CN85109491A - 生产防治动植物内、外寄生虫的13β-梅耳拜霉素衍生物的方法 - Google Patents

生产防治动植物内、外寄生虫的13β-梅耳拜霉素衍生物的方法 Download PDF

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Publication number
CN85109491A
CN85109491A CN198585109491A CN85109491A CN85109491A CN 85109491 A CN85109491 A CN 85109491A CN 198585109491 A CN198585109491 A CN 198585109491A CN 85109491 A CN85109491 A CN 85109491A CN 85109491 A CN85109491 A CN 85109491A
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CN
China
Prior art keywords
formula
group
alkyl
compound
haloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN198585109491A
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English (en)
Chinese (zh)
Inventor
布鲁诺·弗赖博士
安东尼·科尼利厄斯·奥沙利文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
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Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of CN85109491A publication Critical patent/CN85109491A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN198585109491A 1984-12-04 1985-12-03 生产防治动植物内、外寄生虫的13β-梅耳拜霉素衍生物的方法 Pending CN85109491A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH05750/84-2 1984-12-04
CH575084 1984-12-04

Publications (1)

Publication Number Publication Date
CN85109491A true CN85109491A (zh) 1986-07-23

Family

ID=4298719

Family Applications (1)

Application Number Title Priority Date Filing Date
CN198585109491A Pending CN85109491A (zh) 1984-12-04 1985-12-03 生产防治动植物内、外寄生虫的13β-梅耳拜霉素衍生物的方法

Country Status (20)

Country Link
US (1) US4696945A (enExample)
EP (1) EP0184173B1 (enExample)
JP (1) JPH072748B2 (enExample)
CN (1) CN85109491A (enExample)
AU (1) AU584950B2 (enExample)
CA (1) CA1261823A (enExample)
DD (2) DD250457A5 (enExample)
DE (1) DE3587746D1 (enExample)
DK (1) DK559985A (enExample)
ES (3) ES8704473A1 (enExample)
FI (1) FI854773A7 (enExample)
GB (1) GB2167751B (enExample)
GR (1) GR852893B (enExample)
HU (1) HUT39739A (enExample)
IL (1) IL77198A (enExample)
MA (1) MA20583A1 (enExample)
NZ (1) NZ214425A (enExample)
PT (1) PT81591B (enExample)
ZA (1) ZA859247B (enExample)
ZW (1) ZW21785A1 (enExample)

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US4857509A (en) * 1985-01-22 1989-08-15 Ciba-Geigy Corporation 13β-alkylmilbemycin derivatives for controlling parasites of animals and plants
US4587247A (en) * 1985-02-25 1986-05-06 Merck & Co., Inc. Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
EP0235085A1 (de) * 1986-02-20 1987-09-02 Ciba-Geigy Ag 13-Beta-Zuckerderivate von Milbemycinen, deren Herstellung und Verwendung gegen Ekto-und Endoparasiten am Nutztier oder an der Nutzpflanze
ES2059366T3 (es) * 1986-03-12 1994-11-16 American Cyanamid Co Compuestos macrolidos.
EP0240274A3 (en) * 1986-04-03 1990-03-14 Merck & Co. Inc. Avermectins as growth promotant agents
DE3778768D1 (de) * 1986-07-02 1992-06-11 Ciba Geigy Ag Pestizide.
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
JPS6393796A (ja) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
US5212322A (en) * 1986-12-11 1993-05-18 Sankyo Company, Limited Macrolide compounds, their preparation and their use
AR243528A1 (es) * 1986-12-11 1993-08-31 Sankyo Co Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida.
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5183749A (en) * 1987-02-04 1993-02-02 Sankyo Company, Ltd. Microbial process for the preparation of milbemycin derivatives
US4897416A (en) * 1987-02-18 1990-01-30 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
GB8721647D0 (en) * 1987-09-15 1987-10-21 Pfizer Ltd Antiparasitic agents
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
PT88952B (pt) * 1987-11-09 1993-02-26 Pfizer Processo para a preparacao de avermectinas etiladas
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
US4918097A (en) * 1988-03-11 1990-04-17 Ciba-Geigy Corporation Insecticides and parasiticides
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
US5428034A (en) * 1988-09-02 1995-06-27 Sankyo Co., Ltd. Milbemycin derivatives, their preparation and their use
AU613521B2 (en) * 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
NZ232422A (en) * 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
TW202452B (enExample) * 1989-12-01 1993-03-21 Ciba Geigy Ag
JPH085894B2 (ja) * 1990-03-01 1996-01-24 三共株式会社 ミルベマイシンエーテル誘導体
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US5114930A (en) * 1990-05-14 1992-05-19 Merck & Co., Inc. Avermectin derivatives with a spacer inserted between the disaccharide and the aglycone useful as antiparasitic agents
US5188944A (en) * 1990-06-22 1993-02-23 Merck & Co., Inc. Process for the glycosylation of avermectin agylcones
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
EP0530901A1 (en) * 1991-09-04 1993-03-10 Merck & Co. Inc. 13-beta-O-methoxymethyl-22,23-dihydro avermectin B1A/B1B aglycone
JP2591552B2 (ja) * 1991-10-04 1997-03-19 三共株式会社 １５−ヒドロキシミルベマイシン誘導体及びその製法
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
JP2654337B2 (ja) * 1992-09-01 1997-09-17 三共株式会社 １３−エーテル置換ミルベマイシン誘導体の新規中間体
WO1996025852A1 (en) * 1995-02-24 1996-08-29 Novartis Ag Composition for controlling parasites
AU9785698A (en) 1997-10-02 1999-04-27 Microcide Pharmaceuticals, Inc. Fungal efflux pump inhibitors
MX2009011852A (es) * 2007-05-03 2009-12-11 Merial Ltd Composiciones que comprenden compuestos macrolidos de alcoxieter de c-13 y compuestos de fenilpirazol.
US7919522B2 (en) 2007-05-03 2011-04-05 Merial Limited Compositions comprising C-13 alkoxyether macrolide compounds and phenylpyrazole compounds
JP5740676B2 (ja) * 2013-10-17 2015-06-24 メリアル リミテッド Ｃ−１３アルコキシエーテルマクロライド化合物及びフェニルピラゾール化合物を含む組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
ES474155A1 (es) * 1977-10-11 1979-10-16 Glaxo Group Ltd Un procedimiento para la preparacion de nuevos derivados de aminoalquilfurano
PH16612A (en) * 1977-12-19 1983-11-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
US4427663A (en) * 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
US4587247A (en) * 1985-02-25 1986-05-06 Merck & Co., Inc. Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use

Also Published As

Publication number Publication date
FI854773A0 (fi) 1985-12-02
GB2167751B (en) 1988-04-27
PT81591B (de) 1987-10-16
DE3587746D1 (de) 1994-03-17
DK559985A (da) 1986-06-05
US4696945A (en) 1987-09-29
ES556926A0 (es) 1987-10-01
ZA859247B (en) 1986-07-30
GB8529637D0 (en) 1986-01-08
EP0184173A2 (de) 1986-06-11
DD262662A5 (de) 1988-12-07
FI854773A7 (fi) 1986-06-05
ES549508A0 (es) 1987-04-01
AU584950B2 (en) 1989-06-08
DK559985D0 (da) 1985-12-03
JPS61178986A (ja) 1986-08-11
MA20583A1 (fr) 1986-07-01
ES556927A0 (es) 1987-10-01
EP0184173A3 (en) 1989-03-15
DD250457A5 (de) 1987-10-14
HUT39739A (en) 1986-10-29
ZW21785A1 (en) 1986-07-02
ES8708232A1 (es) 1987-10-01
NZ214425A (en) 1988-05-30
ES8704473A1 (es) 1987-04-01
JPH072748B2 (ja) 1995-01-18
IL77198A (en) 1989-06-30
GB2167751A (en) 1986-06-04
AU5071985A (en) 1986-06-12
CA1261823A (en) 1989-09-26
EP0184173B1 (de) 1994-02-02
PT81591A (de) 1986-01-01
ES8708233A1 (es) 1987-10-01
GR852893B (enExample) 1986-04-01

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