CN1698609A - 一种新型匹伐他汀钙可溶片组合物及其制备方法 - Google Patents
一种新型匹伐他汀钙可溶片组合物及其制备方法 Download PDFInfo
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- CN1698609A CN1698609A CN 200510039157 CN200510039157A CN1698609A CN 1698609 A CN1698609 A CN 1698609A CN 200510039157 CN200510039157 CN 200510039157 CN 200510039157 A CN200510039157 A CN 200510039157A CN 1698609 A CN1698609 A CN 1698609A
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- fuse
- lubricant
- pitavastatin
- carboxymethyl cellulose
- filler
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- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 229960002797 pitavastatin Drugs 0.000 title abstract description 12
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 title abstract description 12
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- RHGYHLPFVJEAOC-FFNUKLMVSA-L pitavastatin calcium Chemical compound [Ca+2].[O-]C(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1.[O-]C(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 RHGYHLPFVJEAOC-FFNUKLMVSA-L 0.000 claims abstract description 27
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Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
试验项目 | 溶解时限 | 溶出度 | 加速试验的稳定性 |
可溶片 | <1min全溶 | 15min,80% | 未见有关物质明显增加 |
普通片/胶囊 | ≥10min崩解 | 30min,75% | 未见有关物质明显增加 |
原辅料名称 | 投料量(g) | 重量比 |
匹伐他汀钙 | 1.0g | 1.80% |
赤藓糖醇 | 32.0g | 57.66% |
乳糖 | 15.0g | 27.03% |
交联羧甲基纤维素钠 | 6.0g | 11.06% |
聚乙烯吡咯烷酮K30 | 0.5g | 0.9% |
己二酸 | 1.0g | 1.80% |
Claims (10)
Priority Applications (1)
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CNB2005100391576A CN100335055C (zh) | 2005-04-29 | 2005-04-29 | 一种新型匹伐他汀钙可溶片组合物及其制备方法 |
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CNB2005100391576A CN100335055C (zh) | 2005-04-29 | 2005-04-29 | 一种新型匹伐他汀钙可溶片组合物及其制备方法 |
Publications (2)
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CN1698609A true CN1698609A (zh) | 2005-11-23 |
CN100335055C CN100335055C (zh) | 2007-09-05 |
Family
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CNB2005100391576A Expired - Fee Related CN100335055C (zh) | 2005-04-29 | 2005-04-29 | 一种新型匹伐他汀钙可溶片组合物及其制备方法 |
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CN (1) | CN100335055C (zh) |
Cited By (7)
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CN102302452A (zh) * | 2011-09-14 | 2012-01-04 | 海南美大制药有限公司 | 匹伐他汀钙脂质体固体制剂 |
CN102861018A (zh) * | 2011-07-05 | 2013-01-09 | 南京长澳医药科技有限公司 | 一种匹伐他汀钙制剂及其制备工艺 |
CN104367560A (zh) * | 2014-10-23 | 2015-02-25 | 万全万特制药江苏有限公司 | 一种新型匹伐他汀钙口腔崩解片组合物及其制备方法 |
CN104644587A (zh) * | 2015-03-20 | 2015-05-27 | 王雪雁 | 一种治疗心血管疾病的药物组合物的制备方法 |
CN105213339A (zh) * | 2015-10-19 | 2016-01-06 | 迪沙药业集团有限公司 | 一种匹伐他汀钙组合物 |
EP2883547A4 (en) * | 2012-08-08 | 2016-02-10 | Kowa Co | MEDICINE |
CN105982874A (zh) * | 2015-10-19 | 2016-10-05 | 迪沙药业集团有限公司 | 匹伐他汀钙组合物 |
Family Cites Families (8)
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CN1197556C (zh) * | 2003-02-12 | 2005-04-20 | 刘智 | 一种防治放疗、化疗呕吐的口腔快速崩解片剂及制备方法 |
CN1245154C (zh) * | 2003-06-27 | 2006-03-15 | 刘辉 | 中药或天然来源药用物质口腔速崩片及其制备方法 |
CN1267092C (zh) * | 2003-07-03 | 2006-08-02 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 口腔内使用的莫达芬尼药物组合物 |
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CN1269480C (zh) * | 2004-04-24 | 2006-08-16 | 深圳海王药业有限公司 | 氯雷他定口腔崩解片及其制备方法 |
CN1589797A (zh) * | 2004-06-10 | 2005-03-09 | 范敏华 | 盐酸洛美利嗪口腔崩解片及其制备方法 |
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2005
- 2005-04-29 CN CNB2005100391576A patent/CN100335055C/zh not_active Expired - Fee Related
Cited By (10)
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CN102861018A (zh) * | 2011-07-05 | 2013-01-09 | 南京长澳医药科技有限公司 | 一种匹伐他汀钙制剂及其制备工艺 |
CN102302452A (zh) * | 2011-09-14 | 2012-01-04 | 海南美大制药有限公司 | 匹伐他汀钙脂质体固体制剂 |
CN102302452B (zh) * | 2011-09-14 | 2012-11-21 | 海南美大制药有限公司 | 匹伐他汀钙脂质体固体制剂 |
EP2883547A4 (en) * | 2012-08-08 | 2016-02-10 | Kowa Co | MEDICINE |
EP3124017A1 (en) * | 2012-08-08 | 2017-02-01 | Kowa Company, Ltd. | Pharmaceutical composition comprising pitavastatine |
EP3269362A1 (en) * | 2012-08-08 | 2018-01-17 | KOWA Co., Ltd. | Pharmaceutical composition comprising pitavastatine |
CN104367560A (zh) * | 2014-10-23 | 2015-02-25 | 万全万特制药江苏有限公司 | 一种新型匹伐他汀钙口腔崩解片组合物及其制备方法 |
CN104644587A (zh) * | 2015-03-20 | 2015-05-27 | 王雪雁 | 一种治疗心血管疾病的药物组合物的制备方法 |
CN105213339A (zh) * | 2015-10-19 | 2016-01-06 | 迪沙药业集团有限公司 | 一种匹伐他汀钙组合物 |
CN105982874A (zh) * | 2015-10-19 | 2016-10-05 | 迪沙药业集团有限公司 | 匹伐他汀钙组合物 |
Also Published As
Publication number | Publication date |
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CN100335055C (zh) | 2007-09-05 |
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