CN1679938A - 药物组合物 - Google Patents

药物组合物 Download PDF

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Publication number
CN1679938A
CN1679938A CNA2005100712990A CN200510071299A CN1679938A CN 1679938 A CN1679938 A CN 1679938A CN A2005100712990 A CNA2005100712990 A CN A2005100712990A CN 200510071299 A CN200510071299 A CN 200510071299A CN 1679938 A CN1679938 A CN 1679938A
Authority
CN
China
Prior art keywords
acid
compositions
macrolide
rapamycin
preferred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005100712990A
Other languages
English (en)
Chinese (zh)
Inventor
S·科顿斯
B·黑伯林
R·萨特林尼
J·冯德斯彻
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9421613A external-priority patent/GB9421613D0/en
Priority claimed from GB9422084A external-priority patent/GB9422084D0/en
Priority claimed from GBGB9425353.1A external-priority patent/GB9425353D0/en
Priority claimed from GBGB9517133.6A external-priority patent/GB9517133D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1679938A publication Critical patent/CN1679938A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Colloid Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CNA2005100712990A 1994-10-26 1995-10-25 药物组合物 Pending CN1679938A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB9421613A GB9421613D0 (en) 1994-10-26 1994-10-26 Organic compounds
GB9421613.2 1994-10-26
GB9422084.5 1994-11-02
GB9422084A GB9422084D0 (en) 1994-11-02 1994-11-02 Organic compounds
GBGB9425353.1A GB9425353D0 (en) 1994-12-15 1994-12-15 Organic compounds
GB9425353.1 1994-12-15
GBGB9517133.6A GB9517133D0 (en) 1995-08-22 1995-08-22 Pharmaceutical compositions
GB9517133.6 1995-08-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN02118150A Division CN1404833A (zh) 1994-10-26 2002-04-20 药物组合物

Publications (1)

Publication Number Publication Date
CN1679938A true CN1679938A (zh) 2005-10-12

Family

ID=27451224

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA2005100712990A Pending CN1679938A (zh) 1994-10-26 1995-10-25 药物组合物
CN95195882A Expired - Fee Related CN1124157C (zh) 1994-10-26 1995-10-25 药物组合物
CN02118150A Pending CN1404833A (zh) 1994-10-26 2002-04-20 药物组合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN95195882A Expired - Fee Related CN1124157C (zh) 1994-10-26 1995-10-25 药物组合物
CN02118150A Pending CN1404833A (zh) 1994-10-26 2002-04-20 药物组合物

Country Status (25)

Country Link
EP (2) EP0787011B1 (enExample)
JP (3) JPH10509699A (enExample)
KR (2) KR100518135B1 (enExample)
CN (3) CN1679938A (enExample)
AT (1) ATE411800T1 (enExample)
AU (1) AU714360B2 (enExample)
BR (1) BR9509496A (enExample)
CA (1) CA2200967C (enExample)
CY (1) CY2210B1 (enExample)
CZ (1) CZ289838B6 (enExample)
DE (2) DE69535869D1 (enExample)
ES (1) ES2316150T3 (enExample)
FI (1) FI119497B (enExample)
HU (1) HU225535B1 (enExample)
IL (3) IL115742A (enExample)
MY (1) MY129435A (enExample)
NO (2) NO323078B1 (enExample)
NZ (1) NZ295655A (enExample)
PE (1) PE52896A1 (enExample)
PL (1) PL184368B1 (enExample)
PT (1) PT787011E (enExample)
SK (2) SK286178B6 (enExample)
TR (2) TR199500299A2 (enExample)
TW (1) TW308544B (enExample)
WO (1) WO1996013273A1 (enExample)

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BR9509496A (pt) 1997-09-30
DE19581805T1 (de) 1997-10-16
ATE411800T1 (de) 2008-11-15
FI119497B (fi) 2008-12-15
IL129547A (en) 2001-01-11
MX9702701A (es) 1997-10-31
KR20040074104A (ko) 2004-08-21
SK285809B6 (sk) 2007-08-02
FI970995A0 (fi) 1997-03-10
NO20031901L (no) 1997-06-24
CN1161652A (zh) 1997-10-08
CA2200967A1 (en) 1996-05-09
CZ123197A3 (en) 1997-07-16
PE52896A1 (es) 1996-12-12
TR199501321A2 (tr) 1996-06-21
CN1404833A (zh) 2003-03-26
PL184368B1 (pl) 2002-10-31
EP0787011B1 (en) 2008-10-22
KR100541198B1 (ko) 2007-04-11
NZ295655A (en) 1998-12-23
NO323063B1 (no) 2006-12-27
KR970706837A (ko) 1997-12-01
PT787011E (pt) 2009-01-23
CA2200967C (en) 2007-09-25
ES2316150T3 (es) 2009-04-01
CY2210B1 (en) 2002-11-08
CN1124157C (zh) 2003-10-15
EP0787011A1 (en) 1997-08-06
JPH10509699A (ja) 1998-09-22
HU225535B1 (en) 2007-02-28
NO20031901D0 (no) 2003-04-28
FI970995L (fi) 1997-04-25
AU3924895A (en) 1996-05-23
IL129547A0 (en) 2000-02-29
DE69535869D1 (de) 2008-12-04
PL319691A1 (en) 1997-08-18
SK286178B6 (sk) 2008-04-07
EP2039358A1 (en) 2009-03-25
IL115742A (en) 2000-06-01
NO971898L (no) 1997-06-24
HUT76858A (en) 1997-12-29
AU714360B2 (en) 1999-12-23
JP2005247870A (ja) 2005-09-15
TR199500299A2 (tr) 1997-06-23
NO323078B1 (no) 2006-12-27
TW308544B (enExample) 1997-06-21
KR100518135B1 (ko) 2005-10-04
MY129435A (en) 2007-04-30
NO971898D0 (no) 1997-04-24
WO1996013273A1 (en) 1996-05-09
CZ289838B6 (cs) 2002-04-17
IL115742A0 (en) 1996-01-19
SK52197A3 (en) 1997-09-10

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