CN1649848A - 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 - Google Patents
作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 Download PDFInfo
- Publication number
- CN1649848A CN1649848A CNA028107462A CN02810746A CN1649848A CN 1649848 A CN1649848 A CN 1649848A CN A028107462 A CNA028107462 A CN A028107462A CN 02810746 A CN02810746 A CN 02810746A CN 1649848 A CN1649848 A CN 1649848A
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- China
- Prior art keywords
- methyl
- pyrimidine
- dihydro
- pyrrolo
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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Applications Claiming Priority (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0110569.1 | 2001-04-30 | ||
GB0110570A GB0110570D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110569A GB0110569D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110570.9 | 2001-04-30 | ||
GB0110567.5 | 2001-04-30 | ||
GB0110567A GB0110567D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0117401.0 | 2001-07-17 | ||
GB0117401A GB0117401D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117420A GB0117420D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117399.6 | 2001-07-17 | ||
GB0117399A GB0117399D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117420.0 | 2001-07-17 | ||
GB0203201.9 | 2002-02-11 | ||
GB0203201A GB0203201D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
GB0206834.4 | 2002-03-22 | ||
GB0206834A GB0206834D0 (en) | 2002-03-22 | 2002-03-22 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1649848A true CN1649848A (zh) | 2005-08-03 |
Family
ID=27571152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028107462A Pending CN1649848A (zh) | 2001-04-30 | 2002-04-30 | 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 |
Country Status (19)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104193745A (zh) * | 2014-07-30 | 2014-12-10 | 天津市斯芬克司药物研发有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2002100863A1 (en) * | 2001-06-12 | 2002-12-19 | Glaxo Group Limited | Corticotropin releasing factor antagonists |
GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
EP1583531B1 (en) * | 2003-01-16 | 2007-04-18 | SB Pharmco Puerto Rico Inc | Heteroaryl-substituted pyrrolo[2, 3- b]pyridine derivatives as crf receptor antagonists |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
CN100372851C (zh) * | 2003-05-05 | 2008-03-05 | 弗·哈夫曼-拉罗切有限公司 | 具有crf活性的稠合的嘧啶衍生物 |
JP2007501822A (ja) | 2003-08-12 | 2007-02-01 | エフ.ホフマン−ラ ロシュ アーゲー | コルチコトロピン放出性因子(crf)アンタゴニストとしてのスピロ置換テトラヒドロキナゾリン |
CN100398524C (zh) | 2003-08-12 | 2008-07-02 | 弗·哈夫曼-拉罗切有限公司 | 作为crf拮抗剂的四氢喹唑啉衍生物 |
CA2550948A1 (en) * | 2003-12-22 | 2005-07-14 | Sb Pharmco Puerto Rico Inc. | Crf receptor antagonists and methods relating thereto |
CN1910190A (zh) * | 2004-01-06 | 2007-02-07 | 大正制药株式会社 | 环氨基取代的噻吩并嘧啶和噻吩并吡啶衍生物 |
CA2556946A1 (en) * | 2004-03-05 | 2005-09-15 | Taisho Pharmaceutical Co., Ltd. | Pyrrolopyrimidine derivatives |
MEP8409A (en) | 2004-06-02 | 2011-12-20 | Fused heterocyclic compound | |
BRPI0512514A (pt) * | 2004-06-25 | 2008-03-11 | Taisho Pharmaceutical Co Ltd | composto, antagonista para receptores de crf, e, uso de um composto |
GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
WO2006044821A1 (en) * | 2004-10-19 | 2006-04-27 | Sb Pharmco Puerto Rico Inc. | Crf receptor antagonists and methods relating thereto |
US8088779B2 (en) * | 2005-09-30 | 2012-01-03 | Smithkline Beecham (Cork) Limited | Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists |
US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
ATE523499T1 (de) * | 2006-07-06 | 2011-09-15 | Array Biopharma Inc | Cyclopenta [d]-pyrimidine als akt-proteinkinasehemmer |
DE602007011628D1 (de) | 2006-07-06 | 2011-02-10 | Array Biopharma Inc | Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren |
CA2656364C (en) | 2006-07-06 | 2014-11-25 | Array Biopharma Inc. | Dihydrothieno pyrimidines as akt protein kinase inhibitors |
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- 2002-04-30 JP JP2002585397A patent/JP2004528349A/ja active Pending
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104193745A (zh) * | 2014-07-30 | 2014-12-10 | 天津市斯芬克司药物研发有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
CN104193745B (zh) * | 2014-07-30 | 2016-09-28 | 斯芬克司药物研发(天津)股份有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
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HUP0304054A2 (hu) | 2004-04-28 |
MXPA03009938A (es) | 2005-09-07 |
ES2301633T3 (es) | 2008-07-01 |
KR20040015206A (ko) | 2004-02-18 |
CA2446514A1 (en) | 2002-11-07 |
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AR033295A1 (es) | 2003-12-10 |
PL366934A1 (en) | 2005-02-07 |
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AU2002253357B2 (en) | 2006-08-24 |
NO20034836L (no) | 2003-10-29 |
ATE386727T1 (de) | 2008-03-15 |
WO2002088095A1 (en) | 2002-11-07 |
DE60225127D1 (en) | 2008-04-03 |
CZ20032946A3 (en) | 2004-05-12 |
DE60225127T2 (de) | 2009-02-19 |
BR0209267A (pt) | 2004-06-15 |
US7279474B2 (en) | 2007-10-09 |
JP2004528349A (ja) | 2004-09-16 |
EP1383747B1 (en) | 2008-02-20 |
US20040176400A1 (en) | 2004-09-09 |
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