ATE466069T1 - Peptid-konjugierte antikrebs-prodrugs - Google Patents

Peptid-konjugierte antikrebs-prodrugs

Info

Publication number
ATE466069T1
ATE466069T1 AT01967657T AT01967657T ATE466069T1 AT E466069 T1 ATE466069 T1 AT E466069T1 AT 01967657 T AT01967657 T AT 01967657T AT 01967657 T AT01967657 T AT 01967657T AT E466069 T1 ATE466069 T1 AT E466069T1
Authority
AT
Austria
Prior art keywords
peptide
conjugated anti
cancer
chemotherapeutic drug
cancer prodrugs
Prior art date
Application number
AT01967657T
Other languages
English (en)
Inventor
Stela Gengrinovitch
Original Assignee
Biosight Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosight Ltd filed Critical Biosight Ltd
Application granted granted Critical
Publication of ATE466069T1 publication Critical patent/ATE466069T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01967657T 2000-09-05 2001-09-05 Peptid-konjugierte antikrebs-prodrugs ATE466069T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22973300P 2000-09-05 2000-09-05
PCT/IL2001/000839 WO2002020715A2 (en) 2000-09-05 2001-09-05 Peptide conjugated anti-cancer prodrugs

Publications (1)

Publication Number Publication Date
ATE466069T1 true ATE466069T1 (de) 2010-05-15

Family

ID=22862481

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01967657T ATE466069T1 (de) 2000-09-05 2001-09-05 Peptid-konjugierte antikrebs-prodrugs

Country Status (7)

Country Link
US (2) US7135547B2 (de)
EP (2) EP1581615B1 (de)
AT (1) ATE466069T1 (de)
AU (1) AU2001288025A1 (de)
DE (1) DE60141992D1 (de)
IL (1) IL154696A (de)
WO (1) WO2002020715A2 (de)

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SE0201863D0 (en) * 2002-06-18 2002-06-18 Cepep Ab Cell penetrating peptides
US7230101B1 (en) 2002-08-28 2007-06-12 Gpc Biotech, Inc. Synthesis of methotrexate-containing heterodimeric molecules
AU2004232314B2 (en) * 2003-04-22 2007-11-22 Ipsen Pharma S.A.S. Peptide vectors
WO2004111192A2 (en) * 2003-05-29 2004-12-23 The Scripps Research Institute Targeted delivery to legumain-expressing cells
AT412785B (de) * 2003-12-04 2005-07-25 Kungl Andreas J Dr Gag-bindungsproteine
WO2005097089A2 (en) * 2004-04-02 2005-10-20 Wisconsin Alumni Research Foundation Derivatives of leinamycin for use as anticancer agents
JP2009509510A (ja) * 2005-09-26 2009-03-12 メダレックス インコーポレーティッド Ｃｄ７０に対するヒトモノクローナル抗体
WO2007064759A2 (en) * 2005-11-29 2007-06-07 The Scripps Research Institute Inhibiting tumour cell invasion, metastasis and angiogenesis through targetting legumain
IN2009KN02404A (de) * 2006-12-14 2015-08-07 Medarex Inc
WO2008139457A2 (en) * 2007-05-10 2008-11-20 Clear Direction Ltd. Methods and compositions for drug targeting
KR101032860B1 (ko) * 2008-10-22 2011-05-06 한국식품연구원 췌장 조직 특이적 유전자 ｍｍｐ1
CN101747411B (zh) * 2008-11-28 2012-07-25 北京大学 氨基酰色氨酰色氨酸三肽苄酯及其制备方法和应用
CA2777235A1 (en) * 2009-10-13 2011-04-21 The Johns Hopkins University Biomarker for identification of melanoma tumor cells
AR077384A1 (es) 2010-07-05 2011-08-24 Eriochem Sa Una formulacion farmaceutica inyectable de melfalano.
CN103237808B (zh) * 2010-12-03 2016-02-24 阿达梅德公司 抗癌融合蛋白
PL394618A1 (pl) * 2011-04-19 2012-10-22 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe bialko fuzyjne
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US8940684B2 (en) 2012-11-19 2015-01-27 Mimedx Group, Inc. Cross-linked collagen comprising an antifungal agent
US9155799B2 (en) 2012-11-19 2015-10-13 Mimedx Group, Inc. Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent
US8946163B2 (en) 2012-11-19 2015-02-03 Mimedx Group, Inc. Cross-linked collagen comprising metallic anticancer agents
US10029030B2 (en) 2013-03-15 2018-07-24 Mimedx Group, Inc. Molded placental tissue compositions and methods of making and using the same
US10335433B2 (en) 2013-04-10 2019-07-02 Mimedx Group, Inc. NDGA polymers and metal complexes thereof
US9446142B2 (en) 2013-05-28 2016-09-20 Mimedx Group, Inc. Polymer chelator conjugates
EP3038630B1 (de) 2013-08-30 2020-03-18 MIMEDX Group Inc. Mikronisierte plazentale zusammensetzungen mit einem chelatbildner
KR102272213B1 (ko) * 2014-07-08 2021-07-01 삼성전자주식회사 표적화 부위, 절단 부위, 및 세포막 투과 부위를 포함하는 융합 단백질 및 그의 용도
JP2018535987A (ja) 2015-12-03 2018-12-06 バイオサイト リミテッド 癌療法のためのコンジュゲートの塩
US11939609B2 (en) 2017-07-24 2024-03-26 The Board Of Trustees Of The Leland Stanford Junior University Rewiring aberrant cancer signaling to a therapeutic effector response with a synthetic two-component system
AU2019205279A1 (en) * 2018-01-08 2020-07-30 Susavion Biosciences, Inc. Compositions and methods of treating cancer with glycomimetic peptides
KR102544277B1 (ko) * 2020-01-15 2023-06-16 재단법인대구경북과학기술원 세포외 기질 및 항암제로 이루어진 접합체 및 이의 의학적 용도
US20210402001A1 (en) * 2020-06-30 2021-12-30 David I. Cohen Zinc Porters, and their Monoclonal Antibody Conjugates, for the Prevention and Treatment of COVID-19 (SARS-CoV-2), Other Infections, and Cancers
US20230144608A1 (en) * 2021-09-14 2023-05-11 Xilio Development, Inc. Cleavable linkers

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1188988A (en) * 1981-07-02 1985-06-18 Alan G. Walton Chondroitin drug complexes
GB8907617D0 (en) * 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
EP0688327B1 (de) 1993-03-01 1999-05-06 Glycan Pharmaceuticals, Inc. Analoge für spezifische oligosaccharid-protein-wechselwirkungen und ihre verwendungen
DE69434115T2 (de) 1993-03-25 2005-10-27 Merck & Co., Inc. Inhibitor des wachstumsfaktors für gefässendothelzellen
US5612474A (en) * 1994-06-30 1997-03-18 Eli Lilly And Company Acid labile immunoconjugate intermediates
US5871723A (en) 1995-06-06 1999-02-16 The Regent Of The University Of Michigan CXC chemokines as regulators of angiogenesis
DE19701141C1 (de) * 1997-01-16 1998-04-09 Hoechst Ag Genkonstrukte für durch Proteasen aktivierbare Wirksubstanzen
EP1179541B1 (de) * 1999-04-28 2004-06-16 Board Of Regents, The University Of Texas System Zusammensetzungen und Verfahren zur Krebsbehandlung durch die selektive Hemmung von VEGF
WO2007064759A2 (en) * 2005-11-29 2007-06-07 The Scripps Research Institute Inhibiting tumour cell invasion, metastasis and angiogenesis through targetting legumain

Also Published As

Publication number Publication date
US7638127B2 (en) 2009-12-29
WO2002020715A3 (en) 2006-01-12
EP1581615A4 (de) 2005-10-05
EP2272947A1 (de) 2011-01-12
US20030216298A1 (en) 2003-11-20
AU2001288025A1 (en) 2002-03-22
WO2002020715A2 (en) 2002-03-14
US7135547B2 (en) 2006-11-14
IL154696A0 (en) 2003-09-17
IL154696A (en) 2008-11-03
EP1581615A2 (de) 2005-10-05
EP1581615B1 (de) 2010-04-28
US20070160573A1 (en) 2007-07-12
AU2001288025A8 (en) 2006-11-02
DE60141992D1 (de) 2010-06-10
EP2272947B1 (de) 2016-08-10

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