CO2018008447A2 - Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano - Google Patents
Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decanoInfo
- Publication number
- CO2018008447A2 CO2018008447A2 CONC2018/0008447A CO2018008447A CO2018008447A2 CO 2018008447 A2 CO2018008447 A2 CO 2018008447A2 CO 2018008447 A CO2018008447 A CO 2018008447A CO 2018008447 A2 CO2018008447 A2 CO 2018008447A2
- Authority
- CO
- Colombia
- Prior art keywords
- diaza
- spiro
- hetero
- oxo
- aryl
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151012 | 2016-01-13 | ||
| PCT/EP2017/025005 WO2017121647A1 (en) | 2016-01-13 | 2017-01-13 | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2018008447A2 true CO2018008447A2 (es) | 2018-08-31 |
Family
ID=55129633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2018/0008447A CO2018008447A2 (es) | 2016-01-13 | 2018-08-13 | Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
Country Status (30)
| Country | Link |
|---|---|
| US (7) | US20170197970A1 (enExample) |
| EP (2) | EP3722284B1 (enExample) |
| JP (2) | JP6893516B2 (enExample) |
| KR (2) | KR102768715B1 (enExample) |
| CN (2) | CN114149413A (enExample) |
| AR (2) | AR107434A1 (enExample) |
| AU (1) | AU2017206908B2 (enExample) |
| BR (1) | BR112018014305B1 (enExample) |
| CA (1) | CA3011176C (enExample) |
| CL (1) | CL2018001911A1 (enExample) |
| CO (1) | CO2018008447A2 (enExample) |
| CY (1) | CY1122923T1 (enExample) |
| DK (2) | DK3402781T5 (enExample) |
| EA (2) | EA037598B1 (enExample) |
| EC (1) | ECSP18060834A (enExample) |
| ES (2) | ES3014458T3 (enExample) |
| FI (1) | FI3722284T3 (enExample) |
| HR (2) | HRP20200782T1 (enExample) |
| HU (2) | HUE070444T2 (enExample) |
| IL (2) | IL260496B (enExample) |
| LT (2) | LT3722284T (enExample) |
| MX (1) | MX378607B (enExample) |
| PE (1) | PE20221732A1 (enExample) |
| PL (2) | PL3402781T3 (enExample) |
| PT (2) | PT3402781T (enExample) |
| RS (2) | RS60307B1 (enExample) |
| SI (2) | SI3722284T1 (enExample) |
| TW (1) | TWI635082B (enExample) |
| WO (1) | WO2017121647A1 (enExample) |
| ZA (1) | ZA201805356B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017121647A1 (en) * | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| EA034898B1 (ru) | 2016-01-13 | 2020-04-03 | Грюненталь Гмбх | Производные 8-амино-2-оксо-1,3-диазаспиро[4,5]декана |
| CN108602777B (zh) | 2016-01-13 | 2022-05-03 | 格吕伦塔尔有限公司 | 3-((杂-)芳基)-烷基-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 |
| HUE049134T2 (hu) | 2016-01-13 | 2020-08-28 | Gruenenthal Gmbh | 3-(karboximetil)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-dekán származékok |
| US10961242B2 (en) * | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
| MX2021008364A (es) | 2019-01-11 | 2021-08-05 | Gruenenthal Gmbh | Amidas de pirrolidina iii sustituidas. |
| CN110862395B (zh) * | 2019-11-13 | 2020-09-29 | 株洲千金药业股份有限公司 | 一种制备他达拉非重要杂质的原料化合物的制备方法 |
| US20240400537A1 (en) | 2023-04-25 | 2024-12-05 | Gruenenthal Gmbh | Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| JP4380992B2 (ja) | 2001-04-18 | 2009-12-09 | ユーロ−セルティーク エス．エイ． | ノシセプチン類似体 |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| EP1519939B9 (en) | 2002-07-05 | 2011-04-06 | Targacept, Inc. | N-aryl diazaspirocyclic compounds and methods of preparation and use thereof |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| NZ544282A (en) | 2003-05-23 | 2009-07-31 | Zealand Pharma As | Triaza-spiro compounds as nociceptin analogues and uses thereof |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005023784A1 (de) | 2005-05-19 | 2006-11-30 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| WO2008046758A2 (en) | 2006-10-19 | 2008-04-24 | F. Hoffmann-La Roche Ag | Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes |
| EP2121624A1 (en) * | 2007-02-01 | 2009-11-25 | Glaxo Group Limited | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
| JP5490677B2 (ja) | 2007-04-09 | 2014-05-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体 |
| CN103183630A (zh) | 2008-03-27 | 2013-07-03 | 格吕伦塔尔有限公司 | 取代的4-氨基环己烷衍生物 |
| TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
| WO2010151815A2 (en) | 2009-06-25 | 2010-12-29 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| WO2015192039A1 (en) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| WO2017121647A1 (en) | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| CN108602777B (zh) | 2016-01-13 | 2022-05-03 | 格吕伦塔尔有限公司 | 3-((杂-)芳基)-烷基-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 |
| HUE049134T2 (hu) | 2016-01-13 | 2020-08-28 | Gruenenthal Gmbh | 3-(karboximetil)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-dekán származékok |
| RU2747877C2 (ru) | 2016-01-13 | 2021-05-17 | Ново Нордиск А/С | Аналоги эфр(а) с заместителями - жирными кислотами |
| UY37073A (es) | 2016-01-13 | 2017-07-31 | Bristol-Myers Squibb Company Una Corporación Del Estado De Delaware | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock, y las composiciones que los contienen |
| EA034898B1 (ru) | 2016-01-13 | 2020-04-03 | Грюненталь Гмбх | Производные 8-амино-2-оксо-1,3-диазаспиро[4,5]декана |
| EP3722283A1 (en) | 2016-01-13 | 2020-10-14 | Grünenthal GmbH | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
-
2017
- 2017-01-13 WO PCT/EP2017/025005 patent/WO2017121647A1/en not_active Ceased
- 2017-01-13 US US15/405,485 patent/US20170197970A1/en not_active Abandoned
- 2017-01-13 JP JP2018536436A patent/JP6893516B2/ja active Active
- 2017-01-13 EA EA201891611A patent/EA037598B1/ru unknown
- 2017-01-13 CA CA3011176A patent/CA3011176C/en active Active
- 2017-01-13 ES ES20155715T patent/ES3014458T3/es active Active
- 2017-01-13 HR HRP20200782TT patent/HRP20200782T1/hr unknown
- 2017-01-13 PL PL17700389T patent/PL3402781T3/pl unknown
- 2017-01-13 EA EA202190281A patent/EA202190281A1/ru unknown
- 2017-01-13 RS RS20200593A patent/RS60307B1/sr unknown
- 2017-01-13 DK DK17700389.4T patent/DK3402781T5/da active
- 2017-01-13 SI SI201731589T patent/SI3722284T1/sl unknown
- 2017-01-13 EP EP20155715.4A patent/EP3722284B1/en active Active
- 2017-01-13 ES ES17700389T patent/ES2807549T3/es active Active
- 2017-01-13 TW TW106101124A patent/TWI635082B/zh active
- 2017-01-13 HU HUE20155715A patent/HUE070444T2/hu unknown
- 2017-01-13 KR KR1020247014797A patent/KR102768715B1/ko active Active
- 2017-01-13 CN CN202111487304.1A patent/CN114149413A/zh active Pending
- 2017-01-13 PE PE2022001338A patent/PE20221732A1/es unknown
- 2017-01-13 HR HRP20250176TT patent/HRP20250176T1/hr unknown
- 2017-01-13 LT LTEP20155715.4T patent/LT3722284T/lt unknown
- 2017-01-13 DK DK20155715.4T patent/DK3722284T3/da active
- 2017-01-13 FI FIEP20155715.4T patent/FI3722284T3/fi active
- 2017-01-13 AU AU2017206908A patent/AU2017206908B2/en active Active
- 2017-01-13 LT LTEP17700389.4T patent/LT3402781T/lt unknown
- 2017-01-13 PT PT177003894T patent/PT3402781T/pt unknown
- 2017-01-13 PL PL20155715.4T patent/PL3722284T3/pl unknown
- 2017-01-13 HU HUE17700389A patent/HUE049771T2/hu unknown
- 2017-01-13 EP EP17700389.4A patent/EP3402781B1/en active Active
- 2017-01-13 RS RS20250212A patent/RS66559B1/sr unknown
- 2017-01-13 SI SI201730263T patent/SI3402781T1/sl unknown
- 2017-01-13 PT PT201557154T patent/PT3722284T/pt unknown
- 2017-01-13 KR KR1020187021552A patent/KR102719137B1/ko active Active
- 2017-01-13 AR ARP170100091A patent/AR107434A1/es active IP Right Grant
- 2017-01-13 BR BR112018014305-7A patent/BR112018014305B1/pt active IP Right Grant
- 2017-01-13 MX MX2018008643A patent/MX378607B/es unknown
- 2017-01-13 CN CN201780006506.5A patent/CN108699006B/zh active Active
-
2018
- 2018-03-16 US US15/923,948 patent/US20180201616A1/en not_active Abandoned
- 2018-07-09 IL IL260496A patent/IL260496B/en unknown
- 2018-07-13 CL CL2018001911A patent/CL2018001911A1/es unknown
- 2018-08-10 ZA ZA2018/05356A patent/ZA201805356B/en unknown
- 2018-08-13 CO CONC2018/0008447A patent/CO2018008447A2/es unknown
- 2018-08-13 EC ECSENADI201860834A patent/ECSP18060834A/es unknown
- 2018-12-03 US US16/207,854 patent/US20190106429A1/en not_active Abandoned
-
2019
- 2019-06-24 US US16/450,331 patent/US10807988B2/en active Active
-
2020
- 2020-05-21 CY CY20201100466T patent/CY1122923T1/el unknown
- 2020-09-02 US US17/010,089 patent/US20210032256A1/en not_active Abandoned
-
2021
- 2021-03-01 US US17/188,860 patent/US20210188860A1/en not_active Abandoned
- 2021-03-02 JP JP2021032291A patent/JP7148660B2/ja active Active
- 2021-08-04 IL IL285355A patent/IL285355B2/en unknown
-
2022
- 2022-01-18 AR ARP220100097A patent/AR124672A2/es not_active Application Discontinuation
- 2022-11-14 US US17/986,207 patent/US20230303573A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2018008444A2 (es) | Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano | |
| CO2018008447A2 (es) | Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano | |
| CL2018001909A1 (es) | Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano | |
| CL2018001910A1 (es) | Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano | |
| CO2018008445A2 (es) | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-deca | |
| CL2018002012A1 (es) | Derivados de maitansinoide, conjugados de los mismos y métodos de uso. | |
| MX2022007994A (es) | Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos. | |
| MX386328B (es) | Derivados de maitansinoide, conjugados de los mismos, y metodos de uso. | |
| CL2015002835A1 (es) | Nuevos derivados de piridina | |
| CL2015002897A1 (es) | Inhibidores de bace1 | |
| DK3452465T3 (da) | Substituerede 2,4-diaminoquinolinderivater til anvendelse til behandling af proliferative sygdomme | |
| MX2018005987A (es) | Compuestos heterociclicos para el tratamiento de enfermedades. | |
| MX390441B (es) | Formulaciones liquidas de fosfaplatino. | |
| LT3867244T (lt) | 4-pirazin-2-ilmetil-morfolino dariniai ir jų naudojimas kaip vaisto | |
| IL273242B1 (en) | 6chloro-3-(2,4-dichloro-5-methoxyphenyl)-2-mercapto-7- methoxyquinazolin-4(3h)-one and derivative compounds, compositions comprising same and uses thereof | |
| EA202091403A1 (ru) | Производные 2-оксо-1-пирролидинилимидазотиадиазола |