CN1845989A - 抗微生物剂的重组产生 - Google Patents
抗微生物剂的重组产生 Download PDFInfo
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- 229910052711 selenium Inorganic materials 0.000 description 1
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- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 1
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- 239000000758 substrate Substances 0.000 description 1
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- 238000010998 test method Methods 0.000 description 1
- OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
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- 230000002103 transcriptional effect Effects 0.000 description 1
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- 108700004896 tripeptide FEG Proteins 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 101150016309 trpC gene Proteins 0.000 description 1
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- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
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- 210000003934 vacuole Anatomy 0.000 description 1
- 108010009962 valyltyrosine Proteins 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
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- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
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- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 101150052264 xylA gene Proteins 0.000 description 1
- 101150110790 xylB gene Proteins 0.000 description 1
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- KRJOFJHOZZPBKI-KSWODRSDSA-N α-defensin-1 Chemical compound C([C@H]1C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=4C=CC(O)=CC=4)NC(=O)[C@H](CSSC[C@H](NC2=O)C(O)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C)C(=O)N3)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](C)C(=O)N1)[C@@H](C)CC)[C@@H](C)O)=O)[C@@H](C)CC)C1=CC=CC=C1 KRJOFJHOZZPBKI-KSWODRSDSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Husbandry (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
保护肽 | 氨基酸数 | D/E残基数 | D/E残基百分数 |
DP | 2 | 1 | 50 |
DDDDDP(SEQ ID NO:101) | 6 | 5 | 83 |
EEEEEDP(SEQ ID NO:102) | 7 | 6 | 86 |
DDDDE(SEQ ID NO:94) | 5 | 5 | 100 |
DEDEDEDP(SEQ ID NO:104) | 8 | 7 | 88 |
DDDGGEEEGGDDDP(SEQ ID NO:105) | 14 | 9 | 64 |
DDDGGDDDPPDDDE(SEQ ID NO:106) | 14 | 10 | 71 |
衍生物 | PCR模板 | 正向引物 | 反向引物 |
pHH3857(E-PR39) | pHH1531 | pHH3857fwd | pBAD rev |
pHH3858(DE-PR39) | pHH1532 | pHH3858fwd | pBAD rev |
pHH3859(DDE-PR39) | pHH1533 | pHH3859fwd | pBAD rev |
pHH3860(DDDE-PR39 | pHH1534 | pHH3860fwd | pBAD rev |
pHH3861(DDDDE-PR39) | pHH1535 | pHH3861fwd | pBAD rev |
Claims (21)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200301310 | 2003-09-11 | ||
DKPA200301310 | 2003-09-11 | ||
PCT/DK2004/000605 WO2005024002A1 (en) | 2003-09-11 | 2004-09-13 | Recombinant production of antimicrobial agents |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1845989A true CN1845989A (zh) | 2006-10-11 |
CN1845989B CN1845989B (zh) | 2011-10-12 |
Family
ID=34259082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2004800249767A Expired - Fee Related CN1845989B (zh) | 2003-09-11 | 2004-09-13 | 抗微生物剂的重组产生 |
Country Status (14)
Country | Link |
---|---|
US (1) | US7935501B2 (zh) |
EP (1) | EP1680503B1 (zh) |
JP (1) | JP2007504810A (zh) |
CN (1) | CN1845989B (zh) |
AT (1) | ATE513904T1 (zh) |
AU (1) | AU2004270815B2 (zh) |
BR (1) | BRPI0413833A (zh) |
CA (1) | CA2536782A1 (zh) |
DK (1) | DK1680503T3 (zh) |
ES (1) | ES2368221T3 (zh) |
IL (1) | IL173656A0 (zh) |
NZ (1) | NZ545564A (zh) |
WO (1) | WO2005024002A1 (zh) |
ZA (1) | ZA200601544B (zh) |
Cited By (5)
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CN102220295A (zh) * | 2011-05-26 | 2011-10-19 | 长沙理工大学 | 以稻谷加工副产物为原料生产饲用葡萄糖氧化酶的方法 |
CN105255939A (zh) * | 2015-11-13 | 2016-01-20 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产菌丝霉素的方法 |
CN105274137A (zh) * | 2015-11-13 | 2016-01-27 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产乳铁蛋白的方法 |
CN105734029A (zh) * | 2014-12-12 | 2016-07-06 | 丰益(上海)生物技术研发中心有限公司 | 磷脂酶抗菌肽 |
CN114478795A (zh) * | 2020-11-13 | 2022-05-13 | 安徽新熙盟生物科技有限公司 | 提高多肽类药物口服给药稳定性的融合蛋白及其应用 |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6855548B2 (en) * | 2000-02-08 | 2005-02-15 | F. Hoffman-La Roche Ag | Use of acid-stable proteases in animal feed |
BRPI0407294B1 (pt) * | 2003-02-07 | 2017-06-13 | Novozymes A/S | Use of a protease of the peptidases family s2a and / or peptidasis fmilia s1e, method for producing polipeptide, animal feed additive, animal feed composition, and, detergent composition |
US7763706B1 (en) * | 2003-07-17 | 2010-07-27 | Campina B.V. | Arginine/lysine-enriched peptides |
EP2308966A1 (en) | 2003-10-10 | 2011-04-13 | Novozymes A/S | Protease variants |
ES2380105T3 (es) * | 2004-06-21 | 2012-05-08 | Novozymes A/S | Proteasas de Nocardiopsis |
GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
BRPI1006076B8 (pt) | 2009-01-13 | 2021-05-25 | Pergamum Ab | composições farmacêuticas |
DK2445515T3 (en) * | 2009-06-26 | 2016-07-04 | Katholieke Univ Leuven K U Leuven R&D | antimicrobial agents |
JP6034188B2 (ja) | 2009-06-26 | 2016-11-30 | ライサンド アクツィエンゲゼルシャフト | 抗微生物剤 |
EP2782458B1 (en) * | 2011-11-17 | 2018-09-12 | DSM IP Assets B.V. | Use of acid stable proteases in animal feed to increase performance of cocci-vaccinated broiler chickens |
US10597430B2 (en) * | 2012-03-05 | 2020-03-24 | Instituto De Investigaciones Agropecuarias | Chimeric gene for heterologous expression which encodes for peptides with antimicrobial activity |
US9925223B2 (en) | 2012-09-25 | 2018-03-27 | Regents Of The University Of Minnesota | Methods for making and using antimicrobial peptides |
CN108794635B (zh) * | 2018-04-04 | 2021-03-19 | 浙江工业大学 | 一种牛乳铁蛋白肽-人溶菌酶融合蛋白、基因及其应用 |
CN109295075B (zh) * | 2018-10-31 | 2021-04-20 | 上海市农业生物基因中心 | NfOCP1抗旱基因、其编码的氨基酸序列及其在提高植物抗旱性中的用途 |
CN111118091A (zh) * | 2018-10-31 | 2020-05-08 | 宁夏乙征生物工程有限公司 | 一种抗菌肽的生产方法 |
CN111349177B (zh) * | 2020-03-13 | 2022-04-22 | 西北农林科技大学 | 一种融合抗菌肽cat的制备方法和应用 |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
CN113125689B (zh) * | 2021-03-29 | 2022-02-22 | 创芯国际生物科技(广州)有限公司 | 一种新型mtt细胞活力检测试剂盒及其应用 |
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US5094951A (en) | 1988-06-21 | 1992-03-10 | Chiron Corporation | Production of glucose oxidase in recombinant systems |
US5571697A (en) | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
US5789377A (en) * | 1992-08-21 | 1998-08-04 | University Of British Columbia | Treatment of endotoxin-associated disorders with cationic peptides |
KR100263583B1 (ko) | 1997-05-28 | 2000-08-01 | 박종헌 | 항균 펩타이드의 대량 제조방법 및 그에 유용한 플라즈미드 벡타 |
EP1187925B1 (en) | 1999-06-02 | 2005-03-30 | Novozymes A/S | Pectate lyase fusion for expression and secretion of polypeptides |
-
2004
- 2004-09-13 EP EP04762825A patent/EP1680503B1/en not_active Expired - Lifetime
- 2004-09-13 ES ES04762825T patent/ES2368221T3/es not_active Expired - Lifetime
- 2004-09-13 AU AU2004270815A patent/AU2004270815B2/en not_active Ceased
- 2004-09-13 DK DK04762825.0T patent/DK1680503T3/da active
- 2004-09-13 WO PCT/DK2004/000605 patent/WO2005024002A1/en active Application Filing
- 2004-09-13 AT AT04762825T patent/ATE513904T1/de not_active IP Right Cessation
- 2004-09-13 BR BRPI0413833-3A patent/BRPI0413833A/pt not_active Application Discontinuation
- 2004-09-13 CN CN2004800249767A patent/CN1845989B/zh not_active Expired - Fee Related
- 2004-09-13 CA CA002536782A patent/CA2536782A1/en not_active Abandoned
- 2004-09-13 US US10/572,016 patent/US7935501B2/en not_active Expired - Fee Related
- 2004-09-13 JP JP2006525631A patent/JP2007504810A/ja not_active Ceased
- 2004-09-13 NZ NZ545564A patent/NZ545564A/en not_active IP Right Cessation
-
2006
- 2006-02-09 IL IL173656A patent/IL173656A0/en not_active IP Right Cessation
- 2006-02-22 ZA ZA200601544A patent/ZA200601544B/en unknown
Cited By (11)
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CN102220295A (zh) * | 2011-05-26 | 2011-10-19 | 长沙理工大学 | 以稻谷加工副产物为原料生产饲用葡萄糖氧化酶的方法 |
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CN105255939A (zh) * | 2015-11-13 | 2016-01-20 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产菌丝霉素的方法 |
CN105274137A (zh) * | 2015-11-13 | 2016-01-27 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产乳铁蛋白的方法 |
CN105274137B (zh) * | 2015-11-13 | 2018-12-25 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产乳铁蛋白的方法 |
CN105255939B (zh) * | 2015-11-13 | 2018-12-25 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产菌丝霉素的方法 |
CN114478795A (zh) * | 2020-11-13 | 2022-05-13 | 安徽新熙盟生物科技有限公司 | 提高多肽类药物口服给药稳定性的融合蛋白及其应用 |
WO2022099963A1 (zh) * | 2020-11-13 | 2022-05-19 | 安徽新熙盟生物科技有限公司 | 提高多肽类药物口服给药稳定性的融合蛋白及其应用 |
CN114478795B (zh) * | 2020-11-13 | 2024-06-04 | 安徽新熙盟生物科技有限公司 | 提高多肽类药物口服给药稳定性的融合蛋白及其应用 |
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IL173656A0 (en) | 2006-07-05 |
WO2005024002A1 (en) | 2005-03-17 |
US7935501B2 (en) | 2011-05-03 |
ES2368221T3 (es) | 2011-11-15 |
AU2004270815A1 (en) | 2005-03-17 |
ZA200601544B (en) | 2007-04-25 |
EP1680503B1 (en) | 2011-06-22 |
CN1845989B (zh) | 2011-10-12 |
NZ545564A (en) | 2008-07-31 |
ATE513904T1 (de) | 2011-07-15 |
AU2004270815B2 (en) | 2011-06-02 |
CA2536782A1 (en) | 2005-03-17 |
DK1680503T3 (da) | 2011-10-03 |
JP2007504810A (ja) | 2007-03-08 |
US20070104764A1 (en) | 2007-05-10 |
EP1680503A1 (en) | 2006-07-19 |
BRPI0413833A (pt) | 2006-10-24 |
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