CN1948343A - p53四聚化结构域介导的四价单链抗体 - Google Patents
p53四聚化结构域介导的四价单链抗体 Download PDFInfo
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- CN1948343A CN1948343A CN200510109319.9A CN200510109319A CN1948343A CN 1948343 A CN1948343 A CN 1948343A CN 200510109319 A CN200510109319 A CN 200510109319A CN 1948343 A CN1948343 A CN 1948343A
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Abstract
Description
治疗方式 | 数量(只) | 临床评分 |
对照组模型组地塞米松(0.1mg/kg/天)TNF-TeAb(16mg/kg/3天) | 51066 | 02.30±1.640(p<0.05)0.83±0.41(p<0.05) |
治疗方式 | 数量 | 左足踝关节周长(cm) | 右足踝关节周长(cm) |
对照组模型组地塞米松(0.1mg/kg/天)TNF-TeAb(16mg/kg/3天) | 51066 | 2.5±0.13.21±0.282.87±0.08(p<0.05)2.97±0.05(p<0.05) | 2.5±02.74±0.312.48±0.13(NS)2.60±0.09(NS) |
治疗方式 | 数量(只) | 嘶叫次数 |
对照组模型组地塞米松(0.1mg/kg/天)TNF-TeAb(16mg/kg/3天) | 51066 | 05.83±5.360(p<0.05)1.67±9.87(p<0.05) |
治疗方式 | 数量 | 抗CII抗体(U/ml) |
对照组模型组地塞米松(0.1mg/kg/天) | 5106 | 0690324.968±13620.84569031.991±75374.77(p<0.05) |
TNF-TeAb(16mg/kg/3天) | 6 | 613998.897±98748.94(p<0.05) |
治疗方式 | 数量 | TNF-α(pg/ml) | IL-1β(pg/ml) |
对照组模型组地塞米松(0.1mg/kg/天)TNF-TeAb(16mg/kg/3天) | 51066 | 32±9413±13318±95(p<0.05)267±68(p<0.05) | 18.7±5.4107±878±23(p<0.05)87±27(p<0.05) |
Claims (20)
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CN100475849C CN100475849C (zh) | 2009-04-08 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101987873A (zh) * | 2009-08-07 | 2011-03-23 | 普罗特奥姆技术公司 | P53融合蛋白及应用 |
CN101602809B (zh) * | 2008-12-29 | 2011-12-07 | 中国人民解放军疾病预防控制所 | 具有抗炎作用的抗体靶向补体抑制物 |
CN102924600A (zh) * | 2012-11-14 | 2013-02-13 | 河南大学 | 死亡受体5激动性多价抗体及其在制备抗肿瘤药物中的应用 |
CN110248958A (zh) * | 2017-08-20 | 2019-09-17 | 夸德卢普生物公司 | 多聚体、四聚体和八聚体 |
CN110272497A (zh) * | 2019-02-26 | 2019-09-24 | 内蒙古医科大学附属医院 | 一种高亲和力抗环瓜氨酸肽四价小分子抗体及其制备方法与应用 |
CN113061191A (zh) * | 2021-03-17 | 2021-07-02 | 托比康尔生物科技(武汉)有限公司 | 一种IgG样三功能抗体及其应用 |
-
2005
- 2005-10-14 CN CNB2005101093199A patent/CN100475849C/zh not_active Expired - Fee Related
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101602809B (zh) * | 2008-12-29 | 2011-12-07 | 中国人民解放军疾病预防控制所 | 具有抗炎作用的抗体靶向补体抑制物 |
CN101987873A (zh) * | 2009-08-07 | 2011-03-23 | 普罗特奥姆技术公司 | P53融合蛋白及应用 |
CN102924600A (zh) * | 2012-11-14 | 2013-02-13 | 河南大学 | 死亡受体5激动性多价抗体及其在制备抗肿瘤药物中的应用 |
CN110248958A (zh) * | 2017-08-20 | 2019-09-17 | 夸德卢普生物公司 | 多聚体、四聚体和八聚体 |
CN110272497A (zh) * | 2019-02-26 | 2019-09-24 | 内蒙古医科大学附属医院 | 一种高亲和力抗环瓜氨酸肽四价小分子抗体及其制备方法与应用 |
CN110272497B (zh) * | 2019-02-26 | 2022-04-08 | 内蒙古医科大学附属医院 | 一种高亲和力抗环瓜氨酸肽四价小分子抗体及其制备方法与应用 |
CN113061191A (zh) * | 2021-03-17 | 2021-07-02 | 托比康尔生物科技(武汉)有限公司 | 一种IgG样三功能抗体及其应用 |
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