CN1931137A - 盐酸小檗碱掩味微丸及其制剂 - Google Patents
盐酸小檗碱掩味微丸及其制剂 Download PDFInfo
- Publication number
- CN1931137A CN1931137A CN 200610113218 CN200610113218A CN1931137A CN 1931137 A CN1931137 A CN 1931137A CN 200610113218 CN200610113218 CN 200610113218 CN 200610113218 A CN200610113218 A CN 200610113218A CN 1931137 A CN1931137 A CN 1931137A
- Authority
- CN
- China
- Prior art keywords
- berberine hydrochloride
- masked
- pill
- micropill
- sucrose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 title claims abstract description 100
- 239000006187 pill Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 claims abstract description 62
- 239000011248 coating agent Substances 0.000 claims abstract description 33
- 238000000576 coating method Methods 0.000 claims abstract description 33
- 239000008187 granular material Substances 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 24
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 20
- 229930006000 Sucrose Natural products 0.000 claims abstract description 20
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 20
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 20
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 20
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 18
- 229920001353 Dextrin Polymers 0.000 claims abstract description 13
- 239000004375 Dextrin Substances 0.000 claims abstract description 13
- 235000019425 dextrin Nutrition 0.000 claims abstract description 13
- 239000004014 plasticizer Substances 0.000 claims abstract description 12
- 229920002472 Starch Polymers 0.000 claims abstract description 5
- 235000019698 starch Nutrition 0.000 claims abstract description 5
- 239000008107 starch Substances 0.000 claims abstract description 5
- 239000000725 suspension Substances 0.000 claims abstract description 3
- 235000019640 taste Nutrition 0.000 claims description 32
- 230000000873 masking effect Effects 0.000 claims description 27
- 239000005720 sucrose Substances 0.000 claims description 19
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 14
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 239000000375 suspending agent Substances 0.000 claims description 11
- 206010013786 Dry skin Diseases 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 239000011230 binding agent Substances 0.000 claims description 9
- 239000007919 dispersible tablet Substances 0.000 claims description 9
- 238000009472 formulation Methods 0.000 claims description 9
- 238000003475 lamination Methods 0.000 claims description 9
- 229940109275 cyclamate Drugs 0.000 claims description 8
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims description 7
- 239000011812 mixed powder Substances 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 235000009508 confectionery Nutrition 0.000 claims description 4
- -1 hydroxypropyl Chemical group 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 229960003943 hypromellose Drugs 0.000 claims description 4
- 239000007779 soft material Substances 0.000 claims description 4
- 238000005563 spheronization Methods 0.000 claims description 4
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical group CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 claims description 3
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims description 3
- 229920003119 EUDRAGIT E PO Polymers 0.000 claims description 3
- 229920003149 Eudragit® E 100 Polymers 0.000 claims description 3
- 229920003139 Eudragit® L 100 Polymers 0.000 claims description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 3
- 235000010489 acacia gum Nutrition 0.000 claims description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 3
- 239000007947 dispensing tablet Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 3
- 229940093430 polyethylene glycol 1500 Drugs 0.000 claims description 3
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 239000001069 triethyl citrate Substances 0.000 claims description 3
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 3
- 235000013769 triethyl citrate Nutrition 0.000 claims description 3
- 125000000185 sucrose group Chemical group 0.000 claims 2
- 208000019505 Deglutition disease Diseases 0.000 abstract description 3
- 238000010030 laminating Methods 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 238000005096 rolling process Methods 0.000 abstract 1
- 229940032147 starch Drugs 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
- 238000009495 sugar coating Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 7
- 235000019658 bitter taste Nutrition 0.000 description 5
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 4
- 229940093265 berberine Drugs 0.000 description 4
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 241000167880 Hirundinidae Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
Claims (7)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510317470.5A CN105030689A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
CN 200610113218 CN1931137A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
CN201510385195.0A CN104997735A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200610113218 CN1931137A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
Related Child Applications (2)
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CN201510385195.0A Division CN104997735A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
CN201510317470.5A Division CN105030689A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
Publications (1)
Publication Number | Publication Date |
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CN1931137A true CN1931137A (zh) | 2007-03-21 |
Family
ID=37877259
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200610113218 Pending CN1931137A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
CN201510317470.5A Pending CN105030689A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
CN201510385195.0A Pending CN104997735A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
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CN201510317470.5A Pending CN105030689A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
CN201510385195.0A Pending CN104997735A (zh) | 2006-09-19 | 2006-09-19 | 盐酸小檗碱掩味微丸及其制剂 |
Country Status (1)
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CN (3) | CN1931137A (zh) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102525952A (zh) * | 2011-11-29 | 2012-07-04 | 昆明邦宇制药有限公司 | 一种黄连素微丸的生产方法 |
WO2015097642A1 (en) * | 2013-12-26 | 2015-07-02 | Rao Raavi Chandra Sekhar | Composition for treating cancer and method of synthesizing the same |
CN105106127A (zh) * | 2015-07-09 | 2015-12-02 | 河南蓝图制药有限公司 | 一种蒙脱石微丸干混悬剂及其制备方法 |
CN106511260A (zh) * | 2016-12-05 | 2017-03-22 | 黑龙江童医生儿童生物制药有限公司 | 一种盐酸小檗碱口服微丸干凝胶及其制备方法和应用 |
CN107233331A (zh) * | 2017-07-28 | 2017-10-10 | 昆明邦宇制药有限公司 | 一种黄连素细粒剂及其制备方法 |
CN107308126A (zh) * | 2017-07-11 | 2017-11-03 | 山西省芮城县红宝兽药有限责任公司 | 黄连素微囊包丸工艺 |
CN110638785A (zh) * | 2019-09-29 | 2020-01-03 | 黄山中皇制药有限公司 | 一种穿心莲内酯干混悬剂 |
CN112587499A (zh) * | 2020-12-29 | 2021-04-02 | 成都锦华药业有限责任公司 | 一种盐酸小檗碱微丸及其制备方法 |
CN112972398A (zh) * | 2021-02-25 | 2021-06-18 | 江苏睿实生物科技有限公司 | 一种盐酸小檗碱颗粒剂及其制备方法 |
CN117379467A (zh) * | 2023-10-23 | 2024-01-12 | 广东万年青制药股份有限公司 | 一种用于消化道疾病的药物组合物及其制备方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3661508B1 (en) * | 2017-08-02 | 2024-05-22 | Pro.Med.CS Praha A.S. | Manufacturing method of oral dosage form containing berberine, oral dosage form containing berberine and use thereof |
WO2019038430A1 (en) | 2017-08-25 | 2019-02-28 | Eleonor Sprl | COMPOSITION COMPRISING AT LEAST ONE PROTOBERBERIN ALKALOID AND METHOD FOR PRODUCING THE SAME |
CN107536807A (zh) * | 2017-09-11 | 2018-01-05 | 潘正茂 | 一种盐酸小檗碱干混悬颗粒及其制备方法 |
CN114699384A (zh) * | 2022-03-22 | 2022-07-05 | 中国科学院宁波材料技术与工程研究所 | 一种药物掩味方法、药物及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3034592B2 (ja) * | 1990-11-20 | 2000-04-17 | わかもと製薬株式会社 | 経口用固形製剤及びその製造法 |
CN1269478C (zh) * | 2004-06-14 | 2006-08-16 | 湖北丽益医药科技有限公司 | 盐酸小檗碱微囊及其制备方法 |
CN1273133C (zh) * | 2004-11-12 | 2006-09-06 | 北京昭衍博纳新药研究有限公司 | 掩味盐酸小檗碱颗粒及其制剂 |
CN100337627C (zh) * | 2005-02-23 | 2007-09-19 | 广东怡康制药有限公司 | 一种盐酸小檗碱分散片及其制备方法 |
-
2006
- 2006-09-19 CN CN 200610113218 patent/CN1931137A/zh active Pending
- 2006-09-19 CN CN201510317470.5A patent/CN105030689A/zh active Pending
- 2006-09-19 CN CN201510385195.0A patent/CN104997735A/zh active Pending
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102525952A (zh) * | 2011-11-29 | 2012-07-04 | 昆明邦宇制药有限公司 | 一种黄连素微丸的生产方法 |
WO2015097642A1 (en) * | 2013-12-26 | 2015-07-02 | Rao Raavi Chandra Sekhar | Composition for treating cancer and method of synthesizing the same |
CN105106127A (zh) * | 2015-07-09 | 2015-12-02 | 河南蓝图制药有限公司 | 一种蒙脱石微丸干混悬剂及其制备方法 |
CN105106127B (zh) * | 2015-07-09 | 2017-06-20 | 河南蓝图制药有限公司 | 一种蒙脱石微丸干混悬剂及其制备方法 |
CN107198679A (zh) * | 2015-07-09 | 2017-09-26 | 河南蓝图制药有限公司 | 一种蒙脱石微丸干混悬剂及其制备方法 |
CN106511260A (zh) * | 2016-12-05 | 2017-03-22 | 黑龙江童医生儿童生物制药有限公司 | 一种盐酸小檗碱口服微丸干凝胶及其制备方法和应用 |
CN107308126A (zh) * | 2017-07-11 | 2017-11-03 | 山西省芮城县红宝兽药有限责任公司 | 黄连素微囊包丸工艺 |
CN107233331A (zh) * | 2017-07-28 | 2017-10-10 | 昆明邦宇制药有限公司 | 一种黄连素细粒剂及其制备方法 |
CN110638785A (zh) * | 2019-09-29 | 2020-01-03 | 黄山中皇制药有限公司 | 一种穿心莲内酯干混悬剂 |
CN110638785B (zh) * | 2019-09-29 | 2021-09-24 | 黄山中皇制药有限公司 | 一种穿心莲内酯干混悬剂 |
CN112587499A (zh) * | 2020-12-29 | 2021-04-02 | 成都锦华药业有限责任公司 | 一种盐酸小檗碱微丸及其制备方法 |
CN112972398A (zh) * | 2021-02-25 | 2021-06-18 | 江苏睿实生物科技有限公司 | 一种盐酸小檗碱颗粒剂及其制备方法 |
CN117379467A (zh) * | 2023-10-23 | 2024-01-12 | 广东万年青制药股份有限公司 | 一种用于消化道疾病的药物组合物及其制备方法 |
CN117379467B (zh) * | 2023-10-23 | 2024-04-30 | 广东万年青制药股份有限公司 | 一种用于消化道疾病的药物组合物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104997735A (zh) | 2015-10-28 |
CN105030689A (zh) | 2015-11-11 |
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