JP2005503358A5 - - Google Patents
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- JP2005503358A5 JP2005503358A5 JP2003506646A JP2003506646A JP2005503358A5 JP 2005503358 A5 JP2005503358 A5 JP 2005503358A5 JP 2003506646 A JP2003506646 A JP 2003506646A JP 2003506646 A JP2003506646 A JP 2003506646A JP 2005503358 A5 JP2005503358 A5 JP 2005503358A5
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- JP
- Japan
- Prior art keywords
- nucleoside
- hiv
- triphosphate
- chem
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 2-Fluoroadenosine-5′-phosphate ester Chemical class 0.000 description 37
- 239000001226 triphosphate Substances 0.000 description 16
- 235000011178 triphosphate Nutrition 0.000 description 15
- 229910052717 sulfur Inorganic materials 0.000 description 14
- 238000003786 synthesis reaction Methods 0.000 description 14
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- 239000002773 nucleotide Substances 0.000 description 10
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- 239000000651 prodrug Substances 0.000 description 10
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- 125000003835 nucleoside group Chemical group 0.000 description 9
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- 229910019142 PO4 Inorganic materials 0.000 description 8
- 125000003118 aryl group Chemical group 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
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| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
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| EP1360325A2 (en) * | 2000-10-18 | 2003-11-12 | Pharmasset Limited | Multiplex quantification of nucleic acids in diseased cells |
| US8481712B2 (en) | 2001-01-22 | 2013-07-09 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| EP1355916B1 (en) | 2001-01-22 | 2007-01-10 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| US7105499B2 (en) | 2001-01-22 | 2006-09-12 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| AU2002343604C1 (en) | 2001-10-30 | 2009-09-17 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
| MXPA04012802A (es) | 2002-06-28 | 2005-04-19 | Idenix Cayman Ltd | Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae. |
| US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
| ES2624353T3 (es) | 2002-11-15 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
| EP1610797A1 (en) * | 2003-03-27 | 2006-01-04 | Boehringer Ingelheim International GmbH | Antiviral combination of nevirapine and a further antiretroviral compound |
| EP2345658A1 (en) | 2003-05-30 | 2011-07-20 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| WO2005028434A2 (en) | 2003-09-18 | 2005-03-31 | Conforma Therapeutics Corporation | Novel heterocyclic compounds as hsp90-inhibitors |
| JP2005289964A (ja) * | 2004-03-12 | 2005-10-20 | Ajinomoto Co Inc | ２−デオキシ−ｌ−リボース化合物の製造方法 |
| GB0505781D0 (en) * | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
| KR20080004550A (ko) | 2005-03-30 | 2008-01-09 | 콘포마 세러퓨틱스 코포레이션 | Ｈｓｐ９０-억제제로서 알키닐 피롤로피리미딘 및 관련유사체 |
| CA2623522C (en) | 2005-09-26 | 2015-12-08 | Pharmasset, Inc. | Modified 4'-nucleosides as antiviral agents |
| WO2007075876A2 (en) | 2005-12-23 | 2007-07-05 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| CA2717788A1 (en) * | 2007-07-09 | 2009-01-15 | Eastern Virginia Medical School | Substituted nucleoside derivatives with antiviral and antimicrobial properties |
| WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| JP2014511875A (ja) | 2011-04-13 | 2014-05-19 | メルク・シャープ・アンド・ドーム・コーポレーション | ２’−シアノ置換ヌクレオシド誘導体およびウイルス疾患の治療のためのその使用方法 |
| BR112013026345A2 (pt) | 2011-04-13 | 2019-04-24 | Merck Sharp & Dohe Corp. | composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv |
| WO2013009735A1 (en) | 2011-07-13 | 2013-01-17 | Merck Sharp & Dohme Corp. | 5'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| EP2731433A4 (en) | 2011-07-13 | 2014-12-31 | Merck Sharp & Dohme | 5'-SUBSTITUTED NUCLEOSIDE ANALOGA AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES |
| WO2013123138A2 (en) | 2012-02-14 | 2013-08-22 | University Of Georgia Research Foundation, Inc. | Spiro [2.4]heptanes for treatment of flaviviridae infections |
| WO2013146833A1 (ja) | 2012-03-28 | 2013-10-03 | 富士フイルム株式会社 | １－（２－デオキシ－２－フルオロ－４－チオ－β－Ｄ－アラビノフラノシル）シトシンの塩 |
| DK2883866T3 (da) | 2012-08-13 | 2019-05-13 | Fujifilm Corp | MELLEMPRODUKT TIL SYNTESE AF 1-(2-DEOXY-2-FLUOR-4-THIO-beta-D- ARABINOFURANOSYL)CYTOSIN, MELLEMPRODUKT TIL SYNTESE AF THIONUKLEOSID OG FREMGANGSMÅDER TIL FREMSTILLING AF DISSE MELLEMPRODUKTER |
| JP6175553B2 (ja) * | 2014-02-18 | 2017-08-09 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| CN107427530B (zh) | 2015-03-06 | 2020-09-08 | 阿堤亚制药公司 | 用于HCV治疗的β-D-2’-脱氧-2’α-氟-2’-β-C-取代的-2-改性的-N6-取代的嘌呤核苷酸 |
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| CN109689672B (zh) | 2016-09-07 | 2023-05-30 | 阿堤亚制药公司 | 用于rna病毒治疗的2’-取代的-n6-取代的嘌呤核苷酸 |
| GEP20227457B (en) | 2017-02-01 | 2023-01-10 | Atea Pharmaceuticals Inc | Nucleotide hemi-sulfate salt for treatment of hepatitis c virus |
| TW201932119A (zh) | 2018-01-29 | 2019-08-16 | 日商富士軟片股份有限公司 | 膽道癌用抗腫瘤劑和膽道癌的處理方法 |
| JP2021521118A (ja) | 2018-04-10 | 2021-08-26 | アテア ファーマシューティカルズ， インコーポレイテッド | 肝硬変を伴うｈｃｖ感染患者の治療 |
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-
2002
- 2002-06-24 BR BR0210594-2A patent/BR0210594A/pt not_active IP Right Cessation
- 2002-06-24 WO PCT/US2002/020245 patent/WO2003000200A2/en not_active Ceased
- 2002-06-24 KR KR1020037016775A patent/KR20050059975A/ko not_active Ceased
- 2002-06-24 EP EP02756310A patent/EP1478322A4/en not_active Withdrawn
- 2002-06-24 JP JP2003506646A patent/JP2005503358A/ja active Pending
- 2002-06-24 US US10/179,612 patent/US6949522B2/en not_active Expired - Fee Related
- 2002-06-24 CN CNB028164555A patent/CN100343268C/zh not_active Expired - Fee Related
- 2002-06-24 CA CA002451745A patent/CA2451745A1/en not_active Abandoned
- 2002-06-24 AU AU2002322325A patent/AU2002322325A1/en not_active Abandoned
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