CN1694895A - 被修饰的转铁蛋白抗体的融合蛋白 - Google Patents

被修饰的转铁蛋白抗体的融合蛋白 Download PDF

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Publication number
CN1694895A
CN1694895A CNA038247453A CN03824745A CN1694895A CN 1694895 A CN1694895 A CN 1694895A CN A038247453 A CNA038247453 A CN A038247453A CN 03824745 A CN03824745 A CN 03824745A CN 1694895 A CN1694895 A CN 1694895A
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fusion rotein
antibody variable
variable region
transferrin
residue
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Chinese (zh)
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霍马扬·萨德吉
克里斯托弗·P·普里奥尔
安德鲁·特纳
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Biorexis Pharmaceutical Corp
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Biorexis Pharmaceutical Corp
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
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CNA038247453A 2002-08-30 2003-08-28 被修饰的转铁蛋白抗体的融合蛋白 Pending CN1694895A (zh)

Applications Claiming Priority (3)

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US40697702P 2002-08-30 2002-08-30
US60/406,977 2002-08-30
US10/384,060 2003-03-10

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CNA038247453A Pending CN1694895A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白抗体的融合蛋白
CNA038247399A Pending CN1713920A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白融合蛋白
CN201110175090A Pending CN102268094A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白抗体的融合蛋白

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CNA038247399A Pending CN1713920A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白融合蛋白
CN201110175090A Pending CN102268094A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白抗体的融合蛋白

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US (1) US20060130158A1 (enExample)
EP (1) EP1545595B1 (enExample)
JP (1) JP4873860B2 (enExample)
CN (3) CN1694895A (enExample)
AT (1) ATE473011T1 (enExample)
AU (2) AU2003262886A1 (enExample)
DE (1) DE60333306D1 (enExample)
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Cited By (15)

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CN105358578A (zh) * 2013-05-20 2016-02-24 豪夫迈·罗氏有限公司 运铁蛋白受体的抗体及其使用方法
CN105555310A (zh) * 2013-07-08 2016-05-04 南京金斯瑞生物科技有限公司 一种提高蛋白血清半衰期的组合物和方法
CN107010616A (zh) * 2017-04-13 2017-08-04 浙江理工大学 一种具有靶向传递功能的纳米药物载体的制备方法
CN108273040A (zh) * 2006-05-22 2018-07-13 加利福尼亚大学董事会 用于氧输送的组合物及方法
CN110100000A (zh) * 2016-12-26 2019-08-06 Jcr制药股份有限公司 含有bdnf的融合蛋白
CN110167585A (zh) * 2016-09-02 2019-08-23 美国卫生与公众服务部 稳定化的第2组流感血凝素茎区三聚体及其用途
CN110506055A (zh) * 2017-02-17 2019-11-26 戴纳立制药公司 工程改造的转铁蛋白受体结合多肽
CN111057147A (zh) * 2014-01-06 2020-04-24 豪夫迈·罗氏有限公司 单价血脑屏障穿梭模块
CN111278859A (zh) * 2017-10-02 2020-06-12 戴纳立制药公司 包含酶替代疗法酶的融合蛋白
CN111526887A (zh) * 2017-10-11 2020-08-11 南京传奇生物科技有限公司 用于使血清中的蛋白质半衰期增加的组合物和方法
CN111741977A (zh) * 2018-01-10 2020-10-02 戴纳立制药公司 转铁蛋白受体结合性多肽和其用途
CN114014936A (zh) * 2015-10-02 2022-02-08 豪夫迈·罗氏有限公司 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法
CN115368460A (zh) * 2015-03-17 2022-11-22 纪念斯隆-凯特林癌症中心 抗muc16抗体及其应用
US11958905B2 (en) 2015-06-24 2024-04-16 Jcr Pharmaceuticals Co., Ltd. Fusion proteins containing a BDNF and an anti-human transferrin receptor antibody
US12145995B2 (en) 2016-12-26 2024-11-19 Jcr Pharmaceuticals Co., Ltd. Anti-human transferrin receptor antibody capable of penetrating blood-brain barrier

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176278B2 (en) * 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US20070031440A1 (en) * 2001-08-30 2007-02-08 Prior Christopher P Modified transferin-antibody fusion proteins
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
JP2005508623A (ja) * 2001-08-30 2005-04-07 バイオレクシス ファーマシューティカル コーポレイション 改変されたトランスフェリン融合タンパク質
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2007512001A (ja) * 2003-08-28 2007-05-17 バイオレクシス ファーマシューティカル コーポレイション Ｅｐｏミメティックペプチドおよび融合タンパク質
US20060205037A1 (en) * 2003-08-28 2006-09-14 Homayoun Sadeghi Modified transferrin fusion proteins
AU2005271403A1 (en) * 2004-08-03 2006-02-16 Biorexis Pharmaceutical Corporation Combination therapy using transferrin fusion proteins comprising GLP-1
EP1893635A4 (en) * 2005-06-17 2009-02-25 Biorexis Pharmaceutical Corp LIBRARIES ANCHORED TRANSFERRINFUSION PROTEINS
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
CN101088502B (zh) * 2006-06-16 2012-11-21 中国科学院化学研究所 一种含有转铁蛋白和槲皮素的结合物的混合溶液及其用途
AU2007274035A1 (en) 2006-07-13 2008-01-17 Novozymes Biopharma Dk A/S Process for preparing particles of proteinaceous material
ATE524493T1 (de) 2006-07-24 2011-09-15 Biorexis Pharmaceutical Corp Exendin-fusionsproteine
CN101578373A (zh) * 2006-09-06 2009-11-11 费斯生物制药公司 融合肽治疗组合物
JP5492563B2 (ja) 2006-12-12 2014-05-14 バイオレクシス ファーマシューティカル コーポレーション トランスフェリン融合タンパク質ライブラリー
EP3412300A1 (en) 2008-06-27 2018-12-12 Duke University Therapeutic agents comprising elastin-like peptides
AU2010240569A1 (en) * 2009-04-20 2011-10-20 Pfizer Inc. Control of protein glycosylation and compositions and methods relating thereto
US20130079382A1 (en) 2009-10-12 2013-03-28 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
CN107188970A (zh) * 2010-06-04 2017-09-22 株式会社蒂奥姆生物 具有因子vii活性的融合蛋白质
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WO2013138338A2 (en) 2012-03-12 2013-09-19 Massachusetts Institute Of Technology Methods for treating tissue damage associated with ischemia with apoliporotein d
CN104797933A (zh) 2012-09-07 2015-07-22 阿尔伯达大学董事会 用于诊断发炎性肝病的方法和组合物
CN105491982B (zh) * 2013-08-12 2019-09-10 3M创新有限公司 用于增强透皮递送的肽
KR102058864B1 (ko) * 2013-12-16 2019-12-24 주식회사 티움바이오 인자 vii의 융합 단백질을 포함하는 안정성이 개선된 약학적 조성물
JP2015224327A (ja) * 2014-05-29 2015-12-14 花王株式会社 繊維製品用洗浄剤組成物
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
CN106967171B (zh) * 2017-02-23 2021-04-27 郑州大学 一种全人源重组CD40L单抗Fab片段及其制备方法
JP7403441B2 (ja) * 2017-09-14 2023-12-22 デナリ セラピューティクス インコーポレイテッド 抗ｔｒｅｍ２抗体及びその使用方法
US11753455B2 (en) 2018-06-21 2023-09-12 Novo Nordisk A/S Compounds for treatment of obesity
CN109180819A (zh) * 2018-09-14 2019-01-11 苏州康宇生物科技有限公司 一种胰岛素衍生物的制备方法
CN113677800A (zh) * 2018-11-13 2021-11-19 索元生物医药(美国)有限公司 包含用于结合结构域和可分泌肽的基因的重组载体
AU2020371793A1 (en) * 2019-10-25 2022-06-02 Northwestern University Cell-free extract preparation protocol for enrichment of membrane vesicles and increased glycoprotein yields
CN111948388B (zh) * 2020-08-18 2022-03-22 山东农业大学 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用
CN112661862B (zh) * 2020-12-25 2023-03-31 深圳大学 一种融合蛋白及其制备方法和应用
CN113267631A (zh) * 2021-05-17 2021-08-17 江苏普若维生物技术有限责任公司 一种检测TNF-α的电化学试剂盒制备方法
WO2023142109A1 (zh) * 2022-01-30 2023-08-03 领诺(上海)医药科技有限公司 一种长效重组人生长激素及其应用
CN120282983A (zh) * 2022-12-02 2025-07-08 百奥赛图(北京)医药科技股份有限公司 抗tfr1抗体及其应用
CN118931931B (zh) * 2024-07-23 2025-02-21 中国农业科学院北京畜牧兽医研究所 一种产气荚膜梭菌epsilon毒素-铁蛋白纳米颗粒抗原的制备方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
DE3273787D1 (en) * 1981-02-04 1986-11-20 Japan Found Cancer Human interferon-beta gene
US4816449A (en) * 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents
US5026651A (en) * 1985-04-25 1991-06-25 Board Of Regents, The University Of Texas System Methods and compositions for the production of human transferrin
US5262177A (en) * 1986-02-07 1993-11-16 Oncogen Recombinant viruses encoding the human melanoma-associated antigen
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
GB8901778D0 (en) 1989-01-27 1989-03-15 Univ Court Of The University O Manipulatory technique
US5571691A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
US5672683A (en) * 1989-09-07 1997-09-30 Alkermes, Inc. Transferrin neuropharmaceutical agent fusion protein
US5977307A (en) * 1989-09-07 1999-11-02 Alkermes, Inc. Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
US6066469A (en) * 1990-03-08 2000-05-23 Ferro Dynamics, Inc. Cloning, expression, and uses of human lactoferrin
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5986067A (en) 1991-02-08 1999-11-16 The University Of Vermont And State Agricultural College Recombinant transferrins, transferrin half-molecules and mutants thereof
US5656272A (en) * 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
EP0603187A4 (en) * 1991-05-31 1995-08-30 Us Health Human lactoferrin.
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
ZA932568B (en) * 1992-04-24 1993-11-12 Baylor College Midecine A Non Production of recombinant human lactoferrin
EP0599303A3 (en) * 1992-11-27 1998-07-29 Takeda Chemical Industries, Ltd. Peptide conjugate
WO1994023744A1 (en) 1993-04-16 1994-10-27 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
US5455933A (en) * 1993-07-14 1995-10-03 Dell Usa, L.P. Circuit and method for remote diagnosis of personal computers
US5843882A (en) * 1995-04-27 1998-12-01 The United States Of America As Represented By The Department Of Health And Human Services Antiviral proteins and peptides
US5817789A (en) * 1995-06-06 1998-10-06 Transkaryotic Therapies, Inc. Chimeric proteins for use in transport of a selected substance into cells
US5849293A (en) * 1996-01-11 1998-12-15 Cornell Research Foundation, Inc. Use of human transferrin in controlling insulin levels
US7235627B2 (en) * 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6458924B2 (en) * 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
US6258782B1 (en) * 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
EP1180121B9 (en) * 1999-05-17 2004-09-08 Conjuchem, Inc. Long lasting insulinotropic peptides
US6380362B1 (en) * 1999-12-23 2002-04-30 Genesis Research & Development Corporation Ltd. Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use
US6420346B1 (en) * 2000-02-07 2002-07-16 Rappaport Family Institute For Research In The Medical Sciences Polynucleotides encoding MIP-1α, MCP-1, MIP-1β, Rantes and TNF-α, and methods for treating rheumatoid arthritis
UA93662C2 (uk) * 2000-12-07 2011-03-10 Эли Лилли Энд Компани Гетерологічний пептидильований глюкагон-подібний білок та його застосування для виготовлення лікарського засобу для лікування пацієнтів, що страждають на ожиріння або інсулінонезалежний цукровий діабет
JP2002247847A (ja) * 2001-02-20 2002-08-30 Internatl Business Mach Corp <Ibm> Ａｃアダプタ、電源供給装置、電気機器、および電源供給装置の制御方法
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
JP2005508623A (ja) * 2001-08-30 2005-04-07 バイオレクシス ファーマシューティカル コーポレイション 改変されたトランスフェリン融合タンパク質
US7176278B2 (en) * 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US20060105387A1 (en) * 2002-08-30 2006-05-18 Prior Christopher P Transferrin fusion proteins libraries
DK1407985T3 (da) * 2002-10-11 2006-03-06 Habasit Ag Transportbåndsmodul med en höjfriktionsoverflade
US20060205037A1 (en) * 2003-08-28 2006-09-14 Homayoun Sadeghi Modified transferrin fusion proteins

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108273040A (zh) * 2006-05-22 2018-07-13 加利福尼亚大学董事会 用于氧输送的组合物及方法
CN105358578A (zh) * 2013-05-20 2016-02-24 豪夫迈·罗氏有限公司 运铁蛋白受体的抗体及其使用方法
CN105555310A (zh) * 2013-07-08 2016-05-04 南京金斯瑞生物科技有限公司 一种提高蛋白血清半衰期的组合物和方法
CN111057147B (zh) * 2014-01-06 2023-11-10 豪夫迈·罗氏有限公司 单价血脑屏障穿梭模块
CN111057147A (zh) * 2014-01-06 2020-04-24 豪夫迈·罗氏有限公司 单价血脑屏障穿梭模块
CN115368460A (zh) * 2015-03-17 2022-11-22 纪念斯隆-凯特林癌症中心 抗muc16抗体及其应用
US11958905B2 (en) 2015-06-24 2024-04-16 Jcr Pharmaceuticals Co., Ltd. Fusion proteins containing a BDNF and an anti-human transferrin receptor antibody
CN114014936A (zh) * 2015-10-02 2022-02-08 豪夫迈·罗氏有限公司 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法
US12030952B2 (en) 2015-10-02 2024-07-09 Hoffmann-La Roche Inc. Bispecific anti-human CD20/human transferrin receptor antibodies and methods of use
CN110167585A (zh) * 2016-09-02 2019-08-23 美国卫生与公众服务部 稳定化的第2组流感血凝素茎区三聚体及其用途
CN110167585B (zh) * 2016-09-02 2024-03-08 美国卫生与公众服务部 稳定化的第2组流感血凝素茎区三聚体及其用途
US12527857B2 (en) 2016-09-02 2026-01-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof
US11793871B2 (en) 2016-09-02 2023-10-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof
US12214007B2 (en) 2016-12-26 2025-02-04 Jcr Pharmaceuticals Co., Ltd. Fusion protein including BDNF
USRE50240E1 (en) 2016-12-26 2024-12-24 Jcr Pharmaceuticals Co., Ltd. Anti-human transferrin receptor antibody capable of penetrating blood-brain barrier
CN110100000B (zh) * 2016-12-26 2023-06-20 Jcr制药股份有限公司 含有bdnf的融合蛋白
CN110100000A (zh) * 2016-12-26 2019-08-06 Jcr制药股份有限公司 含有bdnf的融合蛋白
US12145995B2 (en) 2016-12-26 2024-11-19 Jcr Pharmaceuticals Co., Ltd. Anti-human transferrin receptor antibody capable of penetrating blood-brain barrier
CN110506055A (zh) * 2017-02-17 2019-11-26 戴纳立制药公司 工程改造的转铁蛋白受体结合多肽
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