CN1774239A - 用于胃肠道的有效药物递送 - Google Patents

用于胃肠道的有效药物递送 Download PDF

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Publication number
CN1774239A
CN1774239A CNA2004800085220A CN200480008522A CN1774239A CN 1774239 A CN1774239 A CN 1774239A CN A2004800085220 A CNA2004800085220 A CN A2004800085220A CN 200480008522 A CN200480008522 A CN 200480008522A CN 1774239 A CN1774239 A CN 1774239A
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China
Prior art keywords
capsule
gastrointestinal
change
state
drug
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Pending
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CNA2004800085220A
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English (en)
Chinese (zh)
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约西·格罗斯
约拉姆·塞拉
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E-PILL PHARMA Ltd
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E-PILL PHARMA Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0008—Temperature signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Radiation-Therapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Endoscopes (AREA)
CNA2004800085220A 2003-01-29 2004-01-29 用于胃肠道的有效药物递送 Pending CN1774239A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44317303P 2003-01-29 2003-01-29
US60/443,173 2003-01-29

Publications (1)

Publication Number Publication Date
CN1774239A true CN1774239A (zh) 2006-05-17

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CNA2004800085220A Pending CN1774239A (zh) 2003-01-29 2004-01-29 用于胃肠道的有效药物递送

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US (1) US20040253304A1 (cg-RX-API-DMAC7.html)
EP (1) EP1594477A4 (cg-RX-API-DMAC7.html)
JP (1) JP2006517827A (cg-RX-API-DMAC7.html)
KR (1) KR20050098277A (cg-RX-API-DMAC7.html)
CN (1) CN1774239A (cg-RX-API-DMAC7.html)
AU (1) AU2004208580A1 (cg-RX-API-DMAC7.html)
CA (1) CA2514392A1 (cg-RX-API-DMAC7.html)
RU (1) RU2334506C2 (cg-RX-API-DMAC7.html)
WO (1) WO2004066903A2 (cg-RX-API-DMAC7.html)

Cited By (44)

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CN101721194B (zh) * 2008-10-14 2011-11-09 鸿富锦精密工业（深圳）有限公司 胶囊内视镜及其镜片的制造方法
CN102724907A (zh) * 2010-01-27 2012-10-10 奥林巴斯株式会社 电源系统以及搭载该电源系统的医疗用胶囊装置
CN102811762A (zh) * 2009-08-12 2012-12-05 皇家飞利浦电子股份有限公司 用于药物输送装置的药物容器
CN102905753A (zh) * 2009-12-24 2013-01-30 因卡伯实验室有限责任公司 可吞咽式药剂递送装置和药剂递送方法
CN102920418A (zh) * 2012-10-24 2013-02-13 刘思德 一种消化道自稳探路胶囊
CN102088281B (zh) * 2009-12-04 2013-05-29 北京华清益康科技有限责任公司 一种基于消化道内体液酸碱度的电开关装置
CN104023740A (zh) * 2011-06-29 2014-09-03 拉尼医疗有限公司 用于使用可吞服药物递送装置递送到肠道内腔中的治疗药剂制剂
CN104271028A (zh) * 2011-12-15 2015-01-07 基文影像公司 用于体内检测胃肠道中出血的设备、系统和方法
CN104287685A (zh) * 2014-10-08 2015-01-21 南京航空航天大学 弹性杆导向式胶囊內镜机器人驻停及位姿调整装置与方法
US8990018B2 (en) 2008-03-31 2015-03-24 MEDIMETRICS Personalized Drug Delivery B.V. Method of preparing a swallowable capsule comprising a sensor
CN105168174A (zh) * 2010-03-10 2015-12-23 因卡伯实验室有限责任公司 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂
CN105361848A (zh) * 2015-11-24 2016-03-02 黄巧玲 施药胃镜
CN106661086A (zh) * 2014-06-12 2017-05-10 巴斯大学 药物递送增强剂
CN106999166A (zh) * 2014-09-17 2017-08-01 马斯公司 装置
CN107041727A (zh) * 2017-05-26 2017-08-15 杭州师范大学 一种智能无线胶囊及其控制方法
CN107205630A (zh) * 2014-12-04 2017-09-26 M·特罗尔萨斯 用于图像撷取控制的胶囊涂层
US9808510B2 (en) 2011-06-29 2017-11-07 Rani Therapeutics, Llc Method for delivering gonadotropin releasing hormone into a lumen of the intestinal tract
US9814763B2 (en) 2010-12-23 2017-11-14 Incube Labs, Llc Method for delivery of somatostatin into a lumen of the intestinal tract
US9844655B2 (en) 2010-12-23 2017-12-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9844505B2 (en) 2010-12-23 2017-12-19 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9907747B2 (en) 2010-12-23 2018-03-06 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9956178B2 (en) 2010-12-23 2018-05-01 Rani Therapeutics, Llc Methods for delivering insulin preparations into a lumen of the intestinal tract using a swallowable drug delivery device
CN108125669A (zh) * 2015-11-24 2018-06-08 温玉桂 具有控制端的胃镜
US10004783B2 (en) 2010-12-23 2018-06-26 Rani Therapeutics, Llc Method for delivering pramlintide into a lumen of the intestinal tract using a swallowable drug delivery device
US10029080B2 (en) 2010-12-23 2018-07-24 Rani Therapeutics, Llc Method for delivering exenatide into a lumen of the intestinal tract using a swallowable drug delivery device
CN108778408A (zh) * 2015-11-06 2018-11-09 Seb公司 包括用于测量产品不存在的测量装置的、用于通过离子电渗疗法将待分配产品涂抹到使用者皮肤上的设备和相应方法
US10179228B2 (en) 2009-12-24 2019-01-15 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
CN110072551A (zh) * 2016-12-14 2019-07-30 普罗根尼蒂公司 使用利用可摄入装置释放的il-12/il-23抑制剂治疗胃肠道疾病
CN110234399A (zh) * 2017-11-08 2019-09-13 首尔伟傲世有限公司 医疗用胶囊装置
US10487145B2 (en) 2010-12-23 2019-11-26 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10632251B2 (en) 2010-12-23 2020-04-28 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
CN111493946A (zh) * 2020-04-27 2020-08-07 上海长海医院 一种用于治疗主动脉夹层的生物纳米机器人
US10752681B2 (en) 2010-12-23 2020-08-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN112315565A (zh) * 2020-12-08 2021-02-05 帝斯博（常州）医疗用品股份有限公司 血管介入给药系统
CN113272001A (zh) * 2019-01-03 2021-08-17 维布兰特公司 用于将可摄入药物递送至使用者的胃肠道中的装置和方法
CN113329784A (zh) * 2019-01-21 2021-08-31 维布兰特公司 用于将可流动的可摄入药物递送至使用者的胃肠道中的装置和方法
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CN115379874A (zh) * 2020-02-18 2022-11-22 拉尼医疗有限公司 将治疗制剂注射到胃肠道的壁中
CN115666704A (zh) * 2019-12-13 2023-01-31 比奥拉治疗股份有限公司 用于将治疗剂递送至胃肠道的可摄取装置
CN117137609A (zh) * 2023-08-25 2023-12-01 上海交通大学医学院附属瑞金医院 一种具有消融记录和球囊定位功能的冷冻消融装置
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