CN1308951A - Medicine for treating hepatitis B and its preparing process - Google Patents
Medicine for treating hepatitis B and its preparing process Download PDFInfo
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- CN1308951A CN1308951A CN 00135644 CN00135644A CN1308951A CN 1308951 A CN1308951 A CN 1308951A CN 00135644 CN00135644 CN 00135644 CN 00135644 A CN00135644 A CN 00135644A CN 1308951 A CN1308951 A CN 1308951A
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Abstract
A medicine for treating hepatitis B is prepared from 13 Chinese-medicinal materials including eucommia bark, psoralea fruit, immature bitter orange, white mustard seed, etc. and serves to improve immunity and microcirculation of liver, promote regeneration of liver cells, suppress the fibrosis of liver, and eliminate copy and hepatitis B virus, resulting in high conversion of positive to negative reaction up to 99.5%.
Description
The present invention relates to a kind of medicine for the treatment of hepatitis B and preparation method thereof.
Hepatitis B is the frequently-occurring disease of serious harm human health, and prolonged illness is not controlled or obstinate usually causes hepatogenous diabetes, fatty liver, and serious diseases such as posthepatitic hyperbilirubinemia even liver cirrhosis, hepatocarcinoma still do not have the specific drug for the treatment of hepatitis B at present both at home and abroad.China is the district occurred frequently of hepatitis B, reflects that according to interrelated data national hepatitis B patient and virus carrier reach five, 600,000,000.Chinese herbal medicine resource and clinical research according to China's abundant, the many at present Chinese herbal medicine with heat-clearing and toxic substances removing, heat clearing and damp drying, promoting the circulation of QI to relieve pain of the medicine of state's internal therapy hepatitis B are main formula treatment hepatitis B, wherein used medicine such as Radix Bupleuri, Flos Chrysanthemi, Rhizoma Coptidis, Radix Et Rhizoma Rhei, Lignum Aquilariae Resinatum, Fructus Aurantii etc., they mostly are cold and cool class medicine, belong to negative medicine, and hepatopathy mostly is YIN diseasei, and YIN diseasei is more contained with cloudy rule of treatment the moon, and it is dark to recover.By retrieval, many pieces of the patent applications of domestic useful Chinese herbal treatment hepatitis B, the have application number comparatively approaching with the present invention is 97110634 " pills for treating hepatitis B "." Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi " among this side has the side effect of the cloudy blood of the body of hurting sb.'s feelings, relieving the exterior syndrome by diaphoresis; " Fructus Amomi, Cortex Magnoliae Officinalis " has deficiency of YIN-blood and the side effect of interior-heat caused by deficiency of YIN occurs; " Herba Ephedrae, Ramulus Cinnamomi " because diaphoresis power is strong, theory of Chinese medical science has saying of " profuse sweating such as massive hemorrhage ", so be prone to the side effect of " excessive rising of liver-YANG "; " Fructus Aurantii " effect is split; The medicine of big benefits such as " Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae, Fructus Lycii, Radix Angelicae Sinensis, Radix Pseudostellariae, Radix Glycyrrhizae " is contrary to the saying of theory of Chinese medical science " hepatitis B should be controlled be main but not benefit is main ", in addition, 6 kinds of mild medicines and 13 kinds of cold and cool medicines are arranged in this prescription, be difficult to find out that this side belongs to the cold partially or prescription of inclined to one side warm nature.Clinical Practice proves, this type of medicine treatment hepatitis B poor effect, and and hepatitis B two half negative conversion rates are low, and hepatalgia alleviates slowly, and weak being difficult to of two lower limb alleviated, and side effect is arranged, and treatment is long the course of treatment, the more high problems of expense.
The object of the present invention is to provide a kind of promoting flow of QI and blood that has, detoxifying, removing dampness, energy human body immunity improving ability is improved the dirty microcirculation of tripe, promotes liver cell regeneration, and anti-hepatic fibrosis is eliminated hepatitis B virus, good effect, the treating hepatitis B medicine of short treating period.
Solution of the present invention is based on motherland's medical science to pathogenetic understanding of hepatitis B and Therapeutic Principle, achieve with reference to modern pharmacological research, sum up the inapt experience and lessons of general Drug therapy, from motherland's medicine treasure-house, filter out the warming the interior cold expelling, promoting the circulation of QI to relieve pain, supporing YANG and nourishing YANG, the natural edible-plant medicine of blood circulation promoting and blood stasis dispelling by the theory of Chinese medical science prescription, carries out compatibility according to various medicine pharmacology and biochemical characteristic, make formula adjustment in conjunction with clinical practice, reach the purpose of treatment hepatitis B.Medicine of the present invention is to be made by following component: (consumption is a weight portion)
Cortex Eucommiae 2-15 Fructus Psoraleae 2-20 Fructus Aurantii Immaturus 2-15 Semen Sinapis Albae 2-15 Radix Linderae 2-15
Fructus Foeniculi 2-10 Pericarpium Citri Reticulatae 2-15 Herba Dendrobii 2-15 Sal 2-15 Folium Perillae 2-15
Herba Asari 1-6 Rhizoma Curcumae Longae 2-15 Rhizoma Curcumae 2-15
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Cortex Eucommiae 4-10 Fructus Psoraleae 4-10 Fructus Aurantii Immaturus 4-10 Semen Sinapis Albae 4-10 Radix Linderae 4-10
Fructus Foeniculi 1-4 Pericarpium Citri Reticulatae 4-10 Herba Dendrobii 4-12 Sal 3-8 Folium Perillae 4-10
Herba Asari 1-2 Rhizoma Curcumae Longae 2-15 Rhizoma Curcumae 2-15
The optimum weight of medicine of the present invention (part) proportioning is:
The Cortex Eucommiae 6 Fructus Psoraleaes 6 Fructus Aurantii Immaturuss 6 Semen Sinapis Albaes 6 Radixs Linderae 6
Fructus Foeniculi 3 Pericarpium Citri Reticulataes 6 Herba Dendrobiis 6 Sal 5 Folium Perillaes 6
Herba Asari 1.2 Rhizoma Curcumae Longaes 5 Rhizoma Curcumae 5
Above-mentioned each prescription can be made various dosage forms by pharmaceutics is said, as water preparation, powder, pill or tablet etc.
Have the following characteristics and the mechanism of action between the selected Chinese herbal medicine of the present invention:
Fructus Foeniculi, Herba Asari: be hot using warming therapy product, have the effect of warming the interior dispersing cold for relieving pain, be adapted to yin-cold excess disease.
Fructus Aurantii Immaturus, the Radix Linderae, Pericarpium Citri Reticulatae: have suffering, using warming therapy, be all qi-activating drug, can promoting the circulation of QI to relieve pain, be applicable to stagnation of QI disease.
Semen Sinapis Albae, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae: having reduces phlegm removes the effect of drink, is applicable to phlegm retention syndrome.
The Cortex Eucommiae, Fructus Psoraleae, the Radix Linderae: have warming and recuperating the kidney-YANG, make the kidney yang abundance, thus also foot of spleen sun, liver-yang, all sun of whole body are also sufficient, and rib helps Fructus Foeniculi, the Herba Asari warming the interior is supporing yang and pain relieving.Because kidney yang is the source of all sun.
Rhizoma Curcumae, Rhizoma Curcumae Longae: be blood circulation promoting medicine, Rhizoma Curcumae can break the blood stasis of liver, the Rhizoma Curcumae Longae blood stasis of spleen of dispelling, thus can treat the liver spleen simultaneously, be adapted to the disease of blood stasis.
Herba Dendrobii, Sal: have cold, salty nature and flavor, and cold saltyly all belong to negative medicine, and other compatibility drug is positive medicine among the present invention, thereby reach sun is arranged in the moon, and the moon is arranged in the sun, the compatibility of medicines in a prescription that negative and positive condition each other.It is high partially not occur the interior sun of human body or the moon behind the clothes.Simultaneously, Herba Dendrobii has the effect of reducing the asthenic fever, can move back the hot using warming therapy mistake of other medicines, and Sal belongs to the salty part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels position that can guide medicine into the liver place, reaches " shooting the arrow at the target ".
Folium Perillae: purple goes into blood system, and flavor perfume (or spice) is gone into edema caused by disorder of QI, has into gas, goes into blood, the settling five organs effect.
The Cortex Eucommiae, Herba Dendrobii, Folium Perillae: all have sugariness, have tonification, strengthening vital QI to eliminate pathogenic factors, emergency and in, the effect of coordinating the actions of various ingredients in a prescription.
The selected Chinese herbal medicine of the present invention has above effect, and the Clinical Practice proof has following effect:
1,20 days (course of treatment) of taking this magistral medicines afterwards, patient's hepatalgia, the weak grade of poor appetite all can obviously improve rapidly, and liver, splenomegaly disappear, the luminous point that increases thick liver on the B ultrasonic check liver section image obviously dwindles, and recovers normal liver B ultrasonic tangent plane echological picture substantially.
2, take the 1st course of treatment after, and hepatitis B two half negative conversion rates reach 99.5%, hepatitis B recovery from illness.
3, the present invention is adapted to acute and chronic hepatitis B, early stage liver cirrhosis, hepatitis B virus carriers, cholecystitis etc.
4, it is without any side effects that this magistral medicines is taken the back.
For showing the therapeutic effect of medicine of the present invention to hepatitis B, the present invention therefrom selects optimization formula through system's clinical observation, regularly the patient is checked, 20 days is a course of treatment, needs 1-2 the course of treatment altogether.
Instructions of taking: once a day, a potion
Embodiment:
1, takes by weighing raw material (gram) by following proportioning
The Cortex Eucommiae 3 Fructus Psoraleaes 3 Fructus Aurantii Immaturuss 3 Semen Sinapis Albaes 4 Radixs Linderae 4
Fructus Foeniculi 3 Pericarpium Citri Reticulataes 3 Herba Dendrobiis 4 Sal 4 Folium Perillaes 4
Herba Asari 1 Rhizoma Curcumae Longae 4 Rhizoma Curcumae 4
The result shows: hepatalgia among the patient, weak, poor appetite etc. improve slowly, and negative conversion rate is 30%.
2, take by weighing raw material (gram) by following proportioning
The Cortex Eucommiae 6 Fructus Psoraleaes 6 Fructus Aurantii Immaturuss 6 Semen Sinapis Albaes 6 Radixs Linderae 6
Fructus Foeniculi 3 Pericarpium Citri Reticulataes 6 Herba Dendrobiis 6 Sal 5 Folium Perillaes 6
Herba Asari 1.2 Rhizoma Curcumae Longaes 5 Rhizoma Curcumae 5
The result is: patient's hepatalgia, and symptom such as weak, poor appetite, face green grass or young crops is obviously improved, and negative conversion rate is 99.5%.
3, take by weighing raw material (gram) by following proportioning
The Cortex Eucommiae 12 Fructus Psoraleaes 12 Fructus Aurantii Immaturuss 12 Semen Sinapis Albaes 12 Radixs Linderae 12
Fructus Foeniculi 8 Pericarpium Citri Reticulataes 12 Herba Dendrobiis 12 Sal 12 Folium Perillaes 12
Herba Asari 4 Rhizoma Curcumae Longaes 12 Rhizoma Curcumae 12
The result is: the blue or green doing well,improving such as dark of patient's hepatalgia, weak, poor appetite, face is not obvious, and has the part patient to occur that the pain increased, and negative conversion rate is 30%.
4, take by weighing raw material (gram) by following proportioning
The Cortex Eucommiae 8 Fructus Psoraleaes 8 Fructus Aurantii Immaturuss 8 Semen Sinapis Albaes 8 Radixs Linderae 8
Pericarpium Citri Reticulatae 7 Herba Dendrobiis 7 Sal 7 Folium Perillaes 6 Rhizoma Curcumae Longaes 8 Rhizoma Curcumae 8
The result is: patient's hepatalgia, weak, improve not obviously, and two half negative conversion rates are 0%.
5, take by weighing raw material (gram) by following proportioning
Fructus Aurantii Immaturus 8 Semen Sinapis Albaes 8 Radixs Linderae 8 Fructus Foeniculi 7 Pericarpium Citri Reticulataes 7
Herba Dendrobii 7 Sal 7 Folium Perillaes 6 Herba Asaris 3 Rhizoma Curcumae 8 Rhizoma Curcumae Longaes 8
The result is: patient's hepatalgia alleviates, and the constipation phenomenon appears in some cases, and and two half negative conversion rates are 5%.
6, take by weighing raw material (gram) by following proportioning
The Cortex Eucommiae 8 Fructus Psoraleaes 8 Fructus Aurantii Immaturuss 8 Semen Sinapis Albaes 8 Radixs Linderae 8
Fructus Foeniculi 7 Folium Perillaes 6 Pericarpium Citri Reticulataes 7 Herba Asaris 3 Rhizoma Curcumae 8 Rhizoma Curcumae Longaes 8
The result is: various symptoms make moderate progress among the patient, occur the headache phenomenon, and and two half negative conversion rates are 0%.
7, connect following proportioning and take by weighing raw material (gram)
The Cortex Eucommiae 8 Fructus Psoraleaes 8 Fructus Aurantii Immaturuss 8 Semen Sinapis Albaes 8 Radixs Linderae 8
Fructus Foeniculi 7 Sal 7 Pericarpium Citri Reticulataes 7 Herba Dendrobiis 7 Folium Perillaes 6 Herba Asaris 6
The result is: various doing well,improvings are better among the patient, but and two half negative conversion rates are 0%.
8, take by weighing raw material (gram) by following proportioning
The Cortex Eucommiae 8 Fructus Psoraleaes 8 Fructus Foeniculi 7 Semen Sinapis Albaes 8 Herba Dendrobiis 7
Sal 7 Rhizoma Curcumae Longaes 8 Rhizoma Curcumae 8 Folium Perillaes 6 Herba Asaris 3
The result is: hepatalgia among the patient, and poor appetite improves obviously, but weak improvement is not obvious, and and two half negative conversion rates are 0%.
Can find out that from above embodiment optimum weight proportioning of the present invention is a proportioning cited in the example 2.
Medicine production method of the present invention is as follows:
With water after other various proportioning raw materials decoct add in the way Folium Perillae continuous fry in shallow oil water preparation.
Make powder or pill or tablet by the Chinese herbal medicine conventional method.
Claims (6)
1, a kind of medicine for the treatment of hepatitis B and preparation method thereof is characterized in that it is the medicament of being made by following weight proportioning raw material.
Cortex Eucommiae 2-15 Fructus Psoraleae 2-20 Fructus Aurantii Immaturus 2-15 Semen Sinapis Albae 2-15 Radix Linderae 2-15
Fructus Foeniculi 2-10 Pericarpium Citri Reticulatae 2-15 Herba Dendrobii 2-15 Sal 2-15 Folium Perillae 2-15
Herba Asari 1-6 Rhizoma Curcumae Longae 2-15 Rhizoma Curcumae 2-15
2, a kind of medicine for the treatment of hepatitis B according to claim 1 and preparation method thereof, wherein the weight proportion of each raw material is:
Cortex Eucommiae 4-10 Fructus Psoraleae 4-10 Fructus Aurantii Immaturus 4-10 Semen Sinapis Albae 4-10 Radix Linderae 4-10
Fructus Foeniculi 1-4 Pericarpium Citri Reticulatae 4-10 Herba Dendrobii 3-8 Sal 4-10 Folium Perillae 4-10
Herba Asari 1-3 Rhizoma Curcumae Longae 3-8 Rhizoma Curcumae 3-8
3, a kind of medicine for the treatment of hepatitis B according to claim 1 and preparation method thereof wherein the weight proportion of each raw material be:
The Cortex Eucommiae 6 Fructus Psoraleaes 6 Fructus Aurantii Immaturuss 6 Semen Sinapis Albaes 6 Radixs Linderae 6
Fructus Foeniculi 3 Pericarpium Citri Reticulataes 6 Herba Dendrobiis 6 Sal 5 Folium Perillaes 6
Herba Asari 1.2 Rhizoma Curcumae Longaes 5 Rhizoma Curcumae 5
4,, it is characterized in that said medicament is a said dosage form on any pharmaceutics according to claim 1,2 or 3 described a kind of medicines for the treatment of hepatitis B and preparation method thereof.
5, a kind of medicine for the treatment of hepatitis B according to claim 4 and preparation method thereof is characterized in that said medicament is water preparation or powder or pill or tablet.
6, a kind of medicine for the treatment of hepatitis B according to claim 5 and preparation method thereof, it is characterized in that after other various proportioning raw materials water decoct add in the way Folium Perillae continuous fry in shallow oil water preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00135644 CN1308951A (en) | 2000-12-14 | 2000-12-14 | Medicine for treating hepatitis B and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00135644 CN1308951A (en) | 2000-12-14 | 2000-12-14 | Medicine for treating hepatitis B and its preparing process |
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| Publication Number | Publication Date |
|---|---|
| CN1308951A true CN1308951A (en) | 2001-08-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00135644 Pending CN1308951A (en) | 2000-12-14 | 2000-12-14 | Medicine for treating hepatitis B and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491661B (en) * | 2008-11-27 | 2011-04-20 | 北京宏泰康达医药科技有限公司 | Traditional Chinese medicine composition for treating liver disease |
| CN102961689A (en) * | 2012-11-30 | 2013-03-13 | 宋彩云 | Traditional Chinese medicine preparation for treating chronic cholecystitis or cholelithiasis |
-
2000
- 2000-12-14 CN CN 00135644 patent/CN1308951A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491661B (en) * | 2008-11-27 | 2011-04-20 | 北京宏泰康达医药科技有限公司 | Traditional Chinese medicine composition for treating liver disease |
| CN102961689A (en) * | 2012-11-30 | 2013-03-13 | 宋彩云 | Traditional Chinese medicine preparation for treating chronic cholecystitis or cholelithiasis |
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