CN1612739A - 治疗或预防炎性疾病的方法 - Google Patents
治疗或预防炎性疾病的方法 Download PDFInfo
- Publication number
- CN1612739A CN1612739A CNA028267281A CN02826728A CN1612739A CN 1612739 A CN1612739 A CN 1612739A CN A028267281 A CNA028267281 A CN A028267281A CN 02826728 A CN02826728 A CN 02826728A CN 1612739 A CN1612739 A CN 1612739A
- Authority
- CN
- China
- Prior art keywords
- uridine
- phosphoric acid
- amino
- group
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 60
- 208000027866 inflammatory disease Diseases 0.000 title claims abstract description 26
- -1 nucleoside diphosphate Chemical class 0.000 claims abstract description 79
- 239000002773 nucleotide Substances 0.000 claims abstract description 27
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 27
- 230000002757 inflammatory effect Effects 0.000 claims abstract description 20
- 201000010105 allergic rhinitis Diseases 0.000 claims abstract description 19
- 206010039085 Rhinitis allergic Diseases 0.000 claims abstract description 18
- 206010039094 Rhinitis perennial Diseases 0.000 claims abstract description 16
- 239000002777 nucleoside Substances 0.000 claims abstract description 16
- 208000022719 perennial allergic rhinitis Diseases 0.000 claims abstract description 16
- 229920000388 Polyphosphate Polymers 0.000 claims abstract description 14
- 239000001205 polyphosphate Substances 0.000 claims abstract description 14
- 235000011176 polyphosphates Nutrition 0.000 claims abstract description 14
- 239000000018 receptor agonist Substances 0.000 claims abstract description 13
- 229940044601 receptor agonist Drugs 0.000 claims abstract description 13
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims abstract description 12
- 208000002205 allergic conjunctivitis Diseases 0.000 claims abstract description 12
- 208000024998 atopic conjunctivitis Diseases 0.000 claims abstract description 11
- 208000015181 infectious disease Diseases 0.000 claims abstract description 11
- 206010039083 rhinitis Diseases 0.000 claims abstract description 11
- 208000006673 asthma Diseases 0.000 claims abstract description 7
- 239000001177 diphosphate Substances 0.000 claims abstract description 7
- 235000011180 diphosphates Nutrition 0.000 claims abstract description 7
- 201000009890 sinusitis Diseases 0.000 claims abstract description 6
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 claims abstract description 5
- 206010010741 Conjunctivitis Diseases 0.000 claims abstract description 5
- 201000004624 Dermatitis Diseases 0.000 claims abstract description 5
- 208000029147 Collagen-vascular disease Diseases 0.000 claims abstract description 4
- 206010018364 Glomerulonephritis Diseases 0.000 claims abstract description 4
- 230000002458 infectious effect Effects 0.000 claims abstract description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 205
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims description 173
- 229940045145 uridine Drugs 0.000 claims description 131
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims description 130
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims description 130
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 103
- 229940048102 triphosphoric acid Drugs 0.000 claims description 70
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims description 65
- 150000001875 compounds Chemical class 0.000 claims description 54
- 125000000217 alkyl group Chemical group 0.000 claims description 50
- 125000003118 aryl group Chemical group 0.000 claims description 46
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 36
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- 208000024891 symptom Diseases 0.000 claims description 31
- 229910052739 hydrogen Inorganic materials 0.000 claims description 30
- 125000003545 alkoxy group Chemical group 0.000 claims description 29
- 229910052760 oxygen Inorganic materials 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 24
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 24
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 23
- 125000004414 alkyl thio group Chemical group 0.000 claims description 20
- 125000005110 aryl thio group Chemical group 0.000 claims description 20
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 claims description 19
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 claims description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
- PGAVKCOVUIYSFO-XVFCMESISA-N UTP Chemical group O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-XVFCMESISA-N 0.000 claims description 18
- 125000004104 aryloxy group Chemical group 0.000 claims description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 18
- 150000002431 hydrogen Chemical class 0.000 claims description 18
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- 125000001424 substituent group Chemical group 0.000 claims description 17
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- 229910052736 halogen Inorganic materials 0.000 claims description 14
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- 125000004442 acylamino group Chemical group 0.000 claims description 13
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- 229940097496 nasal spray Drugs 0.000 claims description 13
- 239000007922 nasal spray Substances 0.000 claims description 13
- 229910052757 nitrogen Chemical group 0.000 claims description 13
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 13
- 125000003107 substituted aryl group Chemical group 0.000 claims description 13
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims description 12
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims description 12
- 125000000304 alkynyl group Chemical group 0.000 claims description 12
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 12
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- VGONTNSXDCQUGY-UHFFFAOYSA-N desoxyinosine Natural products C1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 VGONTNSXDCQUGY-UHFFFAOYSA-N 0.000 claims description 12
- 230000002265 prevention Effects 0.000 claims description 11
- 125000002252 acyl group Chemical group 0.000 claims description 10
- 239000002269 analeptic agent Substances 0.000 claims description 10
- SKOLWUPSYHWYAM-UHFFFAOYSA-N carbonodithioic O,S-acid Chemical compound SC(S)=O SKOLWUPSYHWYAM-UHFFFAOYSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 229920006395 saturated elastomer Polymers 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9
- 125000003282 alkyl amino group Chemical group 0.000 claims description 9
- 125000003435 aroyl group Chemical group 0.000 claims description 9
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Natural products NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 9
- 229940104302 cytosine Drugs 0.000 claims description 9
- MWEQTWJABOLLOS-UHFFFAOYSA-L disodium;[[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;trihydrate Chemical compound O.O.O.[Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C1O MWEQTWJABOLLOS-UHFFFAOYSA-L 0.000 claims description 9
- OLXZPDWKRNYJJZ-UHFFFAOYSA-N 2'-dA Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(CO)O1 OLXZPDWKRNYJJZ-UHFFFAOYSA-N 0.000 claims description 8
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 8
- PCDQPRRSZKQHHS-XVFCMESISA-N CTP Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 PCDQPRRSZKQHHS-XVFCMESISA-N 0.000 claims description 8
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims description 8
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 8
- 125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 claims description 8
- 125000002883 imidazolyl group Chemical group 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 7
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 7
- 150000001408 amides Chemical class 0.000 claims description 7
- 239000000460 chlorine Substances 0.000 claims description 7
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- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims description 7
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- 239000000825 pharmaceutical preparation Substances 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 7
- YKBGVTZYEHREMT-UHFFFAOYSA-N 2'-deoxyguanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1CC(O)C(CO)O1 YKBGVTZYEHREMT-UHFFFAOYSA-N 0.000 claims description 6
- FCZOVUJWOBSMSS-UHFFFAOYSA-N 5-[(6-aminopurin-9-yl)methyl]-5-methyl-3-methylideneoxolan-2-one Chemical compound C1=NC2=C(N)N=CN=C2N1CC1(C)CC(=C)C(=O)O1 FCZOVUJWOBSMSS-UHFFFAOYSA-N 0.000 claims description 6
- CKTSBUTUHBMZGZ-UHFFFAOYSA-N Deoxycytidine Natural products O=C1N=C(N)C=CN1C1OC(CO)C(O)C1 CKTSBUTUHBMZGZ-UHFFFAOYSA-N 0.000 claims description 6
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- 125000004423 acyloxy group Chemical group 0.000 claims description 6
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- 125000005843 halogen group Chemical group 0.000 claims description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
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- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims description 5
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33782801P | 2001-11-06 | 2001-11-06 | |
| US60/337,828 | 2001-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1612739A true CN1612739A (zh) | 2005-05-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA028267281A Pending CN1612739A (zh) | 2001-11-06 | 2002-11-06 | 治疗或预防炎性疾病的方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7256183B2 (enExample) |
| EP (1) | EP1450820A4 (enExample) |
| JP (1) | JP2005532254A (enExample) |
| KR (1) | KR20050043761A (enExample) |
| CN (1) | CN1612739A (enExample) |
| AR (1) | AR037263A1 (enExample) |
| BR (1) | BR0213897A (enExample) |
| CA (1) | CA2465894A1 (enExample) |
| MX (1) | MXPA04004215A (enExample) |
| TW (1) | TW200300692A (enExample) |
| WO (1) | WO2003039473A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106102773A (zh) * | 2013-11-27 | 2016-11-09 | 全球橡果有限公司 | 组合物 |
| CN106163561A (zh) * | 2013-11-27 | 2016-11-23 | 全球橡果有限公司 | 组合物 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003028712A2 (en) * | 2001-09-28 | 2003-04-10 | Universite Libre De Bruxelles | Purinergic and pyrimidinergic receptor agonists for the treatment of activated cd4+ t lymphocyte-mediated immune diseases |
| US20060177517A1 (en) * | 2003-02-26 | 2006-08-10 | Toshikazu Shiba | Antiinflammtory agent and antiinflammatory medical material |
| GB0417886D0 (en) * | 2004-08-11 | 2004-09-15 | Univ Cardiff | Method and means for enhanced pulmonary delivery |
| SE529064C2 (sv) * | 2005-01-03 | 2007-04-24 | Selectica Pharmaceuticals Ab | Topiska kompositioner |
| GB0502250D0 (en) * | 2005-02-03 | 2005-03-09 | Ic Vec Ltd | Use |
| WO2007041495A2 (en) * | 2005-09-29 | 2007-04-12 | University Of California, San Diego | Dampening humoral and innate immunity by inhibition of ppgalnact-1 |
| US8618074B2 (en) * | 2007-03-15 | 2013-12-31 | Board Of Regents Of The University Of Texas System | GPCR enhanced neuroprotection to treat brain injury |
| US8168597B2 (en) * | 2008-10-22 | 2012-05-01 | Inspire Pharmaceuticals, Inc. | Method for treating cystic fibrosis |
| GB201209244D0 (en) * | 2012-05-25 | 2012-07-04 | Globalacorn Ltd | Compositions |
| US10111904B2 (en) * | 2013-01-09 | 2018-10-30 | Berlock Aps | Micron-sized gold, kit comprising said gold and its use as a non-toxic immune suppressor |
| US20150031712A1 (en) * | 2013-03-12 | 2015-01-29 | Moshe Rogosnitzky | Therapeutic Compositions Containing Dipyridamole and Treatment Packs Including Such Compositions and Methods for Producing Same |
Family Cites Families (26)
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| US5292498A (en) | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| US6255059B1 (en) | 1993-03-31 | 2001-07-03 | Cadus Pharmaceutical Corporation | Methods for identifying G protein coupled receptor effectors |
| US5656256A (en) | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
| US6147056A (en) * | 1995-06-06 | 2000-11-14 | Trustees Of Boston University | Use of locally applied DNA fragments |
| US5635160A (en) | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5628984A (en) | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US6423694B1 (en) | 1996-02-21 | 2002-07-23 | Inspire Pharmaceuticals, Inc. | Method of treating otitis media with uridine triphosphates and related compounds |
| US5900407A (en) | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| AU727314B2 (en) | 1996-03-27 | 2000-12-07 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds |
| US5837861A (en) | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| US5789391A (en) | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
| US5968913A (en) | 1996-07-03 | 1999-10-19 | Inspire Pharmaceuticals, Inc. | Pharmaceutical compositions of uridine triphosphate |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| WO1998015835A1 (en) | 1996-10-08 | 1998-04-16 | Inspire Pharmaceuticals, Inc. | Method of early lung cancer detection via sputum induction and analysis of sputum to detect cancer associated substances |
| EP0929218A4 (en) * | 1996-10-30 | 2001-05-16 | Univ North Carolina | P2Y RECEPTOR ANTAGONISTS |
| US6159952A (en) | 1996-11-07 | 2000-12-12 | Inspire Pharmaceuticals, Inc. | Method of treating bronchitis with uridine triphosphate and related compounds |
| ES2264197T3 (es) * | 1997-02-06 | 2006-12-16 | Inspire Pharmaceuticals, Inc. | Dinucleotidos y sus usos. |
| US6372724B1 (en) * | 1997-03-25 | 2002-04-16 | Duska Scientific Co. | Modulation of human mast cell activation |
| US6462028B2 (en) | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
| US6143279A (en) * | 1997-08-29 | 2000-11-07 | The University Of North Carolina At Chapel Hill | Uridine 5'-diphosphate and analogs useful for treating lung diseases |
| JP4633927B2 (ja) * | 1998-05-22 | 2011-02-16 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 治療用ジヌクレオチドおよび誘導体 |
| US6264975B1 (en) * | 1998-10-20 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| WO2000050024A2 (en) * | 1999-02-26 | 2000-08-31 | Inspire Pharmaceuticals, Inc. | Method of promoting mucosal hydration with certain uridine, adenine and cytidine diphosphates and analogs thereof |
| CN1413113A (zh) * | 1999-12-22 | 2003-04-23 | 印斯拜尔药品股份有限公司 | 使用嘌呤能受体激动剂治疗胃肠道疾病的方法 |
| US6610274B1 (en) * | 2000-12-22 | 2003-08-26 | Wallace J. Gardner | Anti-inflammatory composition comprising tetracycline |
| EP1432426A2 (en) * | 2001-09-05 | 2004-06-30 | ACTIAL Farmaceutica Lda. | USE OF UNMETHYLATED CpG |
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2002
- 2002-11-06 CN CNA028267281A patent/CN1612739A/zh active Pending
- 2002-11-06 TW TW091132682A patent/TW200300692A/zh unknown
- 2002-11-06 EP EP02789499A patent/EP1450820A4/en not_active Withdrawn
- 2002-11-06 AR ARP020104238A patent/AR037263A1/es unknown
- 2002-11-06 MX MXPA04004215A patent/MXPA04004215A/es active IP Right Grant
- 2002-11-06 WO PCT/US2002/035775 patent/WO2003039473A2/en not_active Ceased
- 2002-11-06 BR BRPI0213897-2A patent/BR0213897A/pt not_active IP Right Cessation
- 2002-11-06 JP JP2003541765A patent/JP2005532254A/ja active Pending
- 2002-11-06 KR KR1020047006855A patent/KR20050043761A/ko not_active Withdrawn
- 2002-11-06 CA CA002465894A patent/CA2465894A1/en not_active Abandoned
- 2002-11-06 US US10/290,213 patent/US7256183B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106102773A (zh) * | 2013-11-27 | 2016-11-09 | 全球橡果有限公司 | 组合物 |
| CN106163561A (zh) * | 2013-11-27 | 2016-11-23 | 全球橡果有限公司 | 组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0213897A (pt) | 2006-05-23 |
| WO2003039473A3 (en) | 2003-10-23 |
| MXPA04004215A (es) | 2004-07-08 |
| CA2465894A1 (en) | 2003-05-15 |
| EP1450820A2 (en) | 2004-09-01 |
| JP2005532254A (ja) | 2005-10-27 |
| WO2003039473A2 (en) | 2003-05-15 |
| TW200300692A (en) | 2003-06-16 |
| US20030125299A1 (en) | 2003-07-03 |
| EP1450820A4 (en) | 2009-02-18 |
| KR20050043761A (ko) | 2005-05-11 |
| US7256183B2 (en) | 2007-08-14 |
| AR037263A1 (es) | 2004-11-03 |
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