DE69635806D1 - Diphosphonat derivate von therapeutisch wirksamen stoffen - Google Patents
Diphosphonat derivate von therapeutisch wirksamen stoffenInfo
- Publication number
- DE69635806D1 DE69635806D1 DE69635806T DE69635806T DE69635806D1 DE 69635806 D1 DE69635806 D1 DE 69635806D1 DE 69635806 T DE69635806 T DE 69635806T DE 69635806 T DE69635806 T DE 69635806T DE 69635806 D1 DE69635806 D1 DE 69635806D1
- Authority
- DE
- Germany
- Prior art keywords
- active substances
- therapeutically active
- diphosphonate derivatives
- urinary tract
- diphosphonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013543 active substance Substances 0.000 title 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical class [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 title 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 208000009911 Urinary Calculi Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- -1 diphosphonate compound Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 208000019206 urinary tract infection Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/478,245 US5880111A (en) | 1995-06-07 | 1995-06-07 | Therapeutic derivations of diphosphonates |
| PCT/US1996/009259 WO1996040190A1 (en) | 1995-06-07 | 1996-06-06 | Diphosphonate derivatives of therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69635806D1 true DE69635806D1 (de) | 2006-04-20 |
Family
ID=23899129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69635806T Expired - Lifetime DE69635806D1 (de) | 1995-06-07 | 1996-06-06 | Diphosphonat derivate von therapeutisch wirksamen stoffen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5880111A (de) |
| EP (1) | EP0831869B1 (de) |
| AT (1) | ATE317263T1 (de) |
| AU (1) | AU715705B2 (de) |
| CA (1) | CA2224069A1 (de) |
| DE (1) | DE69635806D1 (de) |
| WO (1) | WO1996040190A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0944635A4 (de) * | 1996-10-09 | 2000-07-05 | Elizanor Biopharmaceuticals In | Therapeutische diphosphonatverbindungen |
| US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| EP1881974A4 (de) * | 2005-04-21 | 2011-03-16 | Targanta Therapeutics Inc | Phosphonierte fluorchinoline, antibakterielle analoga davon und verfahren zur vorbeugung und behandlung von knochen- und gelenkinfektionen |
| JP5368092B2 (ja) * | 2005-08-11 | 2013-12-18 | ターガンタ セラピュティクス，インコーポレイティド | ホスホン化リファマイシン類および骨と関節感染の予防と治療のためのその投与法 |
| WO2007138381A2 (en) * | 2005-10-14 | 2007-12-06 | Targanta Therapeutics Inc. | Phosphonated oxazolidinones and uses thereof for the prevention and treatment of bone and joint infections |
| US20080139574A1 (en) | 2006-11-30 | 2008-06-12 | Cadila Healthcare Limited | Novel quinoline derivatives |
| WO2008077241A1 (en) | 2006-12-22 | 2008-07-03 | Targanta Therapeutics, Inc. | Phosphonated glycopeptide and lipoglycopeptide antibiotics and uses thereof for the prevention and treatment of bone and joint infections |
| DE102008054524B4 (de) * | 2008-12-11 | 2021-06-17 | Koenig & Bauer Ag | Verfahren zum Ablegen von Bogen auf einem Auslegerstapel im Ausleger einer bogenverarbeitenden Maschine und Vorrichtung hierfür |
| US10865220B2 (en) * | 2016-06-03 | 2020-12-15 | Biovinc, Llc | Bisphosphonate quinolone conjugates and uses thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4186268A (en) * | 1979-01-29 | 1980-01-29 | E. R. Squibb & Sons, Inc. | Mercaptoacylpyrrolidine phosphonic acids and related compounds |
| FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| ES8802468A1 (es) * | 1985-05-02 | 1988-07-16 | Research Corp | Metodo de preparar medicamentos que incluyen un agente buscador de hueso y un inhibidor de anhidrasa carbonica, para impedir y curar enfermedades oseas. |
| US5057506A (en) * | 1985-05-24 | 1991-10-15 | Ciba-Geigy Corporation | Certain phosphonic acids and derivatives useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade |
| ATE64397T1 (de) * | 1986-11-21 | 1991-06-15 | Ciba Geigy Ag | Aromatisch substituierte azacycloalkylalkandiphosphons|uren. |
| IL84497A (en) * | 1986-11-21 | 1994-10-21 | Ciba Geigy Ag | History 2-) Imidazol-1-yl (ethane-1,1-diphosphonic acid, their preparation and pharmaceutical preparations containing them |
| IL84494A (en) * | 1986-11-21 | 1992-08-18 | Ciba Geigy Ag | Heteroaryl substituted aminomethane-diphosphonic acids,their preparation and pharmaceutical compositions containing them |
| IL84731A0 (en) * | 1986-12-19 | 1988-05-31 | Norwich Eaton Pharma | Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them |
| FR2611203B1 (fr) * | 1987-02-20 | 1989-06-09 | Sturtz Georges | Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent |
| GB8808138D0 (en) * | 1988-04-07 | 1988-05-11 | Leo Pharm Prod Ltd | Chemical compounds |
| US4990503A (en) * | 1988-08-12 | 1991-02-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic bisphosphonic acid derivatives |
| AU642336B2 (en) * | 1991-02-07 | 1993-10-14 | Kaken Pharmaceutical Co., Ltd. | Bisphosphonic acid derivatives, their intermediates and bone resorption inhibitors containing them as active ingredients |
| EP0521622B1 (de) * | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimiden- und Pyrimidinylbisphosphonsäureester als entzündungshemmende Mittel |
| US5128328A (en) * | 1991-10-25 | 1992-07-07 | American Home Products Corporation | Heterocyclic bisphosphonic acid derivatives |
| FR2683528A1 (fr) * | 1991-11-12 | 1993-05-14 | Bretagne Occidentale Universit | Prodrogues et analogues gem-bisphosphoniques d'antiinflammatoires non-sterouidiens de type arylacetique ou arylpropionique. |
| EP0663919A1 (de) * | 1992-10-09 | 1995-07-26 | PHARMACIA & UPJOHN COMPANY | Pyrimidin bisphosphonsäureestern als anti-inflammatorisches mittel |
| US5543396A (en) * | 1994-04-28 | 1996-08-06 | Georgia Tech Research Corp. | Proline phosphonate derivatives |
-
1995
- 1995-06-07 US US08/478,245 patent/US5880111A/en not_active Expired - Fee Related
-
1996
- 1996-06-06 DE DE69635806T patent/DE69635806D1/de not_active Expired - Lifetime
- 1996-06-06 CA CA002224069A patent/CA2224069A1/en not_active Abandoned
- 1996-06-06 AU AU61567/96A patent/AU715705B2/en not_active Ceased
- 1996-06-06 EP EP96919157A patent/EP0831869B1/de not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/009259 patent/WO1996040190A1/en active IP Right Grant
- 1996-06-06 AT AT96919157T patent/ATE317263T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE317263T1 (de) | 2006-02-15 |
| US5880111A (en) | 1999-03-09 |
| EP0831869B1 (de) | 2006-02-08 |
| CA2224069A1 (en) | 1996-12-19 |
| AU6156796A (en) | 1996-12-30 |
| AU715705B2 (en) | 2000-02-10 |
| EP0831869A4 (de) | 1999-04-21 |
| WO1996040190A1 (en) | 1996-12-19 |
| EP0831869A1 (de) | 1998-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |