CO2021000326A2 - Composiciones y métodos para aumentar o mejorar la transducción de vectores de terapia genética y para eliminar o reducir las inmunoglobulinas - Google Patents

Composiciones y métodos para aumentar o mejorar la transducción de vectores de terapia genética y para eliminar o reducir las inmunoglobulinas

Info

Publication number
CO2021000326A2
CO2021000326A2 CONC2021/0000326A CO2021000326A CO2021000326A2 CO 2021000326 A2 CO2021000326 A2 CO 2021000326A2 CO 2021000326 A CO2021000326 A CO 2021000326A CO 2021000326 A2 CO2021000326 A2 CO 2021000326A2
Authority
CO
Colombia
Prior art keywords
immunoglobulins
methods
gene therapy
eliminating
compositions
Prior art date
Application number
CONC2021/0000326A
Other languages
English (en)
Spanish (es)
Inventor
Sébastien Lacroix-Desmazes
Federico Mingozzi
Jordan Dimitrov
Christian Leborgne
Sean Armour
Original Assignee
Genethon
Inst Nat Sante Rech Med
Univ Sorbonne
Univ Paris
Spark Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=67303476&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2021000326(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genethon, Inst Nat Sante Rech Med, Univ Sorbonne, Univ Paris, Spark Therapeutics Inc filed Critical Genethon
Publication of CO2021000326A2 publication Critical patent/CO2021000326A2/es

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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
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    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
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  • Hematology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Food Science & Technology (AREA)
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CONC2021/0000326A 2018-07-17 2021-01-15 Composiciones y métodos para aumentar o mejorar la transducción de vectores de terapia genética y para eliminar o reducir las inmunoglobulinas CO2021000326A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18305971 2018-07-17
US201862768731P 2018-11-16 2018-11-16
PCT/EP2019/069280 WO2020016318A1 (en) 2018-07-17 2019-07-17 Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins

Publications (1)

Publication Number Publication Date
CO2021000326A2 true CO2021000326A2 (es) 2021-04-19

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CONC2021/0000326A CO2021000326A2 (es) 2018-07-17 2021-01-15 Composiciones y métodos para aumentar o mejorar la transducción de vectores de terapia genética y para eliminar o reducir las inmunoglobulinas

Country Status (28)

Country Link
US (3) US20210228738A1 (https=)
EP (2) EP4154904A1 (https=)
JP (2) JP2021529821A (https=)
KR (1) KR20210042308A (https=)
CN (2) CN112689515A (https=)
AU (2) AU2019306121B2 (https=)
BR (1) BR112021000807A8 (https=)
CA (1) CA3106368A1 (https=)
CL (1) CL2021000112A1 (https=)
CO (1) CO2021000326A2 (https=)
DK (1) DK3768304T3 (https=)
ES (1) ES2935970T3 (https=)
FI (1) FI3768304T3 (https=)
HR (1) HRP20221542T1 (https=)
HU (1) HUE060720T2 (https=)
IL (1) IL280099A (https=)
LT (1) LT3768304T (https=)
MX (1) MX2021000580A (https=)
PE (1) PE20211859A1 (https=)
PH (1) PH12021550115A1 (https=)
PL (1) PL3768304T3 (https=)
RS (1) RS63878B1 (https=)
SG (1) SG11202100306VA (https=)
SI (1) SI3768304T1 (https=)
SM (1) SMT202300005T1 (https=)
UA (1) UA130604C2 (https=)
WO (1) WO2020016318A1 (https=)
ZA (1) ZA202100202B (https=)

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