CN1694895A - 被修饰的转铁蛋白抗体的融合蛋白 - Google Patents

被修饰的转铁蛋白抗体的融合蛋白 Download PDF

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Publication number
CN1694895A
CN1694895A CNA038247453A CN03824745A CN1694895A CN 1694895 A CN1694895 A CN 1694895A CN A038247453 A CNA038247453 A CN A038247453A CN 03824745 A CN03824745 A CN 03824745A CN 1694895 A CN1694895 A CN 1694895A
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fusion protein
antibody variable
fusion
variable region
transferrin
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CNA038247453A
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Chinese (zh)
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霍马扬·萨德吉
克里斯托弗·P·普里奥尔
安德鲁·特纳
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Biorexis Pharmaceutical Corp
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Biorexis Pharmaceutical Corp
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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CNA038247453A 2002-08-30 2003-08-28 被修饰的转铁蛋白抗体的融合蛋白 Pending CN1694895A (zh)

Applications Claiming Priority (3)

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US40697702P 2002-08-30 2002-08-30
US60/406,977 2002-08-30
US10/384,060 2003-03-10

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CN201110175090A Division CN102268094A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白抗体的融合蛋白

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CNA038247453A Pending CN1694895A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白抗体的融合蛋白
CNA038247399A Pending CN1713920A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白融合蛋白
CN201110175090A Pending CN102268094A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白抗体的融合蛋白

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CNA038247399A Pending CN1713920A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白融合蛋白
CN201110175090A Pending CN102268094A (zh) 2002-08-30 2003-08-28 被修饰的转铁蛋白抗体的融合蛋白

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US (1) US20060130158A1 (enExample)
EP (1) EP1545595B1 (enExample)
JP (1) JP4873860B2 (enExample)
CN (3) CN1694895A (enExample)
AT (1) ATE473011T1 (enExample)
AU (2) AU2003262886A1 (enExample)
DE (1) DE60333306D1 (enExample)
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Cited By (15)

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CN105358578A (zh) * 2013-05-20 2016-02-24 豪夫迈·罗氏有限公司 运铁蛋白受体的抗体及其使用方法
CN105555310A (zh) * 2013-07-08 2016-05-04 南京金斯瑞生物科技有限公司 一种提高蛋白血清半衰期的组合物和方法
CN107010616A (zh) * 2017-04-13 2017-08-04 浙江理工大学 一种具有靶向传递功能的纳米药物载体的制备方法
CN108273040A (zh) * 2006-05-22 2018-07-13 加利福尼亚大学董事会 用于氧输送的组合物及方法
CN110100000A (zh) * 2016-12-26 2019-08-06 Jcr制药股份有限公司 含有bdnf的融合蛋白
CN110167585A (zh) * 2016-09-02 2019-08-23 美国卫生与公众服务部 稳定化的第2组流感血凝素茎区三聚体及其用途
CN110506055A (zh) * 2017-02-17 2019-11-26 戴纳立制药公司 工程改造的转铁蛋白受体结合多肽
CN111057147A (zh) * 2014-01-06 2020-04-24 豪夫迈·罗氏有限公司 单价血脑屏障穿梭模块
CN111278859A (zh) * 2017-10-02 2020-06-12 戴纳立制药公司 包含酶替代疗法酶的融合蛋白
CN111526887A (zh) * 2017-10-11 2020-08-11 南京传奇生物科技有限公司 用于使血清中的蛋白质半衰期增加的组合物和方法
CN111741977A (zh) * 2018-01-10 2020-10-02 戴纳立制药公司 转铁蛋白受体结合性多肽和其用途
CN114014936A (zh) * 2015-10-02 2022-02-08 豪夫迈·罗氏有限公司 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法
CN115368460A (zh) * 2015-03-17 2022-11-22 纪念斯隆-凯特林癌症中心 抗muc16抗体及其应用
US11958905B2 (en) 2015-06-24 2024-04-16 Jcr Pharmaceuticals Co., Ltd. Fusion proteins containing a BDNF and an anti-human transferrin receptor antibody
US12145995B2 (en) 2016-12-26 2024-11-19 Jcr Pharmaceuticals Co., Ltd. Anti-human transferrin receptor antibody capable of penetrating blood-brain barrier

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US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
IL160289A0 (en) * 2001-08-30 2004-07-25 Biorexis Pharmaceutical Corp Modified transferrin fusion proteins
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
US20070031440A1 (en) * 2001-08-30 2007-02-08 Prior Christopher P Modified transferin-antibody fusion proteins
US7176278B2 (en) * 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20060205037A1 (en) * 2003-08-28 2006-09-14 Homayoun Sadeghi Modified transferrin fusion proteins
WO2005021579A2 (en) * 2003-08-28 2005-03-10 Biorexis Pharmaceutical Corporation Epo mimetic peptides and fusion proteins
JP2008509153A (ja) * 2004-08-03 2008-03-27 バイオレクシス ファーマシューティカル コーポレイション Ｇｌｐ−１を含むトランスフェリン融合タンパク質用いた併用療法
JP2008546392A (ja) * 2005-06-17 2008-12-25 バイオレクシス ファーマシューティカル コーポレーション 固定されたトランスフェリン融合タンパク質ライブラリー
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
CN101088502B (zh) * 2006-06-16 2012-11-21 中国科学院化学研究所 一种含有转铁蛋白和槲皮素的结合物的混合溶液及其用途
CA2657277C (en) 2006-07-13 2015-11-24 Upperton Limited Process for preparing particles of proteinaceous material
ATE524493T1 (de) 2006-07-24 2011-09-15 Biorexis Pharmaceutical Corp Exendin-fusionsproteine
MX2009002547A (es) * 2006-09-06 2009-06-19 Phasebio Pharmaceuticals Inc Composiciones terapeuticas de peptido de fusion.
KR20090098880A (ko) 2006-12-12 2009-09-17 바이오렉시스 파마슈티칼 코포레이션 트랜스페린 융합 단백질 라이브러리
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