CN1554393A - Chinese medicine composition for treating cerebral infarction inacute stage and early recovering stage and preparing process - Google Patents
Chinese medicine composition for treating cerebral infarction inacute stage and early recovering stage and preparing process Download PDFInfo
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- CN1554393A CN1554393A CNA200310114532XA CN200310114532A CN1554393A CN 1554393 A CN1554393 A CN 1554393A CN A200310114532X A CNA200310114532X A CN A200310114532XA CN 200310114532 A CN200310114532 A CN 200310114532A CN 1554393 A CN1554393 A CN 1554393A
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- chinese medicine
- cerebral infarction
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- radix salviae
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- 239000003814 drug Substances 0.000 title claims abstract description 27
- 206010008118 cerebral infarction Diseases 0.000 title claims abstract description 15
- 208000026106 cerebrovascular disease Diseases 0.000 title claims abstract description 13
- 239000000203 mixture Substances 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 230000001154 acute effect Effects 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000341 volatile oil Substances 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 238000010992 reflux Methods 0.000 claims abstract description 6
- 229920002472 Starch Polymers 0.000 claims abstract description 5
- 230000006837 decompression Effects 0.000 claims abstract description 5
- 238000004821 distillation Methods 0.000 claims abstract description 5
- 238000000605 extraction Methods 0.000 claims abstract description 5
- 235000019698 starch Nutrition 0.000 claims abstract description 5
- 239000008107 starch Substances 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 238000005516 engineering process Methods 0.000 claims description 8
- 238000004064 recycling Methods 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 5
- 241000237903 Hirudo Species 0.000 claims description 5
- 239000009636 Huang Qi Substances 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims 2
- 239000012567 medical material Substances 0.000 claims 1
- 239000002893 slag Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 3
- 240000007164 Salvia officinalis Species 0.000 abstract 3
- 239000000463 material Substances 0.000 abstract 3
- 235000005412 red sage Nutrition 0.000 abstract 3
- 244000001632 Acorus gramineus Species 0.000 abstract 2
- 235000013073 Acorus gramineus Nutrition 0.000 abstract 2
- 206010004542 Bezoar Diseases 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 7
- 239000000706 filtrate Substances 0.000 description 6
- 206010008190 Cerebrovascular accident Diseases 0.000 description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 208000006011 Stroke Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 206010008132 Cerebral thrombosis Diseases 0.000 description 4
- 231100000862 numbness Toxicity 0.000 description 4
- 238000011084 recovery Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 201000006474 Brain Ischemia Diseases 0.000 description 2
- 206010008120 Cerebral ischaemia Diseases 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 206010048962 Brain oedema Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 102000005686 Serum Globulins Human genes 0.000 description 1
- 108010045362 Serum Globulins Proteins 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000036581 peripheral resistance Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The Chinese medicine composition for treating cerebral infarction in acute stage and early recovering stage is prepared with ten kinds of Chinese medicinal materials including red sage, Chuanxiong rhizome, grassleaved sweetflag rhizome, etc. The preparation process includes ethanol reflux extraction of partial of red sage material and decompression concentration to obtain dense paste of density 1.25-1.30 while recovering ethanol; water adding distillation of Chuanxiong rhizome and grassleaved sweetflag rhizome to obtain volatile oil and water solution; decoction of the dregs and other six materials to obtain decoction; merging water solution and decoction; adding ethanol to filter, concentration to obtain dense paste; mixing the two kinds of dense paste, red sage, artificial bezoar and starch; pelletizing, drying and spraying volatile oil. The present invention is used in treating cerebral infarction in acute stage and early recovering stage.
Description
One, technical field: the present invention relates to a kind of Chinese medicine new product, particularly a kind of treatment acute period of cerebral infarction, the early stage Chinese medicine composition of recovery and preparation technology.
Two, prior art: cerebral thrombosis is middle old man's commonly encountered diseases, and the sickness rate of China's apoplexy is 150-174/10 ten thousand people, and wherein ischemic cerebrovascular accounts for 2/3, and the ischemic cerebrovascular overwhelming majority is a cerebral infarction.Apoplexy is one of human three big causes of the death, also is the modal cause of disease that disables, and apoplexy brings very big burden to family and society, influences development of social productivity.Thereby the successive dynasties physician is all at the medicine of seeking to prevent and treat safely and effectively cerebral thrombosis.Though at present the Chinese and western drugs of treatment cerebral thrombosis is many, lacks even more ideal medicine, more lacks at acute stage and recover early stage medicine.
Three, summary of the invention: the present invention is a kind of treatment acute period of cerebral infarction, the early stage Chinese medicine composition of recovery and the preparation technology who proposes in conjunction with the modern pharmacology test according to prominent domestic old docter of TCM clinical application for many years practice.
Its technical scheme comprises the treatment acute period of cerebral infarction, recovers early stage Chinese medicine composition: comprise Rhizoma Chuanxiong, Herba Siegesbeckiae, Radix Salviae Miltiorrhizae, Hirudo, Rhizoma Gastrodiae, Flos Sophorae, Rhizoma Acori Graminei, artificial Calculus Bovis, the Radix Astragali, Radix Achyranthis Bidentatae.Preparation technology is: get that the part Radix Salviae Miltiorrhizae powder is broken into fine powder and artificial Calculus Bovis's fine powder is standby; Other gets the residue Radix Salviae Miltiorrhizae, adds the alcohol reflux secondary, and each 1.5 hours, merge extractive liquid, filtered, and decompression filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (50 ℃); Get Rhizoma Chuanxiong, that Rhizoma Acori Graminei adds water distillation and extraction volatile oil is standby, aqueous solution device is in addition collected; Six-elements such as medicinal residues and Radix Salviae Miltiorrhizae decoction dregs and all the other Herba Siegesbeckiae decoct with water three times, each 2 hours, collecting decoction filtered, filtrate and above-mentioned aqueous solution merge, being concentrated into relative density is 1.15-1.18 (50 ℃), adds ethanol, makes to contain the alcohol amount and reach 70%, placed 24 hours, filter, filtrate recycling ethanol, and be concentrated into the close relatively thick paste of 1.25-1.30 (50 ℃) that is; Mix with above-mentioned Radix Salviae Miltiorrhizae extractum, and add Radix Salviae Miltiorrhizae, artificial Calculus Bovis's fine powder and appropriate amount of starch, vacuum drying is pulverized, and mixing is granulated, and drying sprays into volatile oil, stirs evenly, and packing is granulated, promptly.
Function with cure mainly: promoting blood circulation to remove obstruction in the collateral relieves dizziness, high fever, infantile convulsions, epilepsy, etc. and reduces phlegm.Be used for acute period of cerebral infarction, recover early stage, belong to traditional Chinese medical science apoplex involving the channels and collaterals wind-phlegm blood stasis numbness resistance venation person, cure mainly hemiplegia, crooked mouth and tongue, hemianesthesia, the not smoothgoing plug of language etc.
The present invention can reduce cerebral edema and the cerebrovascular permeability due to the acute cerebral ischemia in rats, alleviate brain tissue impairment, decreased heart rate, bring high blood pressure down, cerebral vascular resistance and total peripheral resistance, prolong the artery thrombosis time, platelet aggregation rate is reduced, the depolymerization rate increases, shorten euglobulin lysis time, prolong thrombin, thrombinogen and KPTT, and can improve hemorheology of blood stasis rat.The above-mentioned edema pathological changes of organizing when alleviating cerebral ischemia suppresses thrombosis, promotes thromboclastic pharmacological action, is the basis of QI and blood regulating, blood circulation promoting and blood stasis dispelling, calming wind and dredging collateral treatment apoplexy.
The present invention by in Heilongjiang University of Chinese Medicine clinical pharmacology base, attached first hospital of Heilongjiang University of Chinese Medicine, Attached Hospital, Changchun Chinese Medicinal College, the clinical hospital in Provincial Medicine Research Institute, Jilin, Jilin Renmin Hospital, Changchun, Jilin Province institute of traditional Chinese medicine carry out clinical trial to the cerebral thrombus patient of 420 routine wind-phlegm blood stasis, numbness resistance venation card, find that it is to treatment apoplexy (cerebral thrombosis), recover early stage wind-phlegm blood stasis numbness resistance venation card, clinical total effective rate 90%, and can obviously improve wind-phlegm blood stasis numbness resistance venation card syndrome, improve hemorheology, blood viscosity lowering.To routine blood test, routine urinalysis, just routine, liver function, kidney merit, electrocardiogram have no adverse effects, and also do not send out untoward reaction, and clinical value is arranged, be worthy of popularization.
Attached: the clinical hospital in (1) Provincial Medicine Research Institute, Jilin to 60 routine cerebral thrombus patients take respectively this medicine with
The total effects controlled trial of contrast medicine:
Group example digital display is imitated the enabledisable total effective rate that is almost recovered
((((example/%) (%) of example/%) of example/%) of example/%)
Test group 30 13/43.3 11/36.7 3,/10 3/10% 90
Matched group 30 8/26.7 1,7/5 6.7 5/16.7 0 83.33
(2) Jilin Renmin Hospital takes this medicine and the total effects controlled trial that contrasts medicine respectively to 90 routine cerebral thrombus patients:
Group example digital display is imitated the enabledisable total effective rate (%) that is almost recovered
Test group 60 26 24 64 90
Matched group 30 8 14 71 76.67
Four, description of drawings: do not have
Five, embodiment:
The following weight ratio example is 0.825: 0.825: 0.825 in proportion: 0.275: 0.825: 0.55: 0.55: 0.0275: 1: 0.55 gets Rhizoma Chuanxiong, Herba Siegesbeckiae, Radix Salviae Miltiorrhizae, Hirudo, Rhizoma Gastrodiae, Flos Sophorae, Rhizoma Acori Graminei, artificial Calculus Bovis, the Radix Astragali, Radix Achyranthis Bidentatae respectively.
Preparation technology is 1, above ten flavors, gets that Radix Salviae Miltiorrhizae 69.7% is ground into fine powder and artificial Calculus Bovis's fine powder is standby; Other gets residue Radix Salviae Miltiorrhizae 30.3%, adds the alcohol reflux secondary, and each 1.5 hours, merge extractive liquid, filtered, and decompression filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (50 ℃); 2, Rhizoma Chuanxiong, Rhizoma Acori Graminei add water distillation and extraction volatile oil, and it is standby to collect volatile oil, and aqueous solution device is in addition collected; Last medicinal residues and Radix Salviae Miltiorrhizae decoction dregs and all the other Six-elements decoct with water three times, and each 2 hours, collecting decoction filtered, and filtrate and above-mentioned aqueous solution merge, and being concentrated into relative density is 1.15-1.18 (50 ℃); In above-mentioned concentrated solution, add as ethanol.Make pure content reach 70%, placed 24 hours, filter, filtrate recycling ethanol, and be concentrated into the close relatively thick paste of 1.25-1.30 (50 ℃) that is; 3, the gained thick paste is mixed with the thick paste of gained Radix Salviae Miltiorrhizae described in (1), and add Radix Salviae Miltiorrhizae, artificial Calculus Bovis's fine powder and appropriate amount of starch, vacuum drying is pulverized, and mixing is granulated, and drying sprays into volatile oil, stirs evenly, and fine grained is made in packing, promptly.
Claims (4)
1, a kind of treatment acute period of cerebral infarction, recover early stage Chinese medicine composition, it is characterized in that: the shared weight ratio of each component is: Rhizoma Chuanxiong 12%-14%, Herba Siegesbeckiae 12%-14%, Radix Salviae Miltiorrhizae 12%-14%, Hirudo 3%-5%, Rhizoma Gastrodiae 12%-14%, Flos Sophorae 7%-9%, Rhizoma Acori Graminei 7%-9%, artificial Calculus Bovis 0.3%-0.5%, Radix Astragali 15%-17%, Radix Achyranthis Bidentatae 7%-9%.
2, according to claims 1 described treatment acute period of cerebral infarction, recover the preparation technology of early stage Chinese medicine composition, it is characterized in that: (1) gets the part Radix Salviae Miltiorrhizae, add the alcohol reflux medicinal liquid, the filtered liquid medicine decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 under 50 ℃ temperature conditions; (2) get Rhizoma Chuanxiong, that Rhizoma Acori Graminei adds water distillation and extraction volatile oil is standby, aqueous solution device is in addition collected; (3) medicinal residues in above-mentioned (1) and (2) and Herba Siegesbeckiae, Hirudo, Rhizoma Gastrodiae, Flos Sophorae, the Radix Astragali, Radix Achyranthis Bidentatae Six-element are decocted with water, the aqueous solution that decocting liquid filters back and above-mentioned (2) merges, after being concentrated into relative density under the condition of 50 ℃ of temperature and being 1.15-1.18, add ethanol, make and contain alcohol amount and reach 70%, placed 24 hours, filtered and recycled ethanol, and be concentrated into the close relatively thick paste of 1.25-1.30 that is under the condition of 50 ℃ of temperature; (4) Radix Salviae Miltiorrhizae extractum with above-mentioned (1) mixes, and adds Radix Salviae Miltiorrhizae, artificial Calculus Bovis's fine powder and appropriate amount of starch, be in harmonious proportion, dry, pulverize after, spray into the volatile oil that extracts in (2), make fine grained.
3, according to claims 2 described treatment acute period of cerebral infarction, recover the preparation technology of early stage Chinese medicine composition, it is characterized in that: get whole Radix Salviae Miltiorrhizaes, add the alcohol reflux medicinal liquid, the filtered liquid medicine decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 under 50 ℃ temperature conditions; (2) get Rhizoma Chuanxiong, that Rhizoma Acori Graminei adds water distillation and extraction volatile oil is standby, aqueous solution device is in addition collected; (3) medicinal residues in above-mentioned (1) and (2) and Herba Siegesbeckiae, Hirudo, Rhizoma Gastrodiae, Flos Sophorae, the Radix Astragali, Radix Achyranthis Bidentatae Six-element are decocted with water, the aqueous solution that decocting liquid filters back and above-mentioned (2) merges, after being concentrated into relative density under the condition of 50 ℃ of temperature and being 1.15-1.18, add ethanol, make and contain alcohol amount and reach 70%, placed 24 hours, filtered and recycled ethanol, and be concentrated into the close relatively thick paste of 1.25-1.30 that is under the condition of 50 ℃ of temperature; (4) Radix Salviae Miltiorrhizae extractum with above-mentioned (1) mixes, and adds Radix Salviae Miltiorrhizae, artificial Calculus Bovis's fine powder and appropriate amount of starch, be in harmonious proportion, dry, pulverize after, spray into the volatile oil that extracts in (2), make fine grained.
4, according to claim 2 or 3 described treatment acute period of cerebral infarction, recover the preparation technology of early stage Chinese medicine composition, it is characterized in that: flow process adds the alcohol reflux secondary in (1), each 1.5 hours, merge extractive liquid; Flow process (3) Chinese medicine slag and Six-element medical material thereof decoct with water three times, and each 2 hours, collecting decoction.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200310114532XA CN1291744C (en) | 2003-12-23 | 2003-12-23 | Chinese medicine composition for treating cerebral infarction inacute stage and early recovering stage and preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200310114532XA CN1291744C (en) | 2003-12-23 | 2003-12-23 | Chinese medicine composition for treating cerebral infarction inacute stage and early recovering stage and preparing process |
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| Publication Number | Publication Date |
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| CN1554393A true CN1554393A (en) | 2004-12-15 |
| CN1291744C CN1291744C (en) | 2006-12-27 |
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| CNB200310114532XA Expired - Lifetime CN1291744C (en) | 2003-12-23 | 2003-12-23 | Chinese medicine composition for treating cerebral infarction inacute stage and early recovering stage and preparing process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100346857C (en) * | 2005-12-01 | 2007-11-07 | 谭登平 | Method for quickening filter of starch type traditional Chinese medicine extracting solution |
| CN102441125A (en) * | 2011-11-30 | 2012-05-09 | 宋爱民 | Traditional Chinese medicine preparation for treating cerebral apoplexy sequelae |
| CN103083559A (en) * | 2013-01-10 | 2013-05-08 | 山东凤凰制药股份有限公司 | Novel preparation method and application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage |
| CN103083558A (en) * | 2013-01-10 | 2013-05-08 | 山东凤凰制药股份有限公司 | Novel application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage |
-
2003
- 2003-12-23 CN CNB200310114532XA patent/CN1291744C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100346857C (en) * | 2005-12-01 | 2007-11-07 | 谭登平 | Method for quickening filter of starch type traditional Chinese medicine extracting solution |
| CN102441125A (en) * | 2011-11-30 | 2012-05-09 | 宋爱民 | Traditional Chinese medicine preparation for treating cerebral apoplexy sequelae |
| CN102441125B (en) * | 2011-11-30 | 2014-01-15 | 宋爱民 | Traditional Chinese medicine preparation for treating cerebral apoplexy sequelae |
| CN103083559A (en) * | 2013-01-10 | 2013-05-08 | 山东凤凰制药股份有限公司 | Novel preparation method and application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage |
| CN103083558A (en) * | 2013-01-10 | 2013-05-08 | 山东凤凰制药股份有限公司 | Novel application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage |
| CN103083558B (en) * | 2013-01-10 | 2015-07-22 | 山东凤凰制药股份有限公司 | Novel application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage |
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| Publication number | Publication date |
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| CN1291744C (en) | 2006-12-27 |
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