CN1822857A - 去免疫原性抗cd3抗体 - Google Patents

去免疫原性抗cd3抗体 Download PDF

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Publication number
CN1822857A
CN1822857A CNA2004800202578A CN200480020257A CN1822857A CN 1822857 A CN1822857 A CN 1822857A CN A2004800202578 A CNA2004800202578 A CN A2004800202578A CN 200480020257 A CN200480020257 A CN 200480020257A CN 1822857 A CN1822857 A CN 1822857A
Authority
CN
China
Prior art keywords
antibody
deimmunized
chain variable
variable region
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800202578A
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English (en)
Chinese (zh)
Inventor
R·P·罗特尔
S·法斯－奈特
邬大洋
F·J·卡尔
A·汉密尔顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alexion Pharmaceuticals Inc
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Alexion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharmaceuticals Inc filed Critical Alexion Pharmaceuticals Inc
Publication of CN1822857A publication Critical patent/CN1822857A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/467—Igs with modifications in the FR-residues only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CNA2004800202578A 2003-06-02 2004-05-28 去免疫原性抗cd3抗体 Pending CN1822857A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47515503P 2003-06-02 2003-06-02
US60/475,155 2003-06-02

Publications (1)

Publication Number Publication Date
CN1822857A true CN1822857A (zh) 2006-08-23

Family

ID=33511652

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800202578A Pending CN1822857A (zh) 2003-06-02 2004-05-28 去免疫原性抗cd3抗体

Country Status (7)

Country Link
US (1) US20070292416A1 (enExample)
EP (1) EP1658095A4 (enExample)
JP (1) JP2006526414A (enExample)
CN (1) CN1822857A (enExample)
AU (1) AU2004245038A1 (enExample)
CA (1) CA2527726A1 (enExample)
WO (1) WO2004108158A1 (enExample)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020224529A1 (zh) * 2019-05-07 2020-11-12 北京天成新脉生物技术有限公司 低免疫原性低ADCC/CDC功能抗TNF-α人源化单克隆抗体TCX060及其应用

Also Published As

Publication number Publication date
CA2527726A1 (en) 2004-12-16
US20070292416A1 (en) 2007-12-20
EP1658095A4 (en) 2006-06-14
AU2004245038A1 (en) 2004-12-16
JP2006526414A (ja) 2006-11-24
WO2004108158A1 (en) 2004-12-16
EP1658095A1 (en) 2006-05-24

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Open date: 20060823