CN1890264B - Gag结合蛋白 - Google Patents

Gag结合蛋白 Download PDF

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Publication number
CN1890264B
CN1890264B CN200480036160.6A CN200480036160A CN1890264B CN 1890264 B CN1890264 B CN 1890264B CN 200480036160 A CN200480036160 A CN 200480036160A CN 1890264 B CN1890264 B CN 1890264B
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China
Prior art keywords
albumen
binding affinity
gag
increased
gag binding
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Expired - Fee Related
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CN200480036160.6A
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Chinese (zh)
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CN1890264A (zh
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安德烈亚斯·J·孔格尔
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Protaffin Biotechnologie AG
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Protaffin Biotechnologie AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5421—IL-8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200480036160.6A 2003-12-04 2004-12-02 Gag结合蛋白 Expired - Fee Related CN1890264B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ATA1952/2003 2003-12-04
AT0195203A AT412785B (de) 2003-12-04 2003-12-04 Gag-bindungsproteine
PCT/EP2004/013670 WO2005054285A1 (en) 2003-12-04 2004-12-02 Gag binding proteins

Publications (2)

Publication Number Publication Date
CN1890264A CN1890264A (zh) 2007-01-03
CN1890264B true CN1890264B (zh) 2014-01-22

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CN200480036160.6A Expired - Fee Related CN1890264B (zh) 2003-12-04 2004-12-02 Gag结合蛋白

Country Status (20)

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US (4) US7585937B2 (enExample)
EP (5) EP2311866A1 (enExample)
JP (3) JP4980721B2 (enExample)
KR (2) KR101188785B1 (enExample)
CN (1) CN1890264B (enExample)
AT (3) AT412785B (enExample)
AU (1) AU2004295104B2 (enExample)
BR (1) BRPI0416544A (enExample)
CA (1) CA2546789A1 (enExample)
CY (2) CY1109480T1 (enExample)
DE (1) DE602004022595D1 (enExample)
DK (2) DK1689775T3 (enExample)
ES (2) ES2330362T3 (enExample)
IL (1) IL175565A0 (enExample)
NZ (1) NZ547612A (enExample)
PL (2) PL1752470T3 (enExample)
PT (2) PT1752470E (enExample)
SG (1) SG149000A1 (enExample)
SI (2) SI1689775T1 (enExample)
WO (1) WO2005054285A1 (enExample)

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AT412785B (de) * 2003-12-04 2005-07-25 Kungl Andreas J Dr Gag-bindungsproteine
AU2006291990B2 (en) 2005-09-13 2012-05-31 National Research Council Of Canada Methods and compositions for modulating tumor cell activity
CN100366637C (zh) * 2005-11-17 2008-02-06 中国人民解放军第四军医大学 人白细胞介素8拮抗蛋白及其制备方法
US9422356B2 (en) * 2006-01-31 2016-08-23 Republic Of Korea (Republic Of National Fisheries Research And Development Institute) Artificial signal peptide for expressing an insoluble protein as a soluble active form
DK1994155T4 (da) 2006-02-13 2022-07-25 Daiichi Sankyo Co Ltd Polynukleotid- og polypeptidsekvenser involveret i fremgangsmåden med knogleremodellering
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
EP1894571A1 (en) * 2006-08-29 2008-03-05 Protaffin Biotechnologie AG Use of modified interleukin-8 proteins for treating reperfusion injury or transplant rejection
US20100075918A1 (en) * 2006-12-08 2010-03-25 Lokeshwar Vinata B Hyaluronidase inhibitors as anti-cancer agents
AT504685B1 (de) * 2006-12-20 2009-01-15 Protaffin Biotechnologie Ag Fusionsproteine
WO2009023047A2 (en) * 2007-05-07 2009-02-19 Peptimmune, Inc. Methods for the directed expansion of epitopes for use as antibody ligands
EP2042516A1 (en) * 2007-09-27 2009-04-01 Protaffin Biotechnologie AG Glycosaminoglycan-antagonising MCP-1 mutants and methods of using same
EP2185719B1 (en) * 2007-08-02 2013-11-13 NovImmune SA Anti-rantes antibodies and methods of use thereof
EP2053060A1 (en) 2007-10-24 2009-04-29 Protaffin Biotechnologie AG SDF-1-based glyocosaminoglycan antagonists and methods of using same
US8314212B2 (en) 2008-02-08 2012-11-20 Lindsey Miles Plasminogen receptor PLG-RKT and antibodies thereof
JP2012516143A (ja) 2009-01-30 2012-07-19 プロットアフィン ビオテヒノロギー アクチエンゲゼルシャフト グリコサミノグリカンを拮抗するｍｃｐ−１突然変異体およびその使用方法
AU2010294225A1 (en) 2009-09-11 2012-04-05 Protaffin Biotechnologie Ag Composition for treatment of CXCL8-mediated lung inflammation
CA2776513C (en) 2009-11-24 2017-08-01 Alethia Biotherapeutics Inc. Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
US20140073557A1 (en) 2011-03-16 2014-03-13 Protaffin Biotechnologie Ag Fgfri-based antagonists with improved glycosaminoglycan affinity and methods of using same
EP2729487A2 (en) 2011-07-08 2014-05-14 Protaffin Biotechnologie AG Novel sdf-1-based glycosaminoglycan antagonist and methods of using same
MX2014010164A (es) 2012-02-22 2014-11-25 Alethia Biotherapeutics Inc Co-uso de un inhibidor de clusterina con un inhibidor de egfr para tratar cancer.
US9493562B2 (en) 2012-07-19 2016-11-15 Alethia Biotherapeutics Inc. Anti-Siglec-15 antibodies
WO2014079957A1 (de) * 2012-11-23 2014-05-30 Bayer Cropscience Ag Selektive inhibition der ethylensignaltransduktion
WO2014109519A1 (ko) * 2013-01-10 2014-07-17 강원대학교산학협력단 작은안구증-연관 전사인자 유래의 펩타이드 및 이를 포함하는 조성물
US10047133B2 (en) 2014-01-22 2018-08-14 Antagonis Biotherapeutics Gmbh Glycosaminoglycan-antagonising fusion proteins and methods of using same
EP4021927A1 (en) 2019-08-29 2022-07-06 Antagonis Biotherapeutics GmbH T-cell mobilizing cxcl10 mutant with increased glycosaminoglycan binding affinity
CN110791523B (zh) * 2019-12-13 2022-05-10 南京农业大学 一种棉花抗旱相关基因GhRCHY1及其应用
KR20250040765A (ko) * 2023-09-15 2025-03-25 (주)케어젠 펩타이드를 유효성분으로 하는 발모 촉진 또는 탈모증의 억제, 예방 또는 개선용 조성물

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Publication number Publication date
JP2012165747A (ja) 2012-09-06
ATE439376T1 (de) 2009-08-15
ES2330362T3 (es) 2009-12-09
PL1689775T3 (pl) 2011-12-30
JP2007536906A (ja) 2007-12-20
DK1689775T3 (da) 2011-09-26
US7585937B2 (en) 2009-09-08
US20090005541A1 (en) 2009-01-01
CY1112330T1 (el) 2015-12-09
US7807413B2 (en) 2010-10-05
CY1109480T1 (el) 2014-08-13
JP2012139226A (ja) 2012-07-26
JP4980721B2 (ja) 2012-07-18
CA2546789A1 (en) 2005-06-16
US20080112926A1 (en) 2008-05-15
ES2369139T3 (es) 2011-11-25
ATA19522003A (de) 2004-12-15
KR20070001917A (ko) 2007-01-04
EP1689775B1 (en) 2011-07-06
NZ547612A (en) 2009-07-31
BRPI0416544A (pt) 2007-01-09
EP2270038A3 (en) 2011-02-23
US20110144305A1 (en) 2011-06-16
CN1890264A (zh) 2007-01-03
EP1752470A1 (en) 2007-02-14
AU2004295104A1 (en) 2005-06-16
EP1689775A1 (en) 2006-08-16
PT1689775E (pt) 2011-10-13
PT1752470E (pt) 2009-10-15
PL1752470T3 (pl) 2010-01-29
US20100331237A1 (en) 2010-12-30
SI1752470T1 (sl) 2009-12-31
EP2311866A1 (en) 2011-04-20
SI1689775T1 (sl) 2011-11-30
WO2005054285A1 (en) 2005-06-16
KR101278459B1 (ko) 2013-07-01
EP2363411A1 (en) 2011-09-07
DK1752470T3 (da) 2009-12-14
EP1752470B1 (en) 2009-08-12
SG149000A1 (en) 2009-01-29
KR101188785B1 (ko) 2012-10-16
AT412785B (de) 2005-07-25
AU2004295104B2 (en) 2010-07-22
EP2270038A2 (en) 2011-01-05
IL175565A0 (en) 2006-09-05
ATE515269T1 (de) 2011-07-15
DE602004022595D1 (de) 2009-09-24
KR20120063542A (ko) 2012-06-15

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