ATE513904T1 - Rekombinante herstellung antimikrobieller agentien - Google Patents
Rekombinante herstellung antimikrobieller agentienInfo
- Publication number
- ATE513904T1 ATE513904T1 AT04762825T AT04762825T ATE513904T1 AT E513904 T1 ATE513904 T1 AT E513904T1 AT 04762825 T AT04762825 T AT 04762825T AT 04762825 T AT04762825 T AT 04762825T AT E513904 T1 ATE513904 T1 AT E513904T1
- Authority
- AT
- Austria
- Prior art keywords
- antimicrobial
- enzyme
- alpha
- expression
- enzymes
- Prior art date
Links
- 239000004599 antimicrobial Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 229940088598 enzyme Drugs 0.000 abstract 4
- 102000044503 Antimicrobial Peptides Human genes 0.000 abstract 2
- 108700042778 Antimicrobial Peptides Proteins 0.000 abstract 2
- 108010011619 6-Phytase Proteins 0.000 abstract 1
- 101710152845 Arabinogalactan endo-beta-1,4-galactanase Proteins 0.000 abstract 1
- 102100032487 Beta-mannosidase Human genes 0.000 abstract 1
- 108010059892 Cellulase Proteins 0.000 abstract 1
- 108010001682 Dextranase Proteins 0.000 abstract 1
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 abstract 1
- 101710147028 Endo-beta-1,4-galactanase Proteins 0.000 abstract 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 abstract 1
- 102100022624 Glucoamylase Human genes 0.000 abstract 1
- 239000004366 Glucose oxidase Substances 0.000 abstract 1
- 108010015776 Glucose oxidase Proteins 0.000 abstract 1
- 108010014251 Muramidase Proteins 0.000 abstract 1
- 102000016943 Muramidase Human genes 0.000 abstract 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 102000004139 alpha-Amylases Human genes 0.000 abstract 1
- 108090000637 alpha-Amylases Proteins 0.000 abstract 1
- 102000005840 alpha-Galactosidase Human genes 0.000 abstract 1
- 108010030291 alpha-Galactosidase Proteins 0.000 abstract 1
- 229940024171 alpha-amylase Drugs 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 235000019730 animal feed additive Nutrition 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 108010055059 beta-Mannosidase Proteins 0.000 abstract 1
- 230000004186 co-expression Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 229940116332 glucose oxidase Drugs 0.000 abstract 1
- 235000019420 glucose oxidase Nutrition 0.000 abstract 1
- 229960000274 lysozyme Drugs 0.000 abstract 1
- 239000004325 lysozyme Substances 0.000 abstract 1
- 235000010335 lysozyme Nutrition 0.000 abstract 1
- 108010087558 pectate lyase Proteins 0.000 abstract 1
- 229940085127 phytase Drugs 0.000 abstract 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000010791 quenching Methods 0.000 abstract 1
- 230000000171 quenching effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301310 | 2003-09-11 | ||
| PCT/DK2004/000605 WO2005024002A1 (en) | 2003-09-11 | 2004-09-13 | Recombinant production of antimicrobial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE513904T1 true ATE513904T1 (de) | 2011-07-15 |
Family
ID=34259082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04762825T ATE513904T1 (de) | 2003-09-11 | 2004-09-13 | Rekombinante herstellung antimikrobieller agentien |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7935501B2 (de) |
| EP (1) | EP1680503B1 (de) |
| JP (1) | JP2007504810A (de) |
| CN (1) | CN1845989B (de) |
| AT (1) | ATE513904T1 (de) |
| AU (1) | AU2004270815B2 (de) |
| BR (1) | BRPI0413833A (de) |
| CA (1) | CA2536782A1 (de) |
| DK (1) | DK1680503T3 (de) |
| ES (1) | ES2368221T3 (de) |
| IL (1) | IL173656A0 (de) |
| NZ (1) | NZ545564A (de) |
| WO (1) | WO2005024002A1 (de) |
| ZA (1) | ZA200601544B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6855548B2 (en) * | 2000-02-08 | 2005-02-15 | F. Hoffman-La Roche Ag | Use of acid-stable proteases in animal feed |
| EP1594963B1 (de) * | 2003-02-07 | 2007-07-25 | Novozymes A/S | Proteasen |
| US7763706B1 (en) * | 2003-07-17 | 2010-07-27 | Campina B.V. | Arginine/lysine-enriched peptides |
| DE602004030595D1 (de) * | 2003-10-10 | 2011-01-27 | Novozymes As | Proteasevarianten |
| WO2005123911A2 (en) * | 2004-06-21 | 2005-12-29 | Novozymes A/S | Proteases |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| JP5646507B2 (ja) * | 2009-01-13 | 2014-12-24 | ペルガムム・エイビーＰｅｒｇａｍｕｍ ＡＢ | 創傷、傷跡、および手術後の癒着形成を治療するためのヒアルロン酸含有組成物 |
| KR20170024129A (ko) * | 2009-06-26 | 2017-03-06 | 카톨리에케 유니버시테이트 루벤 | 항균제 |
| BRPI1015203B1 (pt) | 2009-06-26 | 2021-06-01 | Lysando Ag | Proteína de fusão composta por uma endolisina e uma extensão de peptídeo anfifática, usos da mesma e composição farmacêutica que compreende a dita proteína |
| CN102220295B (zh) * | 2011-05-26 | 2013-02-06 | 长沙理工大学 | 以稻谷加工副产物为原料生产饲用葡萄糖氧化酶的方法 |
| MX358174B (es) * | 2011-11-17 | 2018-08-08 | Dsm Ip Assets Bv | Uso de proteasas estables en medio acido en la alimentacion animal, preferentemente para incrementar el rendimiento de pollos de engorde vacunados contra la coccidiosis. |
| US10597430B2 (en) * | 2012-03-05 | 2020-03-24 | Instituto De Investigaciones Agropecuarias | Chimeric gene for heterologous expression which encodes for peptides with antimicrobial activity |
| WO2014052438A1 (en) | 2012-09-25 | 2014-04-03 | Regents Of The University Of Minnesota | Methods for making and using antimicrobial peptides |
| CN105734029B (zh) * | 2014-12-12 | 2020-09-25 | 丰益(上海)生物技术研发中心有限公司 | 磷脂酶抗菌肽 |
| CN105255939B (zh) * | 2015-11-13 | 2018-12-25 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产菌丝霉素的方法 |
| CN105274137B (zh) * | 2015-11-13 | 2018-12-25 | 长沙中科晶博生物科技有限公司 | 一种用青蒿生产乳铁蛋白的方法 |
| CN108794635B (zh) * | 2018-04-04 | 2021-03-19 | 浙江工业大学 | 一种牛乳铁蛋白肽-人溶菌酶融合蛋白、基因及其应用 |
| CN111118091A (zh) * | 2018-10-31 | 2020-05-08 | 宁夏乙征生物工程有限公司 | 一种抗菌肽的生产方法 |
| CN109295075B (zh) * | 2018-10-31 | 2021-04-20 | 上海市农业生物基因中心 | NfOCP1抗旱基因、其编码的氨基酸序列及其在提高植物抗旱性中的用途 |
| CN111349177B (zh) * | 2020-03-13 | 2022-04-22 | 西北农林科技大学 | 一种融合抗菌肽cat的制备方法和应用 |
| CN114478795B (zh) * | 2020-11-13 | 2024-06-04 | 安徽新熙盟生物科技有限公司 | 提高多肽类药物口服给药稳定性的融合蛋白及其应用 |
| CN113125689B (zh) * | 2021-03-29 | 2022-02-22 | 创芯国际生物科技(广州)有限公司 | 一种新型mtt细胞活力检测试剂盒及其应用 |
| WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| CN114790237B (zh) * | 2022-05-31 | 2024-04-05 | 合肥工业大学 | 一种抗菌肽及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5094951A (en) | 1988-06-21 | 1992-03-10 | Chiron Corporation | Production of glucose oxidase in recombinant systems |
| US5571697A (en) | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
| US5789377A (en) | 1992-08-21 | 1998-08-04 | University Of British Columbia | Treatment of endotoxin-associated disorders with cationic peptides |
| KR100263583B1 (ko) | 1997-05-28 | 2000-08-01 | 박종헌 | 항균 펩타이드의 대량 제조방법 및 그에 유용한 플라즈미드 벡타 |
| EP1187925B1 (de) | 1999-06-02 | 2005-03-30 | Novozymes A/S | Pektat lyase-fusion zur expression und ausscheidung von polypeptiden |
-
2004
- 2004-09-13 EP EP04762825A patent/EP1680503B1/de not_active Not-in-force
- 2004-09-13 NZ NZ545564A patent/NZ545564A/en not_active IP Right Cessation
- 2004-09-13 AU AU2004270815A patent/AU2004270815B2/en not_active Ceased
- 2004-09-13 JP JP2006525631A patent/JP2007504810A/ja not_active Ceased
- 2004-09-13 ES ES04762825T patent/ES2368221T3/es active Active
- 2004-09-13 DK DK04762825.0T patent/DK1680503T3/da active
- 2004-09-13 CA CA002536782A patent/CA2536782A1/en not_active Abandoned
- 2004-09-13 AT AT04762825T patent/ATE513904T1/de not_active IP Right Cessation
- 2004-09-13 CN CN2004800249767A patent/CN1845989B/zh not_active Expired - Fee Related
- 2004-09-13 US US10/572,016 patent/US7935501B2/en not_active Expired - Fee Related
- 2004-09-13 WO PCT/DK2004/000605 patent/WO2005024002A1/en active Application Filing
- 2004-09-13 BR BRPI0413833-3A patent/BRPI0413833A/pt not_active Application Discontinuation
-
2006
- 2006-02-09 IL IL173656A patent/IL173656A0/en not_active IP Right Cessation
- 2006-02-22 ZA ZA200601544A patent/ZA200601544B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2368221T3 (es) | 2011-11-15 |
| CA2536782A1 (en) | 2005-03-17 |
| US20070104764A1 (en) | 2007-05-10 |
| JP2007504810A (ja) | 2007-03-08 |
| AU2004270815A1 (en) | 2005-03-17 |
| AU2004270815B2 (en) | 2011-06-02 |
| US7935501B2 (en) | 2011-05-03 |
| DK1680503T3 (da) | 2011-10-03 |
| IL173656A0 (en) | 2006-07-05 |
| NZ545564A (en) | 2008-07-31 |
| WO2005024002A1 (en) | 2005-03-17 |
| CN1845989B (zh) | 2011-10-12 |
| EP1680503A1 (de) | 2006-07-19 |
| BRPI0413833A (pt) | 2006-10-24 |
| CN1845989A (zh) | 2006-10-11 |
| EP1680503B1 (de) | 2011-06-22 |
| ZA200601544B (en) | 2007-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |