CN1131050C - Medicinal particles for treating diabetic peripheral neuropathy - Google Patents
Medicinal particles for treating diabetic peripheral neuropathy Download PDFInfo
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- CN1131050C CN1131050C CN 01106342 CN01106342A CN1131050C CN 1131050 C CN1131050 C CN 1131050C CN 01106342 CN01106342 CN 01106342 CN 01106342 A CN01106342 A CN 01106342A CN 1131050 C CN1131050 C CN 1131050C
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Abstract
The present invention relates to granules for treating diabetic peripheral neuropathy. Notoginseng is pulverized into a fine powder, and corydalis tuber is refluxed and extracted by adding ethanol; extracts are refluxed, extracted and combined by adding solvent so as to be concentrated into an extractum by pressure reduction, and red sage root is refluxed and filtered by adding ethanol; the ethanol is recycled, and the red sage root is concentrated into an extractum; dregs of decoction are refluxed and filtered by adding ethanol, and are decocted by adding water, and filtrates at the second time and the third time are combined to recycle the ethanol so as to be concentrated into an extractum by pressure reduction; astragalus, red peony root, chuanxiong rhizome, suberect spatholobus, sappanwood and safflower are decocted by adding water, and are filtered, and filtrates are combined and concentrated into an extractum by pressure reduction; the extractums are combined and evenly mixed with the notoginseng fine powder so as to be dried into a fine powder by pressure reduction, and dextrin is added; after being evenly mixed, the fine powder and the dextrin are granulated and dried by 85% ethanol so as to obtain the granules. When used for treating symptoms such as limb needling pain, scorching pain, numb pain, etc. appearing in diabetic peripheral neuropathy, the drug has a total effective rate of 96.6% and an effective rate of 50%, and has the advantages of safety, no toxic or side effect, and long-term and stable curative effect.
Description
The present invention relates to a kind of granule for the treatment of diabetic peripheral neuropathy, and have the effect of invigorating blood circulation and pressing down disease.
Diabetic peripheral neuropathy is one of diabetes modal three big chronic complicating diseases, and its sickness rate can reach 90% with the prolongation of the course of disease, has become the main cause that causes the diabetics disability.This disease mainly shows as distal limbs and torso portion numb pain and sensory disturbance, its pain characteristics be the acupuncture sample or burn sample, the sample that lancinates, very person pain to attach most importance to night, has had a strong impact on patient's orthobiosis especially as amputation.Along with the carrying out of electric physiological detection technology, this sick early detective rate increases greatly in recent years.Pathogenesis about primary disease is unclear fully as yet, thinks at present mainly to cause that with diabetic supersession the opening and the perineural microangiopathies of polyhydric alcohol (mainly being sorbitol, inositol) metabolic bypass are relevant, and original vitamin theory gets the brush-off.Cause the degeneration of neural axis to be dwindled and the Schwann cell edema and the nerve segment demyelination that occur subsequently for above-mentioned reasons, and then cause the degeneration necrosis of neurocyte.Treatment at primary disease has been considered to the clinical a great problem of present endocrine, the common drug of treatment primary disease has opioid analgesics (dolantin, lignocaine etc.) both at home and abroad, tranquilizer (dilantin etc.), antidepressant (imipramine etc.), and aldose reductase inhibitor (ARI) etc., be the product of symptomatic treatment, curative effect is undesirable takes in addition for a long time, be difficult to avoid such as toxic and side effects such as orthostatic hypotension, respiratory arrest, easy addiction, most scholars have now advocated the continuation application of these medicines of absolute limitations.Aldose reductase inhibitor (ARI) once was considered to cause the treatment effect by suppressing opening of polyhydric alcohol metabolic bypass abroad, but curative effect is excessive in yet clinical as yet by generally acknowledged, domestic also still untapped application.
The purpose of this invention is to provide a kind of new granule that utilizes the Chinese medicine diabetic peripheral neuropathy safely and effectively.
For achieving the above object, technical scheme of the present invention is: a kind of granule for the treatment of diabetic peripheral neuropathy, make by weight percentage by following raw materials according:
The Radix Astragali 10.2% Rhizoma Corydalis (processed with vinegar) 20.4% Radix Notoginseng 8.2%
Radix Paeoniae Rubra 12.2% Radix Salviae Miltiorrhizae 10.2% Rhizoma Chuanxiong 10.2%
Flos Carthami 10.2% Lignum Sappan 8.2% Caulis Spatholobi 10.2%
Its manufacture method is: above nine flavors, and Radix Notoginseng powder is broken into fine powder; Rhizoma Corydalis adds 70% alcohol reflux three times, adds the solvent amount and is respectively 4 times, 4 times, 2 times, and reflux extracting time is 3 hours, 2 hours, 1 hour, and merge extractive liquid, reclaims ethanol, and the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35; Get Radix Salviae Miltiorrhizae and add 6 times of amounts of ethanol, refluxed 1.5 hours, filter, reclaim ethanol, the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35, and medicinal residues add 6 times of amounts of 50% ethanol, refluxes 1.5 hours, filter, medicinal residues add 8 times of amounts of water, decoct 2 hours, merge second and third time filtrate, reclaim ethanol, the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35; Getting the Radix Astragali, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Caulis Spatholobi, Lignum Sappan, Flos Carthami decocts with water 3 times, amount of water is followed successively by 8 times, 6 times, 4 times, and decocting time was followed successively by 2 hours .2 hour, 1 hour, filters, merging filtrate, the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35, merges above-mentioned extractum and Radix Notoginseng fine powder mixing, drying under reduced pressure, powder becomes fine powder, add an amount of dextrin, use 85% alcohol granulation behind the mixing, be drying to obtain.
The present invention shows through clinical, to limbs acupuncture sample pain that diabetic peripheral neuropathy showed, burn symptoms such as sample pain or numb sample pain, total effective rate is 96.6%, obvious effective rate 50%, for the treatment of primary disease provides new active drug, and safe without toxic side effect, late result is stable.
Function of the present invention cures mainly: benefiting QI for activating blood circulation, promoting tissue regeneration by removing blood stasis, removing obstruction in the collateral to relieve pain.Medicine " the sugar end is peaceful " by name.Wherein the principal agent Radix Astragali is classical QI invigorating key medicine, sweet in the mouth, and tepor is got blood circulation depending on qi flow in the side, the meaning of the prosperous blood life of gas.Because at diabetes with the passing of time primary disease be, under the pathomechanism of blood stasis due to qi deficiency, form, so the meaning of getting its replenishing qi and promoting blood flow with this medicine is principal agent in the side.Rhizoma Corydalis is worked hard, tepor, function: promoting blood circulation to remove blood stasis, and regulating QI to relieve pain, the stagnation of QI in the energy promoting the circulation of blood, stasis in the gas is gone up the purgation pain all over the body so specially control, can be warm in nature freely in the QI and blood energy of manageing it with it, be principal agent in the side.Radix Notoginseng, sweet and slightly bitter taste, the property suffering is nontoxic, promoting blood circulation to remove blood stasis, pain relieving more can method stasis of blood tissue regeneration promoting, is principal agent in the side.Accessory drugs is a Rhizoma Chuanxiong, and the hot temperature of property is gas medicine in the blood, blood circulation promoting and blood stasis dispelling, and removing obstruction in the collateral to relieve pain, auxiliary principal agent is strengthened the merit of promoting blood circulation, dredging meridian and relieving pain.Radix Salviae Miltiorrhizae, the bitter tepor of property is the key medicine of blood circulation promoting and blood stasis dispelling, auxiliary principal agent promoting tissue regeneration by removing blood stasis in the side, removing obstruction in the collateral to relieve pain.Radix Paeoniae Rubra is auxiliary principal agent promoting blood circulation, dredging meridian and relieving pain in the side.Flos Carthami, Lignum Sappan, Caulis Spatholobi, equal tool blood circulation promoting and blood stasis dispelling, the merit of removing obstruction in the collateral to relieve pain, with the more clinical experience approval of Lignum Sappan, Flos Carthami, three medicines are adjuvant drug altogether, play the blood circulation promoting and blood stasis dispelling tissue regeneration promoting in the side, the merit of removing obstruction in the collateral to relieve pain especially.
The clinical basic pathogenesis of diabetes shows as scorching impairment of YIN, and the cloudy QI consumed of decreasing causes deficiency of both QI and YIN.The deficiency of vital energy blood vessels stasis of blood stagnates, and venation is obstructed, and stagnation of QI and blood may bring about pain has constituted the key link of diabetic peripheral neuropathy basic pathogenesis, and result of study in recent years shows that obstruction of collaterals by blood stasis is to run through diabetes and complication important pathogenesis all the time thereof.The present invention's prescription is with benefiting QI for activating blood circulation, and promoting tissue regeneration by removing blood stasis, removing obstruction in the collateral to relieve pain are the principles of formulating prescriptions, as principal agent, gets its benefiting QI for activating blood circulation, blood circulation depending on qi flow, the meaning of promoting tissue regeneration by removing blood stasis with the Radix Astragali, Rhizoma Corydalis, Radix Notoginseng.As accessory drugs, with blood circulation promoting and blood stasis dispelling, stagnating assisted the merit of principal agent in the promoting the circulation of blood with Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra.Product with Flos Carthami, Lignum Sappan, Caulis Spatholobi promoting blood circulation, dredging meridian and relieving pain are adjuvant drug altogether, play blood circulation promoting and blood stasis dispelling tissue regeneration promoting, the merit of removing obstruction in the collateral to relieve pain in the side altogether.
Embodiment 1
A kind of granule for the treatment of diabetic peripheral neuropathy is made by weight percentage by following raw materials according: (is unit with the gram)
The Radix Astragali 312 Rhizoma Corydalis (processed with vinegar) 625 Radix Notoginseng 250
Radix Paeoniae Rubra 375 Radix Salviae Miltiorrhizaes 312 Rhizoma Chuanxiongs 312
Flos Carthami 312 Lignum Sappans 250 Caulis Spatholobis 312
Its manufacture method is: above nine flavors, and Radix Notoginseng powder is broken into fine powder; Rhizoma Corydalis adds 70% alcohol reflux three times, adds the solvent amount and is respectively 4 times, 4 times, 2 times, and reflux extracting time is 3 hours, 2 hours, 1 hour, and merge extractive liquid, reclaims ethanol, and the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35; Get Radix Salviae Miltiorrhizae and add 6 times of amounts of ethanol, refluxed 1.5 hours, filter, reclaim ethanol, the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35, and medicinal residues add 6 times of amounts of 50% ethanol, refluxes 1.5 hours, filter, medicinal residues add 8 times of amounts of water, decoct 2 hours, merge second and third time filtrate, reclaim ethanol, the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35; Get the Radix Astragali, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Caulis Spatholobi, Lignum Sappan, Flos Carthami and decoct with water 3 times, amount of water is followed successively by 8 times, 6 times, 4 times, and decocting time was followed successively by 2 hours, 2 hours, 1 hour, filter, merging filtrate, the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35, merges above-mentioned extractum and Radix Notoginseng fine powder mixing, drying under reduced pressure, powder becomes fine powder, adds an amount of dextrin, uses 85% alcohol granulation behind the mixing, be drying to obtain, make 1000 grams altogether.
Claims (2)
1, a kind of granule for the treatment of diabetic peripheral neuropathy is characterized in that it is made by following weight percentages:
The Radix Astragali 10.2% Rhizoma Corydalis (processed with vinegar) 20.4% Radix Notoginseng 8.2%
Radix Paeoniae Rubra 12.2% Radix Salviae Miltiorrhizae 10.2% Rhizoma Chuanxiong 10.2%
Flos Carthami 10.2% Lignum Sappan 8.2% Caulis Spatholobi 10.2%.
2, the particulate preparation method of the described treatment diabetic peripheral neuropathy of a kind of claim 1 is characterized in that above nine flavors, and Radix Notoginseng powder is broken into fine powder; Rhizoma Corydalis adds 70% alcohol reflux three times, adds the solvent amount and is respectively 4 times, 4 times, 2 times, and reflux extracting time is 3 hours, 2 hours, 1 hour, and merge extractive liquid, reclaims ethanol, and the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35; Get Radix Salviae Miltiorrhizae and add 6 times of amounts of ethanol, refluxed 1.5 hours, filter, reclaim ethanol, the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35, and medicinal residues add 6 times of amounts of 50% ethanol, refluxes 1.5 hours, filter, medicinal residues add 8 times of amounts of water, decoct 2 hours, merge second and third time filtrate, reclaim ethanol, the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35; Getting the Radix Astragali, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Caulis Spatholobi, Lignum Sappan, Flos Carthami decocts with water 3 times, amount of water is followed successively by 8 times, 6 times, 4 times, and decocting time was followed successively by 2 hours, 2 hours, 1 hour, filters, merging filtrate, the density that is evaporated under relative 60 ℃ is the extractum of 1.30-1.35, merges above-mentioned extractum and Radix Notoginseng fine powder mixing, drying under reduced pressure, powder becomes fine powder, add an amount of dextrin, use 85% alcohol granulation behind the mixing, be drying to obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01106342 CN1131050C (en) | 2001-03-22 | 2001-03-22 | Medicinal particles for treating diabetic peripheral neuropathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01106342 CN1131050C (en) | 2001-03-22 | 2001-03-22 | Medicinal particles for treating diabetic peripheral neuropathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1313119A CN1313119A (en) | 2001-09-19 |
| CN1131050C true CN1131050C (en) | 2003-12-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01106342 Expired - Lifetime CN1131050C (en) | 2001-03-22 | 2001-03-22 | Medicinal particles for treating diabetic peripheral neuropathy |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647855B (en) * | 2008-08-13 | 2011-11-30 | 贵阳中医学院 | Traditional Chinese medicine preparation for treating diabetic neuropathy and preparation method thereof |
| CN101972316B (en) * | 2010-09-29 | 2012-09-05 | 辽宁奥达制药有限公司 | Traditional Chinese medicinal composition, use of traditional Chinese medicinal preparation |
| CN101972315B (en) * | 2010-09-29 | 2012-09-05 | 辽宁奥达制药有限公司 | Use of traditional Chinese medicinal composition |
| CN102512518B (en) * | 2012-01-05 | 2013-12-04 | 首都医科大学 | Chinese medicinal extract for treating diabetic peripheral neuropathy and preparation method thereof |
| CN102652768A (en) * | 2012-04-11 | 2012-09-05 | 南京同仁堂药业有限责任公司 | Medicinal composition for relaxing tendons, activating collaterals, promoting blood circulation and removing blood stasis |
| CN108057077A (en) * | 2018-02-09 | 2018-05-22 | 马飞 | Treat Chinese medicine composition of diabete peripheral herve pathology and preparation method thereof |
| CN111671795B (en) * | 2020-07-06 | 2021-11-09 | 西安交通大学医学院第一附属医院 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy, traditional Chinese medicine preparation and application |
-
2001
- 2001-03-22 CN CN 01106342 patent/CN1131050C/en not_active Expired - Lifetime
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| CN1313119A (en) | 2001-09-19 |
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| C10 | Entry into substantive examination | ||
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
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Owner name: LIAONING AODA PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: YINGKOU AODA PHARMACEUTICAL CO.,LTD |
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| CP03 | Change of name, title or address |
Address after: Lunan hi tech Industrial Development Zone, Liaoning, Yingkou Patentee after: Liaoning Aoda Pharmaceutical Co., Ltd. Address before: Cui Jia 68, old border area, Yingkou, Liaoning Patentee before: Yingkou Aoda Pharmacy Co., Ltd. |
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Granted publication date: 20031217 |