CA2527726A1 - De-immunized anti-cd3 antibody - Google Patents
De-immunized anti-cd3 antibody Download PDFInfo
- Publication number
- CA2527726A1 CA2527726A1 CA002527726A CA2527726A CA2527726A1 CA 2527726 A1 CA2527726 A1 CA 2527726A1 CA 002527726 A CA002527726 A CA 002527726A CA 2527726 A CA2527726 A CA 2527726A CA 2527726 A1 CA2527726 A1 CA 2527726A1
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- antibody
- immunized
- chain variable
- cells
- antibodies
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/467—Igs with modifications in the FR-residues only
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47515503P | 2003-06-02 | 2003-06-02 | |
| US60/475,155 | 2003-06-02 | ||
| PCT/US2004/017219 WO2004108158A1 (en) | 2003-06-02 | 2004-05-28 | De-immunized anti-cd3 antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2527726A1 true CA2527726A1 (en) | 2004-12-16 |
Family
ID=33511652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002527726A Abandoned CA2527726A1 (en) | 2003-06-02 | 2004-05-28 | De-immunized anti-cd3 antibody |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070292416A1 (enExample) |
| EP (1) | EP1658095A4 (enExample) |
| JP (1) | JP2006526414A (enExample) |
| CN (1) | CN1822857A (enExample) |
| AU (1) | AU2004245038A1 (enExample) |
| CA (1) | CA2527726A1 (enExample) |
| WO (1) | WO2004108158A1 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005007809A2 (en) * | 2003-05-30 | 2005-01-27 | Alexion Pharmaceuticals, Inc. | Antibodies and fusion proteins that include engineered constant regions |
| DE102004063494A1 (de) * | 2004-12-23 | 2006-07-13 | Tegenero Ag | Antikörper |
| NZ599035A (en) | 2006-01-12 | 2013-12-20 | Alexion Pharma Inc | Antibodies to ox-2/cd200 and uses thereof |
| DK2359834T5 (en) | 2006-03-15 | 2017-02-06 | Alexion Pharma Inc | Treatment of paroxysmal nocturnal hemoglobinuria patients with a complement inhibitor |
| RS64039B1 (sr) | 2008-11-10 | 2023-04-28 | Alexion Pharma Inc | Metode i kompozicije za lečenje poremećaja povezanih sa komplementom |
| WO2010088522A2 (en) * | 2009-01-30 | 2010-08-05 | Ab Biosciences, Inc. | Novel lowered affinity antibodies and uses therefor |
| US9290577B2 (en) | 2009-07-03 | 2016-03-22 | Avipep Pty Limited | Immuno-conjugates and methods for producing them |
| ES2625470T3 (es) | 2009-11-09 | 2017-07-19 | Alexion Pharmaceuticals, Inc.. | Reactivos y métodos para detectar glóbulos blancos asociados a HPN de tipo II y su identificación como factores de riesgo para trastornos trombóticos |
| SG181814A1 (en) | 2009-12-23 | 2012-07-30 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
| EP2523976B1 (en) | 2010-01-11 | 2018-04-25 | Alexion Pharmaceuticals, Inc. | Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies |
| KR101800913B1 (ko) | 2010-04-30 | 2017-12-20 | 알렉시온 파마슈티칼스, 인코포레이티드 | 항-c5a 항체들과 이 항체들을 이용하는 방법 |
| EP2585110A4 (en) | 2010-06-22 | 2014-01-22 | Univ Colorado Regents | ANTIBODIES AGAINST THE C3D FRAGMENT OF THE COMPLEMENT COMPONENT 3 |
| MX341309B (es) | 2010-07-20 | 2016-08-12 | Cephalon Australia Pty Ltd | Anticuerpos especificos del heterodimero de anti-il-23. |
| JP6150734B2 (ja) | 2011-02-03 | 2017-06-21 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 同種移植片の生存を長期化するための抗ｃｄ２００抗体の使用 |
| US9624294B2 (en) | 2011-03-14 | 2017-04-18 | Cellmid Limited | Antibody recognizing N-domain of midkine |
| WO2012142662A1 (en) | 2011-04-21 | 2012-10-26 | Garvan Institute Of Medical Research | Modified variable domain molecules and methods for producing and using them b |
| CA2838246C (en) | 2011-06-13 | 2018-07-10 | Csl Limited | Antibodies against g-csfr and uses thereof |
| BR112014007426B1 (pt) | 2011-09-30 | 2023-01-03 | Teva Pharmaceuticals Australia Pty Ltd | Anticorpos contra tl1a e seus usos |
| AU2012327878A1 (en) | 2011-10-28 | 2014-05-29 | Patrys Limited | PAT-LM1 epitopes and methods for using same |
| EP3786183A3 (en) | 2012-06-15 | 2021-06-09 | Imaginab, Inc. | Antigen binding constructs to cd3 |
| JP6539585B2 (ja) | 2013-02-01 | 2019-07-03 | デンドロサイト バイオテック ピーティーワイ リミテッド | 抗ｃｄ８３抗体及びその使用 |
| EP2953971B1 (en) | 2013-02-07 | 2023-03-01 | CSL Limited | Il-11r binding proteins and uses thereof |
| DK3074038T3 (en) | 2013-11-28 | 2019-03-11 | Csl Ltd | METHOD OF TREATING DIABETIC NEPHROPATHY |
| JP6553618B2 (ja) | 2013-12-18 | 2019-07-31 | シーエスエル リミティド | 創傷を治療する方法 |
| WO2016061632A1 (en) | 2014-10-23 | 2016-04-28 | La Trobe University | Fn14-binding proteins and uses thereof |
| US10870704B2 (en) | 2014-10-23 | 2020-12-22 | Kira Biotech Pty Limited | CD83 binding proteins and uses thereof |
| ES2717308T3 (es) | 2014-12-06 | 2019-06-20 | Gemoab Monoclonals Gmbh | Células madre pluri- o multi-potentes genéticamente modificadas y sus usos |
| KR102654033B1 (ko) * | 2014-12-08 | 2024-04-02 | 1글로브 바이오메디칼 씨오., 엘티디. | 가용성 유니버셜 adcc 증강 합성 융합 유전자 및 펩티드 기술 및 그 용도 |
| AU2015367224B2 (en) | 2014-12-19 | 2020-12-10 | Monash University | IL-21 antibodies |
| ES3020458T3 (en) | 2015-08-07 | 2025-05-22 | Imaginab Inc | Antigen binding constructs to target molecules |
| SG10201912051TA (en) | 2015-11-27 | 2020-02-27 | Csl Ltd | Cd131 binding proteins and uses thereof |
| BR112018076260A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| US20190248920A1 (en) | 2016-09-23 | 2019-08-15 | Csl Limited | Coagulation factor binding proteins and uses thereof |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| JP7733443B2 (ja) | 2017-09-11 | 2025-09-03 | モナシュ ユニバーシティー | ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質 |
| CN111247165B (zh) | 2017-10-18 | 2023-11-10 | Csl有限公司 | 人血清白蛋白变体及其应用 |
| US20200362054A1 (en) * | 2017-11-21 | 2020-11-19 | Brian Granda | Trispecific binding molecules against tumor-associated antigents and use thereof |
| PL3717011T3 (pl) | 2017-11-29 | 2023-03-27 | Csl Limited | Sposób leczenia lub zapobiegania uszkodzeniu niedokrwienno- reperfuzyjnemu |
| WO2019114768A1 (en) | 2017-12-12 | 2019-06-20 | Biocytogen Jiangsu Co., Ltd. | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD3e |
| US11802154B2 (en) | 2017-12-20 | 2023-10-31 | Alexion Pharmaceuticals, Inc. | Humanized anti-CD200 antibodies and uses thereof |
| WO2019178645A1 (en) | 2018-03-23 | 2019-09-26 | Csl Limited | Method of treating asthma |
| PT3793586T (pt) | 2018-05-16 | 2024-07-10 | Csl Ltd | Variantes do receptor solúvel do complemento de tipo 1 e sua utilização |
| MX2021000239A (es) | 2018-07-10 | 2021-03-25 | Regeneron Pharma | Modificacion de moleculas de union para minimizar interacciones preexistentes. |
| WO2020118011A1 (en) | 2018-12-06 | 2020-06-11 | Alexion Pharmaceuticals, Inc. | Anti-alk2 antibodies and uses thereof |
| CN109776683B (zh) * | 2019-03-19 | 2020-04-07 | 益科思特(北京)医药科技发展有限公司 | 一种双特异性抗体及其制备方法与应用 |
| CN111909268B (zh) * | 2019-05-07 | 2022-04-19 | 北京天成新脉生物技术有限公司 | 低免疫原性低ADCC/CDC功能抗TNF-α人源化单克隆抗体TCX060及其应用 |
| KR102503349B1 (ko) | 2019-05-14 | 2023-02-23 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| US12037378B2 (en) | 2019-05-21 | 2024-07-16 | Novartis Ag | Variant CD58 domains and uses thereof |
| BR112021023048A2 (pt) | 2019-05-21 | 2022-04-19 | Novartis Ag | Moléculas de ligação a cd19 e usos das mesmas |
| JP2023508023A (ja) | 2019-12-20 | 2023-02-28 | ハドソン インスティチュート オブ メディカル リサーチ | Ｃｘｃｌ１０結合タンパク質及びその使用 |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| EP4182475A2 (en) | 2020-07-17 | 2023-05-24 | Onena Medicines S.L. | Antibodies against lefty proteins |
| CN114656562B (zh) * | 2020-12-23 | 2023-11-03 | 北京天广实生物技术股份有限公司 | 结合人和猴cd3的抗体及其应用 |
| US12275798B2 (en) | 2021-06-17 | 2025-04-15 | Boehringer Ingelheim International Gmbh | Tri-specific binding molecules |
| EP4581055A1 (en) | 2022-08-31 | 2025-07-09 | Universität Zürich | Adenoviral-based in situ delivery of bispecific t cell engagers |
| WO2025007195A1 (en) | 2023-07-05 | 2025-01-09 | CSL Innovation Pty Ltd | Methods of treating or preventing a complication of sickle cell disease |
| WO2025171411A1 (en) | 2024-02-09 | 2025-08-14 | Herophilus, Inc. | Compositions and methods related to modulating macrophage migration inhibitory factor (mif)-cd74 signaling and related treatments for neuroinflammatory conditions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5885573A (en) * | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US6491916B1 (en) * | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| ES2258817T3 (es) * | 1997-05-21 | 2006-09-01 | Biovation Limited | Metodo para la produccion de proteinas no inmunogenas. |
| US6768004B2 (en) * | 2001-01-11 | 2004-07-27 | Mueller Sybille | Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies |
| EP1366455B1 (en) * | 2001-02-19 | 2008-07-02 | MERCK PATENT GmbH | Method for identification of t-cell epitopes and use for preparing molecules with reduced immunogenicity |
-
2004
- 2004-05-28 US US10/559,543 patent/US20070292416A1/en not_active Abandoned
- 2004-05-28 JP JP2006515055A patent/JP2006526414A/ja active Pending
- 2004-05-28 CN CNA2004800202578A patent/CN1822857A/zh active Pending
- 2004-05-28 CA CA002527726A patent/CA2527726A1/en not_active Abandoned
- 2004-05-28 EP EP04753940A patent/EP1658095A4/en not_active Withdrawn
- 2004-05-28 AU AU2004245038A patent/AU2004245038A1/en not_active Abandoned
- 2004-05-28 WO PCT/US2004/017219 patent/WO2004108158A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN1822857A (zh) | 2006-08-23 |
| US20070292416A1 (en) | 2007-12-20 |
| EP1658095A4 (en) | 2006-06-14 |
| AU2004245038A1 (en) | 2004-12-16 |
| JP2006526414A (ja) | 2006-11-24 |
| WO2004108158A1 (en) | 2004-12-16 |
| EP1658095A1 (en) | 2006-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |