CN1902176A - 氟取代的环烷酸吲哚,含这种化合物的组合物和治疗方法 - Google Patents

氟取代的环烷酸吲哚,含这种化合物的组合物和治疗方法 Download PDF

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Publication number
CN1902176A
CN1902176A CNA038026759A CN03802675A CN1902176A CN 1902176 A CN1902176 A CN 1902176A CN A038026759 A CNA038026759 A CN A038026759A CN 03802675 A CN03802675 A CN 03802675A CN 1902176 A CN1902176 A CN 1902176A
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China
Prior art keywords
compound
treatment
fluoro
acetate
acid
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CNA038026759A
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English (en)
Chinese (zh)
Inventor
C·伯特莱特
N·拉钱斯
李连海
C·斯图里诺
王召印
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Merck Canada Inc
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Merck Frosst Canada Ltd
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Publication of CN1902176A publication Critical patent/CN1902176A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
CNA038026759A 2002-01-24 2003-01-22 氟取代的环烷酸吲哚,含这种化合物的组合物和治疗方法 Pending CN1902176A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35138402P 2002-01-24 2002-01-24
US60/351,384 2002-01-24

Related Child Applications (2)

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CN201010164113A Division CN101851191A (zh) 2002-01-24 2003-01-22 氟取代的环烷酸吲哚，含这种化合物的组合物和治疗方法
CNA2007101263979A Division CN101092388A (zh) 2002-01-24 2003-01-22 氟取代的环烷酸吲哚,含这种化合物的组合物和治疗方法

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CN1902176A true CN1902176A (zh) 2007-01-24

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CNA038026759A Pending CN1902176A (zh) 2002-01-24 2003-01-22 氟取代的环烷酸吲哚,含这种化合物的组合物和治疗方法
CNA2007101263979A Pending CN101092388A (zh) 2002-01-24 2003-01-22 氟取代的环烷酸吲哚,含这种化合物的组合物和治疗方法
CN201010164113A Pending CN101851191A (zh) 2002-01-24 2003-01-22 氟取代的环烷酸吲哚，含这种化合物的组合物和治疗方法

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CN201010164113A Pending CN101851191A (zh) 2002-01-24 2003-01-22 氟取代的环烷酸吲哚，含这种化合物的组合物和治疗方法

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US (6) US20030158246A1 (OSRAM)
EP (3) EP1470107B1 (OSRAM)
JP (2) JP4008885B2 (OSRAM)
KR (2) KR100859230B1 (OSRAM)
CN (3) CN1902176A (OSRAM)
AR (1) AR038136A1 (OSRAM)
AT (1) ATE414690T1 (OSRAM)
AU (1) AU2003202343B2 (OSRAM)
BR (1) BR0307050A (OSRAM)
CA (1) CA2471952C (OSRAM)
CY (3) CY1108841T1 (OSRAM)
DE (2) DE60324767D1 (OSRAM)
DK (2) DK1470107T3 (OSRAM)
DO (1) DOP2003000566A (OSRAM)
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EC (1) ECSP045203A (OSRAM)
EG (1) EG24978A (OSRAM)
ES (2) ES2391747T3 (OSRAM)
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GE (1) GEP20074078B (OSRAM)
HR (1) HRP20040665B1 (OSRAM)
IL (3) IL162825A0 (OSRAM)
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PE (1) PE20030982A1 (OSRAM)
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PT (2) PT2045241E (OSRAM)
RS (2) RS20100338A (OSRAM)
SI (2) SI1470107T1 (OSRAM)
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