Summary of the invention
The purpose of this invention is to provide a kind of to syndrome of deficiency of kidney-YANG is with strong points, evident in efficacy, prescription is uncomplicated, moderate Chinese patent medicine and production method thereof.
The inventor is in secular medical practice, original national herbal species sky wingceltis wine has been carried out the dosage form improvement, processing technology is also reformed, be prepared into capsule, soft capsule etc., and carried out pharmacodynamics again, the pharmacology, and research experiment such as clinical, finally invented a kind of good effect, the medicine source is extensive, moderate, production technology advanced person is feasible, use Chinese patent medicine more easily, the medicine of this treatment syndrome of deficiency of kidney-YANG is by Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum is made, and its composition and weight proportion are:
0.2~2 part in 1~7 part of Cornu Cervi Pantotrichum of 8~16 portions of Geckos of 2~10 parts of Herba Cistanches of Hippocampus
1~7 part in 2~10 parts of Poria of 8~16 portions of Rhizoma Dioscoreaes of 8~16 parts of Fructus Alpiniae Oxyphyllae of Radix Morindae Officinalis
1~7 part of 1~7 part of Fructus Toosendan of 8~16 parts of Pericarpium Citri Reticulatae Virides of 1~7 portion of Radix Dipsaci of Radix Achyranthis Bidentatae
1~7 part of 0.5~4 portion of Rhizoma Cyperi of 1~7 portion of Flos Caryophylli of 0.2~2 part of Fructus Anisi Stellati of Fructus Amomi
0.5~4 part of 1~7 part of Pheretima of 0.5~4 portion of Rhizoma Curcumae Longae of 0.5~4 portion of Lignum Aquilariae Resinatum of Lignum Santali Albi
2~10 parts of 0.5~4 part of Halitum of Caulis Clematidis Armandii
Above-mentioned Chinese medicine can be from " finding its another name, latin name and the place of production, usage Chinese pharmacopoeia or other Chinese medicine handbook.
Chinese medicine composition optimum weight umber of the present invention is:
0.75 part in 3 parts of Cornu Cervi Pantotrichums of 12 portions of Geckos of 6 parts of Herba Cistanches of Hippocampus
3 parts in 6 parts of Poria of 12 portions of Rhizoma Dioscoreaes of 12 parts of Fructus Alpiniae Oxyphyllae of Radix Morindae Officinalis
3 parts of 3 parts of Fructus Toosendans of 12 parts of Pericarpium Citri Reticulatae Virides of 3 portions of Radix Dipsacis of Radix Achyranthis Bidentatae
3 parts of 1.5 portions of Rhizoma Cyperis of 3 portions of Flos Caryophyllis of 0.75 part of Fructus Anisi Stellati of Fructus Amomi
1.5 parts of 3 parts of Pheretimas of 1.5 portions of Rhizoma Curcumae Longaes of 1.5 portions of Lignum Aquilariae Resinatum of Lignum Santali Albi
6 parts of 1.5 parts of Halitum of Caulis Clematidis Armandii
Above compositions can be used as the prescription of institute of traditional Chinese medicine's treatment syndrome of deficiency of kidney-YANG, patients is fried in shallow oil soup and is taken, be more suitable for modern pharmaceutical enterprise and extract its effective ingredient, make any dosage form on medicated wine, tablet, dispersible tablet, effervescent tablet, capsule, soft capsule, microcapsule, granule, pill, micropill, powder, drop pill, slow releasing preparation, controlled release preparation, gel, suppository, oral liquid, soft extract, extractum, injection, powder pin, freeze-dried powder, membrane or the like the pharmaceutics.
Production method of the present invention is: get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, make different preparations then respectively.
Medicated wine in the preparation of the present invention is to produce like this: get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, add adjuvants such as suitable quantity of water and sucrose, stir evenly, leave standstill, filter fill, sterilization, promptly.
Capsule in the preparation of the present invention is to produce like this: get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into thick paste shape, drying, get dry extract, be ground into fine powder, granulate, with the appropriate amount of auxiliary materials mixing, encapsulated, promptly.
Soft capsule in the preparation of the present invention is to produce like this: get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder.Get fine powder, vegetable oil, Cera Flava again by making suspended matter at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the suspended matter fill is pressed into soft capsule, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out, promptly.
Drop pill in the preparation of the present invention is to produce like this: get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, and drying gets dry extract, be ground into fine powder, add in the polyethylene glycol 6000 of heating and melting, stir moltenly, be transferred on the drop pill device, 86 ℃ of airtight insulations, make coolant with 10 ℃ of-15 ℃ of liquid paraffin, with the 50/component velocity system of dripping, promptly.
Oral solutions in the preparation of the present invention is to produce like this: get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate adds adjuvants such as suitable quantity of water and syrup, stir evenly, filter, sterilization, fill, promptly.
Other dosage form such as tablet, pill or the like can carry out with reference to pharmacopeia or Chinese medicinal preparation method.
Instructions of taking:
Medicated wine, oral, a 15ml, 2 times on the one.
Capsule, oral, one time 4,3 times on the one, every 0.33 the gram.
Soft capsule, oral, one time 4,3 times on the one, every 0.4 the gram.
Drop pill, oral, one time 4,3 times on the one.
Oral solutions, oral, a 10ml, 3 times on the one.
The present invention compared with the prior art, its outstanding substantive distinguishing features and obvious improvement is:
The present invention is preferred above-mentioned Chinese medicine under Chinese medical theory instructs, science compatibility, making in addition, make each medicine cooperatively interact, can guarantee to greatest extent the group effect and the pharmaceutically-active performance of this product reasonable formula, all medicines share, play the effect of warming and recuperating the kidney-YANG, promoting of the circulation of QI and removing the obstruction in the collaterals altogether, can effectively treat syndrome of deficiency of kidney-YANG.
Prove through animal experiment that 1, the present invention has warming and recuperating the kidney-YANG, promoting of the circulation of QI and removing the obstruction in the collaterals effect: can improve mouse sperm number, sperm motility, mating ability obviously promotes to go testis rat accessory sex organ to grow and the female Mus accessory sex organ of removal ovary compensatory increases; Obviously improve and remove testis rat (gonadal hormone) testosterone levels, reduce and remove one-sided ovum rat blood serum estradiol level, improve Turnover of Mouse Peritoneal Macrophages and engulf percent and phagocytic index; Obviously improve mice tolerance to cold, swimming with a load attached to the body time, anti-decompression anoxia ability; Obviously improve the passive light-operated trained reflex ability of mice, improving memory.
2, the medicine of this treatment syndrome of deficiency of kidney-YANG is on the basis of original medicated wine, makes through change dosage form improvement production technology.
3, raw material is easy to get, the prescription science, and moderate product price is fit to suitability for industrialized production.
4, production technology adopts pulverizing, percolation and corresponding sterilizing methods or the like, thereby product active constituent content height, the bioavailability height, and not perishable, long shelf-life.
5, production technology advanced person, workable, according to each flavor Effective Components of Chinese Herb character and preparation requirement, successively adopt international advanced pharmaceutical technology and equipment such as superfine communication technique, multiple-effect decompression technology, spray drying technology, three-dimensional hybrid technology, one-step palletizing technology in the production.
6, the result of product studies on acute toxicity of the present invention and long term toxicity research shows, is safe by intending with using the daily dose and the course of treatment product of the present invention.
The specific embodiment
Embodiment 1
6 parts of Hippocampus, 12 parts of Herba Cistanches, 3 parts of Geckos, 0.75 part in Cornu Cervi Pantotrichum, 12 parts of Radix Morindae Officinaliss, 12 parts of Fructus Alpiniae Oxyphyllae, 6 parts of Rhizoma Dioscoreaes, 3 parts in Poria, 3 parts of Radix Achyranthis Bidentataes, 12 parts of Radix Dipsacis, 3 parts on Pericarpium Citri Reticulatae Viride, 3 parts of Fructus Toosendans, 0.75 part of Fructus Amomi, 3 parts of Fructus Anisi Stellatis, 1.5 parts of Flos Caryophyllis, 3 parts of Rhizoma Cyperis, 1.5 parts in Lignum Santali Albi, 1.5 parts of Lignum Aquilariae Resinatum, 3 parts in Rhizoma Curcumae Longae, 1.5 parts of Pheretimas, 1.5 parts of Caulis Clematidis Armandiis, 6 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, add adjuvants such as suitable quantity of water and sucrose, stir evenly, leave standstill, filter, fill, sterilization promptly gets medicated wine.
Embodiment 2
5 parts of Hippocampus, 10 parts of Herba Cistanches, 5 parts of Geckos, 1.75 parts in Cornu Cervi Pantotrichum, 9 parts of Radix Morindae Officinaliss, 13 parts of Fructus Alpiniae Oxyphyllae, 5 parts of Rhizoma Dioscoreaes, 3 parts in Poria, 5 parts of Radix Achyranthis Bidentataes, 15 parts of Radix Dipsacis, 4 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Fructus Toosendans, 1 part of Fructus Amomi, 5 parts of Fructus Anisi Stellatis, 2 parts of Flos Caryophyllis, 5 parts of Rhizoma Cyperis, 2.5 parts in Lignum Santali Albi, 3.5 parts of Lignum Aquilariae Resinatum, 5 parts in Rhizoma Curcumae Longae, 2.5 parts of Pheretimas, 2 parts of Caulis Clematidis Armandiis, 4 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, add adjuvants such as suitable quantity of water and sucrose, stir evenly, leave standstill, filter, fill, sterilization promptly gets medicated wine.
Embodiment 3
7 parts of Hippocampus, 11 parts of Herba Cistanches, 2 parts of Geckos, 1.5 parts in Cornu Cervi Pantotrichum, 10 parts of Radix Morindae Officinaliss, 10 parts of Fructus Alpiniae Oxyphyllae, 7 parts of Rhizoma Dioscoreaes, 2 parts in Poria, 2.5 parts of Radix Achyranthis Bidentataes, 11 parts of Radix Dipsacis, 4 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Fructus Toosendans, 1.75 parts of Fructus Amomis, 5 parts of Fructus Anisi Stellatis, 2.5 parts of Flos Caryophyllis, 3.5 parts of Rhizoma Cyperis, 2.5 parts in Lignum Santali Albi, 2.5 parts of Lignum Aquilariae Resinatum, 5 parts in Rhizoma Curcumae Longae, 3.5 parts of Pheretimas, 2.5 parts of Caulis Clematidis Armandiis, 5 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, add adjuvants such as suitable quantity of water and sucrose, stir evenly, leave standstill, filter, fill, sterilization promptly gets medicated wine.
Embodiment 4
6 parts of Hippocampus, 12 parts of Herba Cistanches, 3 parts of Geckos, 0.75 part in Cornu Cervi Pantotrichum, 12 parts of Radix Morindae Officinaliss, 12 parts of Fructus Alpiniae Oxyphyllae, 6 parts of Rhizoma Dioscoreaes, 3 parts in Poria, 3 parts of Radix Achyranthis Bidentataes, 12 parts of Radix Dipsacis, 3 parts on Pericarpium Citri Reticulatae Viride, 3 parts of Fructus Toosendans, 0.75 part of Fructus Amomi, 3 parts of Fructus Anisi Stellatis, 1.5 parts of Flos Caryophyllis, 3 parts of Rhizoma Cyperis, 1.5 parts in Lignum Santali Albi, 1.5 parts of Lignum Aquilariae Resinatum, 3 parts in Rhizoma Curcumae Longae, 1.5 parts of Pheretimas, 1.5 parts of Caulis Clematidis Armandiis, 6 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder, granulate, with the appropriate amount of auxiliary materials mixing, encapsulated, promptly get capsule.
Embodiment 5
4 parts of Hippocampus, 10 parts of Herba Cistanches, 2 parts of Geckos, 0.55 part in Cornu Cervi Pantotrichum, 9 parts of Radix Morindae Officinaliss, 10 parts of Fructus Alpiniae Oxyphyllae, 8 parts of Rhizoma Dioscoreaes, 5 parts in Poria, 6 parts of Radix Achyranthis Bidentataes, 11 parts of Radix Dipsacis, 5 parts on Pericarpium Citri Reticulatae Viride, 4 parts of Fructus Toosendans, 1.75 parts of Fructus Amomis, 4 parts of Fructus Anisi Stellatis, 3.5 parts of Flos Caryophyllis, 4.5 parts of Rhizoma Cyperis, 2.5 parts in Lignum Santali Albi, 2.5 parts of Lignum Aquilariae Resinatum, 5 parts in Rhizoma Curcumae Longae, 3.5 parts of Pheretimas, 2.5 parts of Caulis Clematidis Armandiis, 5 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder, granulate, with the appropriate amount of auxiliary materials mixing, encapsulated, promptly get capsule.
Embodiment 6
8 parts of Hippocampus, 10 parts of Herba Cistanches, 5 parts of Geckos, 2 parts in Cornu Cervi Pantotrichum, 9.5 parts of Radix Morindae Officinaliss, 10.5 parts of Fructus Alpiniae Oxyphyllae, 5 parts of Rhizoma Dioscoreaes, 5.5 parts in Poria, 5 parts of Radix Achyranthis Bidentataes, 10 parts of Radix Dipsacis, 5 parts on Pericarpium Citri Reticulatae Viride, 4 parts of Fructus Toosendans, 1 part of Fructus Amomi, 5 parts of Fructus Anisi Stellatis, 2 parts of Flos Caryophyllis, 5 parts of Rhizoma Cyperis, 3 parts in Lignum Santali Albi, 3.5 parts of Lignum Aquilariae Resinatum, 4 parts in Rhizoma Curcumae Longae, 2.5 parts of Pheretimas, 2 parts of Caulis Clematidis Armandiis, 5 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder, granulate, with the appropriate amount of auxiliary materials mixing, encapsulated, promptly get capsule.
Embodiment 7
6 parts of Hippocampus, 12 parts of Herba Cistanches, 3 parts of Geckos, 0.75 part in Cornu Cervi Pantotrichum, 12 parts of Radix Morindae Officinaliss, 12 parts of Fructus Alpiniae Oxyphyllae, 6 parts of Rhizoma Dioscoreaes, 3 parts in Poria, 3 parts of Radix Achyranthis Bidentataes, 12 parts of Radix Dipsacis, 3 parts on Pericarpium Citri Reticulatae Viride, 3 parts of Fructus Toosendans, 0.75 part of Fructus Amomi, 3 parts of Fructus Anisi Stellatis, 1.5 parts of Flos Caryophyllis, 3 parts of Rhizoma Cyperis, 1.5 parts in Lignum Santali Albi, 1.5 parts of Lignum Aquilariae Resinatum, 3 parts in Rhizoma Curcumae Longae, 1.5 parts of Pheretimas, 1.5 parts of Caulis Clematidis Armandiis, 6 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder.Get fine powder, vegetable oil, Cera Flava again by making suspended matter at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the suspended matter fill is pressed into soft capsule, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out, promptly get soft capsule.
Embodiment 8
8 parts of Hippocampus, 13 parts of Herba Cistanches, 5 parts of Geckos, 1 part in Cornu Cervi Pantotrichum, 11 parts of Radix Morindae Officinaliss, 15 parts of Fructus Alpiniae Oxyphyllae, 5 parts of Rhizoma Dioscoreaes, 4 parts in Poria, 5 parts of Radix Achyranthis Bidentataes, 9 parts of Radix Dipsacis, 5 parts on Pericarpium Citri Reticulatae Viride, 4 parts of Fructus Toosendans, 1 part of Fructus Amomi, 5 parts of Fructus Anisi Stellatis, 2.5 parts of Flos Caryophyllis, 2 parts of Rhizoma Cyperis, 2.5 parts in Lignum Santali Albi, 2.5 parts of Lignum Aquilariae Resinatum, 2 parts in Rhizoma Curcumae Longae, 3.5 parts of Pheretimas, 3 parts of Caulis Clematidis Armandiis, 4 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder.Get fine powder, vegetable oil, Cera Flava again by making suspended matter at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the suspended matter fill is pressed into soft capsule, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out, promptly get soft capsule.
Embodiment 9
5 parts of Hippocampus, 11 parts of Herba Cistanches, 5 parts of Geckos, 1.5 parts in Cornu Cervi Pantotrichum, 11 parts of Radix Morindae Officinaliss, 10 parts of Fructus Alpiniae Oxyphyllae, 8 parts of Rhizoma Dioscoreaes, 5 parts in Poria, 5 parts of Radix Achyranthis Bidentataes, 11 parts of Radix Dipsacis, 5 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Fructus Toosendans, 1.75 parts of Fructus Amomis, 4 parts of Fructus Anisi Stellatis, 2.5 parts of Flos Caryophyllis, 2 parts of Rhizoma Cyperis, 3.5 parts in Lignum Santali Albi, 2.5 parts of Lignum Aquilariae Resinatum, 5 parts in Rhizoma Curcumae Longae, 2.5 parts of Pheretimas, 2 parts of Caulis Clematidis Armandiis, 4 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder.Get fine powder, vegetable oil, Cera Flava again by making suspended matter at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the suspended matter fill is pressed into soft capsule, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out, promptly get soft capsule.
Embodiment 10
6 parts of Hippocampus, 12 parts of Herba Cistanches, 3 parts of Geckos, 0.75 part in Cornu Cervi Pantotrichum, 12 parts of Radix Morindae Officinaliss, 12 parts of Fructus Alpiniae Oxyphyllae, 6 parts of Rhizoma Dioscoreaes, 3 parts in Poria, 3 parts of Radix Achyranthis Bidentataes, 12 parts of Radix Dipsacis, 3 parts on Pericarpium Citri Reticulatae Viride, 3 parts of Fructus Toosendans, 0.75 part of Fructus Amomi, 3 parts of Fructus Anisi Stellatis, 1.5 parts of Flos Caryophyllis, 3 parts of Rhizoma Cyperis, 1.5 parts in Lignum Santali Albi, 1.5 parts of Lignum Aquilariae Resinatum, 3 parts in Rhizoma Curcumae Longae, 1.5 parts of Pheretimas, 1.5 parts of Caulis Clematidis Armandiis, 6 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder, add in the polyethylene glycol 6000 of heating and melting, stir molten, be transferred on the drop pill device, 86 ℃ of airtight insulations, make coolant with 10 ℃ of-15 ℃ of liquid paraffin, with the 50/component velocity system of dripping, promptly get drop pill.
Embodiment 11
7 parts of Hippocampus, 11 parts of Herba Cistanches, 2 parts of Geckos, 1 part in Cornu Cervi Pantotrichum, 10 parts of Radix Morindae Officinaliss, 10 parts of Fructus Alpiniae Oxyphyllae, 5 parts of Rhizoma Dioscoreaes, 4 parts in Poria, 5 parts of Radix Achyranthis Bidentataes, 10 parts of Radix Dipsacis, 5 parts on Pericarpium Citri Reticulatae Viride, 4 parts of Fructus Toosendans, 1 part of Fructus Amomi, 4 parts of Fructus Anisi Stellatis, 2.5 parts of Flos Caryophyllis, 4 parts of Rhizoma Cyperis, 3 parts in Lignum Santali Albi, 2 parts of Lignum Aquilariae Resinatum, 2 parts in Rhizoma Curcumae Longae, 2 parts of Pheretimas, 3 parts of Caulis Clematidis Armandiis, 8 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder, add in the polyethylene glycol 6000 of heating and melting, stir molten, be transferred on the drop pill device, 86 ℃ of airtight insulations, make coolant with 10 ℃ of-15 ℃ of liquid paraffin, with the 50/component velocity system of dripping, promptly get drop pill.
Embodiment 12
8 parts of Hippocampus, 9 parts of Herba Cistanches, 4.5 parts of Geckos, 2 parts in Cornu Cervi Pantotrichum, 11 parts of Radix Morindae Officinaliss, 10 parts of Fructus Alpiniae Oxyphyllae, 8 parts of Rhizoma Dioscoreaes, 5 parts in Poria, 4 parts of Radix Achyranthis Bidentataes, 15 parts of Radix Dipsacis, 5 parts on Pericarpium Citri Reticulatae Viride, 5 parts of Fructus Toosendans, 2 parts of Fructus Amomis, 6 parts of Fructus Anisi Stellatis, 2.5 parts of Flos Caryophyllis, 4 parts of Rhizoma Cyperis, 2 parts in Lignum Santali Albi, 3 parts of Lignum Aquilariae Resinatum, 2 parts in Rhizoma Curcumae Longae, 3 parts of Pheretimas, 3 parts of Caulis Clematidis Armandiis, 8 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate is concentrated into the thick paste shape, dry, get dry extract, be ground into fine powder, add in the polyethylene glycol 6000 of heating and melting, stir molten, be transferred on the drop pill device, 86 ℃ of airtight insulations, make coolant with 10 ℃ of-15 ℃ of liquid paraffin, with the 50/component velocity system of dripping, promptly get drop pill.
Embodiment 13
6 parts of Hippocampus, 12 parts of Herba Cistanches, 3 parts of Geckos, 0.75 part in Cornu Cervi Pantotrichum, 12 parts of Radix Morindae Officinaliss, 12 parts of Fructus Alpiniae Oxyphyllae, 6 parts of Rhizoma Dioscoreaes, 3 parts in Poria, 3 parts of Radix Achyranthis Bidentataes, 12 parts of Radix Dipsacis, 3 parts on Pericarpium Citri Reticulatae Viride, 3 parts of Fructus Toosendans, 0.75 part of Fructus Amomi, 3 parts of Fructus Anisi Stellatis, 1.5 parts of Flos Caryophyllis, 3 parts of Rhizoma Cyperis, 1.5 parts in Lignum Santali Albi, 1.5 parts of Lignum Aquilariae Resinatum, 3 parts in Rhizoma Curcumae Longae, 1.5 parts of Pheretimas, 1.5 parts of Caulis Clematidis Armandiis, 6 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate adds adjuvants such as suitable quantity of water and syrup, stir evenly, filter, sterilization, fill promptly gets oral liquid.
Embodiment 14
8 parts of Hippocampus, 15 parts of Herba Cistanches, 6 parts of Geckos, 2 parts in Cornu Cervi Pantotrichum, 15 parts of Radix Morindae Officinaliss, 15 parts of Fructus Alpiniae Oxyphyllae, 9 parts of Rhizoma Dioscoreaes, 6 parts in Poria, 6 parts of Radix Achyranthis Bidentataes, 15 parts of Radix Dipsacis, 6 parts on Pericarpium Citri Reticulatae Viride, 6 parts of Fructus Toosendans, 2 parts of Fructus Amomis, 6 parts of Fructus Anisi Stellatis, 3 parts of Flos Caryophyllis, 6 parts of Rhizoma Cyperis, 3 parts in Lignum Santali Albi, 3 parts of Lignum Aquilariae Resinatum, 6 parts in Rhizoma Curcumae Longae, 3 parts of Pheretimas, 3 parts of Caulis Clematidis Armandiis, 7 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate adds adjuvants such as suitable quantity of water and syrup, stir evenly, filter, sterilization, fill promptly gets oral liquid.
Embodiment 15
5 parts of Hippocampus, 13 parts of Herba Cistanches, 4 parts of Geckos, 2.5 parts in Cornu Cervi Pantotrichum, 14 parts of Radix Morindae Officinaliss, 15 parts of Fructus Alpiniae Oxyphyllae, 7 parts of Rhizoma Dioscoreaes, 6 parts in Poria, 5 parts of Radix Achyranthis Bidentataes, 15 parts of Radix Dipsacis, 5 parts on Pericarpium Citri Reticulatae Viride, 4 parts of Fructus Toosendans, 2.5 parts of Fructus Amomis, 5 parts of Fructus Anisi Stellatis, 2.5 parts of Flos Caryophyllis, 4 parts of Rhizoma Cyperis, 2.5 parts in Lignum Santali Albi, 3.5 parts of Lignum Aquilariae Resinatum, 6 parts in Rhizoma Curcumae Longae, 3 parts of Pheretimas, 3 parts of Caulis Clematidis Armandiis, 5 parts of Halitum, get Hippocampus, Herba Cistanches, Gecko, Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae, Poria, Radix Achyranthis Bidentatae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Fructus Toosendan, Fructus Amomi, Fructus Anisi Stellati, Flos Caryophylli, Rhizoma Cyperi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Curcumae Longae, Pheretima, Caulis Clematidis Armandii, Halitum, after being ground into coarse powder, according to percolation under fluid extract and the extractum item, make solvent with Chinese liquor or ethanol, percolation is carried out in airtight immersion after 24~72 hours, collect percolate, filter, filtrate adds adjuvants such as suitable quantity of water and syrup, stir evenly, filter, sterilization, fill promptly gets oral liquid.