CN108699006B - 3-((杂-)芳基)-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 - Google Patents

3-((杂-)芳基)-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 Download PDF

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CN108699006B
CN108699006B CN201780006506.5A CN201780006506A CN108699006B CN 108699006 B CN108699006 B CN 108699006B CN 201780006506 A CN201780006506 A CN 201780006506A CN 108699006 B CN108699006 B CN 108699006B
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cis
phenyl
diazaspiro
dimethylamino
methyl
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CN108699006A (zh
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S.屈纳特
R.M.克尼希斯
A.克莱斯
A.韦格特
I.科内齐基
P.拉特克利费
R.约施托克
T.科克
K.林茨
W.施勒德
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Gruenenthal GmbH
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN201780006506.5A 2016-01-13 2017-01-13 3-((杂-)芳基)-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 Active CN108699006B (zh)

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EP16151012.8 2016-01-13
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PCT/EP2017/025005 WO2017121647A1 (en) 2016-01-13 2017-01-13 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

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EA034898B1 (ru) 2016-01-13 2020-04-03 Грюненталь Гмбх Производные 8-амино-2-оксо-1,3-диазаспиро[4,5]декана
CN108602777B (zh) 2016-01-13 2022-05-03 格吕伦塔尔有限公司 3-((杂-)芳基)-烷基-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物
HUE049134T2 (hu) 2016-01-13 2020-08-28 Gruenenthal Gmbh 3-(karboximetil)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-dekán származékok
US10961242B2 (en) * 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
MX2021008364A (es) 2019-01-11 2021-08-05 Gruenenthal Gmbh Amidas de pirrolidina iii sustituidas.
CN110862395B (zh) * 2019-11-13 2020-09-29 株洲千金药业股份有限公司 一种制备他达拉非重要杂质的原料化合物的制备方法
US20240400537A1 (en) 2023-04-25 2024-12-05 Gruenenthal Gmbh Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives

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