CN1708322A - 锝络合物和靶标部分的共轭体及其在mri诊断中的用途 - Google Patents

锝络合物和靶标部分的共轭体及其在mri诊断中的用途 Download PDF

Info

Publication number
CN1708322A
CN1708322A CNA2003801020619A CN200380102061A CN1708322A CN 1708322 A CN1708322 A CN 1708322A CN A2003801020619 A CNA2003801020619 A CN A2003801020619A CN 200380102061 A CN200380102061 A CN 200380102061A CN 1708322 A CN1708322 A CN 1708322A
Authority
CN
China
Prior art keywords
technetium
complex compositions
technetium complex
acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2003801020619A
Other languages
English (en)
Chinese (zh)
Inventor
G·布劳尔斯
G·法拉
D·J·巴尼特
H·J·瓦斯沃思
J·S·刘易斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN1708322A publication Critical patent/CN1708322A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4732—Casein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA2003801020619A 2002-10-25 2003-10-24 锝络合物和靶标部分的共轭体及其在mri诊断中的用途 Pending CN1708322A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0224799.7 2002-10-25
GBGB0224799.7A GB0224799D0 (en) 2002-10-25 2002-10-25 Improved complex compositions

Publications (1)

Publication Number Publication Date
CN1708322A true CN1708322A (zh) 2005-12-14

Family

ID=9946533

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801020619A Pending CN1708322A (zh) 2002-10-25 2003-10-24 锝络合物和靶标部分的共轭体及其在mri诊断中的用途

Country Status (16)

Country Link
EP (1) EP1553986B1 (enExample)
JP (1) JP2006508084A (enExample)
KR (1) KR20050070080A (enExample)
CN (1) CN1708322A (enExample)
AT (1) ATE402720T1 (enExample)
AU (1) AU2003279444A1 (enExample)
BR (1) BR0315578A (enExample)
CA (1) CA2501684A1 (enExample)
DE (1) DE60322562D1 (enExample)
ES (1) ES2309361T3 (enExample)
GB (1) GB0224799D0 (enExample)
MX (1) MXPA05004418A (enExample)
NO (1) NO20051811L (enExample)
RU (1) RU2005110960A (enExample)
WO (1) WO2004037297A1 (enExample)
ZA (1) ZA200502835B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103547291A (zh) * 2011-03-04 2014-01-29 通用电气健康护理有限公司 锝标记的肽
CN104066454A (zh) * 2012-01-31 2014-09-24 通用电气公司 螯合剂
CN107362376A (zh) * 2010-07-27 2017-11-21 通用电气健康护理有限公司 放射性药物组合物
CN112830940A (zh) * 2020-09-07 2021-05-25 中国科学院宁波材料技术与工程研究所 2,5-呋喃二甲醛肟金属络合物及其制备方法、及在抗菌除霉消毒剂中的应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0515974D0 (en) * 2005-08-03 2005-09-07 Ge Healthcare Ltd Compounds and imaging methods
GB0520527D0 (en) * 2005-10-10 2005-11-16 Ge Healthcare Ltd Automated method
GB0614337D0 (en) * 2006-07-19 2006-08-30 Acal Energy Ltd Fuel Cells
US20120165650A1 (en) 2010-12-22 2012-06-28 General Electric Company Her2 binders
ES2739504T3 (es) 2010-12-21 2020-01-31 Ge Healthcare Ltd Uso de anilina en la radioestabilización de una ligadura de oxima
JP5934246B2 (ja) * 2010-12-22 2016-06-15 テーエフシム グリコ−ｃｆ２−セリンおよびグリコ−ｃｆ２−トレオニンの誘導体
GB201610176D0 (en) * 2016-06-10 2016-07-27 Edinburgh Molecular Imaging Ltd Imaging agents and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69937996T2 (de) * 1998-05-15 2009-01-02 Ge Healthcare Ltd., Little Chalfont Markierte glutamin- und lysinanaloge
WO2001077145A2 (en) * 2000-04-12 2001-10-18 Amersham Health As Integrin binding peptide derivatives
WO2001089584A2 (en) * 2000-05-23 2001-11-29 Amersham Health As Contrast agents
NO20004795D0 (no) * 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
GB0105224D0 (en) * 2001-03-02 2001-04-18 Nycomed Amersham Plc Improved peptide-chelate conjugates

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107362376A (zh) * 2010-07-27 2017-11-21 通用电气健康护理有限公司 放射性药物组合物
US11723991B2 (en) 2010-07-27 2023-08-15 Serac Healthcare Limited Radiopharmaceutical compositions
CN103547291A (zh) * 2011-03-04 2014-01-29 通用电气健康护理有限公司 锝标记的肽
CN103547291B (zh) * 2011-03-04 2017-12-01 通用电气健康护理有限公司 锝标记的肽
CN104066454A (zh) * 2012-01-31 2014-09-24 通用电气公司 螯合剂
CN109293536A (zh) * 2012-01-31 2019-02-01 通用电气公司 螯合剂
CN112830940A (zh) * 2020-09-07 2021-05-25 中国科学院宁波材料技术与工程研究所 2,5-呋喃二甲醛肟金属络合物及其制备方法、及在抗菌除霉消毒剂中的应用

Also Published As

Publication number Publication date
BR0315578A (pt) 2005-10-25
KR20050070080A (ko) 2005-07-05
WO2004037297A1 (en) 2004-05-06
NO20051811D0 (no) 2005-04-14
ES2309361T3 (es) 2008-12-16
MXPA05004418A (es) 2005-11-23
EP1553986A1 (en) 2005-07-20
DE60322562D1 (de) 2008-09-11
RU2005110960A (ru) 2005-11-20
ZA200502835B (en) 2006-03-29
GB0224799D0 (en) 2002-12-04
ATE402720T1 (de) 2008-08-15
EP1553986B1 (en) 2008-07-30
CA2501684A1 (en) 2004-05-06
JP2006508084A (ja) 2006-03-09
AU2003279444A1 (en) 2004-05-13
NO20051811L (no) 2005-06-27

Similar Documents

Publication Publication Date Title
CN1093424C (zh) 含单胺、联氨、硫羟基的金属螯合剂
JP5015409B2 (ja) 改良キレート剤結合体
CN1158133A (zh) 肽衍生的放射性核素螯合剂
CN1822861A (zh) 稳定的放射性药物组合物及制备方法
CN1622830A (zh) 肽基化合物
CN1154072A (zh) 用于成象的锝-99m标记的肽
CN1155248A (zh) 生长激素抑制素结合肽-金属络合物
CN1708322A (zh) 锝络合物和靶标部分的共轭体及其在mri诊断中的用途
CN1968963A (zh) 基于肽的化合物
JP6055417B2 (ja) 放射性トレーサー組成物
CN1658907A (zh) 放射性药物制剂
JP6609409B2 (ja) 放射性フッ素化方法
CN105849067B (zh) 纯化方法和组合物
JP6574997B2 (ja) 金属錯体とそのフッ素化
US10548995B2 (en) Radiolabelling method
AU2011334881A1 (en) Radioconjugation method
US7481993B2 (en) Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
CN1571680A (zh) Pacap组合物及用于肿瘤成像与治疗的方法
CN117320759A (zh) 放射性药物生长抑素受体配体及其前体
KR20220118464A (ko) 암의 영상화 및 치료법을 위한 개선된 약동학을 갖는 화합물
EP1700608A1 (en) Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
WO2008046493A2 (en) Radioactive metal complexes comprising a tridentate complexing sequence
HK1107102A (en) Peptide-based compounds
HK1226050A1 (en) Purification method and compositions

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication