CN1362176A - Nano shugan medicine for dispersing stagnated liver-energy and its preparation - Google Patents
Nano shugan medicine for dispersing stagnated liver-energy and its preparation Download PDFInfo
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- CN1362176A CN1362176A CN 01100331 CN01100331A CN1362176A CN 1362176 A CN1362176 A CN 1362176A CN 01100331 CN01100331 CN 01100331 CN 01100331 A CN01100331 A CN 01100331A CN 1362176 A CN1362176 A CN 1362176A
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Abstract
The present invention discloses a nano liver-soothing preparation medicine. It is made up by using 13 Chinese medicinal materials of nano toosendan, nano corydalis, nano white peony, nano sliced turmeric, nano saussurea and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the nanometer soothing liver-QI preparation medicine of a kind of soothing liver-QI stomach function regulating, regulating QI to relieve pain, the invention still further relates to the method for this medication preparation
SHUGAN WAN is a kind of traditional Chinese medicine preparation, mainly contain and regulate bile secretion, suppress the spontaneous contraction of intestinal, promote uterine contraction and anti peroxidation of lipid damaging action, be used for diseases such as stagnation of QI due to depression of the liver, costa sternales distension, gastralgia, noisy vomiting, heating installation pantothenic acid, but traditional SHUGAN WAN disintegrate is slower, absorb not exclusively, bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer soothing liver-QI preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer soothing liver-QI preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Fructus Toosendan 100-250 part nanometer Rhizoma Corydalis (vinegar system) 60-250 part nanometer Radix Paeoniae Alba (wine stir-fry) 80-200 part
Nanometer sheet Rhizoma Curcumae Longae 60-250 part nanometer Radix Aucklandiae 40-150 part nanometer Lignum Aquilariae Resinatum 40-150 part
Nanometer Fructus Amomi Rotundus core 25-90 part nanometer Fructus Amomi 40-90 part nanometer thickness is pounced on (processed with Rhizoma Zingiberis Recens) 20-90 part
Nanometer Pericarpium Citri Reticulatae 40-95 part nanometer Fructus Aurantii (parched) 60-140 part nano Poria 60-140 part
Nanometer Cinnabaris 15-55 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Fructus Toosendan 120-180 part nanometer Rhizoma Corydalis (vinegar system) 80-150 part nanometer Radix Paeoniae Alba (wine stir-fry) 100-150 part
Nanometer sheet Rhizoma Curcumae Longae 80-150 part nanometer Radix Aucklandiae 60-100 part nanometer Lignum Aquilariae Resinatum 80-120 part
Nanometer Fructus Amomi Rotundus core 40-80 part nanometer Fructus Amomi 60-80 part nanometer thickness is pounced on (processed with Rhizoma Zingiberis Recens) 40-80 part
Nanometer Pericarpium Citri Reticulatae 60-90 part nanometer Fructus Aurantii (parched) 80-120 part nano Poria 80-120 part
Nanometer Cinnabaris 25-35 part
The optimum weight proportioning of medicine of the present invention is:
120 parts of 100 parts of nanometer Radix Paeoniae Albas of 150 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan (vinegar system) (wine stir-fry)
100 parts of 80 parts of nanometer Lignum Aquilariae Resinatum of 100 parts of nanometer Radix Aucklandiae of nanometer sheet Rhizoma Curcumae Longae
80 parts of nanometer thickness of 60 parts of nanometer Fructus Amomis of nanometer Fructus Amomi Rotundus core are pounced on (processed with Rhizoma Zingiberis Recens) 60 parts
100 parts of 100 parts of nano Porias of 80 parts of nanometer Fructus Aurantii (parched) of nanometer Pericarpium Citri Reticulatae
27 parts in nanometer Cinnabaris
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral dropping liquid agent.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, keep the tower internal pressure under 0 to 0.05MPa pressure,, get the SHUGAN WAN nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer soothing liver-QI preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common antitoxic bolus of honeysuckle flower and forsythia preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum of nanometer soothing liver-QI preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the treatment of diseases such as chronic gastritis, cholecystitis, duodenal diverticulum, duodenojejunal dudenal stasis, and clinical efficacy significantly is better than traditional SHUGAN WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
120 parts of 100 parts of nanometer Radix Paeoniae Albas of 150 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan (vinegar system) (wine stir-fry)
100 parts of 80 parts of nanometer Lignum Aquilariae Resinatum of 100 parts of nanometer Radix Aucklandiae of nanometer sheet Rhizoma Curcumae Longae
80 parts of nanometer thickness of 60 parts of nanometer Fructus Amomis of nanometer Fructus Amomi Rotundus core are pounced on (processed with Rhizoma Zingiberis Recens) 60 parts
100 parts of 100 parts of nano Porias of 80 parts of nanometer Fructus Aurantii (parched) of nanometer Pericarpium Citri Reticulatae
27 parts in nanometer Cinnabaris
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
120 parts of 100 parts of nanometer Radix Paeoniae Albas of 150 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan (vinegar system) (wine stir-fry)
100 parts of 80 parts of nanometer Lignum Aquilariae Resinatum of 100 parts of nanometer Radix Aucklandiae of nanometer sheet Rhizoma Curcumae Longae
80 parts of nanometer thickness of 60 parts of nanometer Fructus Amomis of nanometer Fructus Amomi Rotundus core are pounced on (processed with Rhizoma Zingiberis Recens) 60 parts
100 parts of 100 parts of nano Porias of 80 parts of nanometer Fructus Aurantii (parched) of nanometer Pericarpium Citri Reticulatae
27 parts in nanometer Cinnabaris
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer soothing liver-QI powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
120 parts of 100 parts of nanometer Radix Paeoniae Albas of 150 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan (vinegar system) (wine stir-fry)
100 parts of 80 parts of nanometer Lignum Aquilariae Resinatum of 100 parts of nanometer Radix Aucklandiae of nanometer sheet Rhizoma Curcumae Longae
80 parts of nanometer thickness of 60 parts of nanometer Fructus Amomis of nanometer Fructus Amomi Rotundus core are pounced on (processed with Rhizoma Zingiberis Recens) 60 parts
100 parts of 100 parts of nano Porias of 80 parts of nanometer Fructus Aurantii (parched) of nanometer Pericarpium Citri Reticulatae
27 parts in nanometer Cinnabaris
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer soothing liver-QI membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, chest.
Claims (6)
1, a kind of nanometer soothing liver-QI preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nanometer Fructus Toosendan 100-250 part nanometer Rhizoma Corydalis (vinegar system) 60-250 part nanometer Radix Paeoniae Alba (wine stir-fry) 80-200 part
Nanometer sheet Rhizoma Curcumae Longae 60-250 part nanometer Radix Aucklandiae 40-150 part nanometer Lignum Aquilariae Resinatum 40-150 part
Nanometer Fructus Amomi Rotundus core 25-90 part nanometer Fructus Amomi 40-90 part nanometer thickness is pounced on (processed with Rhizoma Zingiberis Recens) 20-90 part
Nanometer Pericarpium Citri Reticulatae 40-95 part nanometer Fructus Aurantii (parched) 60-140 part nano Poria 60-140 part
Nanometer Cinnabaris 15-55 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer soothing liver-QI preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Fructus Toosendan 120-180 part nanometer Rhizoma Corydalis (vinegar system) 80-150 part nanometer Radix Paeoniae Alba (wine stir-fry) 100-150 part
Nanometer sheet Rhizoma Curcumae Longae 80-150 part nanometer Radix Aucklandiae 60-100 part nanometer Lignum Aquilariae Resinatum 80-120 part
Nanometer Fructus Amomi Rotundus core 40-80 part nanometer Fructus Amomi 60-80 part nanometer thickness is pounced on (processed with Rhizoma Zingiberis Recens) 40-80 part
Nanometer Pericarpium Citri Reticulatae 60-90 part nanometer Fructus Aurantii (parched) 80-120 part nano Poria 80-120 part
Nanometer Cinnabaris 25-35 part
3, nanometer soothing liver-QI preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
120 parts of 100 parts of nanometer Radix Paeoniae Albas of 150 parts of nanometer Rhizoma Corydalis of nanometer Fructus Toosendan (vinegar system) (wine stir-fry)
100 parts of 80 parts of nanometer Lignum Aquilariae Resinatum of 100 parts of nanometer Radix Aucklandiae of nanometer sheet Rhizoma Curcumae Longae
80 parts of nanometer thickness of 60 parts of nanometer Fructus Amomis of nanometer Fructus Amomi Rotundus core are pounced on (processed with Rhizoma Zingiberis Recens) 60 parts
100 parts of 100 parts of nano Porias of 80 parts of nanometer Fructus Aurantii (parched) of nanometer Pericarpium Citri Reticulatae
27 parts in nanometer Cinnabaris
4, according to claim 1 or 2 or 3 described nanometer soothing liver-QI preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer soothing liver-QI preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100331 CN1362176A (en) | 2001-01-02 | 2001-01-02 | Nano shugan medicine for dispersing stagnated liver-energy and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100331 CN1362176A (en) | 2001-01-02 | 2001-01-02 | Nano shugan medicine for dispersing stagnated liver-energy and its preparation |
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| CN1362176A true CN1362176A (en) | 2002-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100331 Pending CN1362176A (en) | 2001-01-02 | 2001-01-02 | Nano shugan medicine for dispersing stagnated liver-energy and its preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638423A (en) * | 2013-12-03 | 2014-03-19 | 陈林穆 | Traditional Chinese medicine for treating chronic gastritis |
| CN105233230A (en) * | 2015-11-18 | 2016-01-13 | 王平平 | Traditional Chinese medicine for treating duodenal stasis |
| CN105497569A (en) * | 2016-03-04 | 2016-04-20 | 许应君 | Medicine for treating duodenal stasis |
| CN113181126A (en) * | 2021-05-07 | 2021-07-30 | 北京葆年堂(菏泽)药业有限公司 | Liver soothing pill and preparation method thereof |
-
2001
- 2001-01-02 CN CN 01100331 patent/CN1362176A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638423A (en) * | 2013-12-03 | 2014-03-19 | 陈林穆 | Traditional Chinese medicine for treating chronic gastritis |
| CN103638423B (en) * | 2013-12-03 | 2016-05-18 | 陈林穆 | The Chinese medicine for the treatment of chronic gastritis |
| CN105233230A (en) * | 2015-11-18 | 2016-01-13 | 王平平 | Traditional Chinese medicine for treating duodenal stasis |
| CN105497569A (en) * | 2016-03-04 | 2016-04-20 | 许应君 | Medicine for treating duodenal stasis |
| CN113181126A (en) * | 2021-05-07 | 2021-07-30 | 北京葆年堂(菏泽)药业有限公司 | Liver soothing pill and preparation method thereof |
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