CN1617739A - 用于治疗呼吸道上皮病变的方法和组合物 - Google Patents

用于治疗呼吸道上皮病变的方法和组合物 Download PDF

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Publication number
CN1617739A
CN1617739A CNA02827590XA CN02827590A CN1617739A CN 1617739 A CN1617739 A CN 1617739A CN A02827590X A CNA02827590X A CN A02827590XA CN 02827590 A CN02827590 A CN 02827590A CN 1617739 A CN1617739 A CN 1617739A
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CN
China
Prior art keywords
composition
trefoil
seq
trefoil peptide
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA02827590XA
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English (en)
Chinese (zh)
Inventor
D·K·波多尔斯基
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General Hospital Corp
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General Hospital Corp
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Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of CN1617739A publication Critical patent/CN1617739A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA02827590XA 2001-11-28 2002-11-27 用于治疗呼吸道上皮病变的方法和组合物 Pending CN1617739A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33383601P 2001-11-28 2001-11-28
US60/333,836 2001-11-28

Publications (1)

Publication Number Publication Date
CN1617739A true CN1617739A (zh) 2005-05-18

Family

ID=23304463

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA02827590XA Pending CN1617739A (zh) 2001-11-28 2002-11-27 用于治疗呼吸道上皮病变的方法和组合物

Country Status (8)

Country Link
US (2) US20030114384A1 (enExample)
EP (1) EP1461076A4 (enExample)
JP (1) JP2005532988A (enExample)
CN (1) CN1617739A (enExample)
AU (1) AU2002351181B2 (enExample)
CA (1) CA2468344A1 (enExample)
MX (1) MXPA04005053A (enExample)
WO (1) WO2003045332A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103096917A (zh) * 2010-06-04 2013-05-08 三叶草私人有限公司 用于治疗慢性肺病的三叶因子（tff）
CN105582526A (zh) * 2016-02-25 2016-05-18 上海市公共卫生临床中心 三叶因子2在制备治疗及预防肺/支气管急性炎症疾病药物方面的应用
WO2021195883A1 (zh) * 2020-03-30 2021-10-07 山东睿鹰制药集团有限公司 TFF2蛋白和IFN-κ蛋白联用在治疗新型冠状病毒感染中的应用

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) * 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
US20030185838A1 (en) * 2001-11-28 2003-10-02 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
US20030186882A1 (en) * 2001-07-31 2003-10-02 Podolsky Daniel K. Methods and compositions for treating and preventing distal bowel lesions
US6610043B1 (en) 1999-08-23 2003-08-26 Bistech, Inc. Tissue volume reduction
US7654998B1 (en) 1999-08-23 2010-02-02 Aeris Therapeutics, Inc. Tissue volume reduction
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
MXPA04003267A (es) * 2001-10-05 2004-07-08 Gen Hospital Corp Metodos y composiciones para tratar lesiones dermicas.
JP2005522465A (ja) * 2002-03-11 2005-07-28 エアリス セラピューティクス，インコーポレイテッド 気腫を治療するための組成物および方法
JP2005527547A (ja) * 2002-03-26 2005-09-15 ザ ジェネラル ホスピタル コーポレーション トレフォイル・ペプチドを使用した組み合わせ療法
US20060188471A1 (en) * 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
JP2006516035A (ja) * 2003-01-17 2006-06-15 チルドレンズ ホスピタル メディカル センター アレルギー治療におけるｔｆｆ２、またはｔｆｆ２誘導剤の使用
WO2005097095A1 (en) * 2004-04-05 2005-10-20 Sepracor Inc. (r,r)-formoterol in combination with other pharmacological agents
US8075771B2 (en) * 2005-02-17 2011-12-13 E. I. Du Pont De Nemours And Company Apparatus for magnetic field gradient enhanced centrifugation
WO2008073627A2 (en) * 2006-11-03 2008-06-19 Alba Therapeutics Corporation Method of diagnosing and treating asthma
US9044391B2 (en) * 2007-01-10 2015-06-02 Board Of Regents, The University Of Texas System Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery
US20110201543A1 (en) * 2007-06-29 2011-08-18 Blake Paterson Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress
US8580787B2 (en) * 2008-08-01 2013-11-12 Eye Therapies Llc Compositions and methods for reducing activation of alpha-1 receptors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002A (en) * 1841-03-12 Tor and planter for plowing
US4370317A (en) * 1980-09-10 1983-01-25 Novo Industri A/S Pancreatic spasmolytic polypeptide
CA2104104A1 (en) * 1991-02-14 1992-09-03 Daniel K. Podolsky Intestinal trefoil proteins
US6221840B1 (en) * 1991-02-14 2001-04-24 The General Hospital Corporation Intestinal trefoil proteins
US6063755A (en) * 1991-02-14 2000-05-16 The General Hospital Corporation Intestinal trefoil proteins
DK6893D0 (da) * 1993-01-21 1993-01-21 Novo Nordisk As Peptid
US5563046A (en) * 1993-08-02 1996-10-08 Celtrix Pharmaceuticals, Inc. Fusion polypeptides and proteins
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
US6426404B1 (en) * 1997-08-25 2002-07-30 The General Hospital Corporation Receptor for intestinal trefoil factor
NZ527232A (en) * 1998-08-26 2005-03-24 Smithkline Beecham Corp A composition contaning a PDE 4 inhibitor and a beta adrenergic bronchodilator useful for treating pulmonary diseases
US6372439B2 (en) * 1998-10-01 2002-04-16 James R. Goldenring Screen for gastric adenocarcinoma
WO2001046475A1 (en) * 1999-12-23 2001-06-28 Human Genome Sciences, Inc. Trefoil domain-containing polynucleotides, polypeptides, and antibodies
AU2002221565A1 (en) * 2000-12-08 2002-06-18 Novo-Nordisk A/S Trefoil factor 2 (tff2) peptides with moiety attached to asn15
MXPA03009772A (es) * 2001-04-24 2004-02-23 Gen Hospital Corp Metodos y composiciones para tratar lesiones orales y del esofago.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103096917A (zh) * 2010-06-04 2013-05-08 三叶草私人有限公司 用于治疗慢性肺病的三叶因子（tff）
CN105582526A (zh) * 2016-02-25 2016-05-18 上海市公共卫生临床中心 三叶因子2在制备治疗及预防肺/支气管急性炎症疾病药物方面的应用
CN105582526B (zh) * 2016-02-25 2020-07-17 山东睿鹰制药集团有限公司 三叶因子2在制备治疗及预防肺/支气管急性炎症疾病药物方面的应用
WO2021195883A1 (zh) * 2020-03-30 2021-10-07 山东睿鹰制药集团有限公司 TFF2蛋白和IFN-κ蛋白联用在治疗新型冠状病毒感染中的应用

Also Published As

Publication number Publication date
EP1461076A4 (en) 2005-03-09
CA2468344A1 (en) 2003-06-05
WO2003045332A2 (en) 2003-06-05
WO2003045332A3 (en) 2003-07-24
AU2002351181B2 (en) 2008-08-07
MXPA04005053A (es) 2004-09-10
US20080167230A1 (en) 2008-07-10
EP1461076A2 (en) 2004-09-29
AU2002351181A1 (en) 2003-06-10
JP2005532988A (ja) 2005-11-04
US20030114384A1 (en) 2003-06-19

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