CN1720915A - 抗β-内酰胺酶抗菌素复方制剂 - Google Patents
抗β-内酰胺酶抗菌素复方制剂 Download PDFInfo
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- CN1720915A CN1720915A CN 200510085079 CN200510085079A CN1720915A CN 1720915 A CN1720915 A CN 1720915A CN 200510085079 CN200510085079 CN 200510085079 CN 200510085079 A CN200510085079 A CN 200510085079A CN 1720915 A CN1720915 A CN 1720915A
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- tic
- taz
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- ticarcillin
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- 230000003115 biocidal effect Effects 0.000 title claims abstract description 20
- 239000002131 composite material Substances 0.000 title claims description 16
- OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 claims abstract description 447
- 229960004659 ticarcillin Drugs 0.000 claims abstract description 445
- 150000003839 salts Chemical class 0.000 claims abstract description 45
- 229960005256 sulbactam Drugs 0.000 claims abstract description 30
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 claims abstract description 24
- 229960000373 tazobactam sodium Drugs 0.000 claims description 27
- NDIURPSCHWTXDC-UHFFFAOYSA-N 2-(4,5-dimethoxy-2-nitrophenyl)acetohydrazide Chemical compound COC1=CC(CC(=O)NN)=C([N+]([O-])=O)C=C1OC NDIURPSCHWTXDC-UHFFFAOYSA-N 0.000 claims description 24
- -1 alkali metal salt Chemical class 0.000 claims description 19
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229960003865 tazobactam Drugs 0.000 abstract description 17
- 150000001875 compounds Chemical class 0.000 abstract description 8
- 238000001228 spectrum Methods 0.000 abstract description 5
- 230000000845 anti-microbial effect Effects 0.000 abstract description 4
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 abstract 3
- 239000000843 powder Substances 0.000 description 86
- 102000004190 Enzymes Human genes 0.000 description 81
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- 239000011591 potassium Substances 0.000 description 25
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 22
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- 238000000338 in vitro Methods 0.000 description 14
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- 241000191967 Staphylococcus aureus Species 0.000 description 12
- 210000001072 colon Anatomy 0.000 description 12
- 229940079593 drug Drugs 0.000 description 12
- 241000588724 Escherichia coli Species 0.000 description 10
- 229960000614 sulbactam sodium Drugs 0.000 description 9
- 241000588624 Acinetobacter calcoaceticus Species 0.000 description 8
- 241000588697 Enterobacter cloacae Species 0.000 description 8
- 201000008225 Klebsiella pneumonia Diseases 0.000 description 8
- 241000588747 Klebsiella pneumoniae Species 0.000 description 8
- 206010035717 Pneumonia klebsiella Diseases 0.000 description 8
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- NKZMPZCWBSWAOX-IBTYICNHSA-M Sulbactam sodium Chemical compound [Na+].O=S1(=O)C(C)(C)[C@H](C([O-])=O)N2C(=O)C[C@H]21 NKZMPZCWBSWAOX-IBTYICNHSA-M 0.000 description 8
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 8
- 229930182555 Penicillin Natural products 0.000 description 7
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- 229940088710 antibiotic agent Drugs 0.000 description 4
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- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 description 1
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- 229960004075 ticarcillin disodium Drugs 0.000 description 1
Landscapes
- Enzymes And Modification Thereof (AREA)
Abstract
Description
细菌 | 株数 | 药物 | MIC(μg/ml) | |||||||
≤6 | 32 | 64 | ≥128 | MIC50 | MIC90 | MIC范围 | 敏感率(%) | |||
株数 | ||||||||||
金黄色葡萄球菌(产酶) | 30 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 1142017116 | 676424 | 963434 | 143151416 | 643216166464 | 2566464128256256 | 4~≥2564~≥2564~2564~≥25616~≥2568~≥256 | 3.346.766.756.736.720 |
金黄色葡萄球菌 | 30 | TICTIC/SBT(1∶1)TIC/SBT(2∶1) | 232323 | 345 | 422 | 010 | 242 | 323232 | 1~642~1282~64 | 76.776.776.7 |
TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 242424 | 324 | 232 | 110 | 222 | 326432 | 0.5~1281~1281~64 | 808080 | ||
表皮葡萄球菌(产酶) | 20 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 09151430 | 043350 | 451245 | 16211815 | 12832886464 | ≥256643264≥256≥256 | 64~≥2564~1282~1284~12816~≥25664~≥256 | 0457570150 |
表皮葡萄球菌 | 20 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 191418181918 | 041102 | 121110 | 000000 | 242221 | 832161688 | 0.5~640.5~640.25~640.5~640.5~640.5~32 | 957090909590 |
肺炎链球菌(产酶) | 10 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 258853 | 422123 | 220122 | 210012 | 3216441632 | 12864163264128 | 16~2564~1280.5~321~642~1282~128 | 205080805030 |
肺炎链球菌 | 10 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 957799 | 122201 | 021110 | 010000 | 488844 | 166432321616 | 2~322~1281~642~642~641~32 | 905070709090 |
大肠埃希氏菌(产酶) | 20 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 011151482 | 323255 | 421333 | 13111410 | 64168163264 | ≥256643264128≥256 | 2~≥2562~2561~1284~1288~≥2564~≥256 | 05575704010 |
大肠埃希氏菌 | 32 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 291622222928 | 156733 | 193301 | 121000 | 816161688 | 166432321632 | 0.25~1282~1282~1280.5~640.5~321~64 | 90.65068.868.890.687.5 |
铜绿假单胞菌(产酶) | 18 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1) | 0111312 | 0334 | 1111 | 17311 | 12816816 | ≥2561283232 | 64~≥2564~≥2562~1282~128 | 061.172.266.7 |
TIC/SBT(8∶1)TIC/SBT(10∶1) | 30 | 45 | 35 | 88 | 6464 | 256≥256 | 16~≥25632~≥256 | 16.70 | ||
铜绿假单胞菌 | 16 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 77761312 | 445832 | 432101 | 122121 | 163232321616 | 641281286412864 | 2~1284~≥2564~1284~≥2562~≥2564~128 | 43.843.843.837.581.375 |
肺炎克雷伯氏菌(产酶) | 16 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 05121032 | 342343 | 541234 | 831167 | 64328166464 | ≥2561286464128256 | 16~≥2564~≥2562~1284~1284~≥25616~≥256 | 031.37562.518.812.5 |
肺炎克雷伯氏菌 | 25 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 221619232324 | 376221 | 010111 | 010000 | 4168844 | 83216323216 | 1~324~1281~322~641~641~64 | 886472929296 |
不动杆菌(产酶) | 10 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 779986 | 221012 | 110112 | 000000 | 842488 | 32328163264 | 4~641~641~321~642~644~64 | 707090908060 |
不动杆菌 | 12 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 12812101111 | 040211 | 000000 | 000000 | 142211 | 43288816 | 0.5~161~320.5~160.5~320.25~320.5~32 | 10066.710083.391.791.7 |
产气杆菌(产酶) | 10 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 699989 | 301110 | 010011 | 100000 | 821288 | 3216883216 | 2~1280.5~640.25~320.5~322~640.5~64 | 609090908090 |
产气杆菌 | 10 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1) | 88998 | 21101 | 01011 | 00000 | 28444 | 832161632 | 1~322~640.5~320.5~641~64 | 8080909080 |
TIC/SBT(10∶1) | 9 | 0 | 1 | 0 | 2 | 16 | 1~64 | 90 | ||
福氏痢疾杆菌(产酶) | 10 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/S8T(10∶1) | 6610975 | 310024 | 120100 | 110011 | 8162284 | 64648163232 | 4~1282~1280.5~160.25~644~1281~128 | 6060100907050 |
福氏痢疾杆菌 | 10 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 1079989 | 020021 | 011100 | 000000 | 284442 | 83216163216 | 0.25~162~641~641~640.5~320.5~32 | 1007090908090 |
阴沟肠杆菌(产酶) | 16 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 048600 | 032253 | 443535 | 1253488 | 1286432646464 | ≥256≥256256256≥256≥256 | 64~≥25616~≥25616~≥25616~≥25632~≥25632~≥256 | 0255037.500 |
阴沟肠杆菌 | 20 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 141013141616 | 345333 | 241200 | 121111 | 163216163216 | 646432643232 | 4~1288~1282~1282~1282~1284~128 | 705065708080 |
伤寒沙氏门氏菌 | 10 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 899899 | 201211 | 010000 | 000000 | 244422 | 16161632168 | 0.5~322~641~321~320.5~321~32 | 809090809090 |
金葡ATCC25923 | 1 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 0.2510.510.50.5 | |||||||
大肠杆菌ATCC25922 | 1 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 484442 |
绿脓杆菌ATCC27853 | 1 | TICTIC/SBT(1∶1)TIC/SBT(2∶1)TIC/SBT(4∶1)TIC/SBT(8∶1)TIC/SBT(10∶1) | 142212 |
细菌 | 株数 | 药物 | MIC(μg/ml) | MBC(μg/ml) | MBC/MIC | ||
第一株 | 第二株 | 第一株 | 第二株 | ||||
S.auresE | 2 | TICTIC/SBT | 324 | 644 | 25616 | ≥25632 | 4~84~8 |
S.aures | 2 | TICTIC/SBT | 48 | 84 | 3216 | 3216 | 4~82~4 |
E.coliE | 2 | TICTIC/SBT | 328 | 328 | 25632 | 12832 | 4~84 |
E.coli | 2 | TICTIC/SBT | 44 | 84 | 1632 | 6432 | 4~88 |
P.aeruginosaE | 2 | TICTIC/SBT | 6416 | 6416 | ≥256128 | ≥25664 | ≥44~8 |
P.aeruginosa | 2 | TICTIC/SBT | 816 | 1616 | 6464 | 6464 | 4~84 |
S.aures(ATCC25923) | 1 | TICTIC/SBT | 0.250.25 | 21 | 84 | ||
E.coli(ATCC25922) | 1 | TICTIC/SBT | 44 | 3216 | 84 | ||
P.aeruginosa(ATCC27853) | 1 | TICTIC/SBT | 12 | 816 | 88 |
细菌 | 株数 | 药物 | MIC(μg/ml) | |||||||
≤6 | 32 | 64 | ≥128 | MIC50 | MIC90 | MIC范围 | 敏感率(%) | |||
株数 | ||||||||||
金黄色葡萄球菌(产酶) | 30 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 1122126174 | 664146 | 993259 | 14321211 | 643232163264 | 25664643264128 | 4~≥25616~≥2568~≥2564~≥2568~≥25616~≥256 | 3.3407086.756.713.3 |
金黄色葡萄球菌 | 30 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 231924262524 | 363234 | 432222 | 021000 | 284222 | 326432163232 | 1~642~1281~1280.5~641~640.5~64 | 76.763.38086.783.380 |
表皮葡萄球菌(产酶) | 20 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 08141882 | 054135 | 431034 | 1641169 | 12832883264 | ≥2561283216128256 | 64~≥2568~≥2564~1284~1284~≥25616~≥256 | 04070904010 |
表皮葡萄球菌 | 20 | TICTIC/TAZ(1∶1) | 1914 | 03 | 12 | 01 | 28 | 864 | 0.5~641~128 | 9570 |
TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 16181919 | 2210 | 200 | 0000 | 4224 | 32888 | 0.5~640.5~321~322~64 | 80909595 | ||
肺炎链球菌(产酶) | 10 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 225752 | 423233 | 242112 | 2200I2 | 3216881632 | 12864643264128 | 16~2564~1284~642~648~1288~256 | 202050705020 |
肺炎链球菌 | 10 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 968998 | 121112 | 011000 | 010000 | 488444 | 1632168816 | 2~324~2564~641~322~321~32 | 906080909080 |
大肠埃希氏菌(产酶) | 20 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 09131452 | 364342 | 432257 | 1321169 | 643216166464 | 256646464128128 | 2~≥2564~≥2561~2560.5~1284~≥2568~≥256 | 04565702510 |
大肠埃希氏菌 | 32 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 292325272427 | 153253 | 132211 | 112121 | 8168448 | 166464163216 | 0.25~1281~≥2562~2560.5~1281~2560.5~128 | 90.671.978.184.47584.4 |
铜绿假单胞菌(产酶) | 18 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 025800 | 033342 | 144554 | 17962912 | 12864643264128 | ≥256128128128≥256≥256 | 64~≥25616~≥25616~≥2568~≥25632~≥25664~≥256 | 011.127.844.400 |
铜绿假单胞菌 | 16 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 7711131413 | 442102 | 432110 | 121111 | 163216161616 | 6412864646432 | 2~1288~1288~1284~1282~1284~128 | 43.843.868.881.387.581.3 |
肺炎克雷伯氏菌(产 | 16 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1) | 067 | 334 | 533 | 842 | 643232 | ≥25612864 | 16~≥2568~2564~128 | 037.543.8 |
酶) | TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 1120 | 244 | 234 | 178 | 166464 | 64128≥256 | 4~12816~≥25632~≥256 | 68.812.50 | |
肺炎克雷伯氏菌 | 25 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 221313242324 | 311010 | 011111 | 000000 | 484444 | 81616888 | 1~322~641~641~321~320.5~32 | 885252969296 |
不动杆菌(产酶) | 10 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 799979 | 200120 | 111001 | 000010 | 844288 | 3216843216 | 4~641~641~641~322~1282~64 | 709090907090 |
不动杆菌 | 12 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 121212121212 | 000000 | 000000 | 000000 | 122111 | 488444 | 0.5~161~160.5~160.5~80.25~160.5~8 | 100100100100100100 |
产气杆菌(产酶) | 10 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 668866 | 321033 | 011111 | 110000 | 884248 | 32643283232 | 2~1282~1282~641~641~642~64 | 606080806060 |
产气杆菌 | 10 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 889999 | 210110 | 011001 | 000000 | 282222 | 83216888 | 1~321~642~640.5~321~321~64 | 808090909090 |
福氏痢疾杆菌(产酶) | 10 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 688956 | 311023 | 101121 | 110011 | 8884168 | 643232166464 | 4~1282~1282~642~644~1284~128 | 608080905060 |
福氏痢疾杆菌 | 10 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1) | 10889 | 0001 | 0110 | 0000 | 2422 | 816168 | 0.25~161~640.5~640.5~32 | 100808090 |
TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 910 | 00 | 10 | 00 | 22 | 168 | 0.5~640.5~32 | 90100 | ||
阴沟肠杆菌(产酶) | 16 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 003400 | 043400 | 444556 | 128631112 | 128646432128128 | ≥256≥256≥256≥256≥256≥256 | 64~≥25632~≥25616~25616~12864~≥25664~≥256 | 0018.82500 |
阴沟肠杆菌 | 20 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 14912131414 | 354332 | 232323 | 132111 | 163216888 | 6412864646432 | 4~1288~≥2568~1284~1284~1284~128 | 704560657070 |
伤寒沙氏门氏菌 | 10 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 878899 | 221211 | 011000 | 000000 | 244222 | 16323281616 | 0.5~321~642~641~320.5~321~32 | 807080809090 |
金葡ATCC25923 | 1 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 0.250.50.250.250.250.25 | |||||||
大肠杆菌ATCC25922 | 1 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 4168444 | |||||||
绿脓杆菌ATCC27853 | 1 | TICTIC/TAZ(1∶1)TIC/TAZ(2∶1)TIC/TAZ(4∶1)TIC/TAZ(8∶1)TIC/TAZ(10∶1) | 182111 |
细菌 | 株数 | 药物 | MIC(μg/ml) | MBC(μg/ml) | MBC/MIC | ||
第一株 | 第二株 | 第一株 | 第二株 | ||||
S.auresE | 2 | TICTIC/TAZ | 328 | 6416 | 25664 | ≥25664 | 4~84~8 |
S.aures | 2 | TICTIC/TAZ | 44 | 84 | 3216 | 3232 | 84~8 |
E.coliE | 2 | TICTIC/TAZ | 3216 | 328 | 25664 | 12864 | 4~84~8 |
E.coli | 2 | TICTIC/TAZ | 48 | 88 | 1632 | 6432 | 4~84 |
P.aeruginosaE | 2 | TICTIC/TAZ | 6432 | 6416 | ≥256256 | ≥25664 | ≥44~8 |
P.aeruginosa | 2 | TICTIC/TAZ | 88 | 1616 | 6432 | 6464 | 4~84 |
S.aures(ATCC25923) | 1 | TICTIC/TAZ | 0.250.25 | 21 | 84 | ||
E.coli(ATCC25922) | 1 | TICTIC/TAZ | 44 | 3216 | 84 | ||
P.aeruginosa(ATCC27853) | 1 | TICTIC/TAZ | 11 | 84 | 84 |
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