CN1622953A - 肽衍生物及其药学上可接受的盐、其制造法及用途 - Google Patents
肽衍生物及其药学上可接受的盐、其制造法及用途 Download PDFInfo
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- CN1622953A CN1622953A CNA02822647XA CN02822647A CN1622953A CN 1622953 A CN1622953 A CN 1622953A CN A02822647X A CNA02822647X A CN A02822647XA CN 02822647 A CN02822647 A CN 02822647A CN 1622953 A CN1622953 A CN 1622953A
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- acceptable salt
- pharmacy acceptable
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- peptide derivant
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- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
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- 125000004111 sulfinimidoyl group Chemical group [H]\N=S(\*)* 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
- C07C279/32—N-nitroguanidines
- C07C279/36—Substituted N-nitroguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物(实施例号) | 浓度(mol/l) | 酶抑制活性(%) | |
KGP | RGP | ||
3 | 10-4 | 100.0 | 99.4 |
10-5 | 99.9 | 96.8 | |
10-6 | 99.9 | 81.1 |
Claims (19)
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JP352012/2001 | 2001-11-16 | ||
JP2001352012 | 2001-11-16 |
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CN1622953A true CN1622953A (zh) | 2005-06-01 |
CN1274712C CN1274712C (zh) | 2006-09-13 |
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US (1) | US7067476B2 (zh) |
EP (1) | EP1445262B1 (zh) |
JP (1) | JP4006598B2 (zh) |
KR (1) | KR100603948B1 (zh) |
CN (1) | CN1274712C (zh) |
AT (1) | ATE338057T1 (zh) |
AU (1) | AU2002343783B2 (zh) |
CA (1) | CA2465080A1 (zh) |
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WO (1) | WO2003042237A1 (zh) |
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CN101260086B (zh) * | 2007-03-06 | 2011-08-10 | 中国科学院上海药物研究所 | 蛋白酪氨酸磷酸酯酶1b抑制剂及其制备方法和用途 |
JP5397851B2 (ja) * | 2009-05-21 | 2014-01-22 | Nsマテリアルズ株式会社 | ペプチド誘導体又はその塩の製造方法 |
WO2017201322A1 (en) * | 2016-05-19 | 2017-11-23 | Cortexyme, Inc. | Treatment of osteoarthritis with gingipain blocking agents |
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JPH0597708A (ja) | 1991-10-02 | 1993-04-20 | Lion Corp | 歯周病治療剤 |
JPH11139947A (ja) | 1997-11-11 | 1999-05-25 | Sunstar Inc | マトリックスメタロプロテアーゼ阻害剤含有口腔用組成物 |
JP3873429B2 (ja) | 1998-02-20 | 2007-01-24 | 大鵬薬品工業株式会社 | ペプチド誘導体及びその薬学的に許容される塩、その製造方法及びその用途 |
JPH11335274A (ja) | 1998-03-20 | 1999-12-07 | Sagami Chem Res Center | アルギンギパイン阻害剤、歯周病菌生育阻害剤および抗歯周病剤 |
JP2000191487A (ja) | 1998-12-29 | 2000-07-11 | Sunstar Inc | マトリクスメタロプロテア―ゼ阻害用口腔剤組成物及び飲食品組成物 |
ATE420067T1 (de) | 2000-11-06 | 2009-01-15 | Univ Kyushu Nat Univ Corp | Peptid-derivate und ihre pharmazeutisch akzeptablensalze, verfahren zur herstellung von beiden und ihre verwendung |
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Publication number | Publication date |
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CN1274712C (zh) | 2006-09-13 |
EP1445262A1 (en) | 2004-08-11 |
DE60214414D1 (de) | 2006-10-12 |
US7067476B2 (en) | 2006-06-27 |
EP1445262A4 (en) | 2005-06-15 |
JPWO2003042237A1 (ja) | 2005-03-10 |
EP1445262A8 (en) | 2004-10-27 |
ATE338057T1 (de) | 2006-09-15 |
KR20050044448A (ko) | 2005-05-12 |
KR100603948B1 (ko) | 2006-07-24 |
US20040214780A1 (en) | 2004-10-28 |
JP4006598B2 (ja) | 2007-11-14 |
CA2465080A1 (en) | 2003-05-22 |
EP1445262B1 (en) | 2006-08-30 |
DE60214414T2 (de) | 2007-02-22 |
AU2002343783B2 (en) | 2007-01-18 |
WO2003042237A1 (fr) | 2003-05-22 |
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