (en) 2023-09-26
AU2021293694A1 (en) 2023-01-19
CL2022003601A1 (es) 2023-07-07
TWI797645B (zh) 2023-04-01
BR112022025613A2 (pt) 2023-01-17
KR20210156234A (ko) 2021-12-24
MX2022016515A (es) 2023-01-30

Similar Documents

Publication Publication Date Title
CO2023000396A2 (es) Nuevo inhibidor de la secreción de ácido y uso del mismo
AR111495A1 (es) Compuestos de imidazo-piperidina fusionada como inhibidores de jak
ECSP21000990A (es) Derivados de 3-(5-hidroxi-1-oxoisoindolin-2-il)piperidina-2,6-diona y su uso en el tratamiento de trastornos dependientes de la proteína con dedos de zinc 2 de la familia ikaros (ikzf2)
EA201691401A1 (ru) Индазольные соединения в качестве ингибиторов irak4
AR115949A1 (es) Compuestos heterocíclicos
AR107864A1 (es) ÁCIDO 7a,11b-DIHIDROXI-6a-ETIL-5b-COLAN-24-OICO Y COMPOSICIONES FARMACÉUTICAS
ECSP20035590A (es) Derivado de oxi-fluoropiperidina como inhibidor de quinasa
MY196186A (en) Amino-Fluoropiperidine Derivatitves as Kinase Inhibitor
CO2020007156A2 (es) Derivado de amino-metil piperidina como inhibidor de quinasa
CY1126067T1 (el) Συντηγμενες πυρρολινες που δρουν σαν ειδικοι για ουβικιτινη αναστολεις πρωτεασης 30 (usp30)
AR119672A1 (es) Inhibidor de 15-pgdh
PE20191103A1 (es) Inhibidores de dopamina-b-hidroxilasa
CO2022008968A2 (es) Nuevos derivados de metilquinazolinona
MX2023006194A (es) Inhibidor de molecula peque?a de catepsina c y uso medicinal del mismo.
CO2021001849A2 (es) Nuevo derivado de amina heterocíclico y composición farmacéutica que lo comprende
ZA202301937B (en) Compounds
MX2023007476A (es) Derivado de tetrahidroquinolina y uso medico del mismo.
CO2022010431A2 (es) Nuevo derivado de pirazol
CO2019013254A2 (es) Compuestos bicíclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias
AR114418A1 (es) Compuesto cíclico de metilactama y su utilización farmacéutica
AR116428A1 (es) Compuestos de 6-fluoro-2-metilbenzo[d]tiazol-5-ilo
EA202190452A1 (ru) Ингибиторы cdk8/19
AR083780A1 (es) Composicion farmaceutica para tratar infecciones del hcv
MX2019003907A (es) Combinaciones farmaceuticas de inhibidor de histona desacetilasa e inhibidor de proteasoma o farmaco inmunomodulador para el tratamiento de cancer hematologico.
AR126552A1 (es) Composición farmacéutica para prevenir o tratar la esclerosis sistémica