CN1980648A - 使用ice抑制剂治疗癫痫发作 - Google Patents

使用ice抑制剂治疗癫痫发作 Download PDF

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Publication number
CN1980648A
CN1980648A CNA2005800228318A CN200580022831A CN1980648A CN 1980648 A CN1980648 A CN 1980648A CN A2005800228318 A CNA2005800228318 A CN A2005800228318A CN 200580022831 A CN200580022831 A CN 200580022831A CN 1980648 A CN1980648 A CN 1980648A
Authority
CN
China
Prior art keywords
compound
ice
seizures
caspase
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800228318A
Other languages
English (en)
Chinese (zh)
Inventor
A·韦扎尼
J·C·R·兰德尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CN1980648A publication Critical patent/CN1980648A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CNA2005800228318A 2004-05-15 2005-05-16 使用ice抑制剂治疗癫痫发作 Pending CN1980648A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57131404P 2004-05-15 2004-05-15
US60/571,314 2004-05-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2011101550931A Division CN102362867A (zh) 2004-05-15 2005-05-16 使用ice抑制剂治疗癫痫发作

Publications (1)

Publication Number Publication Date
CN1980648A true CN1980648A (zh) 2007-06-13

Family

ID=34969808

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2011101550931A Pending CN102362867A (zh) 2004-05-15 2005-05-16 使用ice抑制剂治疗癫痫发作
CNA2005800228318A Pending CN1980648A (zh) 2004-05-15 2005-05-16 使用ice抑制剂治疗癫痫发作

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2011101550931A Pending CN102362867A (zh) 2004-05-15 2005-05-16 使用ice抑制剂治疗癫痫发作

Country Status (12)

Country Link
US (2) US20060128696A1 (enExample)
EP (1) EP1750689A1 (enExample)
JP (2) JP4848367B2 (enExample)
CN (2) CN102362867A (enExample)
AU (1) AU2005247409B2 (enExample)
CA (1) CA2566362C (enExample)
IL (1) IL179248A0 (enExample)
MX (1) MXPA06013256A (enExample)
NZ (1) NZ588448A (enExample)
PL (1) PL217743B1 (enExample)
WO (1) WO2005115362A1 (enExample)
ZA (1) ZA200610133B (enExample)

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ATE481089T1 (de) * 2006-05-31 2010-10-15 Vertex Pharma Orale formulierungen mit kontrollierter freisetzung eines interleukin-1-beta-converting- enzyme inhibitors
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
RU2537361C1 (ru) * 2013-07-18 2015-01-10 Общество С Ограниченной Ответственностью "Синтегал" Оптические изомеры (+) и (-)-бензгидрилмочевин и (+) и (-)-1-[(3-хлорфенил)-фенил-метил]мочевины, фармацевтическая композиция на их основе и способ их получения
ES2985625T3 (es) 2016-03-10 2024-11-06 Orphelia Pharma Formas de dosificación sólidas de vigabatrina
JP2023524745A (ja) * 2020-05-01 2023-06-13 メッドスター ヘルス インコーポレイテッド Ｃｏｖｉｄ－１９を治療するための方法
WO2024097731A2 (en) * 2022-11-02 2024-05-10 Medstar Health, Inc. Methods for treating covid-19

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Also Published As

Publication number Publication date
US20060128696A1 (en) 2006-06-15
IL179248A0 (en) 2008-04-13
MXPA06013256A (es) 2007-02-08
JP4848367B2 (ja) 2011-12-28
AU2005247409A1 (en) 2005-12-08
JP2011213741A (ja) 2011-10-27
PL217743B1 (pl) 2014-08-29
ZA200610133B (en) 2008-05-28
CN102362867A (zh) 2012-02-29
CA2566362C (en) 2013-09-10
JP2007538013A (ja) 2007-12-27
NZ588448A (en) 2012-01-12
CA2566362A1 (en) 2005-12-08
US20150190404A1 (en) 2015-07-09
WO2005115362A1 (en) 2005-12-08
AU2005247409B2 (en) 2011-11-10
PL381823A1 (pl) 2007-07-23
EP1750689A1 (en) 2007-02-14

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