CO2019011582A2 - Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares - Google Patents
Composiciones de anticuerpo optimizadas para el tratamiento de trastornos ocularesInfo
- Publication number
- CO2019011582A2 CO2019011582A2 CO2019011582A CO2019011582A CO2019011582A2 CO 2019011582 A2 CO2019011582 A2 CO 2019011582A2 CO 2019011582 A CO2019011582 A CO 2019011582A CO 2019011582 A CO2019011582 A CO 2019011582A CO 2019011582 A2 CO2019011582 A2 CO 2019011582A2
- Authority
- CO
- Colombia
- Prior art keywords
- treatment
- eye disorders
- antibody compositions
- optimized antibody
- polymers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762475163P | 2017-03-22 | 2017-03-22 | |
| PCT/US2018/023812 WO2018175752A1 (en) | 2017-03-22 | 2018-03-22 | Optimized antibody compositions for treatment of ocular disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019011582A2 true CO2019011582A2 (es) | 2019-10-31 |
Family
ID=61837830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO2019011582A CO2019011582A2 (es) | 2017-03-22 | 2019-10-18 | Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11111291B2 (https=) |
| EP (1) | EP3600442A1 (https=) |
| JP (2) | JP7227151B2 (https=) |
| KR (1) | KR20190138636A (https=) |
| CN (1) | CN110612124B (https=) |
| AR (1) | AR111249A1 (https=) |
| AU (1) | AU2018237359B2 (https=) |
| BR (1) | BR112019019706A2 (https=) |
| CA (1) | CA3056248A1 (https=) |
| CL (1) | CL2019002658A1 (https=) |
| CO (1) | CO2019011582A2 (https=) |
| CR (1) | CR20190481A (https=) |
| IL (1) | IL269378A (https=) |
| MA (1) | MA49279A (https=) |
| MX (1) | MX2019011141A (https=) |
| MY (1) | MY201701A (https=) |
| PE (1) | PE20191758A1 (https=) |
| PH (1) | PH12019502149A1 (https=) |
| SG (1) | SG11201908650PA (https=) |
| TW (1) | TWI839327B (https=) |
| UA (1) | UA129242C2 (https=) |
| WO (1) | WO2018175752A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2268673B1 (en) | 2008-03-28 | 2017-10-25 | The Regents of The University of California | Polypeptide-polymer conjugates and methods of use thereof |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| ES2925248T3 (es) | 2015-12-09 | 2022-10-14 | Univ California | Métodos para tratar una enfermedad o un trastorno oculares |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| JP6871948B2 (ja) | 2016-04-27 | 2021-05-19 | アッヴィ・インコーポレイテッド | 抗ｉｌ−１３抗体を使用する、ｉｌ−１３活性が有害である疾患の治療方法 |
| EP3758737A4 (en) | 2018-03-02 | 2022-10-12 | Kodiak Sciences Inc. | IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF |
| AU2019232001B2 (en) | 2018-03-09 | 2025-02-20 | Valitor, Inc. | Multivalent peptide conjugates for sustained intra-articular treatment of joint inflammation |
| MY195550A (en) | 2018-10-29 | 2023-01-31 | Hoffmann La Roche | Antibody Formulation |
| EP3886946A1 (en) | 2019-06-05 | 2021-10-06 | Regeneron Pharmaceuticals, Inc. | Devices and methods for precision dose delivery |
| TWI785360B (zh) * | 2019-08-06 | 2022-12-01 | 美商建南德克公司 | 眼科疾病之個人化治療 |
| US20220306760A1 (en) * | 2019-08-23 | 2022-09-29 | Igm Biosciences, Inc. | Igm glycovariants |
| CA3157509A1 (en) * | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN113493519B (zh) * | 2020-03-19 | 2022-12-27 | 浙江道尔生物科技有限公司 | 一种半衰期显著延长的治疗眼部血管新生疾病的融合蛋白 |
| WO2021231866A2 (en) * | 2020-05-15 | 2021-11-18 | The Regents Of The University Of Michigan | Carbon nanotubes and complexes thereof for treating and detecting ocular tumors |
| WO2022010273A1 (ko) * | 2020-07-07 | 2022-01-13 | 주식회사 카나프테라퓨틱스 | 보체 경로 억제제를 포함하는 융합단백질 및 이의 용도 |
| TW202216761A (zh) * | 2020-07-16 | 2022-05-01 | 瑞士商諾華公司 | 抗β細胞素抗體、其片段及多特異性結合分子 |
| GB202011993D0 (en) | 2020-07-31 | 2020-09-16 | Adc Therapeutics Sa | ANTI-IL 13Ra2 antibodies |
| CN114106190B (zh) | 2020-08-31 | 2025-04-08 | 普米斯生物技术(珠海)有限公司 | 一种抗vegf/pd-l1双特异性抗体及其用途 |
| EP4232474A1 (en) | 2020-10-21 | 2023-08-30 | Boehringer Ingelheim International GmbH | Bispecific anti-vegf and anti-trkb binding molecules for the treatment of eye diseases |
| EP4089133A1 (en) * | 2021-05-14 | 2022-11-16 | Johannes Gutenberg-Universität Mainz | Poly(ethylene glycol) having c1 to c3-alkyloxymethyl side chains, bioconjugates thereof, process for its preparation and its use. |
| IL309035A (en) * | 2021-06-04 | 2024-02-01 | Innovent Biologics Suzhou Co Ltd | A bispecific binding molecule that binds to VEGF and ANG2 and its use |
| CN115770477B (zh) * | 2021-09-08 | 2024-07-02 | 天津工业大学 | 一种β-环糊精修饰透明质酸钠复合纳滤膜的制备方法 |
| EP4147709A1 (en) * | 2021-09-14 | 2023-03-15 | The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth | A composition comprising il-36 and/or il-18 for use in treating ocular disorders |
| KR20230105972A (ko) * | 2022-01-05 | 2023-07-12 | 주식회사 카나프테라퓨틱스 | 혈관신생 억제제가 결합된 항-C3b 항체 또는 항-C5 항체 및 이의 용도 |
| EP4540284A2 (en) | 2022-06-17 | 2025-04-23 | Apogee Therapeutics, Inc. | Antibodies that bind interleukin 13 and methods of use |
| JP2025541722A (ja) * | 2022-11-28 | 2025-12-23 | シェンチェン・オキュルゲン・バイオメディカル・テクノロジー・カンパニー・リミテッド | Ｃ５／ｖｅｇｆ二重特異性結合分子 |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| WO2024182318A2 (en) * | 2023-02-28 | 2024-09-06 | Kodiak Sciences Inc. | Antibodies to htra1 and conjugates thereof |
| AU2024280284A1 (en) * | 2023-05-30 | 2025-12-11 | Ads Therapeutics Llc | Complement antibody-drug conjugates |
| IL326700A (en) * | 2023-09-11 | 2026-04-01 | Hoffmann La Roche | Multispecific fusion proteins targeting angiogenic and inflammatory factors |
| WO2025119329A1 (zh) * | 2023-12-07 | 2025-06-12 | 信达生物制药(苏州)有限公司 | 抗c5和htra1双特异性抗体及其用途 |
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- 2018-03-22 BR BR112019019706A patent/BR112019019706A2/pt unknown
- 2018-03-22 EP EP18717180.6A patent/EP3600442A1/en active Pending
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| TW201838649A (zh) | 2018-11-01 |
| RU2019132064A (ru) | 2021-04-22 |
| CR20190481A (es) | 2020-01-06 |
| BR112019019706A2 (pt) | 2020-04-28 |
| EP3600442A1 (en) | 2020-02-05 |
| RU2019132064A3 (https=) | 2021-07-26 |
| UA129242C2 (uk) | 2025-02-26 |
| CL2019002658A1 (es) | 2019-12-27 |
| SG11201908650PA (en) | 2019-10-30 |
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| PE20191758A1 (es) | 2019-12-12 |
| KR20190138636A (ko) | 2019-12-13 |
| MX2019011141A (es) | 2019-11-05 |
| JP2020514376A (ja) | 2020-05-21 |
| TWI839327B (zh) | 2024-04-21 |
| MY201701A (en) | 2024-03-13 |
| CA3056248A1 (en) | 2018-09-27 |
| IL269378A (en) | 2019-11-28 |
| WO2018175752A1 (en) | 2018-09-27 |
| AU2018237359B2 (en) | 2024-06-27 |
| JP7227151B2 (ja) | 2023-02-21 |
| PH12019502149A1 (en) | 2020-06-29 |
| MA49279A (fr) | 2020-02-05 |
| AR111249A1 (es) | 2019-06-19 |
| CN110612124B (zh) | 2024-04-16 |
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| US20210363231A1 (en) | 2021-11-25 |
| CN110612124A (zh) | 2019-12-24 |
| JP2023065424A (ja) | 2023-05-12 |
| WO2018175752A8 (en) | 2018-11-15 |
| US11891437B2 (en) | 2024-02-06 |
| US20200002411A1 (en) | 2020-01-02 |
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