CN1592624A - 被取代的三唑并嘧啶类化合物作为抗癌药 - Google Patents

被取代的三唑并嘧啶类化合物作为抗癌药 Download PDF

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Publication number
CN1592624A
CN1592624A CNA018120555A CN01812055A CN1592624A CN 1592624 A CN1592624 A CN 1592624A CN A018120555 A CNA018120555 A CN A018120555A CN 01812055 A CN01812055 A CN 01812055A CN 1592624 A CN1592624 A CN 1592624A
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CN
China
Prior art keywords
chloro
carbon atoms
triazolo
pyrimidine
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA018120555A
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English (en)
Chinese (zh)
Inventor
M·R·施密特
D·R·柯施
J·E·哈里斯
C·F·贝耶尔
K·－J·佩斯
P·卡特尔
W·普夫伦格勒
G·阿尔伯特
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Wyeth LLC
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Wyeth LLC
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Publication of CN1592624A publication Critical patent/CN1592624A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNA018120555A 2000-06-30 2001-06-28 被取代的三唑并嘧啶类化合物作为抗癌药 Pending CN1592624A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
US60/215,585 2000-06-30

Publications (1)

Publication Number Publication Date
CN1592624A true CN1592624A (zh) 2005-03-09

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA018120555A Pending CN1592624A (zh) 2000-06-30 2001-06-28 被取代的三唑并嘧啶类化合物作为抗癌药

Country Status (24)

Country Link
US (1) US7329663B2 (https=)
EP (1) EP1307200A2 (https=)
JP (1) JP2004502691A (https=)
KR (1) KR20030013475A (https=)
CN (1) CN1592624A (https=)
AR (1) AR034553A1 (https=)
AU (2) AU2001273062B2 (https=)
BG (1) BG107277A (https=)
BR (1) BR0112038A (https=)
CA (1) CA2413802A1 (https=)
CZ (1) CZ20024150A3 (https=)
EA (1) EA006483B1 (https=)
GE (1) GEP20053688B (https=)
HK (1) HK1052646A1 (https=)
HU (1) HUP0300798A3 (https=)
IL (1) IL152869A0 (https=)
IN (1) IN2003KO00001A (https=)
MX (1) MXPA02011913A (https=)
NO (1) NO20026195L (https=)
NZ (1) NZ523807A (https=)
PL (1) PL360027A1 (https=)
SK (1) SK18412002A3 (https=)
WO (1) WO2002002563A2 (https=)
ZA (1) ZA200300793B (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103360398A (zh) * 2013-07-22 2013-10-23 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
CN104395298A (zh) * 2012-06-22 2015-03-04 住友化学株式会社 稠合杂环化合物
TWI797604B (zh) * 2020-05-01 2023-04-01 美商基利科學股份有限公司 Cd73化合物
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途
US11919869B2 (en) 2021-10-29 2024-03-05 Gilead Sciences, Inc. CD73 compounds

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JPWO2004011467A1 (ja) * 2002-07-29 2005-12-15 北興化学工業株式会社 トリアゾロピリミジン誘導体および農園芸用殺菌剤
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SI1680425T1 (sl) * 2003-09-24 2007-04-30 Wyeth Corp 6-((substituirani)fenil)triazolopirimidini kot sredstva proti raku
ES2308256T3 (es) * 2003-09-24 2008-12-01 Wyeth Holdings Corporation 6-aril-7-halo-imidazo(1,2-a)pirimidinas como agentes anticancerosos.
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JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
JP2007514680A (ja) * 2003-12-17 2007-06-07 ビーエーエスエフ　アクチェンゲゼルシャフト ６−（２，４，６−トリハロフェニル）トリアゾロピリミジン、その製造方法、および植物病原性真菌類を防除するためのその使用、ならびにその物質を含有している農薬
CN1894254A (zh) * 2003-12-17 2007-01-10 巴斯福股份公司 用于防治病原性真菌的6－(2,3,6－三氟苯基)三唑并嘧啶
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WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
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WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP5231829B2 (ja) 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法
PT2188291E (pt) 2007-08-14 2012-12-20 Bayer Ip Gmbh Pirimidinas bicíclicas fundidas
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KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104395298A (zh) * 2012-06-22 2015-03-04 住友化学株式会社 稠合杂环化合物
CN103360398A (zh) * 2013-07-22 2013-10-23 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
TWI797604B (zh) * 2020-05-01 2023-04-01 美商基利科學股份有限公司 Cd73化合物
US12110294B2 (en) 2020-05-01 2024-10-08 Gilead Sciences, Inc. CD73 compounds
US11919869B2 (en) 2021-10-29 2024-03-05 Gilead Sciences, Inc. CD73 compounds
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

Also Published As

Publication number Publication date
SK18412002A3 (sk) 2003-06-03
BR0112038A (pt) 2003-04-01
AU2001273062B2 (en) 2005-11-24
JP2004502691A (ja) 2004-01-29
EA006483B1 (ru) 2005-12-29
EP1307200A2 (en) 2003-05-07
PL360027A1 (en) 2004-09-06
CZ20024150A3 (cs) 2003-09-17
NO20026195D0 (no) 2002-12-23
IL152869A0 (en) 2003-06-24
MXPA02011913A (es) 2003-04-22
NO20026195L (no) 2003-02-27
ZA200300793B (en) 2004-07-20
EA200300091A1 (ru) 2003-08-28
KR20030013475A (ko) 2003-02-14
HUP0300798A3 (en) 2006-02-28
HK1052646A1 (zh) 2003-09-26
US7329663B2 (en) 2008-02-12
WO2002002563A2 (en) 2002-01-10
IN2003KO00001A (https=) 2005-12-02
HUP0300798A2 (hu) 2003-07-28
NZ523807A (en) 2004-09-24
WO2002002563A3 (en) 2003-01-03
US20020068744A1 (en) 2002-06-06
CA2413802A1 (en) 2002-01-10
AR034553A1 (es) 2004-03-03
BG107277A (bg) 2004-01-30
GEP20053688B (en) 2005-12-12
AU7306201A (en) 2002-01-14

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