CN1915952A - 从丹参中提取原儿茶醛和丹参酚酸的方法 - Google Patents
从丹参中提取原儿茶醛和丹参酚酸的方法 Download PDFInfo
- Publication number
- CN1915952A CN1915952A CNA2005100289510A CN200510028951A CN1915952A CN 1915952 A CN1915952 A CN 1915952A CN A2005100289510 A CNA2005100289510 A CN A2005100289510A CN 200510028951 A CN200510028951 A CN 200510028951A CN 1915952 A CN1915952 A CN 1915952A
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- Prior art keywords
- acid
- resin
- red sage
- sage root
- rancinamycin
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- IBGBGRVKPALMCQ-UHFFFAOYSA-N 3,4-dihydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1O IBGBGRVKPALMCQ-UHFFFAOYSA-N 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 title claims abstract description 22
- 240000007164 Salvia officinalis Species 0.000 title claims description 38
- 235000005412 red sage Nutrition 0.000 title claims description 31
- 239000002253 acid Substances 0.000 title claims description 6
- 229960003371 protocatechualdehyde Drugs 0.000 title abstract 3
- PRYXPGFZVGZNBL-ADLFWFRXSA-N salviol Chemical compound CC(C)c1cc2CC[C@H]3C(C)(C)C[C@H](O)C[C@]3(C)c2cc1O PRYXPGFZVGZNBL-ADLFWFRXSA-N 0.000 title 1
- AJSGWTLZEUBGFV-UHFFFAOYSA-N salviol Natural products CC(C)c1cc2CCC3C(CC(O)CC3(C)C)c2cc1O AJSGWTLZEUBGFV-UHFFFAOYSA-N 0.000 title 1
- 239000011347 resin Substances 0.000 claims abstract description 30
- 229920005989 resin Polymers 0.000 claims abstract description 30
- YMGFTDKNIWPMGF-QHCPKHFHSA-N Salvianolic acid A Natural products OC(=O)[C@H](Cc1ccc(O)c(O)c1)OC(=O)C=Cc2ccc(O)c(O)c2C=Cc3ccc(O)c(O)c3 YMGFTDKNIWPMGF-QHCPKHFHSA-N 0.000 claims abstract description 26
- YMGFTDKNIWPMGF-UCPJVGPRSA-N Salvianolic acid A Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C(=C(O)C(O)=CC=1)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 YMGFTDKNIWPMGF-UCPJVGPRSA-N 0.000 claims abstract description 26
- 229930183842 salvianolic acid Natural products 0.000 claims abstract description 26
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- 239000003795 chemical substances by application Substances 0.000 claims description 22
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
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- 239000007788 liquid Substances 0.000 claims description 12
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- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 8
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 8
- 239000011707 mineral Substances 0.000 claims description 8
- 235000010755 mineral Nutrition 0.000 claims description 8
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
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- 230000000994 depressogenic effect Effects 0.000 claims description 5
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 4
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 4
- 238000007796 conventional method Methods 0.000 claims description 4
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- 150000007524 organic acids Chemical class 0.000 claims description 4
- 150000007530 organic bases Chemical class 0.000 claims description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 3
- 229960004418 trolamine Drugs 0.000 claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- KGWDUNBJIMUFAP-KVVVOXFISA-N Ethanolamine Oleate Chemical compound NCCO.CCCCCCCC\C=C/CCCCCCCC(O)=O KGWDUNBJIMUFAP-KVVVOXFISA-N 0.000 claims description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 2
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract 2
- SOXUSBQFIOBYJU-VPIXDIMLSA-N (2r)-2-[(e)-3-[2-[(e)-3-[(1r)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-1-(3,4-dihydroxyphenyl)-3-oxoprop-1-en-2-yl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C(=C(O)C(O)=CC=1)\C(=C/C=1C=C(O)C(O)=CC=1)C(=O)O[C@H](CC=1C=C(O)C(O)=CC=1)C(O)=O)C1=CC=C(O)C(O)=C1 SOXUSBQFIOBYJU-VPIXDIMLSA-N 0.000 abstract 1
- XLXWKULPMYZQSQ-UHFFFAOYSA-N Salvianolic acid E Natural products Cc1ccc(CC(OC(=O)C(=Cc2ccc(O)c(O)c2)c3c(O)c(O)ccc3C=CC(=O)OC(Cc4ccc(O)c(O)c4)C(=O)O)C(=O)O)cc1O XLXWKULPMYZQSQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
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- 239000012071 phase Substances 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 238000007738 vacuum evaporation Methods 0.000 description 3
- 241000207923 Lamiaceae Species 0.000 description 2
- 235000017276 Salvia Nutrition 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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- 244000269722 Thea sinensis Species 0.000 description 1
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- 208000029078 coronary artery disease Diseases 0.000 description 1
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- 241000411851 herbal medicine Species 0.000 description 1
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- 238000011031 large-scale manufacturing process Methods 0.000 description 1
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Images
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN200510028951A CN100594206C (zh) | 2005-08-19 | 2005-08-19 | 从丹参中提取原儿茶醛和丹参酚酸的方法 |
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CN200510028951A CN100594206C (zh) | 2005-08-19 | 2005-08-19 | 从丹参中提取原儿茶醛和丹参酚酸的方法 |
Publications (2)
Publication Number | Publication Date |
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CN1915952A true CN1915952A (zh) | 2007-02-21 |
CN100594206C CN100594206C (zh) | 2010-03-17 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7993928B2 (en) | 2007-04-27 | 2011-08-09 | Shanghai Sundise | Detection of blood plasma Danshensu and Salvianolic acid B dissipating blood stasis botanical |
CN102241574A (zh) * | 2010-05-12 | 2011-11-16 | 天津天士力制药股份有限公司 | 丹参中高纯度原儿茶醛的制备方法 |
US8334110B2 (en) | 2007-04-27 | 2012-12-18 | Shanghai Sundise Chinese Medicine Technology Development Co., Ltd. | Detection of blood plasma amygdalin of dissipating blood stasis botanical |
CN103508867A (zh) * | 2013-10-09 | 2014-01-15 | 青岛农业大学 | 麦冬中原儿茶醛的提取方法及其用途 |
US9161959B2 (en) | 2007-04-29 | 2015-10-20 | Shanghai Sundise Chinese Medicine Technology Development Co., Ltd | Use of a vegetable drug composition in the manufacturing of pharmaceutical preparation for the treatment of portal hypertension caused by hepatocirrhosis |
CN105461530A (zh) * | 2014-09-12 | 2016-04-06 | 天津法莫西医药科技有限公司 | 丹参中原儿茶醛的分离提纯方法 |
CN106478565A (zh) * | 2016-10-14 | 2017-03-08 | 贵州景峰注射剂有限公司 | 一种丹酚酸b的提取方法 |
CN107996931A (zh) * | 2017-12-15 | 2018-05-08 | 绥化学院 | 一种抗菌、强心护肝富氢低糖保健饮料及其制备方法 |
CN109157545A (zh) * | 2018-10-09 | 2019-01-08 | 淮安安莱生物科技有限公司 | 一种从紫草茸中提取紫草茸酸和紫草茸醇酸的方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101042380A (zh) | 2007-04-27 | 2007-09-26 | 上海现代中医药技术发展有限公司 | 扶正化淤植物药血浆五味子乙素的测定方法 |
-
2005
- 2005-08-19 CN CN200510028951A patent/CN100594206C/zh active Active
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8334110B2 (en) | 2007-04-27 | 2012-12-18 | Shanghai Sundise Chinese Medicine Technology Development Co., Ltd. | Detection of blood plasma amygdalin of dissipating blood stasis botanical |
US7993928B2 (en) | 2007-04-27 | 2011-08-09 | Shanghai Sundise | Detection of blood plasma Danshensu and Salvianolic acid B dissipating blood stasis botanical |
US9161959B2 (en) | 2007-04-29 | 2015-10-20 | Shanghai Sundise Chinese Medicine Technology Development Co., Ltd | Use of a vegetable drug composition in the manufacturing of pharmaceutical preparation for the treatment of portal hypertension caused by hepatocirrhosis |
CN102241574A (zh) * | 2010-05-12 | 2011-11-16 | 天津天士力制药股份有限公司 | 丹参中高纯度原儿茶醛的制备方法 |
CN102241574B (zh) * | 2010-05-12 | 2014-08-13 | 天士力制药集团股份有限公司 | 丹参中高纯度原儿茶醛的制备方法 |
CN103508867A (zh) * | 2013-10-09 | 2014-01-15 | 青岛农业大学 | 麦冬中原儿茶醛的提取方法及其用途 |
CN103508867B (zh) * | 2013-10-09 | 2015-05-27 | 青岛农业大学 | 麦冬中原儿茶醛的提取方法及其用途 |
CN105461530A (zh) * | 2014-09-12 | 2016-04-06 | 天津法莫西医药科技有限公司 | 丹参中原儿茶醛的分离提纯方法 |
CN105461530B (zh) * | 2014-09-12 | 2017-05-03 | 天津法莫西医药科技有限公司 | 丹参中原儿茶醛的分离提纯方法 |
CN106478565A (zh) * | 2016-10-14 | 2017-03-08 | 贵州景峰注射剂有限公司 | 一种丹酚酸b的提取方法 |
CN107996931A (zh) * | 2017-12-15 | 2018-05-08 | 绥化学院 | 一种抗菌、强心护肝富氢低糖保健饮料及其制备方法 |
CN109157545A (zh) * | 2018-10-09 | 2019-01-08 | 淮安安莱生物科技有限公司 | 一种从紫草茸中提取紫草茸酸和紫草茸醇酸的方法 |
CN109157545B (zh) * | 2018-10-09 | 2021-10-01 | 海门茂发美术图案设计有限公司 | 一种从紫草茸中提取紫草茸酸和紫草茸醇酸的方法 |
Also Published As
Publication number | Publication date |
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CN100594206C (zh) | 2010-03-17 |
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Address after: 200237 No. 130, Meilong Road, Shanghai Co-patentee after: Shanghai Sundise Chinese Medicine Technology Development Co.,Ltd. Patentee after: EAST CHINA University OF SCIENCE AND TECHNOLOGY Address before: 200237 No. 130, Meilong Road, Shanghai Co-patentee before: Shanghai Sundise Patentee before: East China University of Science and Technology |
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Address after: 200237 No. 130, Meilong Road, Shanghai Patentee after: EAST CHINA University OF SCIENCE AND TECHNOLOGY Patentee after: Shanghai Baiyang Pharmaceutical Co.,Ltd. Address before: 200237 No. 130, Meilong Road, Shanghai Patentee before: EAST CHINA University OF SCIENCE AND TECHNOLOGY Patentee before: Shanghai Sundise Chinese Medicine Technology Development Co.,Ltd. |