ATE126803T1 - Heteroatome enthaltende tricyclische verbindungen. - Google Patents
Heteroatome enthaltende tricyclische verbindungen.Info
- Publication number
- ATE126803T1 ATE126803T1 AT90810854T AT90810854T ATE126803T1 AT E126803 T1 ATE126803 T1 AT E126803T1 AT 90810854 T AT90810854 T AT 90810854T AT 90810854 T AT90810854 T AT 90810854T AT E126803 T1 ATE126803 T1 AT E126803T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- compounds containing
- containing heteroatoms
- tricyclic compounds
- epimerizing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3937336 | 1989-11-09 | ||
DE3938132 | 1989-11-16 | ||
DE3942833 | 1989-12-23 | ||
DE3942831 | 1989-12-23 | ||
DE4006819 | 1990-03-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE126803T1 true ATE126803T1 (de) | 1995-09-15 |
Family
ID=27511355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90810854T ATE126803T1 (de) | 1989-11-09 | 1990-11-07 | Heteroatome enthaltende tricyclische verbindungen. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0427680B1 (de) |
JP (1) | JP2750302B2 (de) |
KR (1) | KR0166074B1 (de) |
AT (1) | ATE126803T1 (de) |
AU (1) | AU640963B2 (de) |
CA (1) | CA2029694C (de) |
DE (2) | DE10299040I2 (de) |
DK (1) | DK0427680T3 (de) |
ES (1) | ES2077663T3 (de) |
GR (1) | GR3017858T3 (de) |
HK (1) | HK30096A (de) |
HU (1) | HU210900A9 (de) |
IE (1) | IE69974B1 (de) |
LU (1) | LU91021I2 (de) |
LV (1) | LV11621B (de) |
MY (1) | MY111430A (de) |
NL (1) | NL300134I2 (de) |
NZ (1) | NZ235991A (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0356399A3 (de) * | 1988-08-26 | 1991-03-20 | Sandoz Ag | Substituierte 4-Azatricyclo (22.3.1.04.9) octacos-18-en-Derivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen |
CA2032159A1 (en) * | 1989-06-14 | 1990-12-15 | Andrew J. F. Edmunds | Heteroatoms-containing tricyclic compounds |
US5208228A (en) * | 1989-11-13 | 1993-05-04 | Merck & Co., Inc. | Aminomacrolides and derivatives having immunosuppressive activity |
MY110418A (en) * | 1990-07-02 | 1998-05-30 | Novartis Ag | Heteroatoms-containing tricyclic compounds. |
EP0480623A1 (de) * | 1990-10-11 | 1992-04-15 | Merck & Co. Inc. | Halomakrolide und Derivate mit immunosuppressiver Wirkung |
US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
US5250678A (en) * | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
WO1992020688A1 (en) * | 1991-05-13 | 1992-11-26 | Merck & Co., Inc. | Amino o-aryl, o-alkyl, o-alkenyl and o-alkynyl macrolides |
US5162334A (en) * | 1991-05-13 | 1992-11-10 | Merck & Co., Inc. | Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity |
US5565560A (en) * | 1991-05-13 | 1996-10-15 | Merck & Co., Inc. | O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
US5189042A (en) * | 1991-08-22 | 1993-02-23 | Merck & Co. Inc. | Fluoromacrolides having immunosuppressive activity |
DE69232630T2 (de) * | 1991-09-05 | 2003-10-09 | Abbott Lab | Makrocyclische immunmodulatoren |
US5708002A (en) * | 1991-09-05 | 1998-01-13 | Abbott Laboratories | Macrocyclic immunomodulators |
US5208241A (en) * | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
US5631235A (en) * | 1992-03-02 | 1997-05-20 | Pfizer, Inc. | 2-Aminosugar derivatives of macrolides |
CA2091194A1 (en) * | 1992-04-08 | 1993-10-09 | Richard D. Connell | 2-oxo-ethyl derivatives as immunosuppressants |
US5284877A (en) * | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkyl and alkenyl macrolides having immunosuppressive activity |
US5284840A (en) * | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkylidene macrolides having immunosuppressive activity |
CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
US5612350A (en) * | 1993-11-30 | 1997-03-18 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
WO1995015328A1 (en) * | 1993-11-30 | 1995-06-08 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
US5880280A (en) * | 1994-06-15 | 1999-03-09 | Merck & Co., Inc. | Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity |
US5550233A (en) * | 1994-06-21 | 1996-08-27 | Merck & Co., Inc. | Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity |
US5693648A (en) * | 1994-09-30 | 1997-12-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity |
US5545734A (en) * | 1994-10-25 | 1996-08-13 | Merck & Co., Inc. | Aryl and heteroaryl macrolides having immunosuppressive activity |
NZ295170A (en) | 1994-10-26 | 1999-02-25 | Novartis Ag | Topical pharmaceutical compositions comprising a fk506 class compound, an unsaturated fatty alcohol, water and diether alcohol, alkanediol or ether diol as a solvent |
IL115742A (en) | 1994-10-26 | 2000-06-01 | Novartis Ag | Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant |
GB9618952D0 (en) * | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
JP3282945B2 (ja) * | 1995-06-07 | 2002-05-20 | 松下電器産業株式会社 | スピンドルモータ |
BE1009856A5 (fr) | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
GB9713730D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
SI1064942T1 (en) | 1998-03-26 | 2004-12-31 | Fujisawa Pharmaceutical Co., Ltd. | Sustained release preparation of a macrolide |
GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
GB0003932D0 (en) * | 2000-02-18 | 2000-04-12 | Novartis Ag | Pharmaceutical compositions |
GB0008785D0 (en) | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
GB0012383D0 (en) * | 2000-05-22 | 2000-07-12 | Novartis Ag | Organic compounds |
AR033151A1 (es) * | 2001-04-12 | 2003-12-03 | Sucampo Pharmaceuticals Inc | Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares |
GB0125443D0 (en) | 2001-10-23 | 2001-12-12 | Novartis Ag | Organic Compounds |
EP2319493A3 (de) | 2002-07-23 | 2011-07-27 | Novartis AG | Ophthalmische Salbenzusammensetzung , einen Wirkstoff, eine Salbengrundlage und eine Löslichkeits-/Dispergierbarkeitsvermittler enthaltend |
EP1585738A2 (de) * | 2002-11-15 | 2005-10-19 | Novartis AG | System zur verabreichung von medikamenten |
BRPI0407350A (pt) * | 2003-02-10 | 2006-01-10 | Novartis Ag | Combinações farmacêuticas compreendendo corticóides e imunosupressores para tratamento de doenças resistentes aos corticóides e/ou inibidores de calcineurina |
AR043504A1 (es) * | 2003-03-17 | 2005-08-03 | Novartis Ag | Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias |
KR20120091378A (ko) | 2004-03-23 | 2012-08-17 | 노파르티스 아게 | 제약 조성물 |
GT200500282A (es) * | 2004-10-12 | 2006-05-04 | Heteroatomos conteniendo compuestos triciclicos. | |
WO2006060615A1 (en) | 2004-12-01 | 2006-06-08 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Non-hygroscopic and powdery amorphous pimecrolimus |
WO2008057511A2 (en) * | 2006-11-06 | 2008-05-15 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
US20100087550A1 (en) | 2008-10-06 | 2010-04-08 | Zora Marlowe | Formulations with a Tertiary Amine Oxide |
US20100106128A1 (en) | 2008-10-23 | 2010-04-29 | Shane Mao | Contact lens cases for delivery of ophthalmic agents |
IT1394309B1 (it) * | 2009-05-22 | 2012-06-06 | Poli Ind Chimica Spa | Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus |
GB0914589D0 (en) * | 2009-08-20 | 2009-09-30 | Biotica Tech Ltd | Novel compounds and methods for their production |
JPWO2016068208A1 (ja) | 2014-10-28 | 2017-08-10 | 晃史 山口 | 妊娠状態を改善するための薬剤及びその利用 |
EP3178824A1 (de) | 2015-12-08 | 2017-06-14 | Medichem, S.A. | Verfahren zur herstellung von pimecrolimus |
CN106074367A (zh) * | 2016-07-20 | 2016-11-09 | 中山大学中山眼科中心 | 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法 |
US10975097B2 (en) | 2017-05-01 | 2021-04-13 | Meda Ab | Process to convert technical ascomycin into purified pimecrolimus |
CN112533599A (zh) | 2018-08-10 | 2021-03-19 | 山口晃史 | 与母体和胎儿的关系中的体液免疫相关的疾病的治疗药 |
AU2019401108A1 (en) | 2018-12-18 | 2021-07-01 | Koushi Yamaguchi | Agent for improving infertility, recurrent miscarriage, and state of pregnancy |
EP3741367A1 (de) | 2019-05-21 | 2020-11-25 | Premark Pharma GmbH | Behandlung von augenerkrankungen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
DE3853477T2 (de) * | 1987-12-09 | 1995-11-09 | Fisons Plc | Makrozyklische verbindungen. |
CA2032159A1 (en) * | 1989-06-14 | 1990-12-15 | Andrew J. F. Edmunds | Heteroatoms-containing tricyclic compounds |
PT98990A (pt) * | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
-
1990
- 1990-11-07 DK DK90810854.1T patent/DK0427680T3/da active
- 1990-11-07 ES ES90810854T patent/ES2077663T3/es not_active Expired - Lifetime
- 1990-11-07 AT AT90810854T patent/ATE126803T1/de active
- 1990-11-07 AU AU65843/90A patent/AU640963B2/en not_active Expired
- 1990-11-07 EP EP90810854A patent/EP0427680B1/de not_active Expired - Lifetime
- 1990-11-07 DE DE2002199040 patent/DE10299040I2/de active Active
- 1990-11-07 NZ NZ235991A patent/NZ235991A/xx unknown
- 1990-11-07 DE DE69021833T patent/DE69021833T2/de not_active Expired - Lifetime
- 1990-11-08 JP JP2305894A patent/JP2750302B2/ja not_active Expired - Lifetime
- 1990-11-08 IE IE402390A patent/IE69974B1/en not_active IP Right Cessation
- 1990-11-08 MY MYPI90001975A patent/MY111430A/en unknown
- 1990-11-08 KR KR1019900018016A patent/KR0166074B1/ko not_active IP Right Cessation
- 1990-11-09 CA CA002029694A patent/CA2029694C/en not_active Expired - Lifetime
-
1995
- 1995-06-02 HU HU95P/P00161P patent/HU210900A9/hu active Protection Beyond IP Right Term
- 1995-10-25 GR GR950402962T patent/GR3017858T3/el unknown
-
1996
- 1996-02-15 HK HK30096A patent/HK30096A/xx not_active IP Right Cessation
- 1996-07-17 LV LVP-96-253A patent/LV11621B/lv unknown
-
2003
- 2003-04-23 LU LU91021C patent/LU91021I2/fr unknown
- 2003-09-05 NL NL300134C patent/NL300134I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
ES2077663T3 (es) | 1995-12-01 |
NZ235991A (en) | 1993-05-26 |
MY111430A (en) | 2000-05-31 |
EP0427680B1 (de) | 1995-08-23 |
DE69021833D1 (de) | 1995-09-28 |
GR3017858T3 (en) | 1996-01-31 |
DE69021833T2 (de) | 1996-03-21 |
HK30096A (en) | 1996-02-23 |
CA2029694C (en) | 2001-05-08 |
LV11621B (en) | 1997-04-20 |
DE10299040I2 (de) | 2006-08-24 |
IE904023A1 (en) | 1991-05-22 |
LV11621A (lv) | 1996-12-20 |
DE10299040I1 (de) | 2003-02-20 |
AU6584390A (en) | 1991-05-23 |
EP0427680A1 (de) | 1991-05-15 |
KR910009711A (ko) | 1991-06-28 |
JP2750302B2 (ja) | 1998-05-13 |
CA2029694A1 (en) | 1991-05-10 |
NL300134I1 (nl) | 2003-11-03 |
IE69974B1 (en) | 1996-10-16 |
KR0166074B1 (ko) | 1999-01-15 |
LU91021I2 (fr) | 2003-06-24 |
DK0427680T3 (da) | 1995-12-18 |
JPH03223291A (ja) | 1991-10-02 |
NL300134I2 (nl) | 2004-05-03 |
AU640963B2 (en) | 1993-09-09 |
HU210900A9 (en) | 1995-09-28 |
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