CN1975422B - 利用o6-烷基鸟嘌呤-dna烷基转移酶的方法 - Google Patents
利用o6-烷基鸟嘌呤-dna烷基转移酶的方法 Download PDFInfo
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- CN1975422B CN1975422B CN2006101603317A CN200610160331A CN1975422B CN 1975422 B CN1975422 B CN 1975422B CN 2006101603317 A CN2006101603317 A CN 2006101603317A CN 200610160331 A CN200610160331 A CN 200610160331A CN 1975422 B CN1975422 B CN 1975422B
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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| AU2004211584B2 (en) | 2003-01-31 | 2009-11-12 | Promega Corporation | Covalent tethering of functional groups to proteins |
| US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
| US7666612B2 (en) * | 2003-05-23 | 2010-02-23 | Epfl-Ecole Polytechnique Federale De Lausanne | Methods for protein labeling based on acyl carrier protein |
| JP2007526282A (ja) * | 2004-03-02 | 2007-09-13 | ウペエフエル・エコル・ポリテクニック・フェデラル・ドゥ・ローザンヌ | Ｏ６−アルキルグアニンｄｎａアルキルトランスフェラーゼ特異的基質 |
| WO2005085431A2 (en) * | 2004-03-02 | 2005-09-15 | Epfl Ecole Polytechnique Federale De Lausanne | Mutants of o6-alkylguanine-dna alkyltransferase |
| US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
| US7825096B2 (en) | 2004-09-08 | 2010-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs |
| US7273714B2 (en) * | 2005-03-11 | 2007-09-25 | Vion Pharmaceuticals, Inc. | Alkylguanyltransferase assays |
| JP2008539198A (ja) * | 2005-04-27 | 2008-11-13 | コヴァリス・バイオサイエンシス・アーゲー | Ｏ６−アルキルグアニン−ｄｎａアルキルトランスフェラーゼと反応するピリミジン |
| FR2890174B1 (fr) | 2005-08-30 | 2009-04-24 | Cis Bio Internat Sa | Procede pour la mise en evidence d'un processus biologique par mesure d'un fret |
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| EP2044219B1 (en) | 2006-06-30 | 2013-05-22 | DiscoveRx Corporation | Detectable nucleic acid tag |
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| JP5513122B2 (ja) * | 2006-12-05 | 2014-06-04 | レーザーゲン インコーポレイテッド | 光開裂性標識ヌクレオチドとヌクレオシドおよび標識ヌクレオチドとヌクレオシドならびにｄｎａ配列決定におけるそれらの使用法 |
| US7897737B2 (en) | 2006-12-05 | 2011-03-01 | Lasergen, Inc. | 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing |
| EP1978093A1 (en) * | 2007-04-04 | 2008-10-08 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Method of crosslinking two objects of interest |
| GB0711560D0 (en) * | 2007-06-14 | 2007-07-25 | Innova Biosciences Ltd | Improvements in or relating to production of conjugates |
| US20100209933A1 (en) * | 2007-10-29 | 2010-08-19 | Mcreynolds Larry A | Methods and Compositions for Detection and Enrichment of Target Small RNAs |
| EP2093564A1 (en) | 2008-02-25 | 2009-08-26 | Technische Universität Dresden Medizinische Fakultät Carl Gustav Carus | Method for distinguishing secretory granules of different ages |
| KR101677772B1 (ko) | 2008-06-11 | 2016-11-18 | 레이저젠, 인코퍼레이티드 | 뉴클레오타이드 및 뉴클레오사이드 그리고 시퀀싱에서의 이들의 이용 방법 |
| FR2936245B1 (fr) * | 2008-09-23 | 2012-07-06 | Cis Bio Int | Nouveaux substrats d'o6-alkylguanine-adn alkyltransferase et ses mutants. |
| DE112011100297B4 (de) | 2010-01-20 | 2017-08-24 | New England Biolabs, Inc. | Zusammensetzungen, Verfahren und damit in Zusammenhang stehende Anwendungen zum Spalten modifizierter DNA |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145622A (zh) * | 1993-06-08 | 1997-03-19 | 癌症研究运动技术有限公司 | O 6取代的鸟嘌呤衍生物，及其制备方法和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9224888D0 (en) * | 1992-11-27 | 1993-01-13 | Univ Singapore | Monoclonal antibody |
| DE19903895A1 (de) * | 1999-02-01 | 2000-08-03 | Kai Johnsson | Selektive Immobilisierung und Nachweis der O·6·-Alkylguanin-DNA-Alkyltransferase in der aktiven Form |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145622A (zh) * | 1993-06-08 | 1997-03-19 | 癌症研究运动技术有限公司 | O 6取代的鸟嘌呤衍生物，及其制备方法和用途 |
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| Damoiseaux et.al.synthesis and applications of chemcal probes for humanO6-alkylguanine-DNA alkyltransferase.《Chembiochem》.2001,285-287. * |
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