CN1774264A - 重组火鸡疱疹病毒及其应用 - Google Patents
重组火鸡疱疹病毒及其应用 Download PDFInfo
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- CN1774264A CN1774264A CNA038030047A CN03803004A CN1774264A CN 1774264 A CN1774264 A CN 1774264A CN A038030047 A CNA038030047 A CN A038030047A CN 03803004 A CN03803004 A CN 03803004A CN 1774264 A CN1774264 A CN 1774264A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16341—Use of virus, viral particle or viral elements as a vector
- C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
rHVT/NDV | HVT FC 126 | 未接种 | |||
MA+*** | SPF**** | MA+ | SPF | MA+ | |
3周** | 2/2* | ND***** | 2/2 | 1/1 | ND |
4周 | 3/3 | 2/2 | 1/3 | 2/2 | 0/2 |
5周 | 3/3 | 2/2 | 1/3 | ND | 0/2 |
6周 | 3/3 | 2/2 | 1/3 | 2/2 | 0/2 |
病毒 | 初级抗体 | |||
兔抗F抗血清 | 鸡抗NDV抗血清 | 抗VP2单克隆抗体(R63) | PBS | |
rHVT/NDV | + | + | - | - |
FC126 | - | - | - | - |
None | - | - | - | - |
接种 | 剂量(PFU/鸡) | 鸡数 | 出现症状鸡数/总数(%) | 孵化HI(ELISA)滴度 | 攻击时ELISA滴度 |
rHVT/NDV | 1950 | 20 | 0/20(0) | 0 | 0.207±0.03 |
商业NDV活疫苗 | 见标签 | 10 | 0/10(0) | 1.089±0.29 | |
阳性对照 | N/A | 10 | 11/12(92) | 0.089±0.01 | |
阴性对照 | N/A | 5 | 0/5(0) | N/A |
接种 | 剂量(PFU/鸡) | 鸡数 | 出现症状鸡数/总数(%) | 孵化时HI(ELISA)滴度 | 攻击时ELISA滴度 |
rHVT/NDV | 1950 | 10 | 0/12(0) | N/A | 0.471±0.108 |
商业NDV活疫苗 | 见标签 | 10 | 1/10(0) | N/A | 1.386±0.287 |
阳性对照组 | N/A | 10 | 10/10(100) | N/A | 0.047±0.003 |
阴性对照组 | N/A | 5 | 0/5(0) | N/A | N/A |
组 | 周龄 | ||||||||||||
2 | 3 | 4 | 5 | 7 | 11 | 15 | 20 | 24 | 30 | 45 | 50 | ||
rHVT/NDV | 抗体滴度 | 0.85 | 0.50 | 0.31 | 0.21 | 0.36 | 0.84 | 0.91 | 0.88 | 1.21 | 0.90 | 1.04 | 1.12 |
保护作用 | + | + | + | + | + | + | + | + | + | + | + | + | |
未接种对照组 | 抗体滴度 | 0.74 | 0.46 | 0.10 | 0.03 | 0.01 | 0.02 | 0.05 | 0.02 | 0.02 | 0.00 | 0.01 | 0.02 |
保护作用 | + | + | - | - | - | - | - | - | - | - | - | - |
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/059,152 | 2002-01-31 | ||
US10/059,152 US6866852B2 (en) | 2002-01-31 | 2002-01-31 | Recombinant herpesvirus of turkeys and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1774264A true CN1774264A (zh) | 2006-05-17 |
CN100335131C CN100335131C (zh) | 2007-09-05 |
Family
ID=27658249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB038030047A Expired - Fee Related CN100335131C (zh) | 2002-01-31 | 2003-01-29 | 重组火鸡疱疹病毒及其应用 |
Country Status (6)
Country | Link |
---|---|
US (1) | US6866852B2 (zh) |
EP (1) | EP1467753B1 (zh) |
JP (1) | JP4265405B2 (zh) |
CN (1) | CN100335131C (zh) |
DE (1) | DE60321129D1 (zh) |
WO (1) | WO2003064595A2 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101812542A (zh) * | 2010-04-28 | 2010-08-25 | 国家兽用生物制品工程技术研究中心 | 一种快速检测细胞内火鸡疱疹病毒的方法 |
CN102405058A (zh) * | 2009-04-15 | 2012-04-04 | 法国诗华大药厂 | 用于免疫接种水禽物种的重组禽疱疹病毒载体和疫苗 |
CN106350475A (zh) * | 2016-08-26 | 2017-01-25 | 江苏省农业科学院 | 一种新型火鸡疱疹病毒的细菌人工染色体、构建方法与应用 |
CN106929483A (zh) * | 2017-01-19 | 2017-07-07 | 北京邦卓生物科技有限公司 | 表达鸡新城疫病毒f基因的重组火鸡疱疹病毒的构建及其应用 |
CN113226363A (zh) * | 2018-12-21 | 2021-08-06 | 法国诗华大药厂 | 含有多个外来基因的重组禽疱疹病毒 |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080241188A1 (en) * | 2007-03-30 | 2008-10-02 | Zeon Corporation | Turkey herpesvirus vectored recombinant containing avian influenza genes |
US20090246226A1 (en) * | 2008-03-28 | 2009-10-01 | Zeon Corporation | Avian vaccines possessing a positive marker gene |
US9114108B2 (en) | 2011-11-30 | 2015-08-25 | Merial, Inc. | Recombinant HVT vectors expressing antigens of avian pathogens and uses thereof |
CN105920598A (zh) | 2011-11-30 | 2016-09-07 | 梅里亚有限公司 | 表达禽类病原体的抗原的重组hvt载体及其用途 |
EP2644702A1 (en) * | 2012-03-30 | 2013-10-02 | Ceva Sante Animale | Multivalent recombinant avian herpes virus and vaccine for immunizing avian species |
EP2845904A1 (en) * | 2013-09-06 | 2015-03-11 | Ceva Sante Animale | Recombinant Marek's disease viruses and uses thereof |
EP3050572A1 (en) | 2015-01-29 | 2016-08-03 | Ceva Sante Animale | Recombinant MDV1 and the uses thereof |
EP3263129A1 (en) | 2016-06-29 | 2018-01-03 | Ceva Sante Animale | Duck enteritis virus and the uses thereof |
KR20230170803A (ko) | 2016-12-14 | 2023-12-19 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 조류 병원체의 다중 항원을 발현하는 재조합 hvt 벡터 및 그를 포함하는 백신 |
CN110331135A (zh) * | 2019-07-18 | 2019-10-15 | 扬州大学 | 表达基因vii型新城疫病毒融合蛋白的重组火鸡疱疹病毒候选疫苗株及制备方法 |
CA3153379A1 (en) | 2019-09-11 | 2021-03-18 | Zoetis Services Llc | Recombinant herpesvirus of turkey vectors expressing antigens of avian pathogens and uses thereof |
WO2021257706A1 (en) | 2020-06-17 | 2021-12-23 | Boehringer Ingelheim Animal Health USA Inc. | Recombinant hvt vectors expressing influenza hemagglutinin and immunogenic compositions, and production and uses thereof |
MX2023004358A (es) | 2020-10-15 | 2023-07-25 | Ceva Sante Animale | Hvt recombinante y usos de este. |
CN114134124A (zh) * | 2021-11-09 | 2022-03-04 | 扬州大学 | 一种重组火鸡疱疹病毒及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69836557T2 (de) | 1997-10-03 | 2007-09-20 | Zeon Corp. | Rekombinanten des infektiösen vogel-herpesvirus und rekombinante impfstoffe, die unter dessen verwendung hergestellt wurden |
JP4257472B2 (ja) * | 1999-06-22 | 2009-04-22 | 日本ゼオン株式会社 | プロモーター、それを含有する組み換え体及びその利用 |
-
2002
- 2002-01-31 US US10/059,152 patent/US6866852B2/en not_active Expired - Lifetime
-
2003
- 2003-01-29 JP JP2003564191A patent/JP4265405B2/ja not_active Expired - Lifetime
- 2003-01-29 EP EP03705764A patent/EP1467753B1/en not_active Expired - Lifetime
- 2003-01-29 DE DE60321129T patent/DE60321129D1/de not_active Expired - Lifetime
- 2003-01-29 CN CNB038030047A patent/CN100335131C/zh not_active Expired - Fee Related
- 2003-01-29 WO PCT/US2003/001066 patent/WO2003064595A2/en active Application Filing
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102405058A (zh) * | 2009-04-15 | 2012-04-04 | 法国诗华大药厂 | 用于免疫接种水禽物种的重组禽疱疹病毒载体和疫苗 |
CN102405058B (zh) * | 2009-04-15 | 2015-11-25 | 法国诗华大药厂 | 用于免疫接种水禽物种的重组禽疱疹病毒载体和疫苗 |
CN101812542A (zh) * | 2010-04-28 | 2010-08-25 | 国家兽用生物制品工程技术研究中心 | 一种快速检测细胞内火鸡疱疹病毒的方法 |
CN106350475A (zh) * | 2016-08-26 | 2017-01-25 | 江苏省农业科学院 | 一种新型火鸡疱疹病毒的细菌人工染色体、构建方法与应用 |
CN106929483A (zh) * | 2017-01-19 | 2017-07-07 | 北京邦卓生物科技有限公司 | 表达鸡新城疫病毒f基因的重组火鸡疱疹病毒的构建及其应用 |
CN113226363A (zh) * | 2018-12-21 | 2021-08-06 | 法国诗华大药厂 | 含有多个外来基因的重组禽疱疹病毒 |
Also Published As
Publication number | Publication date |
---|---|
WO2003064595A3 (en) | 2003-10-16 |
EP1467753A4 (en) | 2006-08-02 |
US20030157703A1 (en) | 2003-08-21 |
JP4265405B2 (ja) | 2009-05-20 |
EP1467753A2 (en) | 2004-10-20 |
CN100335131C (zh) | 2007-09-05 |
DE60321129D1 (de) | 2008-07-03 |
JP2005515775A (ja) | 2005-06-02 |
WO2003064595A2 (en) | 2003-08-07 |
US6866852B2 (en) | 2005-03-15 |
EP1467753B1 (en) | 2008-05-21 |
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CI01 | Correction of invention patent gazette |
Correction item: First inventor Correct: Chris M. Dorsey False: Dorsey Kristi M. Number: 36 Page: 1062 Volume: 23 |
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Correction item: First inventor Correct: Chris M. Dorsey False: Dorsey Kristi M. Number: 36 Page: The title page Volume: 23 |
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Free format text: CORRECT: THE FIRST INVENTOR; FROM: CHRISTOPHER M. DORSEY TO: ROY TAM LEE ADAMS PLYMOUTH |
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