JP2005503358A5 - - Google Patents
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- JP2005503358A5 JP2005503358A5 JP2003506646A JP2003506646A JP2005503358A5 JP 2005503358 A5 JP2005503358 A5 JP 2005503358A5 JP 2003506646 A JP2003506646 A JP 2003506646A JP 2003506646 A JP2003506646 A JP 2003506646A JP 2005503358 A5 JP2005503358 A5 JP 2005503358A5
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- JP
- Japan
- Prior art keywords
- nucleoside
- hiv
- triphosphate
- chem
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 2-Fluoroadenosine-5′-phosphate ester Chemical class 0.000 description 37
- 239000001226 triphosphate Substances 0.000 description 16
- 235000011178 triphosphate Nutrition 0.000 description 15
- 229910052717 sulfur Inorganic materials 0.000 description 14
- 238000003786 synthesis reaction Methods 0.000 description 14
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- 239000002773 nucleotide Substances 0.000 description 10
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- 239000000651 prodrug Substances 0.000 description 10
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- 125000003835 nucleoside group Chemical group 0.000 description 9
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- 229910019142 PO4 Inorganic materials 0.000 description 8
- 125000003118 aryl group Chemical group 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
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| CZ301182B6 (cs) | 2000-05-26 | 2009-12-02 | Idenix (Cayman) Limited | Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry |
| EP2141244A1 (en) * | 2000-10-18 | 2010-01-06 | Pharmasset, Inc. | Multiplex quantification of nucleic acids in diseased cells |
| US7105499B2 (en) | 2001-01-22 | 2006-09-12 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| US8481712B2 (en) | 2001-01-22 | 2013-07-09 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| HUP0400726A3 (en) | 2001-01-22 | 2007-05-29 | Merck & Co Inc | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2003037860A2 (en) | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
| WO2004002422A2 (en) | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| ES2624353T3 (es) | 2002-11-15 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
| WO2004087169A1 (en) * | 2003-03-27 | 2004-10-14 | Boehringer Ingelheim International Gmbh | Antiviral combination of nevirapine and a further antiretroviral compound |
| EP4032897B1 (en) | 2003-05-30 | 2025-01-29 | Gilead Pharmasset LLC | Modified fluorinated nucleoside analogues |
| EA010160B1 (ru) | 2003-09-18 | 2008-06-30 | Конформа Терапьютикс Корпорейшн | Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения |
| JP2005289964A (ja) * | 2004-03-12 | 2005-10-20 | Ajinomoto Co Inc | ２−デオキシ−ｌ−リボース化合物の製造方法 |
| GB0505781D0 (en) | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
| KR20080004550A (ko) | 2005-03-30 | 2008-01-09 | 콘포마 세러퓨틱스 코포레이션 | Ｈｓｐ９０-억제제로서 알키닐 피롤로피리미딘 및 관련유사체 |
| US8569478B2 (en) | 2005-09-26 | 2013-10-29 | Gilead Pharmasset Llc | Modified 4′-nucleosides as antiviral agents |
| JP5254033B2 (ja) | 2005-12-23 | 2013-08-07 | イデニク プハルマセウティカルス，インコーポレイテッド | 分岐型ヌクレオシドを調製するための合成中間体の製造方法 |
| CA2717788A1 (en) * | 2007-07-09 | 2009-01-15 | Eastern Virginia Medical School | Substituted nucleoside derivatives with antiviral and antimicrobial properties |
| WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| AU2012242978A1 (en) | 2011-04-13 | 2013-10-24 | Merck Sharp & Dohme Corp. | 2'-Cyano Substituted Nucleoside Derivatives and methods of use thereof for the treatment of viral diseases |
| BR112013026345A2 (pt) | 2011-04-13 | 2019-04-24 | Merck Sharp & Dohe Corp. | composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv |
| US9408863B2 (en) | 2011-07-13 | 2016-08-09 | Merck Sharp & Dohme Corp. | 5′-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases |
| US9416154B2 (en) | 2011-07-13 | 2016-08-16 | Merck Sharp & Dohme Corp. | 5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| MD20140094A2 (ro) | 2012-02-14 | 2015-03-31 | University Of Georgia Research Foundation, Inc. | Spiro [2.4]heptani pentru tratamentul infecţiilor cauzate de Flaviviridae |
| CN104203969B (zh) | 2012-03-28 | 2016-08-31 | 富士胶片株式会社 | 1-(2-脱氧-2-氟-4-硫代-β-D-阿拉伯呋喃糖基)胞嘧啶的盐 |
| CN107011168B (zh) | 2012-08-13 | 2020-06-09 | 富士胶片株式会社 | 胞嘧啶类的合成中间体和硫代核苷的合成中间体 |
| CN106061959B (zh) * | 2014-02-18 | 2018-11-09 | 富士胶片株式会社 | 四氢噻吩骨架型糖化合物的制造方法及四氢噻吩骨架型糖化合物 |
| JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
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| AU2017319260B2 (en) | 2016-08-31 | 2020-01-30 | Fujifilm Corporation | Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit |
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-
2002
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- 2002-06-24 BR BR0210594-2A patent/BR0210594A/pt not_active IP Right Cessation
- 2002-06-24 US US10/179,612 patent/US6949522B2/en not_active Expired - Fee Related
- 2002-06-24 KR KR1020037016775A patent/KR20050059975A/ko not_active Ceased
- 2002-06-24 CN CNB028164555A patent/CN100343268C/zh not_active Expired - Fee Related
- 2002-06-24 WO PCT/US2002/020245 patent/WO2003000200A2/en not_active Ceased
- 2002-06-24 EP EP02756310A patent/EP1478322A4/en not_active Withdrawn
- 2002-06-24 AU AU2002322325A patent/AU2002322325A1/en not_active Abandoned
- 2002-06-24 CA CA002451745A patent/CA2451745A1/en not_active Abandoned
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